Morgan E. Freney
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View article: A chimeric vaccine derived from Australian genotype IV Japanese encephalitis virus protects mice from lethal challenge
A chimeric vaccine derived from Australian genotype IV Japanese encephalitis virus protects mice from lethal challenge Open
In 2022, a genotype IV (GIV) strain of Japanese encephalitis virus (JEV) caused an unprecedented and widespread outbreak of disease in pigs and humans in Australia. As no veterinary vaccines against JEV are approved in Australia and all cu…
View article: Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology Open
Aging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019 (COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to brain aging, but the impact of virus-induced senescence on …
View article: A chimeric vaccine displaying the prM-E proteins of the Australian genotype IV strain of Japanese encephalitis virus protects mice against lethal challenge
A chimeric vaccine displaying the prM-E proteins of the Australian genotype IV strain of Japanese encephalitis virus protects mice against lethal challenge Open
In 2022, a genotype IV (GIV) strain of Japanese encephalitis virus caused an unprecedented and widespread outbreak of disease in pigs and humans in Australia. As no veterinary vaccines against JEV are approved in Australia and all current …
View article: Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology Open
Aging is the primary risk factor for most neurodegenerative diseases, and recently coronavirus disease 2019 (COVID-19) has been associated with severe neurological manifestations that can eventually impact neurodegenerative conditions in t…
View article: Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology Open
Aging is the primary risk factor for most neurodegenerative diseases, and recently coronavirus disease 2019 (COVID-19) has been associated with severe neurological manifestations that can eventually impact neurodegenerative conditions in t…
View article: Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis
Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis Open
All flaviviruses, including Zika virus, produce noncoding subgenomic flaviviral RNA (sfRNA), which plays an important role in viral pathogenesis. However, the exact mechanism of how sfRNA enables viral evasion of antiviral response is not …
View article: Absence of Anti-RBD Antibodies in SARS-CoV-2 Infected or Naive Individuals Prior to Vaccination with CoronaVac Leads to Short Protection of Only Four Months Duration
Absence of Anti-RBD Antibodies in SARS-CoV-2 Infected or Naive Individuals Prior to Vaccination with CoronaVac Leads to Short Protection of Only Four Months Duration Open
The COVID-19 pandemic is the biggest public health threat facing the world today. Multiple vaccines have been approved; however, the emergence of viral variants such as the recent Omicron raises the possibility of booster doses to achieve …
View article: Absence of Anti-RBD Antibodies in SARS-COV-2 Infected or Naive Individuals Prior to Vaccination With CoronaVac Leads to Short Protection of Only Four Months Duration
Absence of Anti-RBD Antibodies in SARS-COV-2 Infected or Naive Individuals Prior to Vaccination With CoronaVac Leads to Short Protection of Only Four Months Duration Open
The COVID-19 pandemic is the biggest public health threat facing the globe today. Multiple vaccines have been approved, however the emergence of viral variants such as the recent Omicron, raises the possibility of booster doses to achieve …
View article: A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses
A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses Open
The current COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We demonstrate that despite the large size of the viral RNA genome (~30 kb), infectious full-length cDNA is readily assembled in v…
View article: Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis
Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis Open
Zika virus (ZIKV) is a re-emerging pathogenic flavivirus, which causes microcephaly in infants and poses a continuing threat to public health. ZIKV, like all other flaviviruses, produces highly abundant noncoding RNA known as subgenomic fl…
View article: An Optimized High-Throughput Immuno-Plaque Assay for SARS-CoV-2
An Optimized High-Throughput Immuno-Plaque Assay for SARS-CoV-2 Open
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been identified as the causative agent of coronavirus disease 2019 and is capable of human-to-human transmission and rapid global spread. The rapid emergence and global sprea…
View article: Zika Virus sfRNA Plays an Essential Role in the Infection of Insects and Mammals
Zika Virus sfRNA Plays an Essential Role in the Infection of Insects and Mammals Open
Similar to other flaviviruses, Zika virus (ZIKV) produces abundant subgenomic flavivirus RNA (sfRNA) derived from the 3’ untranslated region. The molecular mechanisms that determine the functions of sfRNA are currently not completely under…