Marcus Schmidt
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View article: AGO Breast Commission recommendations for the surgical therapy of breast cancer: Working Group on Gynecologic Cancers (AGO) update 2025
AGO Breast Commission recommendations for the surgical therapy of breast cancer: Working Group on Gynecologic Cancers (AGO) update 2025 Open
The German Guideline Commission (AGO: Working Group on Gynecologic Cancers) updated its recommendations on the diagnosis and treatment of breast cancer in March 2025. Chapters on oncological and oncoplastic-reconstructive surgery are coord…
View article: Ge<sub>5</sub> Clusters in the Trivalent Rare-Earth Compound Sm<sub>3</sub>Ge<sub>5</sub>
Ge<sub>5</sub> Clusters in the Trivalent Rare-Earth Compound Sm<sub>3</sub>Ge<sub>5</sub> Open
The compound Sm3Ge5 adopts two modifications with Pearson symbols hP16 (AlB2-derivative) and oF64 (defect α-ThSi2-type) upon synthesis at ambient pressure. Synthesis at extreme conditions grants access to the modification oS32 (Pu3Pd5-type…
View article: Slab Rotation by Transition‐Metal Relocation in the Layered Zintl Phase Li<sub>2</sub>ZnSi
Slab Rotation by Transition‐Metal Relocation in the Layered Zintl Phase Li<sub>2</sub>ZnSi Open
The layered Zintl phase Li 2 ZnSi is a structural analog of intercalated graphite with hexagonal layers of Zn and Si atoms separated by Li atoms (space group P 6 3 / mmc , a = 4.2458(2) Å, c = 8.224(1) Å). Single‐crystal X‐ray diffraction …
View article: Tunable Dirac nodal line in orthorhombic <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mrow><mml:mi>RuO</mml:mi></mml:mrow><mml:mn>2</mml:mn></mml:msub></mml:math>
Tunable Dirac nodal line in orthorhombic Open
The pressure evolution of RuO2 is studied using single-crystal x-ray diffraction in a diamond anvil cell, combined with band-structure calculations. The tetragonal rutile structure transforms into the orthorhombic CaCl2-type structure abov…
View article: Indirect Treatment Comparison between Ribociclib Combined with Non-Steroidal Aromatase Inhibitors and Ovarian Function Suppression vs. Tamoxifen in Premenopausal Women with Early Breast Cancer
Indirect Treatment Comparison between Ribociclib Combined with Non-Steroidal Aromatase Inhibitors and Ovarian Function Suppression vs. Tamoxifen in Premenopausal Women with Early Breast Cancer Open
This study provides an indirect treatment comparison of ribociclib combined with non-steroidal aromatase inhibitors and ovarian function suppression (ribociclib + NSAI + OFS) vs. a frequently used treatment option in German clinical routin…
View article: AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2025
AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2025 Open
The Breast Committee of the Arbeitsgemeinschaft Gynäkologische Onkologie (German Gynecological Oncology Group, AGO) presents the 2025 update of the evidence-based recommendations for the diagnosis and treatment of patients with early breas…
View article: AGO Recommendations for the Diagnosis and Treatment of Patients with Locally Advanced and Metastatic Breast Cancer: Update 2025
AGO Recommendations for the Diagnosis and Treatment of Patients with Locally Advanced and Metastatic Breast Cancer: Update 2025 Open
The Breast Committee of the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO; German Gynecological Oncology Group) presents the 2025 update of the evidence-based recommendations for the diagnosis and treatment of patients with locally adv…
View article: Impact of Epidural Anesthesia on the Outcome of Elderly Patients with Endometrial Cancer: Results of a Propensity Score-Matched Analysis
Impact of Epidural Anesthesia on the Outcome of Elderly Patients with Endometrial Cancer: Results of a Propensity Score-Matched Analysis Open
Introduction: Epidural anesthesia is a standard procedure to mitigate pain during surgery for endometrial cancer (EC). Little data exist about the influence of epidural anesthesia on the oncological outcome in elderly patients with EC. Thi…
View article: Adjuvant Atezolizumab for Early Triple-Negative Breast Cancer
Adjuvant Atezolizumab for Early Triple-Negative Breast Cancer Open
Importance Triple-negative breast cancer is an aggressive subtype with a high incidence in young patients, a high incidence in non-Hispanic Black women, and a high risk of progression to metastatic cancer, a devastating sequela with a 12- …
View article: Eribulin-Induced Peripheral Neuropathy in Locally Advanced or Metastatic Breast Cancer: Final Analysis of the Prospective Cohort IRENE Study
Eribulin-Induced Peripheral Neuropathy in Locally Advanced or Metastatic Breast Cancer: Final Analysis of the Prospective Cohort IRENE Study Open
Eribulin is a preferred treatment for patients with advanced breast cancer (BC) following anthracyclines and taxanes. The final analysis of the IRENE study assessed the incidence and resolution of eribulin-induced peripheral neuropathy (EI…
View article: Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial
Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial Open
Effective targeting of somatic cancer mutations to enhance the efficacy of cancer immunotherapy requires an individualized approach. Autogene cevumeran is a uridine messenger RNA lipoplex-based individualized neoantigen-specific immunother…
View article: Eribulin-Induced Peripheral Neuropathy in Locally Advanced or Metastatic Breast Cancer: Final Analysis of the Prospective Cohort IRENE Study
Eribulin-Induced Peripheral Neuropathy in Locally Advanced or Metastatic Breast Cancer: Final Analysis of the Prospective Cohort IRENE Study Open
Eribulin is a preferred treatment for patients with advanced breast cancer (BC) following anthracyclines and taxanes. The final analysis of the IRENE study assessed the incidence and resolution of eribulin-induced peripheral neuropathy (EI…
View article: Tunable Dirac nodal line in orthorhombic RuO$_2$
Tunable Dirac nodal line in orthorhombic RuO$_2$ Open
Pressure evolution of RuO2 is studied using single-crystal x-ray diffraction in a diamond anvil cell, combined with \textit{ab initio} band-structure calculations. The tetragonal rutile structure transforms into the orthorhombic CaCl$_2$-t…
View article: Prognostic Impact of Acute and Chronic Inflammatory Interleukin Signatures in the Tumor Microenvironment of Early Breast Cancer
Prognostic Impact of Acute and Chronic Inflammatory Interleukin Signatures in the Tumor Microenvironment of Early Breast Cancer Open
Interleukins play dual roles in breast cancer, acting as both promoters and inhibitors of tumorigenesis within the tumor microenvironment, shaped by their inflammatory functions. This study analyzed the subtype-specific prognostic signific…
View article: Chemotherapy in older patients with early breast cancer
Chemotherapy in older patients with early breast cancer Open
The incidence of breast cancer increases with age. Particularly in ageing societies, breast cancer has a significant impact on both the older patient and the healthcare system. In older patients with early breast cancer, there is a complex…
View article: Physical activity levels are positively related to progression-free survival and reduced adverse events in advanced ER+ breast cancer
Physical activity levels are positively related to progression-free survival and reduced adverse events in advanced ER+ breast cancer Open
Background Increased levels of physical activity are associated with a reduction of breast cancer mortality, especially in postmenopausal women with positive hormone receptor status. So far, previous observational case–control and cohort s…
View article: Palbociclib: Randomized Studies and Real-world Evidence as the Basis for Therapeutic Planning in Metastatic Breast Cancer
Palbociclib: Randomized Studies and Real-world Evidence as the Basis for Therapeutic Planning in Metastatic Breast Cancer Open
Endocrine-based combination therapy with an inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6 inhibitors) is currently the first-line therapy of choice for patients with hormone receptor-positive (HR+) and human epidermal growth fa…
View article: GAIN2 trial overall survival with intense versus tailored dose dense chemotherapy in early breast cancer
GAIN2 trial overall survival with intense versus tailored dose dense chemotherapy in early breast cancer Open
GAIN-2 trial evaluated the optimal intense dose-dense (idd) strategy for high-risk early breast cancer. This study reports the secondary endpoints pathological complete response (pCR) and overall survival (OS). Patients ( n = 2887) were ra…
View article: Changes in modifiable risk factors in women at increased risk for breast and ovarian cancer during the COVID-19 pandemic
Changes in modifiable risk factors in women at increased risk for breast and ovarian cancer during the COVID-19 pandemic Open
Impaired mental health during the pandemic constituted a risk factor for unfavorable changes in PA. Consequently, a surge in BC may arise due to decreased engagement in PA. Healthcare professionals must remain aware of the potential risk f…
View article: Characterization of the nutritional profile of three plant-based drinks
Characterization of the nutritional profile of three plant-based drinks Open
This study aimed to analyze the nutrient composition of plant-based drinks (oat, almond, soy) available on the German market, focusing on 36 samples, representing non-fortified and unsweetened products. Due to the absence of standardized l…
View article: Prognostic Impact of Pro- and Anti-Inflammatory Interleukin mRNA-Expression Signatures in Early Breast Cancer
Prognostic Impact of Pro- and Anti-Inflammatory Interleukin mRNA-Expression Signatures in Early Breast Cancer Open
Background: Interleukins play dual roles in breast cancer, acting as both promoters and inhibitors of tumorigenesis within the tumor microenvironment, which is shaped by their inflammatory functions. This study analyzed the subtype-specifi…
View article: Tailored Dose-Dense Versus Standard Adjuvant Chemotherapy for High-Risk Early Breast Cancer: End-of-Study Results of the Randomized PANTHER Trial
Tailored Dose-Dense Versus Standard Adjuvant Chemotherapy for High-Risk Early Breast Cancer: End-of-Study Results of the Randomized PANTHER Trial Open
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. …
View article: Fermi-liquid behavior of non-altermagnetic RuO$_2$
Fermi-liquid behavior of non-altermagnetic RuO$_2$ Open
Presence of magnetism in potentially altermagnetic RuO$_2$ has been a subject of intense debate. Using broadband infrared spectroscopy combined with density-functional band-structure calculations, we show that optical conductivity of RuO$_…
View article: BRCA1, BRCA2 and PALB2 mRNA Expression as Prognostic Markers in Patients with Early Breast Cancer
BRCA1, BRCA2 and PALB2 mRNA Expression as Prognostic Markers in Patients with Early Breast Cancer Open
Breast cancer (BC) poses a challenge in establishing new treatment strategies and identifying new prognostic and predictive markers due to the extensive genetic heterogeneity of BC. Very few studies have investigated the impact of mRNA exp…
View article: CDK4/6 Inhibition – Therapy Sequences and the Quest to Find the Best Biomarkers – an Overview of Current Programs
CDK4/6 Inhibition – Therapy Sequences and the Quest to Find the Best Biomarkers – an Overview of Current Programs Open
In recent years, new targeted therapies have been developed to treat patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) breast cancer. Some of these therapies have not just become the ne…
View article: Prognostic impact of metabolic syndrome in patients with primary endometrial cancer: a retrospective bicentric study
Prognostic impact of metabolic syndrome in patients with primary endometrial cancer: a retrospective bicentric study Open
Purpose Endometrial cancer (EC) is the most common gynaecological cancer. Its incidence has been rising over the years with ageing and increased obesity of the high-income countries’ populations. Metabolic syndrome (MetS) has been suggeste…
View article: Occurrence and Management of Immunotherapy-Associated Adverse Events in Patients with Gynecological Cancers
Occurrence and Management of Immunotherapy-Associated Adverse Events in Patients with Gynecological Cancers Open
Background: Immune checkpoint inhibitors (ICIs) have emerged as an essential therapeutic approach in treating many solid tumors. ICIs enhance the body’s anti-tumor T-cell activity, resulting in a novel spectrum of immunotherapy-related sid…