Morgan L. Sherer
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View article: Suppression of progesterone by influenza A virus mediates adverse maternal and fetal outcomes in mice
Suppression of progesterone by influenza A virus mediates adverse maternal and fetal outcomes in mice Open
Pregnant individuals are at risk of severe outcomes from both seasonal and pandemic influenza A viruses. Influenza infection during pregnancy is associated with adverse fetal outcomes at birth and adverse consequences for offspring into ad…
View article: Suppression of progesterone by influenza A virus mediates adverse maternal and fetal outcomes in mice
Suppression of progesterone by influenza A virus mediates adverse maternal and fetal outcomes in mice Open
Influenza A virus infection during pregnancy can cause adverse maternal and fetal outcomes, but the mechanism responsible remains elusive. Infection of outbred mice with 2009 H1N1 at embryonic day (E) 10 resulted in significant maternal mo…
View article: Establishment of a Private Foundation-Academic Partnership to Promote Careers of Early-Stage Investigators Examining the Influence of Sex and Gender on Health and Health Care
Establishment of a Private Foundation-Academic Partnership to Promote Careers of Early-Stage Investigators Examining the Influence of Sex and Gender on Health and Health Care Open
Biological sex and gender-based constructs contribute significantly to the diversity of disease outcomes and treatment responses across the life course. To promote research considering sex and gender, the National Institutes of Health (NIH…
View article: Biological Mechanisms in Pregnant Women With Anxiety (Happy Mother-Healthy Baby Supplement Study): Protocol for a Longitudinal Mixed Methods Observational Study
Biological Mechanisms in Pregnant Women With Anxiety (Happy Mother-Healthy Baby Supplement Study): Protocol for a Longitudinal Mixed Methods Observational Study Open
Background Anxiety and depression are common in the perinatal period and negatively affect the health of the mother and baby. Our group has developed “Happy Mother-Healthy Baby” (HMHB), a cognitive behavioral therapy–based psychosocial int…
View article: Biological Mechanisms in Pregnant Women With Anxiety (Happy Mother-Healthy Baby Supplement Study): Protocol for a Longitudinal Mixed Methods Observational Study (Preprint)
Biological Mechanisms in Pregnant Women With Anxiety (Happy Mother-Healthy Baby Supplement Study): Protocol for a Longitudinal Mixed Methods Observational Study (Preprint) Open
BACKGROUND Anxiety and depression are common in the perinatal period and negatively affect the health of the mother and baby. Our group has developed “Happy Mother-Healthy Baby” (HMHB), a cognitive behavioral therapy–based psychosocial in…
View article: Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells
Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells Open
Adult females develop greater antibody responses to influenza vaccines than males. We hypothesized that female-biased immunity and protection would be dependent on the extent of virus diversity as well as molecular mechanisms in B cells wh…
View article: Greater breadth of vaccine-induced immunity in females than males is mediated by increased antibody diversity in germinal center B cells
Greater breadth of vaccine-induced immunity in females than males is mediated by increased antibody diversity in germinal center B cells Open
Inactivated influenza vaccines induce greater antibody responses in females than males among both humans and mice. To test the breadth of protection, we used recombinant mouse-adapted A/California/2009 (maA/Cal/09) H1N1 viruses containing …
View article: Downregulation of Transcriptional Activity, Increased Inflammation, and Damage in the Placenta Following in utero Zika Virus Infection Is Associated With Adverse Pregnancy Outcomes
Downregulation of Transcriptional Activity, Increased Inflammation, and Damage in the Placenta Following in utero Zika Virus Infection Is Associated With Adverse Pregnancy Outcomes Open
Zika virus (ZIKV) infection during pregnancy causes serious adverse outcomes to the developing fetus, including fetal loss and birth defects known as congenital Zika syndrome (CZS). The mechanism by which ZIKV infection causes these advers…
View article: A Rat Model of Prenatal Zika Virus Infection and Associated Long-Term Outcomes
A Rat Model of Prenatal Zika Virus Infection and Associated Long-Term Outcomes Open
Zika virus (ZIKV) is a mosquito-borne flavivirus that became widely recognized due to the epidemic in Brazil in 2015. Since then, there has been nearly a 20-fold increase in the incidence of microcephaly and birth defects seen among women …
View article: An Examination of the Long-Term Neurodevelopmental Impact of Prenatal Zika Virus Infection in a Rat Model Using a High Resolution, Longitudinal MRI Approach
An Examination of the Long-Term Neurodevelopmental Impact of Prenatal Zika Virus Infection in a Rat Model Using a High Resolution, Longitudinal MRI Approach Open
Since Zika virus (ZIKV) first emerged as a public health concern in 2015, our ability to identify and track the long-term neurological sequelae of prenatal Zika virus (ZIKV) infection in humans has been limited. Our lab has developed a rat…
View article: Pregnancy alters interleukin-1 beta expression and antiviral antibody responses during severe acute respiratory syndrome coronavirus 2 infection
Pregnancy alters interleukin-1 beta expression and antiviral antibody responses during severe acute respiratory syndrome coronavirus 2 infection Open
View article: Dysregulated immunity in SARS-CoV-2 infected pregnant women
Dysregulated immunity in SARS-CoV-2 infected pregnant women Open
Importance The effects of SARS-CoV-2 infection on immune responses during pregnancy have not been systematically evaluated. Objective To assess the impact of SARS-CoV-2 infection during pregnancy on inflammatory and humoral responses in ma…
View article: Zika virus infection of pregnant rats and associated neurological consequences in the offspring
Zika virus infection of pregnant rats and associated neurological consequences in the offspring Open
Zika virus (ZIKV) is a mosquito-borne flavivirus associated with microcephaly and other neurological disorders in infants born to infected mothers. Despite being declared an international emergency by the World Health Organization, very li…
View article: An investigation into the immune response of cultured neural rat cells following Zika virus infection
An investigation into the immune response of cultured neural rat cells following Zika virus infection Open
View article: An examination of changes in maternal neuroimmune function during pregnancy and the postpartum period
An examination of changes in maternal neuroimmune function during pregnancy and the postpartum period Open
View article: The effects of gestational stress and Selective Serotonin reuptake inhibitor antidepressant treatment on structural plasticity in the postpartum brain — A translational model for postpartum depression
The effects of gestational stress and Selective Serotonin reuptake inhibitor antidepressant treatment on structural plasticity in the postpartum brain — A translational model for postpartum depression Open