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View article: A time-resolved atlas of histone modifications during mitotic entry
A time-resolved atlas of histone modifications during mitotic entry Open
Mitotic chromosome formation is essential for faithful chromosome segregation in metazoans. While condensin complexes are critical for the formation of rod-shaped mitotic chromosomes, additional mechanisms—particularly those involving phos…
View article: Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin
Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin Open
Centromeres are scaffolds for the assembly of kinetochores that ensure chromosome segregation during cell division. How vertebrate centromeres obtain a three-dimensional structure to accomplish their primary function is unclear. Using supe…
View article: Editorial: Advances in wild type and mutant p53 research in cancer
Editorial: Advances in wild type and mutant p53 research in cancer Open
EDITORIAL article Front. Mol. Biosci., 10 November 2022Sec. Cellular Biochemistry Volume 9 - 2022 | https://doi.org/10.3389/fmolb.2022.1064280
View article: SETD2-mediated epigenetic regulation of noncanonical Wnt5A during osteoclastogenesis
SETD2-mediated epigenetic regulation of noncanonical Wnt5A during osteoclastogenesis Open
To define the role of SETD2 in the WNT5a signaling in the context of osteoclastogenesis, we exploited two different models: in vitro osteoclast differentiation, and K/BxN serum-induced arthritis model. We found that SETD2 and WNT5a were up…
View article: Myeloid Krüppel-Like Factor 2 Critically Regulates K/BxN Serum-Induced Arthritis
Myeloid Krüppel-Like Factor 2 Critically Regulates K/BxN Serum-Induced Arthritis Open
Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease, and Krüppel-like factor 2 (KLF2) regulates immune cell activation and function. Herein, we show that in our experiments 50% global deficiency of KLF2 significantly eleva…
View article: KLF2 (kruppel-like factor 2 [lung]) regulates osteoclastogenesis by modulating autophagy
KLF2 (kruppel-like factor 2 [lung]) regulates osteoclastogenesis by modulating autophagy Open
Macroautophagy/autophagy is involved in myeloid cellular repair, destruction, and osteoclast differentiation; conversely, KLF2 (kruppel-like factor 2 [lung]) regulates myeloid cell activation and differentiation. To investigate the specifi…
View article: KLF2 (kruppel like factor 2 [lung]) regulates osteoclastogenesis by modulating autophagy
KLF2 (kruppel like factor 2 [lung]) regulates osteoclastogenesis by modulating autophagy Open
Macroautophagy/autophagy is involved in myeloid cellular repair, destruction, and osteoclast differentiation; conversely, KLF2 (kruppel-like factor 2 [lung]) regulates myeloid cell activation and differentiation. To investigate the specifi…
View article: KLF2 (kruppel-like factor 2 [lung]) regulates osteoclastogenesis by modulating autophagy
KLF2 (kruppel-like factor 2 [lung]) regulates osteoclastogenesis by modulating autophagy Open
Macroautophagy/autophagy is involved in myeloid cellular repair, destruction, and osteoclast differentiation; conversely, KLF2 (kruppel-like factor 2 [lung]) regulates myeloid cell activation and differentiation. To investigate the specifi…