Morgan R. Little
YOU?
Author Swipe
View article: Application of Youth-Led Participatory Action Research to Examining Adolescent Sexual and Reproductive Health and Rights in Ontario: What Can We Learn?
Application of Youth-Led Participatory Action Research to Examining Adolescent Sexual and Reproductive Health and Rights in Ontario: What Can We Learn? Open
Engaging adolescents and young people as partners in research is increasingly acknowledged as a vital strategy to ensure diverse voices are heard and to catalyze social change. This article, coauthored by adolescent and adult researchers, …
View article: Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine
Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine Open
A systems analysis was conducted to determine the potential molecular mechanisms underlying differential immunogenicity and protective efficacy results of a clinical trial of the radiation-attenuated whole-sporozoite PfSPZ vaccine in Afric…
View article: Creation of a non-Western humanized gnotobiotic mouse model through the transplantation of rural African fecal microbiota
Creation of a non-Western humanized gnotobiotic mouse model through the transplantation of rural African fecal microbiota Open
Gut microbiota are increasingly being recognized as a contributing factor in the etiology of numerous diseases and as a potential determinant in the immune response to various treatments. Recent work has suggested that the suboptimal immun…
View article: Validated graft-specific biomarkers identify patients at risk for chronic graft-versus-host disease and death
Validated graft-specific biomarkers identify patients at risk for chronic graft-versus-host disease and death Open
BACKGROUNDChronic graft-versus-host disease (cGVHD) is a serious complication of allogeneic hematopoietic cell transplantation (HCT). More accurate information regarding the risk of developing cGVHD is required. Bone marrow (BM) grafts con…
View article: 195. How COVID-19 Impacted the Sexual Health Experiences of Assigned Female at Birth Youth in Southwestern Ontario, Canada
195. How COVID-19 Impacted the Sexual Health Experiences of Assigned Female at Birth Youth in Southwestern Ontario, Canada Open
View article: A biomarker panel for risk of early respiratory failure following hematopoietic cell transplantation
A biomarker panel for risk of early respiratory failure following hematopoietic cell transplantation Open
Plasma biomarkers associated with respiratory failure (RF) following hematopoietic cell transplantation (HCT) have not been identified. Therefore, we aimed to validate early (7 and 14 days post-HCT) risk biomarkers for RF. Using tandem mas…
View article: Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine
Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine Open
Baseline innate immune signatures can influence protective immunity following vaccination. Here, we used systems transcriptional analysis to assess the molecular mechanisms underlying differential immunogenicity and protective efficacy res…
View article: Innate Immune Activation Restricts Priming and Protective Efficacy of the Radiation-Attenuated Pfspz Malaria Vaccine
Innate Immune Activation Restricts Priming and Protective Efficacy of the Radiation-Attenuated Pfspz Malaria Vaccine Open
View article: Orexin signaling in rostral lateral hypothalamus and nucleus accumbens shell in the control of spontaneous physical activity in high- and low-activity rats
Orexin signaling in rostral lateral hypothalamus and nucleus accumbens shell in the control of spontaneous physical activity in high- and low-activity rats Open
Spontaneous physical activity (SPA) describes activity outside of formal exercise and shows large interindividual variability. The hypothalamic orexin/hypocretin peptides are key regulators of SPA. Orexins drive SPA within multiple brain s…