Morgan Lynn Hetzel
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View article: Deciphering how PAMP manipulation prevents neutrophils from casting NETs in infection 2821
Deciphering how PAMP manipulation prevents neutrophils from casting NETs in infection 2821 Open
Description Production of phagosomal reactive oxygen species (ROS) drives neutrophil extracellular trap release (NETosis); however, ROS is a universal antimicrobial response, yet only a fraction of neutrophils undergoes NETosis. This indic…
View article: Untangling the immunologic imbalance in SLE NET release 2434
Untangling the immunologic imbalance in SLE NET release 2434 Open
Description The deposition of neutrophil extracellular traps (NETs) is thought to contribute nuclear antigens that exacerbate inflammation in the autoimmune disease systemic lupus erythematosus (SLE). We showed that mitochondrial lactate d…
View article: A TLR7/9-IFNα-LDHB axis drives vital NET release and compromises antibacterial defense in lupus
A TLR7/9-IFNα-LDHB axis drives vital NET release and compromises antibacterial defense in lupus Open
Patients with systemic lupus erythematosus (SLE) are susceptible to bacterial infections, but the underlying dysfunction remains unclear. We found that Staphylococcus aureus triggers mitochondria-dependent suicidal NETosis via lactate sens…
View article: MCMV Centrifugal Enhancement: A New Spin on an Old Topic
MCMV Centrifugal Enhancement: A New Spin on an Old Topic Open
Human cytomegalovirus (HCMV) is a ubiquitous pathogen infecting a majority of people worldwide, with diseases ranging from mild to life-threatening. Its clinical relevance in immunocompromised people and congenital infections have made tre…