Explanipedia

Barriers and Facilitators to Adopting Safe Burial Practices During an Ebola Virus Disease Outbreak in Liberia: A Mixed Methods Study Open

Moses Tende Stephens, Arunrat Tangmunkongvorakul, Natthapol Kosashunhanan, Mosoka Fallah, Julius S.M. Gilayeneh , et al. · 2025

Background Traditional funeral practices were a significant factor in the transmission of Ebola virus disease (EVD) during the West Africa outbreak from 2014–2016. In Liberia, these practices often conflict with public health directives, r…

Addressing the Recurrent and Protracted Cholera Outbreaks in Africa: Challenges and the Way Forward Open

Nebiyu Dereje, Merawi Aragaw, Kyeng Mercy, Hiwot Moges, Tamrat Shaweno , et al. · 2025

The recurrent and protracted outbreaks of cholera in Africa demand concerted multi-sectoral interventions. It is critical to increase investment in water, sanitation and hygiene, enhance multisectoral response coordination, strengthen vacc…

Accelerating community health worker programmes: a key priority of the Global Health Initiatives for the operationalisation of the Lusaka Agenda in Africa Open

Ngashi Ngongo, Nebiyu Dereje, Mosoka Fallah, Morẹ́nikẹ́ Oluwátóyìn Foláyan, Nicaise Ndembi , et al. · 2025

Counteradaptation in Vulnerable Socio-ecological Systems in Sierra Leone Open

Raphael Frankfurter, Sahr David Kpakiwa, Zazie Huml, Smit Chitre, Mohamed Bailor Barrie , et al. · 2025

Sierra Leone is among the countries most vulnerable to climate change yet least resourced toconfront its impacts. Mainstream climate governance often casts adaptation as a technicaladjustment to biophysical hazards, but such framings risk …

Mapping Plasmodium falciparum mutations in Africa: A critical review of emerging drug resistance and implications for malaria control Open

Pierre Gashema, James Kagame, Patrick Gad Iradukunda, Emmanuel Edwar Siddig, Sofonías K. Tessema , et al. · 2025

Artificial Intelligence for Genomics and Bioinformatics: Is Africa Lagging Behind? Open

Sofonías K. Tessema, Collins Kipngetich Tanui, Harris Onywera, Alan Christoffels, Nebiyu Dereje , et al. · 2025

Summary Africa’s diverse pathogen and human genetics present significant opportunities for genomic medicine research using artificial intelligence (AI). We surveyed 250 genomics researchers across 46 of the 55 African Union Member States t…

The mediation role of work environment in the relationship between occupational hygiene practices and the health and safety of waste scavengers in emerging economies Open

Cyrus N. Younquoi, Best Ordinioha, Mosoka Fallah · 2025

Due to the high unemployment rate in Liberia, many individuals engage in waste scavenging as a means of survival. These scavengers are exposed to various hazards, including infections, respiratory illnesses, and accidents, often operating …

Still not over: Africa CDC and WHO issue third reaffirmation of mpox emergency Open

Ngashi Ngongo, Yap Boum, Kyeng Mercy, Mosoka Fallah, Nebiyu Dereje , et al. · 2025

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Leveraging risk communication and community engagement and lessons from previous outbreaks to strengthen a Public Health response: A case study of Disease X in the Panzi region, DRC Open

Pierre Gashema, Patrick Gad Iradukunda, Placide Sesonga, Radjabu Bigirimana, J. Mugisha , et al. · 2025

On 08 December 2024, the World Health Organization (WHO) reported an outbreak of Disease X in the Panzi Health Zone, Kwango province, Democratic Republic of the Congo (DRC). This unknown pathogen, with 406 cases and 31 deaths at the time o…

Strengthening National Regulatory Authorities in Africa: A Critical Step Towards Enhancing Local Manufacturing of Vaccines and Health Products Open

Alemayehu Lelisa Duga, Nebiyu Dereje, Mosoka Fallah, Tedi Angasa, Abebe Genetu Bayih , et al. · 2025

The World Health Organization (WHO) Global Benchmarking Tool (GBT) classifies regulatory systems into four maturity levels, with Maturity Level 3 (ML3) signifying a stable and effective regulatory environment. As of January 2025, eight Afr…

Enhancing Clinical Trial Sites in Low- and Middle-Income Countries to Facilitate Product Development in Response to the COVID-19 Pandemic Open

Sophie Kang, Birkneh Tilahun Tadesse, Hyon Jin Jeon, Mosoka Fallah, Nebiyu Dereje , et al. · 2025

Background The swift development of coronavirus disease 2019 (COVID-19) vaccines marked a monumental effort in global coordination and collaboration; however, there remained major disparities in vaccine access and research capacity across …

Overcoming Vaccine Inequities and Research Gaps in Africa: Challenges and Opportunities Identified During the COVID-19 Pandemic Open

Cara Lynn Kim, Thaint Thwe, Ligia María Cruz Espinoza, Jonathan D. Sugimoto, Mosoka Fallah , et al. · 2025

Before the onset of the coronavirus disease 2019 (COVID-19) pandemic, the African region already faced a substantial communicable disease burden and a rising prevalence of noncommunicable and chronic conditions. The COVID-19 pandemic has u…

Mpox in Africa: What we know and what is still lacking Open

Jia Bainga Kangbai, Umaru Sesay, Ulrich Vickos, Fatmata Kagbanda, Mosoka Fallah , et al. · 2025

Emerging as a major global health threat, Mpox previously known as Monkeypox has drawn attention due to a worrying surge in cases. This zoonotic disease, native to Central and West Africa, is marked by fever, rash, and lymphadenopathy and …

More than two decades since Abuja declaration: A way forward for ending AIDS as a public health threat by 2030 Open

Nebiyu Dereje, Mosoka Fallah, Tajudeen Raji, Marta Minwyelet Terefe, Ngashi Ngongo , et al. · 2025

The Abuja Declaration, which was endorsed in 2001, was a hallmark of African leadership’s decision to prevent and control human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) in Africa. Since this declaration, t…

Barriers and enhancers to COVID-19 vaccination among healthcare workers in a metropolitan city in Nigeria Open

Adewale Victor Opayele, Adeniyi Francis Fagbamigbe, Chinwe Lucia Ochu, Rodgers R Ayebare, Adedayo Omotayo Faneye , et al. · 2025

This study identifies why HCWs in Nigeria are hesitant about getting vaccinated. This information can help to improve vaccination rates in this group. It fits with the journal's focus on making African public health responses stronger.

Diethylene glycol: Unnoticed threat in the landscape of fixed-dose combination medications Open

Alemayehu Lelisa Duga, Mosoka Fallah, Albert Figueras · 2025

Diethylene glycol (DEG) and ethylene glycol (EG) are organic compounds often found in various consumer products, including antifreeze and industrial solvents used in pharmaceutical preparations, as well as serving as raw materials for poly…

COVID-19 vaccine uptake and predictors of hesitancy among healthcare workers in Côte d’Ivoire Open

Richard B. Yapi, Bi Yourou Guillaume Zamina, Martial Bama, Yao Me Raphael Amani, Francis Kakooza , et al. · 2025

This study underscores the importance of Ministry of Health-led interventions to improve HCWs vaccination rates in Africa.

Enhancing health security in Africa: Collaboration between public health institutes and academia Open

Andrew Kambugu, Rodgers R Ayebare, Francis Kakooza, Agnes Kiragga, Aster Tsegaye , et al. · 2025

This paper describes PROVE's innovative approaches to generating new knowledge, developing practical approaches, and building capacity among African researchers in collaboration with policymakers.

COVID-19 severity and vaccine effectiveness in Malawi: A test-negative case-control study Open

Clara Sambani, Victor Chikwapulo, Regina Mankhamba, Tonny Muwonge, Mavuto Thomas , et al. · 2025

The findings can inform strategies on prioritisation for disease vaccination and improving patient outcomes.

Vaccine uptake, barriers and enhancers of COVID-19 vaccination among healthcare workers from high-burden cities in Ethiopia Open

Gutema Bulti Tura, Derbachew Asfaw Teni, Saro Abdella Abrahim, Jaleta Bulti Tura, Yakob Wondarad , et al. · 2025

This study reveals COVID-19 vaccine safety, efficacy and confidence concerns of HCWs, highlighting the need for targeted awareness to strengthen national vaccination efforts against pandemics.

Perceptions about COVID-19 vaccine among healthcare workers in Rwanda: A mixed-methods study Open

Erigene Rutayisire, François Xavier Ndayambaje, S. Senga, Tajudeen Raji, Darius Uzabakiriho , et al. · 2025

This study reveals discrepancies in HCWs vaccine confidence in Rwanda, highlighting the need for targeted educational interventions to strengthen national COVID-19 response efforts.

Filling the funding void would mitigate infectious outbreaks and build resilience in Africa Open

Mosoka Fallah, Anna Mia Ekström, Ole Petter Ottersen, Sofonías K. Tessema, Jean Kaseya · 2025

The Unified Continental Approach to the Mpox Outbreak Preparedness and Response: A Model for Future Outbreaks in Africa Open

Ngashi Ngongo, Nicaise Ndembi, Mosoka Fallah, Wessam Mankoula, Merawi Aragaw Tegegne , et al. · 2025

No abstract available.

Building systems’ resilience in the mpox outbreak response in Africa Open

Ngashi Ngongo, Nicaise Ndembi, Tajudeen Raji, Mosoka Fallah, Wessam Mankoula , et al. · 2025

No abstract available.

Associations of inflammatory markers with post-acute clinical findings among survivors of Ebola virus disease with and without viral RNA shedding in the semen in Liberia: a nested case–control study Open

Mosoka Fallah, Collin Van Ryn, Moses J Soka, Moses Badio, Tamba Fayiah , et al. · 2025

National Cancer Institute and National Institute of Allergy and Infectious Diseases at the US National Institutes of Health.

Implications of COVID-19 pandemic and response approaches in Uganda: Stakeholder perspectives Open

Moses Ocan, Josephine Bayigga, Adelline Twimukye, Hellen Nansiiro, Daphine Sanger , et al. · 2025

Background: The coronavirus disease 2019 (COVID-19) pandemic significantly impacted health systems worldwide.Aim: This study explored the effects of the COVID-19 cascade on health programmes in Uganda.Setting: This study conducted in-depth…

COVID-19 vaccine uptake and associated factors among health workers in Kampala city, Uganda Open

Moses Ocan, Maureen Katusiime, Daniel Kyabayinze, Benon Kwesiga, Rodgers R Ayebare , et al. · 2025

Background: Coronavirus disease 2019 (COVID-19) vaccination is crucial for healthcare workers (HCWs) and understanding their perspectives is vital for promoting vaccine uptake in communities.Aim: This study assessed factors influencing COV…

A call for an Africa-centric health research ethics framework: a way forward for shaping global health research Open

Mosoka Fallah, Nebiyu Dereje, Elvis Temfack, Tajudeen Raji, Jean Kaseya · 2025

Real-world COVID-19 vaccine effectiveness in Zimbabwe: A test-negative case-control study Open

Clara Haruzivishe, Nicholas Midzi, Tafadzwa Madanhire, Senga Sembuche, Masceline Jenipher Mutsaka‐Makuvaza , et al. · 2025

Background: COVID-19 vaccination is critical in sub-Saharan Africa to reduce the disease burden. This study assessed real-world vaccine effectiveness (VE) in Zimbabwe.Aim: To determine COVID-19 VE and factors associated with disease severi…

Barriers and enhancers to COVID-19 vaccination among healthcare workers in Zimbabwe Open

Nicholas Midzi, Clara Haruzivishe, Senga Sembuche, Masceline Jenipher Mutsaka‐Makuvaza, Rodgers R Ayebare , et al. · 2025

Background: Coronavirus disease 2019 (COVID-19) vaccination is crucial for healthcare workers (HCWs). Understanding their vaccine uptake and perceptions is vital to promote acceptance.Aim: This study assessed COVID-19 vaccine uptake, assoc…

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