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View article: Characterizing Common Factors Affecting Replication Initiation During H2O2 Exposure and Genetic Mutation-Induced Oxidative Stress in Escherichia coli
Characterizing Common Factors Affecting Replication Initiation During H2O2 Exposure and Genetic Mutation-Induced Oxidative Stress in Escherichia coli Open
Oxidative stress is prevalent in organisms, and excessive oxidative damage can trigger cell death. Bacteria have evolved multiple pathways to cope with adverse stress, including the regulation of the cell cycle. Previous studies show that …
View article: A Review of Research on Enterprise Digital Transformation
A Review of Research on Enterprise Digital Transformation Open
As digital transformation becomes an inevitable choice for the survival and development of enterprises, rather than an option, this paper systematically combs and analyzes relevant research. The article discusses the concept, type classifi…
View article: Genome and transcriptomic analysis of the adaptation of Escherichia coli to environmental stresses
Genome and transcriptomic analysis of the adaptation of Escherichia coli to environmental stresses Open
In natural niches, bacteria are forced to spend most of their lives under various environmental stresses, such as nutrient limitation, heavy metal pollution, heat and antibiotic stress. To cope with adverse environments, bacterial genome c…
View article: Editorial: Bacterial transcription factors and the cell cycle, volume II
Editorial: Bacterial transcription factors and the cell cycle, volume II Open
EDITORIAL article Front. Microbiol., 25 July 2023Sec. Microbial Physiology and Metabolism Volume 14 - 2023 | https://doi.org/10.3389/fmicb.2023.1252924
View article: A DnaA‐dependent riboswitch for transcription attenuation of the <i>his</i> operon
A DnaA‐dependent riboswitch for transcription attenuation of the <i>his</i> operon Open
Transcription attenuation in response to the availability of a specific amino acid is believed to be controlled by alternative configurations of RNA secondary structures that lead to the arrest of translation or the release of the arrested…
View article: Lysophosphatidic acid suppresses apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promotes cell-cycle progression via EGFR-PI3K/Aurora-AThr288-geminin dual signaling pathways
Lysophosphatidic acid suppresses apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promotes cell-cycle progression via EGFR-PI3K/Aurora-AThr288-geminin dual signaling pathways Open
Lysophosphatidic acid (LPA) and geminin are overexpressed in ovarian cancer, and increasing evidence supports their contribution to ovarian tumor development. Here, we reveal that geminin depletion induces autophagy suppression and enhance…
View article: The antihyperlipidemic drug potassium piperonate impairs the migration and tumorigenesis of breast cancer cells via the upregulation of miR-31
The antihyperlipidemic drug potassium piperonate impairs the migration and tumorigenesis of breast cancer cells via the upregulation of miR-31 Open
Background Breast cancer is the second cause of cancer death in women, and tumor metastasis is the primary cause of mortality. Due to the involvement of many regulatory molecules and signaling pathways, the occurrence and development of me…
View article: Trimethylamine N-Oxide Reduces the Susceptibility of Escherichia coli to Multiple Antibiotics
Trimethylamine N-Oxide Reduces the Susceptibility of Escherichia coli to Multiple Antibiotics Open
Trimethylamine N-oxide (TMAO), an important intestinal flora-derived metabolite, plays a role in the development of cardiovascular disease and tumor immunity. Here, we determined the minimum inhibitory concentration (MIC) of antibiotics ag…
View article: Editorial: Bacterial Transcription Factors and the Cell Cycle
Editorial: Bacterial Transcription Factors and the Cell Cycle Open
EDITORIAL article Front. Microbiol., 24 December 2021Sec. Microbial Physiology and Metabolism https://doi.org/10.3389/fmicb.2021.821394
View article: Lysophosphatidic Acid–Induced EGFR Transactivation Promotes Gastric Cancer Cell DNA Replication by Stabilizing Geminin in the S Phase
Lysophosphatidic Acid–Induced EGFR Transactivation Promotes Gastric Cancer Cell DNA Replication by Stabilizing Geminin in the S Phase Open
Geminin, an inhibitor of the DNA replication licensing factor, chromatin licensing and DNA replication factor (Cdt) 1, is essential for the maintenance of genomic integrity. As a multifunctional protein, geminin is also involved in tumor p…
View article: YfiF, an unknown protein, affects initiation timing of chromosome replication in <i>Escherichia coli</i>
YfiF, an unknown protein, affects initiation timing of chromosome replication in <i>Escherichia coli</i> Open
The Escherichia coli YfiF protein is functionally unknown, being predicted as a transfer RNA/ribosomal RNA (tRNA/rRNA) methyltransferase. We find that absence of the yfiF gene delays initiation of chromosome replication and the delay is re…
View article: The antihyperlipidemic drug Potassium Piperate impairs migration and tumorgenesis of breast cancer cells via upregulation of miR-31
The antihyperlipidemic drug Potassium Piperate impairs migration and tumorgenesis of breast cancer cells via upregulation of miR-31 Open
Background Breast cancer is a leading malignant tumor which causes deaths among women, and metastasis is the primary cause for mortality in breast cancer. Due to the involvement of many regulatory molecules and signaling pathways, the occu…
View article: Lysophosphatidic Acid-induced EGFR Transactivation Promotes Gastric Cancer DNA Replication Through Up-Regulation of Geminin
Lysophosphatidic Acid-induced EGFR Transactivation Promotes Gastric Cancer DNA Replication Through Up-Regulation of Geminin Open
BackgroundLysophosphatidic acid (LPA) is one of the simplest active phospholipid molecules. Binding to its receptors on the cell surface, LPA initiates various intracellular signal cascades, involving in numerous biological processes, such…
View article: DnaA-dependent riboswitch for transcription attenuation
DnaA-dependent riboswitch for transcription attenuation Open
Transcription attenuation has been believed to be controlled by alternative configurations of RNA secondary structures through arresting or releasing the ribosome on the leader RNA molecule in response to limitation or sufficiency of speci…
View article: H‐NS, IHF, and DnaA lead to changes in nucleoid organizations, replication initiation, and cell division
H‐NS, IHF, and DnaA lead to changes in nucleoid organizations, replication initiation, and cell division Open
Histone‐like nucleoid‐structuring protein (H‐NS) and integration host factor (IHF) are major nucleoid‐associated proteins, and DnaA, a replication initiator, may also be related with nucleoid compaction. It has been shown that protein‐depe…
View article: Defects in ribosome function delay the initiation of chromosome replication in <i>Escherichia coli</i>
Defects in ribosome function delay the initiation of chromosome replication in <i>Escherichia coli</i> Open
The Sra protein is a component of the 30S ribosomal subunit while RimJ is a ribosome‐associated protein that plays a role in the maturation of the 30S ribosomal subunit. Here we found that Δ sra and Δ rimJ cells showed a delayed initiation…
View article: DnaA and LexA Proteins Regulate Transcription of the uvrB Gene in Escherichia coli: The Role of DnaA in the Control of the SOS Regulon
DnaA and LexA Proteins Regulate Transcription of the uvrB Gene in Escherichia coli: The Role of DnaA in the Control of the SOS Regulon Open
The uvrB gene belongs to the SOS network, encoding a key component of the nucleotide excision repair. The uvrB promoter region contains three identified promoters with four LexA binding sites, one consensus and six potential DnaA binding s…
View article: Mutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1–1 plasmid
Mutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1–1 plasmid Open
DnaA regulates the copy number of MiniR1-1 as a negative factor through interacting with the RepA protein.
View article: The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis Open
Piper longum L. is a well-known traditional antihyperlipidemic medicine in China, containing medicinal constituents of piperine, pipernonaline and piperlonguminine in its fruit. However, the antitumor properties of these constituents have …
View article: A Spatial Control for Correct Timing of Gene Expression during the Escherichia coli Cell Cycle
A Spatial Control for Correct Timing of Gene Expression during the Escherichia coli Cell Cycle Open
Temporal transcriptions of genes are achieved by different mechanisms such as dynamic interaction of activator and repressor proteins with promoters, and accumulation and/or degradation of key regulators as a function of cell cycle. We fin…
View article: Evaluation of Novel Antibacterial N-Halamine Nanoparticles Prodrugs towards Susceptibility of Escherichia coli Induced by DksA Protein
Evaluation of Novel Antibacterial N-Halamine Nanoparticles Prodrugs towards Susceptibility of Escherichia coli Induced by DksA Protein Open
Novel N-halamine nanoparticles potentially useful for killing pathogenic bacteria, i.e., SiO2@PS/N-halamine NPs, were successfully synthesized via the immobilization of N-halamines onto the polystyrene-coated silica nanoparticles (SiO2@PS …