Moritz Schüssler
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View article: Targeting SUMOylation Triggers IFN-β–dependent Activation of Patient and Allogenic NK Cells in Preclinical Models of Acute Myeloid Leukemia
Targeting SUMOylation Triggers IFN-β–dependent Activation of Patient and Allogenic NK Cells in Preclinical Models of Acute Myeloid Leukemia Open
NK cells can play a significant role in the antitumoral immune response. In patients with acute myeloid leukemia (AML), NK cells are, however, often found in low numbers and exhibit poor activity, contributing to leukemic progression. Allo…
View article: The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling Open
The detection of cytosolic dsDNA is tightly regulated to avoid pathological inflammatory responses. A major pathway involved in their detection relies on the cyclic GMP-AMP synthase (cGAS) that triggers activation of the Stimulator of inte…
View article: Gene editing of <i>SAMHD1</i> in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels
Gene editing of <i>SAMHD1</i> in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels Open
Sterile α motif and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphate triphosphohydrolase (dNTPase) and a potent restriction factor for immunodeficiency virus 1 (HIV-1), active in myeloid and resting CD4 + T cells. The anti-vi…
View article: Gene editing of<i>SAMHD1</i>in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels
Gene editing of<i>SAMHD1</i>in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels Open
Sterile α motif (SAM) and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphate triphosphohydrolase (dNTPase) and a potent restriction factor for immunodeficiency virus 1 (HIV-1), active in myeloid and resting CD4 + T cells. The a…
View article: Harnessing the cooperation between DNA‐PK and cGAS in cancer therapies
Harnessing the cooperation between DNA‐PK and cGAS in cancer therapies Open
The cyclic GMP‐AMP synthase–stimulator of interferon genes (cGAS‐STING) pathway is central for the initiation of anti‐tumoural immune responses. Enormous effort has been made to optimise the design and administration of STING agonists to s…
View article: CRISPR/Cas9 knock-in strategy to evaluate phospho-regulation of SAMHD1
CRISPR/Cas9 knock-in strategy to evaluate phospho-regulation of SAMHD1 Open
Sterile α motif (SAM) and HD domain-containing protein 1 (SAMHD1) is a potent restriction factor for immunodeficiency virus 1 (HIV-1), active in myeloid and resting CD4 + T cells. As a dNTP triphosphate triphosphohydrolase (dNTPase), SAMHD…