Moritz Kleine
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View article: SOCIUS Mentoring—A Novel Course to Encourage Students for a Career as Surgical Oncologists
SOCIUS Mentoring—A Novel Course to Encourage Students for a Career as Surgical Oncologists Open
Surgical disciplines are affected by an increasing shortage of young doctors. Studies show that formerly interested students decide against a career in surgical disciplines at the end of their studies or during practical year. Measures to …
View article: 394 SOCIUS Mentoring – A novel program to encourage and prepare motivated students for a career as surgical oncologists
394 SOCIUS Mentoring – A novel program to encourage and prepare motivated students for a career as surgical oncologists Open
Introduction/Background* The shortage of physicians poses increasing challenges to surgical oncological disciplines. Formerly motivated students lose their interest in surgery during their studies or during their practical year. To counter…
View article: The rate of cholangiocarcinoma in Caroli Disease A German multicenter study
The rate of cholangiocarcinoma in Caroli Disease A German multicenter study Open
There is risk of malignant transformation and patients with CD might also benefit from resection due to improvement of symptoms. Therefore, resection is strongly advised. As certain patients with CS require transplantation, treatment shoul…
View article: The clinical relevance of the Hippo pathway in pancreatic ductal adenocarcinoma
The clinical relevance of the Hippo pathway in pancreatic ductal adenocarcinoma Open
Purpose The Hippo pathway has broadened in cancer research in the past decade and revealed itself to be an important driver for tumorigenesis and metastatic spread. In this study, we investigated the clinical relevance of the Hippo pathway…
View article: Preoperative leukocytosis and the resection severity index are independent risk factors for survival in patients with intrahepatic cholangiocarcinoma
Preoperative leukocytosis and the resection severity index are independent risk factors for survival in patients with intrahepatic cholangiocarcinoma Open
Purpose The incidence of intrahepatic cholangiocarcinoma is increasing worldwide. Despite advances in surgical and non-surgical treatment, reported outcomes are still poor and surgical resection remains to be the only chance for long-term …
View article: Significance of unphosphorylated and phosphorylated heat shock protein 27 as a prognostic biomarker in pancreatic ductal adenocarcinoma
Significance of unphosphorylated and phosphorylated heat shock protein 27 as a prognostic biomarker in pancreatic ductal adenocarcinoma Open
Purpose Few studies reported about the potential of unphosphorylated heat shock protein 27 (HSP27) and phosphorylated heat shock protein 27 (pHSP27) as a predictor for survival and gemcitabine resistance in pancreatic ductal adenocarcinoma…
View article: Alloresponses of Mixed Lymphocyte Hepatocyte Culture to Immunosuppressive Drugs as an
In-Vitro Model of Hepatocyte Transplantation
Alloresponses of Mixed Lymphocyte Hepatocyte Culture to Immunosuppressive Drugs as an
In-Vitro Model of Hepatocyte Transplantation Open
BACKGROUND Hepatocyte transplantation (HCTx) has the potential for the treatment of end-stage liver disease. However, failure of engraftment and the long-term acceptance of cellular allografts remain significant challenges for its clinical…
View article: Porcine model for the study of liver regeneration enhanced by non-invasive 13C-methacetin breath test (LiMAx test) and permanent portal venous access
Porcine model for the study of liver regeneration enhanced by non-invasive 13C-methacetin breath test (LiMAx test) and permanent portal venous access Open
The established porcine model appeared suitable for evaluation of postoperative liver regeneration. Clinical characteristics and progression of liver function impairment as well as subsequent recovery were comparable to courses known from …
View article: Hepatocyte‐induced CD4+ T cell alloresponse is associated with major histocompatibility complex class II up‐regulation on hepatocytes and suppressible by regulatory T cells
Hepatocyte‐induced CD4+ T cell alloresponse is associated with major histocompatibility complex class II up‐regulation on hepatocytes and suppressible by regulatory T cells Open
Hepatocyte transplantation is a promising therapeutic approach for various liver diseases. Despite the liver's tolerogenic potential, early immune‐mediated loss of transplanted cells is observed, and longterm acceptance has not been achiev…
View article: Use of the liver maximum function capacity test (LiMAx) for the management of liver resection in cirrhosis – A case of hypopharyngeal cancer liver metastasis
Use of the liver maximum function capacity test (LiMAx) for the management of liver resection in cirrhosis – A case of hypopharyngeal cancer liver metastasis Open
The LiMAx-test enables determination of liver function at a so far unavailable level (metabolism via cytochrome P450 1A2) and hence might provide crucial additional diagnostic information to allow for safe liver resection even in cirrhotic…
View article: Independent Pre-Transplant Recipient Cancer Risk Factors after Kidney Transplantation and the Utility of G-Chart Analysis for Clinical Process Control
Independent Pre-Transplant Recipient Cancer Risk Factors after Kidney Transplantation and the Utility of G-Chart Analysis for Clinical Process Control Open
Risk-adapted cancer surveillance combined with prospective G-chart analysis likely improves cancer surveillance schemes by adapting processes to identified risk factors and by using G-chart alarm signals to trigger Kaizen events and audits…