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Managing lorlatinib-induced weight gain through a structured exercise intervention in an ALK+ NSCLC patient: a case report Open
Background In non-small cell lung cancer (NSCLC), ALK tyrosine kinase inhibitors (TKIs) have been associated with significant weight gain, predominantly in fat tissues. To date, only one case report has evaluated the impact of pharmacologi…
Coming-Around: Living with Lung Cancer on the Nether Side of Rehabilitation in Denmark Open
Inequality in cancer is often framed as disparities in mortality, incidence, and treatment. Cancer rehabilitation aims to help people live the best possible life with cancer, regardless of their background. In this study, I explore how peo…
The Effect of Exercise on Quality of Life in Patients With Advanced Lung Cancer: A Secondary Analysis of a Randomized Controlled Trial Open
This study demonstrates that a 12-week exercise intervention mitigates worsening of peripheral neuropathy and reduces pain in patients with advanced lung cancer, supporting exercise as a beneficial complementary strategy during chemotherap…
Physical activity guidelines in oncology: A systematic review of the current recommendations Open
This review aims to summarize the recommendations endorsed by scientific societies regarding physical activity for patients with cancer. A systematic search was conducted to identify guidelines endorsed by scientific societies and publishe…
SCAPAS-LungCancer—improving supportive care for patients surgically treated for non-small cell lung cancer: protocol for a prospective, longitudinal, observational and exploratory multicentre study Open
Introduction and aim Despite global advances in lung cancer treatment, challenges persist in symptom management and supportive care, particularly as the incidence of early-stage diagnoses rises. Patients with non-small cell lung cancer (NS…
Dual targeting of <i>CD155</i>/<i>TIGIT</i> and <i>PD-L1</i>/<i>PD-1</i> immune checkpoints potentiates NK cell-mediated cytotoxicity in medulloblastoma Open
Background Medulloblastoma (MB) is one of the most prevalent pediatric brain malignancies and makes up approximately 20% of all primary brain tumors in children. Current treatment options are not curative for approximately 30% of patients …
EXTH-32. DUAL TARGETING OF CD155/TIGIT AND PD-L1/PD-1 IMMUNE CHECKPOINTS POTENTIATES NATURAL KILLER CELL-MEDIATED CYTOTOXICITY IN MEDULLOBLASTOMA Open
Medulloblastoma (MB) is one of the most prevalent pediatric brain malignancies and makes up approximately 20% of all primary brain tumors in children. Current treatment options are not curative for about 30% of patients and leave survivors…
Optimizing treatment success in lung cancer: the role of functional testing Open
Lung cancer, a pervasive and lethal global disease, presents formidable challenges, particularly in advanced stages.The widely used Eastern Cooperative Oncology Group Performance Score (ECOG-PS) faces limitations due to subjectivity and re…
Sarcopenia and loss of muscle mass in patients with lung cancer undergoing chemotherapy treatment: a systematic review and meta-analysis Open
The present data demonstrate a marked loss of skeletal muscle mass in patients with lung cancer undergoing chemotherapy treatment, as well as a high prevalence of sarcopenia. As sarcopenia is associated with poor clinical outcomes, it seem…
Sarcopenia and loss of muscle mass in patients with lung cancer undergoing chemotherapy treatment: a systematic review and meta-analysis Open
In patients with cancer, sarcopenia is associated with treatment related complications, treatment cessation, poor quality of life and reduced overall survival. Despite this, there is limited knowledge about changes in skeletal muscle mass …
Pre-radiotherapy daily exercise training in non-small cell lung cancer: A feasibility study Open
This study demonstrated 'proof of principle' that daily moderate-to-high intensity cycle ergometer exercise was feasible, safe and well tolerated among newly diagnosed patients with locally advanced NSCLC undergoing concomitant chemoradiot…