Mony Chenda Morisse
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View article: Isatuximab-pomalidomide-dexamethasone <i>versus</i> pomalidomide-dexamethasone in patients with relapsed and refractory multiple myeloma: final overall survival analysis
Isatuximab-pomalidomide-dexamethasone <i>versus</i> pomalidomide-dexamethasone in patients with relapsed and refractory multiple myeloma: final overall survival analysis Open
The primary and pre-specified updated analyses of ICARIA-MM (NCT02990338) demonstrated improved progression-free survival and a benefit in overall survival (OS) was reported with the addition of isatuximab, an anti-CD38 monoclonal antibody…
View article: Immune Microenvironment and Lineage Tracing Help to Decipher Rosette-Forming Glioneuronal Tumors: A Multi-Omics Analysis
Immune Microenvironment and Lineage Tracing Help to Decipher Rosette-Forming Glioneuronal Tumors: A Multi-Omics Analysis Open
Rosette-forming glioneuronal tumors (RGNT) are rare low-grade primary central nervous system (CNS) tumors. The methylation class (MC) RGNT (MC-RGNT) delineates RGNT from other neurocytic CNS tumors with similar histological features. We pe…
View article: EFFICACY AND SAFETY OF TISAGENLECLEUCEL (TISA‐CEL) IN ADULT PATIENTS (PTS) WITH RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA (R/R FL): PRIMARY ANALYSIS OF THE PHASE 2 ELARA TRIAL
EFFICACY AND SAFETY OF TISAGENLECLEUCEL (TISA‐CEL) IN ADULT PATIENTS (PTS) WITH RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA (R/R FL): PRIMARY ANALYSIS OF THE PHASE 2 ELARA TRIAL Open
Peer Reviewed
View article: ERK1/2 signaling regulates the immune microenvironment and macrophage recruitment in glioblastoma
ERK1/2 signaling regulates the immune microenvironment and macrophage recruitment in glioblastoma Open
The tumor microenvironment is an important determinant of glioblastoma (GBM) progression and response to treatment. How oncogenic signaling in GBM cells modulates the composition of the tumor microenvironment and its activation is unclear.…
View article: P14.125 Retrospective analysis of long-term response to bevacizumab in combination with irinotecan for recurrent glioblastoma: identification of prognostic factors
P14.125 Retrospective analysis of long-term response to bevacizumab in combination with irinotecan for recurrent glioblastoma: identification of prognostic factors Open
BACKGROUND In absence of standard treatment for recurrent glioblastoma (rGBM), numerous prospective and retrospective studies have evaluated the off-label combination of bevacizumab (BEV) with irinotecan (IRI) in patients with rGBM. We rep…
View article: Corrigendum: Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability
Corrigendum: Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability Open
View article: Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability
Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability Open
In cells lacking telomerase, telomeres gradually shorten during each cell division to reach a critically short length, permanently activate the DNA damage checkpoint, and trigger replicative senescence. The increase in genome instability t…
View article: Combining genomic analyses with tumour-derived slice cultures for the characterization of an EGFR-activating kinase mutation in a case of glioblastoma
Combining genomic analyses with tumour-derived slice cultures for the characterization of an EGFR-activating kinase mutation in a case of glioblastoma Open
Our results highlight (i) the value of comprehensive genomic analyses for identifying patient-specific, targetable alterations, and (ii) the need to combine genomic analyses with functional assays, such as tumour-derived slice cultures.
View article: Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours
Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours Open
Our findings point to potential interest of SERPINB3/B4 for the stratification of HNSCC patients in the therapeutic context.
View article: La modélisation mathématique, un outil essentiel pour l’étude du ciblage thérapeutique des tumeurs solides
La modélisation mathématique, un outil essentiel pour l’étude du ciblage thérapeutique des tumeurs solides Open
\n\t\t\t\tLes progrès de la décennie passée ont rendu l’étude du traitement médical des cancers plus efficace, mais ils ont aussi révélé la complexité des mécanismes de la cancérogenèse. Pour la plupart des tumeurs humaines, on connaît plu…
View article: La modélisation mathématique, un outil essentiel pour l’étude du ciblage thérapeutique des tumeurs solides
La modélisation mathématique, un outil essentiel pour l’étude du ciblage thérapeutique des tumeurs solides Open
Recent progress in biology has made the study of the medical treatment of cancer more effective, but it has also revealed the large complexity of carcinogenesis and cell signaling. For many types of cancer, several therapeutic targets are …
View article: Temozolomide and Bevacizumab Induction before Chemoradiotherapy in Patients with Bulky Glioblastoma and/or with Severe Neurological Impairment
Temozolomide and Bevacizumab Induction before Chemoradiotherapy in Patients with Bulky Glioblastoma and/or with Severe Neurological Impairment Open
Background. New approaches are needed for patients newly diagnosed with bulky glioblastoma (GB) and/or with severe neurological impairment that cannot benefit from first line temozolomide (TMZ)-based chemoradiotherapy. Bevaci…
View article: Thrombotic Microangiopathy Revealing Bone Metastases from an Ethmoid Sinus Carcinoma
Thrombotic Microangiopathy Revealing Bone Metastases from an Ethmoid Sinus Carcinoma Open
Cancer-related thrombotic microangiopathy (TMA) is a rare entity whose clinical and biological characteristics have been described in various tumors. Here we describe the first case of cancer-related TMA revealing diffuse bone metastases f…