Explanipedia

Cryopreserving the intact intervertebral disc without compromising viability Open

Ward Shalash, Ryan J. Forcier, Adam Z. Higgins, Morgan B. Giers · 2024

Background Tissue cryopreservation requires saturation of the structure with cryoprotectants (CPAs) that are also toxic to cells within a short timeframe unless frozen. The race between CPA delivery and cell death is the main barrier to re…

Impact of the COVID‐19 pandemic on the productivity and career prospects of musculoskeletal researchers Open

Lauren Chakraborty, Christine L. Le Maitre, Nadeen O. Chahine, Aaron J. Fields, Rahul Gawri , et al. · 2024

Academic researchers faced a multitude of challenges posed by the COVID‐19 pandemic, including widespread shelter‐in‐place orders, workplace closures, and cessation of in‐person meetings and laboratory activities. The extent to which these…

Accelerating cryoprotectant delivery using vacuum infiltration Open

Ryan J. Forcier, Robert T. Heussner, Lauren Newsom, Morgan B. Giers, Wa’el Al Rawashdeh , et al. · 2023

The ability to cryopreserve bone marrow within the vertebral body (VB) would offer significant clinical and research benefits. However, cryopreservation of large structures, such as VBs, is challenging due to mass transport limitations tha…

Bullying, harassment, and discrimination of musculoskeletal researchers and the impact of the COVID-19 pandemic: an international study Open

John T. Martin, Dimitrios Asimakopoulos, Alexander L. Hornung, Sheila J. Toro, Christine L. Le Maitre , et al. · 2023

PURPOSE: Bullying, harassment, and discrimination (BHD) are prevalent in academic, scientific, and clinical departments, particularly orthopedic surgery, and can have lasting effects on victims. As it is unclear how BHD affects musculoskel…

Editorial: MISS innovations: Approaches, predictive outcomes, and risk avoidance Open

Vadim A. Byvaltsev, Dino Samartzis, Morgan B. Giers · 2023

EDITORIAL article Front. Surg., 09 January 2023Sec. Neurosurgery Volume 9 - 2022 | https://doi.org/10.3389/fsurg.2022.1105855

Molecular and Genetic Mechanisms of Spinal Stenosis Formation: Systematic Review Open

Vadim A. Byvaltsev, А. А. Калинин, Phillip A. Hernandez, Valerii V. Shepelev, Yu. Ya. Pestryakov , et al. · 2022

Spinal stenosis (SS) is a multifactorial polyetiological condition characterized by the narrowing of the spinal canal. This condition is a common source of pain among people over 50 years old. We perform a systematic review of molecular an…

Dynamic Load Model Systems of Tendon Inflammation and Mechanobiology Open

Lindsay G. Benage, James Sweeney, Morgan B. Giers, Ravi Balasubramanian · 2022

Dynamic loading is a shared feature of tendon tissue homeostasis and pathology. Tendon cells have the inherent ability to sense mechanical loads that initiate molecular-level mechanotransduction pathways. While mature tendons require physi…

<span>Patient‐specific</span> apparent diffusion maps used to model nutrient availability in degenerated intervertebral discs Open

Ward Shalash, Sonia R. Ahrens, Liudmila Bardonova, Vadim A. Byvaltsev, Morgan B. Giers · 2021

Introduction In this study, magnetic resonance imaging data was used to (1) model IVD‐specific gradients of glucose, oxygen, lactate, and pH; and (2) investigate possible effects of covariate factors (i.e., disc geometry, and mean apparent…

Development of a standardized histopathology scoring system for human intervertebral disc degeneration: an Orthopaedic Research Society Spine Section Initiative Open

Christine L. Le Maitre, Chitra Lekha Dahia, Morgan B. Giers, Svenja Illien‐Jünger, Claudia Cicione , et al. · 2021

Background Histopathological analysis of intervertebral disc (IVD) tissues is a critical domain of back pain research. Identification, description, and classification of attributes that distinguish abnormal tissues form a basis for probing…

Comparison of MRI Visualization Following Minimally Invasive and Open TLIF: A Retrospective Single-Center Study Open

Vadim A. Byvaltsev, А. А. Калинин, Morgan B. Giers, Valerii Vladimirovich Shepelev, Yu. Ya. Pestryakov , et al. · 2021

Analysis of magnetic resonance image (MRI) quality after open (Op)-transforaminal interbody fusion (TLIF) and minimally invasive (MI)-TLIF with the implantation of structurally different systems has not previously been performed. The objec…

3D-printed cranial models simulating operative field depth for microvascular training in neurosurgery Open

Vadim A. Byvaltsev, Roman A. Polkin, Dmitry Bereznyak, Morgan B. Giers, Phillip A. Hernandez , et al. · 2021

Background: The skills required for neurosurgical operations using microsurgical techniques in a deep operating field are difficult to master in the operating room without risk to patients. Although there are many microsurgical training mo…

Intelligence-Based Spine Care Model: A New Era of Research and Clinical Decision-Making Open

G. Michael Mallow, Zakariah K. Siyaji, Fabio Galbusera, Alejandro A. Espinoza Orías, Morgan B. Giers , et al. · 2020

Keywords artificial, intelligence, machine, learning, computation, data, science, precision, personalized, spine, pain, disc, degeneration, low back pain, tumor, deformity

Surgical treatment of lower lumbar spine pathology in children and adolescents Open

Aleksandr Krutko, A. J. Sanginov, Morgan B. Giers, Alina Alshevskaya, A. Moskalev · 2018

Introduction. Analysis of the modern literature shows that the number of children complaining of low back pain of varying intensity in the spine increases annually. Publications on the surgical treatment of juvenile osteochondrosis were sc…

APOPTOSIS, NUTRITION, AND METABOLISM OF TRANSPLANTED INTERVERTEBRAL DISC CELLS Open

Morgan B. Giers, Liudmila Bardonova, Kyle Eyster, Vadim A. Byvaltsev, Mark C. Preul · 2018

Introduction: Apoptosis is a contributing factor to degenerating intervertebral disc (IVD). Disc regeneration has been attempted by transplanting cells into the disc, with some gains in disc height achieved in animal models. Here, we study…

Proliferative Activity of Healthy and Degenerated Intervertebral Disc Cells in vitro under Bone Morphogenetic Proteins’ Influence: Implications for Cell Therapy Open

Liudmila Bardonova, Evgenii Belykh, Morgan B. Giers, Mark C. Preul, Vadim A. Byvaltsev · 2018

The aim of the study was to evaluate the effect of bone morphogenetic proteins (BMP) on the proliferative activity of healthy and degenerated cells of the intervertebral disc (IVD) in vitro.Materials and Methods.Cells obtained from the hum…

APOPTOSIS, NUTRITION, AND METABOLISM OF TRANSPLANTED INTERVERTEBRAL DISC CELLS Open

Morgan B. Giers, Liudmila Bardonova, Kyle Eyster, Vadim A. Byvaltsev, Mark C. Preul · 2018

Introduction: Apoptosis is a contributing factor to degenerating intervertebral disc (IVD). Disc regeneration has been attempted by transplanting cells into the disc, with some gains in disc height achieved in animal models. Here, we study…

Apparent diffusion coefficient maps in the assessment of surgical patients with lumbar spine degeneration Open

Evgenii Belykh, А. А. Калинин, Arpan Patel, Eric J Miller, Michael A. Bohl , et al. · 2017

Quantitative and qualitative evaluation of ADC mapping may provide additional useful information regarding the fluid dynamics of the degenerated spine and may complement standard MRI imaging protocol for the comprehensive assessment of sur…

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