Mostafa Haji Molla Hoseini
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View article: MiRNA delivery systems in cancer stem cell therapy: exosomes versus chitosan nanoparticles
MiRNA delivery systems in cancer stem cell therapy: exosomes versus chitosan nanoparticles Open
View article: Mir-155-Chitosan Polyplex as a Novel Therapeutic Modality Against L. Major: A Feasibility Study
Mir-155-Chitosan Polyplex as a Novel Therapeutic Modality Against L. Major: A Feasibility Study Open
View article: Potential of a Software Package and Web Tool (SLDAssay) for Estimating Leishmania Parasite Burden in Limiting Dilution Assays
Potential of a Software Package and Web Tool (SLDAssay) for Estimating Leishmania Parasite Burden in Limiting Dilution Assays Open
View article: Expression Patterns of Immune Checkpoints in Breast Cancer Tumors and Their Margins
Expression Patterns of Immune Checkpoints in Breast Cancer Tumors and Their Margins Open
View article: TGF-β Targeted by miR-27a Modulates Anti-Parasite Responses of Immune System
TGF-β Targeted by miR-27a Modulates Anti-Parasite Responses of Immune System Open
Background: Immune cells and their secreted cytokines are known as the first barrier against pathogens. Leishmania major as an intracellular protozoan produces anti-inflammatory cytokines that lead to proliferation and survival of the para…
View article: Evaluation of the long-term immune responses following leishmanization using a live- Lizard Leishmania mixed with chitin
Evaluation of the long-term immune responses following leishmanization using a live- Lizard Leishmania mixed with chitin Open
Background: Leishmanization using non-pathogenic to human Leishmania spp. is considered a reliable approach to immunize subjects against Leishmania infection. Objectives : Here, we evaluated the long-term immune responses (14 weeks) after …
View article: Auraptene Promotes THP-1 Polarization to M1 Macrophages and Improves M1 Function
Auraptene Promotes THP-1 Polarization to M1 Macrophages and Improves M1 Function Open
Background and Objectives: Macrophages play an important role in tumor growth (M2 macrophage) or suppression (M1 macrophage). Auraptene, a prenyloxycoumarin compound extracted from Citrus plants, has anti-cancer and anti-inflammatory prope…
View article: Immune Responses Elevation by Intranasal Administration of Chitosan Microparticles Adjuvanted Poly-Epitope against Streptococcus pneumoniae in BALB/c Mice
Immune Responses Elevation by Intranasal Administration of Chitosan Microparticles Adjuvanted Poly-Epitope against Streptococcus pneumoniae in BALB/c Mice Open
Background: Designing inhaled vaccine formulations against respiratory pathogens like Streptococcus\npneumoniae (S. pneumoniae) lead to more effective mucosal and local immunity in the upper respiratory tract.\nChoosing chitosan (the chiti…
View article: Intranasal administration of immunogenic poly-epitope from <i>influenza</i> H1N1 and H3N2 viruses adjuvanted with chitin and chitosan microparticles in BALB/c mice.
Intranasal administration of immunogenic poly-epitope from <i>influenza</i> H1N1 and H3N2 viruses adjuvanted with chitin and chitosan microparticles in BALB/c mice. Open
The results support the fact that immunogenic poly-tope protein in the presence of chitin and chitosan microparticles as mucosal adjuvants is able to induce humoral and cell-mediated responses in BALB/c mice.
View article: Umbelliprenin Increases the M1/M2 Ratio of Macrophage Polarization and Improves the M1 Macrophage Activity in THP-1 Cells Cocultured with AGS Cells
Umbelliprenin Increases the M1/M2 Ratio of Macrophage Polarization and Improves the M1 Macrophage Activity in THP-1 Cells Cocultured with AGS Cells Open
Background. Gastric adenocarcinoma is the fifth most diagnosed malignancy in the world. The immune system consists of a heterogeneous mixture of macrophages that defense the body through phagocytosis and the production of different cytokin…
View article: Chitin and chitosan as tools to combat COVID-19: A triple approach
Chitin and chitosan as tools to combat COVID-19: A triple approach Open
View article: A Novel Nanoformulation for Reducing the Toxicity and Increasing the Efficacy of Betulinic Acid Using Anionic Linear Globular Dendrimer
A Novel Nanoformulation for Reducing the Toxicity and Increasing the Efficacy of Betulinic Acid Using Anionic Linear Globular Dendrimer Open
Betulinic acid (BA) is an antileishmanial herbal drug with low solubility and high toxicity. To our knowledge, this is the first study in which betulinic acid is loaded into Anionic Linear Globular Dendrimer (ALGD) in order to resolve the …
View article: Parasite Burden Measurement in the Leishmania major Infected Mice by Using the Direct Fluorescent Microscopy, Limiting Dilu-tion Assay, and Real-Time PCR Analysis
Parasite Burden Measurement in the Leishmania major Infected Mice by Using the Direct Fluorescent Microscopy, Limiting Dilu-tion Assay, and Real-Time PCR Analysis Open
Background: We aimed to compare parasite burden in BALB/c mice, using three methods including the direct fluorescent microscopic using recombinant Leishmania major expressing an enhanced green fluorescent protein, limiting dilution assay, …
View article: MicroRNAs Expression Induces Apoptosis of Macrophages in Response to Leishmania major (MRHO/IR/75/ER): An In-Vitro and In-Vivo Study
MicroRNAs Expression Induces Apoptosis of Macrophages in Response to Leishmania major (MRHO/IR/75/ER): An In-Vitro and In-Vivo Study Open
Background: We aimed to investigate the effect of miR-15a mimic and inhibitor of miR-155 expression on apoptosis induction in macrophages infected with Iranian strain of Leishmania major in-vitro and in-vivo. Methods: RAW 264.7 cells were …
View article: Evaluation of Leishmanization Using Iranian Lizard Leishmania Mixed With CpG-ODN as a Candidate Vaccine Against Experimental Murine Leishmaniasis
Evaluation of Leishmanization Using Iranian Lizard Leishmania Mixed With CpG-ODN as a Candidate Vaccine Against Experimental Murine Leishmaniasis Open
Background and Objectives: The live non-pathogenic Leishmania tarantolae has recently provided a promising approach as an effective vaccine candidate against experimental leishmaniasis (ILL). Here, we evaluated the immunoprotective …
View article: Effective materials of medicinal plants for leishmania treatment in vivo environment
Effective materials of medicinal plants for leishmania treatment in vivo environment Open
View article: EL4-derived Exosomes Carry Functional TNF-related Apoptosis-inducing Ligand that are Able to Induce Apoptosis and Necrosis in the Target Cells.
EL4-derived Exosomes Carry Functional TNF-related Apoptosis-inducing Ligand that are Able to Induce Apoptosis and Necrosis in the Target Cells. Open
Exosomes released by tumor cells play critical roles in tumor progression, immune cell suppression, and cancer metastasis. The aim of the present study was to investigate whether the exosomes released by EL4 cells carry a functional TNF-re…
View article: <p>Comparative analysis between four model nanoformulations of amphotericin B-chitosan, amphotericin B-dendrimer, betulinic acid-chitosan and betulinic acid-dendrimer for treatment of <em>Leishmania major</em>: real-time PCR assay plus</p>
Comparative analysis between four model nanoformulations of amphotericin B-chitosan, amphotericin B-dendrimer, betulinic acid-chitosan and betulinic acid-dendrimer for treatment of <em>Leishmania major</em>: real-time PCR assay plus Open
All the synthesized nanodrugs were completely succeeded by 100% to recovery the L. major induced pathological effects in the infected footpad. Also, the results of present study were confirmed with real-time PCR and the results show…
View article: Chitin Micro Particles Regulate Splenocytes Immune Response in Experimental Autoimmune Encephalomyelitis
Chitin Micro Particles Regulate Splenocytes Immune Response in Experimental Autoimmune Encephalomyelitis Open
Contrasting studies are reported on the induction of IL-10 and IFN-γ via chitin microparticles (CMPs) during immune stimulation. Our previous studies have shown marked protection among CMP treated Leishmania-infected mice via regulated IL-…
View article: In Vivo Therapeutic Effects of Four Synthesized Antileishmanial Nanodrugs in the Treatment of Leishmaniasis
In Vivo Therapeutic Effects of Four Synthesized Antileishmanial Nanodrugs in the Treatment of Leishmaniasis Open
Background: Nowadays, nanocarriers are used for leishmaniasis treatment due to development of drug resistance and several side effects with conventional therapeutics. Objectives: In this study we aimed to evaluate in vivo effects of four s…
View article: Serum Cytokines Profile in Treated Celiac Disease Compared with Non-celiac Gluten Sensitivity and Control: a Marker for Differentiation
Serum Cytokines Profile in Treated Celiac Disease Compared with Non-celiac Gluten Sensitivity and Control: a Marker for Differentiation Open
Background & Aims: There is increasing evidence regarding elevated serum levels of inflammatory cytokines in patients with celiac disease (CD), but little is known about their levels in patients with non-celiac gluten sensitivity (NCGS). T…
View article: Novel Nanosized Chitosan-Betulinic Acid Against Resistant Leishmania Major and First Clinical Observation of such parasite in Kidney
Novel Nanosized Chitosan-Betulinic Acid Against Resistant Leishmania Major and First Clinical Observation of such parasite in Kidney Open
View article: Evaluation of the Cytotoxic Effects of Ciprofloxacin on Human Glioblastoma A-172 Cell Line
Evaluation of the Cytotoxic Effects of Ciprofloxacin on Human Glioblastoma A-172 Cell Line Open
Background: Glioblastoma multiforme, the most common, aggressive malignant brain tumor which affects patients of all ages, is principally resistant to treatment. Ciprofloxacin is an antibiotic that belongs to the fluoroquinolones. There ar…
View article: Current Approaches to Develop a Live Vaccine against Leishmania majo
Current Approaches to Develop a Live Vaccine against Leishmania majo Open
Leishmaniasis is an infectious disease that is endemic in 88 countries. Most of the patients after recovery from the infection develop a long-lived natural immunity against re-infection. Reactivation of leishmaniasis subsequent to suppress…
View article: The Synergistic Effects of the Combination of Ciprofloxacin and Temozolomide on Human Glioblastoma A-172 Cell Line
The Synergistic Effects of the Combination of Ciprofloxacin and Temozolomide on Human Glioblastoma A-172 Cell Line Open
Background: Combination therapy has generated remarkable motivation in the clinical setting since it boosts the therapeutic potential of anticancer drugs. Glioblastoma multiforme is the most common, aggressive malignant brain tumor which a…
View article: The effect of fasting on the functioning of the immune system based on the measurement of plasma granulysin level
The effect of fasting on the functioning of the immune system based on the measurement of plasma granulysin level Open
For downloading the full-text of this article please click here. Background and Objectives: Plasma granulysin levels as a biomarker of the immune system are currently being considered. NK cells are a major source of plasma granulysin. Plas…
View article: YKL-40 Gene Expression and Plasma Levels of CD30 are not Affected by Isoflurane or Propofol: Pilot Study
YKL-40 Gene Expression and Plasma Levels of CD30 are not Affected by Isoflurane or Propofol: Pilot Study Open
Background: It has been hypothesized that the body's response to anesthesia techniques can increase risk of cancer recurrence and metastatic disease after surgery and also can modulate immune responses. Some acute inflammatory markers have…
View article: The Effect of Rapamycin on Oxidative Stress in MCF-7 and MDA MB-231 Human Breast Cancer Cell Lines
The Effect of Rapamycin on Oxidative Stress in MCF-7 and MDA MB-231 Human Breast Cancer Cell Lines Open
Background: Mammalian target of rapamycin (mTOR) is a kinase pathway that regulates the cell cycle progression and growth. Rapamycin inhibits this pathway. The useful effects of rapamycin on cell growth have been widely shown in animal stu…
View article: Downregulating the Expression of CHID1 by Chitin Microparticles Mixed Leukocyte Culture
Downregulating the Expression of CHID1 by Chitin Microparticles Mixed Leukocyte Culture Open
Background: chitin and its derivates microparticles (MPs) have immunomodulatory activities. In this study, we examined the effect of size, purity and acetylation degree of chitin MPs on CHID1- encoding SI-CLP, involved in inflammation- gen…
View article: Comparison of Parasite Burden Using Real-Time Polymerase Chain Reaction Assay and Limiting Dilution Assay in Leishmania major Infected Mouse.
Comparison of Parasite Burden Using Real-Time Polymerase Chain Reaction Assay and Limiting Dilution Assay in Leishmania major Infected Mouse. Open
Real-time PCR assay is an appropriate replacement to existing limiting dilution assay in quantifying parasite burden in the experimental model of Leishmania infection.