Monique Bastidas
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View article: B-273 Therapeutic Drug Monitoring (TDM) Assays to Quantify Risankizumab Drug and Anti-Risankizumab Antibodies in Individuals Treated with IL23 Inhibitor Risankizumab for Chronic Autoimmune Diseases
B-273 Therapeutic Drug Monitoring (TDM) Assays to Quantify Risankizumab Drug and Anti-Risankizumab Antibodies in Individuals Treated with IL23 Inhibitor Risankizumab for Chronic Autoimmune Diseases Open
Background Risankizumab (RSK) (Skyrizi®), a humanized monoclonal antibody against the p19 subunit of interleukin 23 (IL23), is used to treat Crohn’s disease (CD), ulcerative colitis (UC), plaque psoriasis (PsO), and psoriatic arthritis (Ps…
View article: Factors Affecting Initial Humoral Immune Response to SARS-CoV-2 Vaccines Among Patients With Inflammatory Bowel Diseases
Factors Affecting Initial Humoral Immune Response to SARS-CoV-2 Vaccines Among Patients With Inflammatory Bowel Diseases Open
INTRODUCTION: Although an additional coronavirus disease 2019 vaccine dose for immunocompromised persons has been recommended in some countries, further data to guide vaccination strategies for patients with inflammatory bowel disease (IBD…
View article: Long-Term Effectiveness and Durability of COVID-19 Vaccination among Patients with Inflammatory Bowel Disease
Long-Term Effectiveness and Durability of COVID-19 Vaccination among Patients with Inflammatory Bowel Disease Open
Background and Aims COVID-19 vaccination prevents severe disease in most patients with IBD, but immunosuppressive medications can blunt serologic response. We followed adults with IBD for >1-year post-COVID-19 vaccination to describe facto…
View article: Durable Immune Response and Long-term Efficacy of COVID-19 Vaccination in Children With Inflammatory Bowel Disease
Durable Immune Response and Long-term Efficacy of COVID-19 Vaccination in Children With Inflammatory Bowel Disease Open
Background Children with inflammatory bowel disease (IBD) may have diminished serologic response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and increased risk for subsequent severe coronavirus disease 2019 …
View article: Humoral immune response and safety of SARS‐CoV‐2 vaccination in very early onset inflammatory bowel disease
Humoral immune response and safety of SARS‐CoV‐2 vaccination in very early onset inflammatory bowel disease Open
Children with very early onset inflammatory bowel disease (VEO‐IBD) may respond differently to coronavirus disease 2019 (COVID‐19) immunization compared to healthy children or other patients with IBD. We recruited children with VEO‐IBD <6 …
View article: Sox2- <i>Evf2</i> lncRNA-mediated mechanisms of chromosome topological control in developing forebrain
Sox2- <i>Evf2</i> lncRNA-mediated mechanisms of chromosome topological control in developing forebrain Open
The Evf2 long non-coding RNA directs Dlx5/6 ultraconserved enhancer(UCE)-intrachromosomal interactions, regulating genes across a 27 Mb region on chromosome 6 in mouse developing forebrain. Here, we show that Evf2 long-range gene repressio…
View article: Sox2-RNA mechanisms of chromosome topological control in developing forebrain
Sox2-RNA mechanisms of chromosome topological control in developing forebrain Open
Summary Precise regulation of gene expression networks requires the selective targeting of DNA enhancers. The Evf2 long non-coding RNA regulates Dlx5/6 ultraconserved enhancer (UCE) interactions with long-range target genes, controlling ge…
View article: Solution Ensemble of the C-Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer
Solution Ensemble of the C-Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer Open
The pancreatic and duodenal homeobox 1 (Pdx1) is an essential pancreatic transcription factor. The C-terminal intrinsically disordered domain of Pdx1 (Pdx1-C) has a heavily biased amino acid composition; most notably, 18 of 83 residues are…