Morvarid Karimi
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View article: Radiation dosimetry and fasting-dependent hepatobiliary clearance of the VAChT-specific PET radioligand 18F-VAT in humans
Radiation dosimetry and fasting-dependent hepatobiliary clearance of the VAChT-specific PET radioligand 18F-VAT in humans Open
Background The vesicular acetylcholine transporter ligand (-)-(1-((2R,3R)-8-(2-[(18)F]fluoro-ethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)piperidin-4-yl)(4-fluorophenyl)-methanone ( 18 F -VAT) enables positron emission tomography PE…
View article: When the wild things are: Defining mammalian diel activity and plasticity
When the wild things are: Defining mammalian diel activity and plasticity Open
Circadian rhythms are a mechanism by which species adapt to environmental variability and fundamental to understanding species behavior. However, we lack data and a standardized framework to accurately assess and compare temporal activity …
View article: Radiation Dosimetry and Fasting-Dependent Hepatobiliary Clearance of the VAChT- Specific PET radioligand 18F-VAT in Humans
Radiation Dosimetry and Fasting-Dependent Hepatobiliary Clearance of the VAChT- Specific PET radioligand 18F-VAT in Humans Open
Background The vesicular acetylcholine transporter ligand (-)-(1-((2R,3R)-8-(2-[(18)F]fluoro-ethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)piperidin-4-yl)(4-fluorophenyl)-methanone (18F -VAT) enables positron emission tomography PET …
View article: PET Quantification of [<sup>18</sup>F]VAT in Human Brain and Its Test–Retest Reproducibility and Age Dependence
PET Quantification of [<sup>18</sup>F]VAT in Human Brain and Its Test–Retest Reproducibility and Age Dependence Open
Molecular imaging of brain vesicular acetylcholine transporter provides a biomarker to explore cholinergic systems in humans. We aimed to characterize the distribution of, and optimize methods to quantify, the vesicular acetylcholine trans…
View article: Resting‐State Functional Connectivity Predicts <scp>STN DBS</scp> Clinical Response
Resting‐State Functional Connectivity Predicts <span>STN DBS</span> Clinical Response Open
Background Deep brain stimulation of the subthalamic nucleus is a widely used adjunctive therapy for motor symptoms of Parkinson's disease, but with variable motor response. Predicting motor response remains difficult, and novel approaches…
View article: Regional, not global, functional connectivity contributes to isolated focal dystonia
Regional, not global, functional connectivity contributes to isolated focal dystonia Open
Regional functional connectivity differences, not global network level dysfunction, contributes to common pathophysiologic mechanisms in isolated focal dystonia. Rigorous quality control eliminated spurious large-scale network differences …
View article: Validation of diffusion tensor imaging measures of nigrostriatal neurons in macaques
Validation of diffusion tensor imaging measures of nigrostriatal neurons in macaques Open
Diffusion measures in the nigrostriatal tract correlate with nigral dopamine neurons and striatal fiber density, but have the same relationship to terminal field measures as a previous report of striatal PET measures of presynaptic neurons…
View article: The Human Experience with Intravenous Levodopa
The Human Experience with Intravenous Levodopa Open
At least 2760 patients have received IV levodopa with a safety profile comparable to that seen with oral administration.
View article: Absorbed radiation dosimetry of the D<sub>3</sub>-specific PET radioligand [<sup>18</sup>F]FluorTriopride estimated using rodent and nonhuman primate.
Absorbed radiation dosimetry of the D<sub>3</sub>-specific PET radioligand [<sup>18</sup>F]FluorTriopride estimated using rodent and nonhuman primate. Open
[18F]FluorTriopride ([18F]FTP) is a dopamine D3-receptor preferring radioligand with potential for investigation of neuropsychiatric disorders including Parkinson disease, dystonia and schizophrenia. Here we estimate human radiation dosime…
View article: Radiation dosimetry of [18F]VAT in nonhuman primates
Radiation dosimetry of [18F]VAT in nonhuman primates Open
The macaque biodistribution data showed high retention of [(18)F]VAT in the liver consistent with hepatobiliary clearance. These dosimetry data support that relatively safe doses of [(18)F]VAT can be administered to obtain imaging in human…
View article: The human experience with intravenous levodopa
The human experience with intravenous levodopa Open
Objective: To compile a comprehensive summary of published human experience with levodopa given intravenously, with a focus on information required by regulatory agencies. Background: While safe intravenous use of levodopa has been documen…
View article: The Role of Dopamine and Dopaminergic Pathways in Dystonia: Insights from Neuroimaging
The Role of Dopamine and Dopaminergic Pathways in Dystonia: Insights from Neuroimaging Open
Background: Dystonia constitutes a heterogeneous group of movement abnormalities, characterized by sustained or intermittent muscle contractions causing abnormal postures. Overwhelming data suggest involvement of basal ganglia and dopamine…