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View article: Real-World Comparison of Lenvatinib and Sorafenib as First-Line Treatments for Hepatocellular Carcinoma: A Multicenter Study
Real-World Comparison of Lenvatinib and Sorafenib as First-Line Treatments for Hepatocellular Carcinoma: A Multicenter Study Open
Leveraging RWD, our study demonstrated that 1L lenvatinib may offer a survival advantage over 1L sorafenib in HCC patients, with both treatments exhibiting safety profiles consistent with clinical trials. RWD complements clinical trials by…
View article: Impact of national reimbursement policy supporting test strips on glycemic control in people with insulin-treated diabetes: retrospective cohort study
Impact of national reimbursement policy supporting test strips on glycemic control in people with insulin-treated diabetes: retrospective cohort study Open
In conclusion, the reimbursement policy supporting the cost of blood glucose strip prescriptions was associated with significant reduction in HbA1c levels in people with T1DM or insulin-treated T2DM.
View article: AI-based Mobile Application for Pressure Injury Healing: Real-World Evidence from a Retrospective Study (Preprint)
AI-based Mobile Application for Pressure Injury Healing: Real-World Evidence from a Retrospective Study (Preprint) Open
BACKGROUND Pressure injuries (PIs) are a major concern in hospital care, contributing to prolonged hospital stays, reduced quality of life, and increased healthcare costs. Accurate and timely staging is critical for effective management, …
View article: Gaps and Similarities in Research Use LOINC Codes Utilized in Korean University Hospitals: Towards Semantic Interoperability for Patient Care
Gaps and Similarities in Research Use LOINC Codes Utilized in Korean University Hospitals: Towards Semantic Interoperability for Patient Care Open
This study reveals a significant inconsistency rate of over 15% in LOINC mappings utilized for research purposes in university hospitals, underlining the necessity for expert verification to enhance interoperability in real patient care.
View article: Single-cell analysis of human PBMCs in healthy and type 2 diabetes populations: dysregulated immune networks in type 2 diabetes unveiled through single-cell profiling
Single-cell analysis of human PBMCs in healthy and type 2 diabetes populations: dysregulated immune networks in type 2 diabetes unveiled through single-cell profiling Open
Abnormalities in glucose metabolism that precede the onset of type 2 diabetes (T2D) activate immune cells, leading to elevated inflammatory factors and chronic inflammation. However, no single-cell RNA sequencing (scRNA-seq) studies have c…
View article: The association between TSH and thyroid hormones in the normal or subclinical dysfunction range with left ventricular diastolic dysfunction
The association between TSH and thyroid hormones in the normal or subclinical dysfunction range with left ventricular diastolic dysfunction Open
Thyroid hormones modulate the cardiovascular system. However, the effects of subclinical thyroid dysfunction and euthyroidism on cardiac function remain unclear. We investigated the association between left ventricular (LV) diastolic dysfu…
View article: Prognostic Efficacy of the Albumin-Bilirubin Score and Treatment Outcomes in Hepatocellular Carcinoma: A Large-Scale, Multi-Center Real-World Database Study
Prognostic Efficacy of the Albumin-Bilirubin Score and Treatment Outcomes in Hepatocellular Carcinoma: A Large-Scale, Multi-Center Real-World Database Study Open
Introduction: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality globally, with treatment outcomes closely tied to liver function. This study evaluates the prognostic utility of the albumin-bil…
View article: Impact of preserved ratio impaired spirometry on coronary artery calcium score progression: a longitudinal cohort study
Impact of preserved ratio impaired spirometry on coronary artery calcium score progression: a longitudinal cohort study Open
Background Preserved ratio impaired spirometry (PRISm) is associated with increased cardiovascular disease (CVD) risk and mortality. However, a causal relationship between PRISm and CVD remains unclear. We investigated the progression of c…
View article: Sex-specific relationship between non-alcoholic fatty liver disease and amyloid-β in cognitively unimpaired individuals
Sex-specific relationship between non-alcoholic fatty liver disease and amyloid-β in cognitively unimpaired individuals Open
Background Non-alcoholic fatty liver disease (NAFLD) is known to be associated with a high risk of clinically diagnosed Alzheimer’s disease (AD). Additionally, the prevalence of NAFLD and AD is higher in elderly females than in males. Howe…
View article: Development and validation of multivariable quantitative ultrasound for diagnosing hepatic steatosis
Development and validation of multivariable quantitative ultrasound for diagnosing hepatic steatosis Open
This study developed and validated multivariable quantitative ultrasound (QUS) model for diagnosing hepatic steatosis. Retrospective secondary analysis of prospectively collected QUS data was performed. Participants underwent QUS examinati…
View article: Increased risk of incident diabetes in patients with MAFLD not meeting the criteria for NAFLD
Increased risk of incident diabetes in patients with MAFLD not meeting the criteria for NAFLD Open
We aimed to compare the risk of incident diabetes according to fatty liver disease (FLD) definition, focusing on the comparison between those who met criteria for either metabolic dysfunction-associated fatty liver disease (MAFLD) or nonal…
View article: Supplementary Table S2 from The Relationship Between Breast Density Change During Menopause and the Risk of Breast Cancer in Korean Women
Supplementary Table S2 from The Relationship Between Breast Density Change During Menopause and the Risk of Breast Cancer in Korean Women Open
Hazard ratios (95% CI) for the incidence of breast cancer by change in breast density among participants who had scattered fibroglandular or heterogeneously dense breasts premenopause
View article: Supplementary Table S1 from The Relationship Between Breast Density Change During Menopause and the Risk of Breast Cancer in Korean Women
Supplementary Table S1 from The Relationship Between Breast Density Change During Menopause and the Risk of Breast Cancer in Korean Women Open
Hazard ratio for incidence of breast cancer by breast density premenopause
View article: Supplementary Table S1 from The Relationship Between Breast Density Change During Menopause and the Risk of Breast Cancer in Korean Women
Supplementary Table S1 from The Relationship Between Breast Density Change During Menopause and the Risk of Breast Cancer in Korean Women Open
Hazard ratio for incidence of breast cancer by breast density premenopause
View article: Data from The Relationship Between Breast Density Change During Menopause and the Risk of Breast Cancer in Korean Women
Data from The Relationship Between Breast Density Change During Menopause and the Risk of Breast Cancer in Korean Women Open
Background:The aim of this study was to investigate the relationship between changes in breast density during menopause and breast cancer risk.Methods:This study was a retrospective, longitudinal cohort study for women over 30 years of age…
View article: Supplementary Table S2 from The Relationship Between Breast Density Change During Menopause and the Risk of Breast Cancer in Korean Women
Supplementary Table S2 from The Relationship Between Breast Density Change During Menopause and the Risk of Breast Cancer in Korean Women Open
Hazard ratios (95% CI) for the incidence of breast cancer by change in breast density among participants who had scattered fibroglandular or heterogeneously dense breasts premenopause
View article: Data from The Relationship Between Breast Density Change During Menopause and the Risk of Breast Cancer in Korean Women
Data from The Relationship Between Breast Density Change During Menopause and the Risk of Breast Cancer in Korean Women Open
Background:The aim of this study was to investigate the relationship between changes in breast density during menopause and breast cancer risk.Methods:This study was a retrospective, longitudinal cohort study for women over 30 years of age…
View article: MAFLD and NAFLD in the prediction of incident chronic kidney disease
MAFLD and NAFLD in the prediction of incident chronic kidney disease Open
Whether metabolic dysfunction-associated fatty liver disease (MAFLD) can replace nonalcoholic fatty liver disease (NAFLD) is under debate. This study evaluated which definition better predicted incident chronic kidney disease (CKD). This w…
View article: Prognostic Impact of Elevation of Cancer Antigen 15-3 (CA15-3) in Patients With Early Breast Cancer With Normal Serum CA15-3 Level
Prognostic Impact of Elevation of Cancer Antigen 15-3 (CA15-3) in Patients With Early Breast Cancer With Normal Serum CA15-3 Level Open
The results of the present study demonstrated that elevation of CA15-3 in patients with early BC and initial normal serum CA15-3 levels has a prognostic impact.
View article: Correction: Frequent Mobile Electronic Medical Records Users Respond More Quickly to Emergency Department Consultation Requests: Retrospective Quantitative Study
Correction: Frequent Mobile Electronic Medical Records Users Respond More Quickly to Emergency Department Consultation Requests: Retrospective Quantitative Study Open
[This corrects the article DOI: 10.2196/14487.].
View article: Frequent Mobile Electronic Medical Records Users Respond More Quickly to Emergency Department Consultation Requests: Retrospective Quantitative Study (Preprint)
Frequent Mobile Electronic Medical Records Users Respond More Quickly to Emergency Department Consultation Requests: Retrospective Quantitative Study (Preprint) Open
UNSTRUCTURED Correction: Frequent Mobile Electronic Medical Records (EMR) Users Respond More Quickly to Emergency Department Consultation Requests In “Frequent Mobile Electronic Medical Records (EMR) Users Respond More Quickly to Emergenc…
View article: Gender-specific relationship between thigh muscle and fat mass and brain amyloid-β positivity
Gender-specific relationship between thigh muscle and fat mass and brain amyloid-β positivity Open
View article: Separate and Joint Associations of Cardiorespiratory Fitness and Healthy Vascular Aging With Subclinical Atherosclerosis in Men
Separate and Joint Associations of Cardiorespiratory Fitness and Healthy Vascular Aging With Subclinical Atherosclerosis in Men Open
Background: Achieving healthy vascular aging (HVA) is important for decelerating age-related cardiovascular disease risk. We evaluated the interplay between HVA, cardiorespiratory fitness (CRF), and subclinical atherosclerosis. Methods: We…
View article: Stakeholders’ Requirements for Artificial Intelligence for Healthcare in Korea
Stakeholders’ Requirements for Artificial Intelligence for Healthcare in Korea Open
Objectives: The outlook of artificial intelligence for healthcare (AI4H) is promising. However, no studies have yet discussed the issues from the perspective of stakeholders in Korea. This research aimed to identify stakeholders’ requireme…
View article: Natural Regression of <i>Helicobacter Pylori</i> Infection is Associated with a Higher Risk of Gastric Cancer Development in Adults Under 50 Years Old: A 5-Year Landmark Analysis
Natural Regression of <i>Helicobacter Pylori</i> Infection is Associated with a Higher Risk of Gastric Cancer Development in Adults Under 50 Years Old: A 5-Year Landmark Analysis Open
View article: Prediction Algorithms for Blood Pressure Based on Pulse Wave Velocity Using Health Checkup Data in Healthy Korean Men: Algorithm Development and Validation
Prediction Algorithms for Blood Pressure Based on Pulse Wave Velocity Using Health Checkup Data in Healthy Korean Men: Algorithm Development and Validation Open
Background Pulse transit time and pulse wave velocity (PWV) are related to blood pressure (BP), and there were continuous attempts to use these to predict BP through wearable devices. However, previous studies were conducted on a small sca…
View article: Mean and Variability of Lipid Measurements and Risk for Development of Subclinical Left Ventricular Diastolic Dysfunction
Mean and Variability of Lipid Measurements and Risk for Development of Subclinical Left Ventricular Diastolic Dysfunction Open
Background: Subclinical left ventricular diastolic dysfunction (LVDD) is an emerging consequence of increased insulin resistance, and dyslipidemia is one of the few correctable risk factors of LVDD. This study evaluated the role of mean an…
View article: Effects of Background Colors, Flashes, and Exposure Values on the Accuracy of a Smartphone-Based Pill Recognition System Using a Deep Convolutional Neural Network: Deep Learning and Experimental Approach
Effects of Background Colors, Flashes, and Exposure Values on the Accuracy of a Smartphone-Based Pill Recognition System Using a Deep Convolutional Neural Network: Deep Learning and Experimental Approach Open
Background Pill image recognition systems are difficult to develop due to differences in pill color, which are influenced by external factors such as the illumination from and the presence of a flash. Objective In this study, the differenc…
View article: Deep Learning-Based Prediction Model for Breast Cancer Recurrence Using Adjuvant Breast Cancer Cohort in Tertiary Cancer Center Registry
Deep Learning-Based Prediction Model for Breast Cancer Recurrence Using Adjuvant Breast Cancer Cohort in Tertiary Cancer Center Registry Open
Several prognosis prediction models have been developed for breast cancer (BC) patients with curative surgery, but there is still an unmet need to precisely determine BC prognosis for individual BC patients in real time. This is a retrospe…
View article: Medication Adherence and Clinical Outcome of Fixed-Dose Combination vs. Free Combination of Angiotensin Receptor Blocker and Statin
Medication Adherence and Clinical Outcome of Fixed-Dose Combination vs. Free Combination of Angiotensin Receptor Blocker and Statin Open
In this real-world data analysis, patients taking FDC of ARB and statin showed higher medication persistence and adherence compared to patients taking FC of ARB and statin up to 540 days. The risk of all-cause death was not different betwe…