Mostafa E. Salem
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View article: Functional Solid–Liquid Interfaces for Electrochemical Blood Glucose Sensing: New Insights and Future Prospects
Functional Solid–Liquid Interfaces for Electrochemical Blood Glucose Sensing: New Insights and Future Prospects Open
Blood glucose monitoring is essential for the treatment of diabetes, a chronic disease that affects millions of people worldwide. Non-electrochemical blood glucose sensors often lack sensitivity and selectivity, especially in complex biolo…
View article: Novel Cyanoacrylamides Incorporating Sulfamethoxazole as Potential Anticancer Agents: DNA Interaction, Apoptotic Induction, and S-Phase Cell Cycle Arrest in Colon Cancer Cells
Novel Cyanoacrylamides Incorporating Sulfamethoxazole as Potential Anticancer Agents: DNA Interaction, Apoptotic Induction, and S-Phase Cell Cycle Arrest in Colon Cancer Cells Open
In the current study, five novel cyanoacrylamides incorporating sulfamethoxazole (5-9) were designed and synthesized as potential candidates for anticancer therapy. The antitumor potential of the synthesized compounds was screened against …
View article: Chitosan-ZnO Nanocomposite Nanocatalyst for the Synthesis of 12-Azatetraphene-8-one and 7-Azatetraphene-11-one Derivatives via Unsymmetrical Hantzsch-Like Reactions
Chitosan-ZnO Nanocomposite Nanocatalyst for the Synthesis of 12-Azatetraphene-8-one and 7-Azatetraphene-11-one Derivatives via Unsymmetrical Hantzsch-Like Reactions Open
The chitosan-ZnO nanocomposite nanocatalyst was employed as a robust, recyclable, and environmentally benign catalyst to efficiently facilitate the regioselective Hantzsch-like multicomponent reactions involving one-mole equivalent of an a…
View article: Novel Hybrid Heterocycles Based on 1,4-Diphenylpiperazine Moiety: Synthesis via Hantzsch and Biginelli Reactions, Molecular Docking Simulation, and Antimicrobial Activities
Novel Hybrid Heterocycles Based on 1,4-Diphenylpiperazine Moiety: Synthesis via Hantzsch and Biginelli Reactions, Molecular Docking Simulation, and Antimicrobial Activities Open
In this study, we have developed new hybrid compounds by connecting bis-heterocycles with the 1,4-diphenylpiperazine core. This is performed by combining 4,4'-(piperazine-1,4-diyl)-dibenzaldehyde with the necessary reagents via Hantzsch an…
View article: Spectroscopic, X‐Ray Crystallographic, and Hirshfeld Surface Analyses for the Investigation of Intermolecular Interactions in Carboxamide Hydrazone Hybrids
Spectroscopic, X‐Ray Crystallographic, and Hirshfeld Surface Analyses for the Investigation of Intermolecular Interactions in Carboxamide Hydrazone Hybrids Open
The current study reports a convenient synthetic approach to carboxamide hydrazone hybrids 2a, b . Their chemical structures are investigated using infrared, nuclear magnetic resonance, and mass spectroscopies. In addition, the 3D structur…
View article: Synthesis and Evaluation of Novel Bis-Chalcone Derivatives Containing a Thiophene Moiety as Potential Anticancer Agents: In Vitro, In Silico , and Mechanistic Studies
Synthesis and Evaluation of Novel Bis-Chalcone Derivatives Containing a Thiophene Moiety as Potential Anticancer Agents: In Vitro, In Silico , and Mechanistic Studies Open
Chalcone compounds have demonstrated potent anticancer activities in the past few decades with few adverse consequences. Using Claisen-Schmidt condensation, two new series of bis-chalcone derivatives (5a-c and 9a-c) bearing the thiophene m…
View article: Synthesis, cytotoxic evaluation, and binding studies of novel sulphamethoxazole-based cyanoacrylamides as potential antitumor agents
Synthesis, cytotoxic evaluation, and binding studies of novel sulphamethoxazole-based cyanoacrylamides as potential antitumor agents Open
Molecular hybridization has become a leading and highly effective method for creating new anticancer chemotherapeutic drugs. In this endeavor, new cyanoacrylamides with derivatives of sulphamethoxazole (5a-5f) have been created and verifie…
View article: Green synthesis of novel hexahydroquinolines and 6-amino-2-oxopyridine-3,5-dicarbonitriles incorporating sulfaguanidine via [3 + 3] atom combination
Green synthesis of novel hexahydroquinolines and 6-amino-2-oxopyridine-3,5-dicarbonitriles incorporating sulfaguanidine via [3 + 3] atom combination Open
The synthesis of sulfa drugs has received extensive interest from researchers for their broad spectrum of biological activities. In this context, N-Carbamimidoyl-4-((5,5-dimethyl-3-oxocyclohex-1-en-1-yl)amino)benzenesulfonamide 3 was readi…
View article: Seeding the future of nanomaterials: a comprehensive review of nanosheet-mediated growth for energy harvesting, energy conversion, and photodetection applications
Seeding the future of nanomaterials: a comprehensive review of nanosheet-mediated growth for energy harvesting, energy conversion, and photodetection applications Open
Seeding growth on nanosheets, termed nanosheet seeding growth (NSG), opens up numerous options for fabricating and engineering functional thin films and plate-like nanomaterials at the atomic/nanometer scale.
View article: Dichromate Contaminated Water Treatment using Novel Crystal Violet Azo Dye- Sulphonated Poly(Glycidyl methacrylate) Nano-Composite Adsorbent
Dichromate Contaminated Water Treatment using Novel Crystal Violet Azo Dye- Sulphonated Poly(Glycidyl methacrylate) Nano-Composite Adsorbent Open
In this study, the Cr(VI) metal ions have been removed from dichromate-contaminated water using a novel Azo Dye-Sulphonated Poly (glycidyl methacrylate) nano-composite adsorbent for the first time. Crystal violet Azo dye model (CV) has bee…
View article: Synthetic approaches and biological evaluation of nitrogen bridgehead thiazolo[3,2-a]pyrimidines
Synthetic approaches and biological evaluation of nitrogen bridgehead thiazolo[3,2-a]pyrimidines Open
Thiazolopyrimidines are bicyclic compounds formed by the fusion of thiazole and pyrimidine rings in a single molecular frame. The fusion of these two heterocyclic systems containing bridgehead nitrogen atom is attracting the attention of m…
View article: Synthesis of novel star-shaped molecules based on a pentaerythritol core linked to different heterocyclic systems
Synthesis of novel star-shaped molecules based on a pentaerythritol core linked to different heterocyclic systems Open
Synthesis of analogs of known active compounds is the most often employed strategy for producing important compounds. The Hantzsch reaction was employed to create new star-shaped compounds with a pentaerythritol core connected to thiazoles…
View article: Synthesis, molecular docking simulation, and antimicrobial activities of novel bis-heterocycles linked to piperazine and vanillin units as novel hybrid molecules via Hantzsch, Biginelli, and Michael’s reactions
Synthesis, molecular docking simulation, and antimicrobial activities of novel bis-heterocycles linked to piperazine and vanillin units as novel hybrid molecules via Hantzsch, Biginelli, and Michael’s reactions Open
Bacterial infections are a global issue, causing sickness and death, mainly in developing nations. Resistance to current medicines is a significant issue in healthcare. Overcoming the resistance problem will necessitate the development of …
View article: Novel hybrid thiazoles, bis-thiazoles linked to azo-sulfamethoxazole: Synthesis, docking, and antimicrobial activity
Novel hybrid thiazoles, bis-thiazoles linked to azo-sulfamethoxazole: Synthesis, docking, and antimicrobial activity Open
The reaction of sulfamethoxazolehydrazonoyl chloride with thiosemicarbazones, bis-thiosemicarbazones, or 4-amino-3-mercapto-1,2,4-triazole in dioxane in the presence of triethylamine as a basic catalyst at reflux resulted in the regioselec…
View article: Utility of 2-Chloro-<i>N</i>-arylacetamide and 1,1′-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines]
Utility of 2-Chloro-<i>N</i>-arylacetamide and 1,1′-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines] Open
A series of novel thieno[2,3-b]pyridines linked to N-aryl carboxamides or (carbonylphenoxy)-N-(aryl)acetamides, as well as bis(thieno[2,3-b]pyridines) linked to piperazine core via methanone or carbonylphenoxyethanone units, were synthesiz…
View article: Synthesis of Novel Diphenyl Ether-Based Bis-Heterocycles as Novel Hybrid Molecules via Michael and Other Cyclocondensation Reactions
Synthesis of Novel Diphenyl Ether-Based Bis-Heterocycles as Novel Hybrid Molecules via Michael and Other Cyclocondensation Reactions Open
Molecular hybridization is a technique used in drug creation that involves combining the pharmacophoric moieties of multiple bioactive compounds to create a new hybrid molecule with better affinity and effectiveness. In this regard, we cre…
View article: Nanostructure Lipid Carrier of Curcumin Co-Delivered with Linalool and Geraniol Monoterpenes as Acetylcholinesterase Inhibitor of Culex pipiens
Nanostructure Lipid Carrier of Curcumin Co-Delivered with Linalool and Geraniol Monoterpenes as Acetylcholinesterase Inhibitor of Culex pipiens Open
(1) Background: A molecular hybridization docking approach was employed to develop and detect a new category of naturally activated compounds against Culex pipiens as acetylcholinesterase inhibitors via designing a one-pot multicomponent n…
View article: Novel Scaffolds Based on Bis-thiazole Connected to Quinoxaline or Thienothiophene through 2-Phenoxy-<i>N</i>-arylacetamide Groups as New Hybrid Molecules: Synthesis, Antibacterial Activity, and Molecular Docking Investigations
Novel Scaffolds Based on Bis-thiazole Connected to Quinoxaline or Thienothiophene through 2-Phenoxy-<i>N</i>-arylacetamide Groups as New Hybrid Molecules: Synthesis, Antibacterial Activity, and Molecular Docking Investigations Open
The resistance of microorganisms to antimicrobials has endangered the health of many people across the world. Overcoming the resistance problem will require the invention of molecules with a new mechanism of action so that no cross-resista…
View article: Synthesis and Anti-Breast Cancer Potency of Mono- and Bis-(pyrazolyl[1,2,4]triazolo[3,4-<i>b</i>][1,3,4]thiadiazine) Derivatives as EGFR/CDK-2 Target Inhibitors
Synthesis and Anti-Breast Cancer Potency of Mono- and Bis-(pyrazolyl[1,2,4]triazolo[3,4-<i>b</i>][1,3,4]thiadiazine) Derivatives as EGFR/CDK-2 Target Inhibitors Open
The target mono- and bis-(6-pyrazolyltriazolo-thiadiazine) derivatives 4a-c and 6a-d were synthesized using a straightforward protocol via reaction of 3-bromoacetylpyrazole 2 with 4-amino-s-triazole-3-thiols 3a-c and bis(4-amino-5-mercapto…
View article: Synthesis of novel mono- and bis-pyrazolylthiazole derivatives as anti-liver cancer agents through EGFR/HER2 target inhibition
Synthesis of novel mono- and bis-pyrazolylthiazole derivatives as anti-liver cancer agents through EGFR/HER2 target inhibition Open
3-Bromoacetyl-4-(2-naphthoyl)-1-phenyl-1H-pyrazole (6) was synthesized from 2-acetylnaphthalene and was used as a new key building block for constructing the title targets. Thus, the reaction of 6 with the thiosemicarbazones 7a–d and 9–11 …
View article: Aminouracil and aminothiouracil as versatile precursors for a variety of heterocyclic systems
Aminouracil and aminothiouracil as versatile precursors for a variety of heterocyclic systems Open
Heterocycles, particularly pyrimidine derivatives, which are present in many natural products and many interesting synthetic compounds, are the most diverse class of organic compounds and have significant chemical, biomedical and industria…
View article: Synthesis and DTF studies of novel aminoimidazodipyridines using 2-(3H-imidazo[4,5-b]pyridin-2-yl)acetonitrile as an efficient key precursor
Synthesis and DTF studies of novel aminoimidazodipyridines using 2-(3H-imidazo[4,5-b]pyridin-2-yl)acetonitrile as an efficient key precursor Open
Novel 9-aminoimidazo[1,2-a:5,4-b']dipyridine-6,8-dicarbonitriles were prepared via the Michael addition reaction of readily accessible 2-(3H-imidazo[4,5-b]pyrid-2-yl)acetonitrile with arylidenemalononitriles.The regioselectivity of the rea…
View article: An expedient synthesis of novel bis[thienopyridines] linked to arene or heteroarene core as novel hybrid molecules
An expedient synthesis of novel bis[thienopyridines] linked to arene or heteroarene core as novel hybrid molecules Open
A series of novel bis(thieno[2,3-b]pyridines) based arenes or heteroarenes have been synthesized from the appropriate bis-bromoacetyl derivatives upon treatment with the corresponding 2-mercaptonicotinonitrile derivatives in ethanolic sodi…
View article: Synthesis of novel star-shaped molecules based on a 1,3,5-triazine core linked to different heterocyclic systems as novel hybrid molecules
Synthesis of novel star-shaped molecules based on a 1,3,5-triazine core linked to different heterocyclic systems as novel hybrid molecules Open
The synthesis of novel star-shaped compounds based on ans-triazine core and linked to different heterocycles as new hybrid molecules through Michael and Hantzsch reactions is reported.
View article: Synthesis of novel bis- and poly(aryldiazenylthiazoles)
Synthesis of novel bis- and poly(aryldiazenylthiazoles) Open
A novel series of bis- and poly(arydiazenyl)thiazoles were prepared in good yields by the reaction of the appropriate α-keto-hydrazonoyl chlorides with the corresponding bis- and poly(hydrazinecarbothioamide) in refluxing EtOH/DMF in the p…
View article: Drinking Water Issue in North-West Sinai: The Problem and Solution in a Case Study
Drinking Water Issue in North-West Sinai: The Problem and Solution in a Case Study Open
RINKING water has received considerable attention recently.…… However, misuse and mismanagement have resulted in a rapid and widespread decline in source-water quality and supply.Drinking water issue in Sinai is the subject of the present …