Moritz von Scheidt
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View article: Sex-specific association of epicardial adipose tissue with coronary artery disease in an Indian cohort: a cross-sectional study
Sex-specific association of epicardial adipose tissue with coronary artery disease in an Indian cohort: a cross-sectional study Open
View article: Cigarette smoking upregulates vascular expression of the novel atherosclerosis risk factor ADAMTS-7
Cigarette smoking upregulates vascular expression of the novel atherosclerosis risk factor ADAMTS-7 Open
Background Cigarette smoking is an established risk factor for coronary artery disease (CAD) and myocardial infarction. Genetic variants in the extracellular matrix protease ADAMTS-7 were also identified to increase CAD risk. Notably, ADAM…
View article: Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease
Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease Open
Background and Aims Clonal haematopoiesis of indeterminate potential (CHIP) has been associated with cardiovascular risk, but its prognostic relevance and mechanistic role in coronary artery disease (CAD) remains incompletely understood. T…
View article: Reticulated platelets in coronary artery disease: a multidimensional approach unveils prothrombotic signalling and novel therapeutic targets
Reticulated platelets in coronary artery disease: a multidimensional approach unveils prothrombotic signalling and novel therapeutic targets Open
Background and Aims Reticulated platelets (RPs), hyperreactive and RNA-rich, are associated with increased risk of cardiovascular events and suboptimal response to antiplatelet therapy in coronary artery disease (CAD). However, the underly…
View article: An interplay of non-coding RNAs regulates CDH13 expression and affects endothelial function and coronary artery disease risk
An interplay of non-coding RNAs regulates CDH13 expression and affects endothelial function and coronary artery disease risk Open
Many common diseases have a polygenic architecture. The responsible alleles are thought to mediate risk by disturbing gene regulation in most cases, however, the precise mechanisms have been elucidated only for a few. Here, we investigated…
View article: Prognostic significance of somatic mutations in myeloid cells of men with chronic heart failure – interaction between loss of Y chromosome and clonal haematopoiesis
Prognostic significance of somatic mutations in myeloid cells of men with chronic heart failure – interaction between loss of Y chromosome and clonal haematopoiesis Open
Aims Age‐associated clonal haematopoiesis of indeterminate potential ( CHIP ) has been linked to increased incidence and worse prognosis of chronic heart failure ( CHF ). CHIP arises from somatic mutations in haematopoietic stem and progen…
View article: Clinical scores fail to sufficiently identify children with familial hypercholesterolaemia
Clinical scores fail to sufficiently identify children with familial hypercholesterolaemia Open
Aims The study aimed to assess the effectiveness of three clinical diagnostic criteria [Simon Broome (SB), MEDPED (MP), and guideline-derived (GL-EAS)] in identifying children with familial hypercholesterolaemia (FH) compared with genetic …
View article: Novel and Known Genetic Players in Hypertension: From Gene Expression to Striking Insights
Novel and Known Genetic Players in Hypertension: From Gene Expression to Striking Insights Open
Cardiovascular diseases (CVDs) are the most common non-communicable diseases, responsible for 17.9 million deaths each year. Hypertension is a major risk factor for CVDs. Gene expression data obtained from RNA sequencing can help identify …
View article: Employment of artificial intelligence for an unbiased evaluation regarding the recovery of right ventricular function after mitral valve transcatheter edge‐to‐edge repair
Employment of artificial intelligence for an unbiased evaluation regarding the recovery of right ventricular function after mitral valve transcatheter edge‐to‐edge repair Open
Aims Long‐standing severe mitral regurgitation (MR) leads to left atrial (LA) enlargement, elevated pulmonary artery pressures, and ultimately right heart failure. While mitral valve transcatheter edge‐to‐edge repair (M‐TEER) alleviates le…
View article: Extent of coronary artery disease and clinical outcomes with ticagrelor monotherapy versus aspirin after coronary artery bypass grafting: insights from the TiCAB trial
Extent of coronary artery disease and clinical outcomes with ticagrelor monotherapy versus aspirin after coronary artery bypass grafting: insights from the TiCAB trial Open
OBJECTIVES Patients with extensive coronary artery disease (CAD) have a higher risk of cardiovascular events. This post hoc analysis of the Ticagrelor in CABG (TiCAB) trial examined the association of ticagrelor monotherapy versus aspirin …
View article: Correction: Sex-specific outcomes in myocardial infarction: a dual-cohort analysis using clinical and real-world data
Correction: Sex-specific outcomes in myocardial infarction: a dual-cohort analysis using clinical and real-world data Open
View article: Sex-specific outcomes in myocardial infarction: a dual-cohort analysis using clinical and real-world data
Sex-specific outcomes in myocardial infarction: a dual-cohort analysis using clinical and real-world data Open
Background Sex-related differences in symptoms, treatment, and outcomes in patients presenting with myocardial infarction have been reported but vary largely between studies. We sought to characterize sex differences in presentation and ou…
View article: Ticagrelor vs Prasugrel for Acute Coronary Syndrome in Routine Care
Ticagrelor vs Prasugrel for Acute Coronary Syndrome in Routine Care Open
Importance In patients with acute coronary syndrome (ACS) undergoing invasive treatment, ticagrelor and prasugrel are guideline-recommended P2Y12 receptor inhibitors. The ISAR-REACT5 randomized clinical trial demonstrated superiority for p…
View article: UNICORN: A Deep Learning Model for Integrating Multi-Stain Data in Histopathology
UNICORN: A Deep Learning Model for Integrating Multi-Stain Data in Histopathology Open
Background: The integration of multi-stain histopathology images through deep learning poses a significant challenge in digital histopathology. Current multi-modal approaches struggle with data heterogeneity and missing data. This study ai…
View article: Prognostic significance of somatic mutations in myeloid cells of men with chronic heart failure – interaction between loss of Y chromosome and clonal hematopoiesis
Prognostic significance of somatic mutations in myeloid cells of men with chronic heart failure – interaction between loss of Y chromosome and clonal hematopoiesis Open
Age-associated clonal hematopoiesis of indeterminate potential (CHIP) has been associated with increased incidence and worse prognosis of chronic heart failure. CHIP is driven by somatic mutations in hematopoietic stem and progenitor cells…
View article: Distinct genetic liability profiles define clinically relevant patient strata across common diseases
Distinct genetic liability profiles define clinically relevant patient strata across common diseases Open
View article: Sex-specific association of epicardial adipose tissue with coronary artery disease in an Indian cohort: a cross-sectional study
Sex-specific association of epicardial adipose tissue with coronary artery disease in an Indian cohort: a cross-sectional study Open
Background Epicardial adipose tissue (EAT) plays an important role in the pathogenesis of coronary artery disease (CAD). The correlation of EAT volume with CAD or its risk factors, especially the sex-specific correlation, has not been full…
View article: Platelet mass cytometry reveals dysregulation of prothrombotic pathways in essential thrombocythemia
Platelet mass cytometry reveals dysregulation of prothrombotic pathways in essential thrombocythemia Open
Thromboembolic events are common in patients with essential thrombocythemia (ET). However, the pathophysiological mechanisms underlying the increased thrombotic risk remain to be determined. Here, we perform the first phenotypical characte…
View article: Invasive Assessment of Right Ventricular to Pulmonary Artery Coupling Improves 1-year Mortality Prediction After Transcatheter Aortic Valve Replacement and Anticipates the Persistence of Extra-Aortic Valve Cardiac Damage
Invasive Assessment of Right Ventricular to Pulmonary Artery Coupling Improves 1-year Mortality Prediction After Transcatheter Aortic Valve Replacement and Anticipates the Persistence of Extra-Aortic Valve Cardiac Damage Open
RV-PA coupling expressed as TAPSE/sPAPinvasive can refine stratification of severe aortic stenosis patients into low-risk and high-risk cohorts for mortality after TAVR. Moreover, it can help to anticipate persistent extra-aorti…
View article: User-centered development of an mHealth app for cardiovascular prevention
User-centered development of an mHealth app for cardiovascular prevention Open
Background Mobile health (mHealth) apps can be used for cardiovascular disease (CVD) prevention. User-centered design, evidence-based content and user testing can be applied to ensure a high level of usability and adequate app access. Obje…
View article: Guideline-Based Cardiovascular Risk Assessment Delivered by an mHealth App: Development Study
Guideline-Based Cardiovascular Risk Assessment Delivered by an mHealth App: Development Study Open
Background Identifying high-risk individuals is crucial for preventing cardiovascular diseases (CVDs). Currently, risk assessment is mostly performed by physicians. Mobile health apps could help decouple the determination of risk from medi…
View article: Unique 40-year survival after heart transplantation with normal graft function and spontaneous operational tolerance
Unique 40-year survival after heart transplantation with normal graft function and spontaneous operational tolerance Open
View article: ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1
ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1 Open
BACKGROUND: The ADAMTS7 locus was genome-wide significantly associated with coronary artery disease. Lack of the ECM (extracellular matrix) protease ADAMTS-7 (A disintegrin and metalloproteinase-7) was shown to reduce atherosclerotic plaqu…
View article: Leukocytes carrying<i>Clonal Hematopoiesis of Indeterminate Potential</i>(CHIP) Mutations invade Human Atherosclerotic Plaques
Leukocytes carrying<i>Clonal Hematopoiesis of Indeterminate Potential</i>(CHIP) Mutations invade Human Atherosclerotic Plaques Open
Background Leukocyte progenitors derived from clonal hematopoiesis of undetermined potential (CHIP) are associated with increased cardiovascular events. However, the prevalence and functional relevance of CHIP in coronary artery disease (C…
View article: Distinct genetic liability profiles define clinically relevant patient strata across common diseases
Distinct genetic liability profiles define clinically relevant patient strata across common diseases Open
Genome-wide association studies have unearthed a wealth of genetic associations across many complex diseases. However, translating these associations into biological mechanisms contributing to disease etiology and heterogeneity has been ch…
View article: Use of big data from health insurance for assessment of cardiovascular outcomes
Use of big data from health insurance for assessment of cardiovascular outcomes Open
Outcome research that supports guideline recommendations for primary and secondary preventions largely depends on the data obtained from clinical trials or selected hospital populations. The exponentially growing amount of real-world medic…
View article: Machine Learning Identifies New Predictors on Restenosis Risk after Coronary Artery Stenting in 10,004 Patients with Surveillance Angiography
Machine Learning Identifies New Predictors on Restenosis Risk after Coronary Artery Stenting in 10,004 Patients with Surveillance Angiography Open
Objective: Machine learning (ML) approaches have the potential to uncover regular patterns in multi-layered data. Here we applied self-organizing maps (SOMs) to detect such patterns with the aim to better predict in-stent restenosis (ISR) …
View article: The novel coronary artery disease risk factor ADAMTS-7 modulates atherosclerotic plaque formation by degradation of TIMP-1
The novel coronary artery disease risk factor ADAMTS-7 modulates atherosclerotic plaque formation by degradation of TIMP-1 Open
Background The ADAMTS7 locus was genome-wide significantly associated with coronary artery disease (CAD). Lack of the extracellular matrix (ECM) protease ADAMTS-7 was shown to reduce atherosclerotic plaque formation. Objective To identify …
View article: Immature Platelet Fraction Predicts Adverse Events in Patients With Acute Coronary Syndrome: the ISAR-REACT 5 Reticulated Platelet Substudy
Immature Platelet Fraction Predicts Adverse Events in Patients With Acute Coronary Syndrome: the ISAR-REACT 5 Reticulated Platelet Substudy Open
Background: Immature or reticulated platelets are associated with impaired efficacy of antiplatelet drugs and adverse events in cardiovascular patients. Their role as a predictive biomarker in patients with acute coronary syndrome treated …
View article: Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants Open
The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) comprising 181,52…