Monika Žilková
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View article: Impact of immunodeficiencies on immunity induced by SARS-CoV-2 infection, mRNA BNT162b2 vaccination, and their combination in children and young adults
Impact of immunodeficiencies on immunity induced by SARS-CoV-2 infection, mRNA BNT162b2 vaccination, and their combination in children and young adults Open
Current understanding of how immunodeficiencies impact protective responses against viral infections and vaccination is primarily derived from adult cohorts that may not accurately reflect the pediatric, adolescent, and young adult populat…
View article: Truncated tau modulates neuron-glia signaling through CX3CL1-CX3CR1 and CD47-SIRP-α pathways.
Truncated tau modulates neuron-glia signaling through CX3CL1-CX3CR1 and CD47-SIRP-α pathways. Open
Tauopathies encompass a group of disorders characterized by abnormal accumulation of tau protein into neurofibbrilary pathology and neuroinflammation. Understanding how glial cells interact with neurons is important to unraveling the compl…
View article: dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments
dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments Open
The microtubule‐associated protein tau forms disease‐specific filamentous aggregates in several different neurodegenerative diseases. In order to understand how tau undergoes misfolding into a specific filament type and to control this pro…
View article: dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments
dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments Open
The microtubule‐associated protein tau forms disease‐specific filamentous aggregates in several different neurodegenerative diseases. In order to understand how tau undergoes misfolding into a specific filament type and to control this pro…
View article: Angiotensin I and II Stimulate Cell Invasion of SARS-CoV-2: Potential Mechanism via Inhibition of ACE2 Arm of RAS
Angiotensin I and II Stimulate Cell Invasion of SARS-CoV-2: Potential Mechanism via Inhibition of ACE2 Arm of RAS Open
Angiotensin-converting enzyme 2 (ACE2), one of the key enzymes of the renin-angiotensin system (RAS), plays an important role in SARS-CoV-2 infection by functioning as a virus receptor. Angiotensin peptides Ang I and Ang II, the substrates…
View article: Astrocytes express aberrant immunoglobulinsas putative gatekeeper of astrocytes to neuronal progenitor conversion
Astrocytes express aberrant immunoglobulinsas putative gatekeeper of astrocytes to neuronal progenitor conversion Open
Using multi-omics analyses including RNAseq, RT-PCR, RACE-PCR, and shotgun proteomic with enrichment strategies, we demonstrated that newborn rat astrocytes produce neural immunoglobulin constant and variable heavy chains as well as light …
View article: dGAE(297-391) tau fragment promotes formation of CTE-like full-length tau filaments
dGAE(297-391) tau fragment promotes formation of CTE-like full-length tau filaments Open
The microtubule-associated protein tau forms disease-specific filamentous aggregates in several different neurodegenerative diseases. In order to understand how tau undergoes misfolding into a specific filament type and to control this pro…
View article: The engagement of microglia in tau-targeted immunotherapy in Alzheimer’s disease
The engagement of microglia in tau-targeted immunotherapy in Alzheimer’s disease Open
Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by progressive memory decline, histopathological lesions such as amyloid β plaques and neurofibrillary tangles, and neuroinflammation driven by glial cells.…
View article: Impact of mesenchymal stem cells derived conditioned media on neural progenitor cells
Impact of mesenchymal stem cells derived conditioned media on neural progenitor cells Open
Neurodegenerative diseases are common problem for companion animals. Due to the limited ability of injured axons to regenerate, innovative therapies combined with rehabilitation have been applied and evaluated. Among them, stem cells and t…
View article: Location of neonatal microglia drives small extracellular vesicles content and biological functions <i>in vitro</i>
Location of neonatal microglia drives small extracellular vesicles content and biological functions <i>in vitro</i> Open
Combining proteomics and systems biology approaches, we demonstrate that neonatal microglial cells derived from two different CNS locations, cortex and spinal cord, and cultured in vitro displayed different phenotypes upon different physio…
View article: AADvac1, an Active Immunotherapy for Alzheimer's Disease and Non Alzheimer Tauopathies: An Overview of Preclinical and Clinical Development
AADvac1, an Active Immunotherapy for Alzheimer's Disease and Non Alzheimer Tauopathies: An Overview of Preclinical and Clinical Development Open
Neurofibrillary tau protein pathology is closely associated with the progression and phenotype of cognitive decline in Alzheimer's disease and other tauopathies, and a high-priority target for disease-modifying therapies. Herein, we provid…