Motohiro Ebisawa
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View article: Eleven‐year trends in walnut‐induced anaphylaxis in children in Japan: A multicenter retrospective study
Eleven‐year trends in walnut‐induced anaphylaxis in children in Japan: A multicenter retrospective study Open
Background In recent years, the prevalence of walnut allergies has been increasing worldwide; however, the trends and clinical characteristics of walnut‐induced anaphylaxis remain unclear. Herein, we evaluated the changes in the incidence …
View article: A bench study comparing the performance of a novel test lung with a conventional model
A bench study comparing the performance of a novel test lung with a conventional model Open
View article: Sodium Reduction Program Incorporating Genetic Profile and an AI-Based App
Sodium Reduction Program Incorporating Genetic Profile and an AI-Based App Open
Importance Excess salt intake is a major modifiable risk factor for hypertension and cardiovascular disease. Personalized interventions using genetic information and digital tools, such as smartphone applications, may enhance sodium reduct…
View article: Long-term efficacy and safety of dupilumab with concomitant topical corticosteroids in Japanese pediatric patients with moderate-to-severe atopic dermatitis: Results from a phase 3 open-label extension study
Long-term efficacy and safety of dupilumab with concomitant topical corticosteroids in Japanese pediatric patients with moderate-to-severe atopic dermatitis: Results from a phase 3 open-label extension study Open
This analysis supports the long-term efficacy and safety of dupilumab in Japanese patients aged ≥6 months to <18 years with moderate-to-severe atopic dermatitis.
View article: Meet the Expert
Meet the Expert Open
View article: National survey on diagnosis and treatment of adult anaphylaxis in Japan: The learning about anaphylaxis in adolescence and adulthood (LANA) survey Part 1
National survey on diagnosis and treatment of adult anaphylaxis in Japan: The learning about anaphylaxis in adolescence and adulthood (LANA) survey Part 1 Open
The survey revealed the uneven geographical distribution of medical departments and the chief barriers for implementation of the examination in adult anaphylaxis.
View article: Optimizing Adrenaline Administration in Anaphylaxis: Clinical Practice Considerations and Safety Insights
Optimizing Adrenaline Administration in Anaphylaxis: Clinical Practice Considerations and Safety Insights Open
Background Anaphylaxis is an acute, severe, and potentially fatal reaction marked by the fast onset of symptoms and organ involvement that may lead to death from vascular collapse or airway obstruction. Despite adrenaline (epinephrine) bei…
View article: Recent Insights into the Epidemiology and Management of Anaphylaxis
Recent Insights into the Epidemiology and Management of Anaphylaxis Open
Anaphylaxis is a severe, rapidly developing systemic hypersensitivity reaction that can be life-threatening if not promptly identified and treated. Its global incidence is on the rise, especially among children, though fatal outcomes remai…
View article: Factors associated with egg aversion after a negative oral food challenge result in children with egg allergies: A multicenter questionnaire survey in Japan
Factors associated with egg aversion after a negative oral food challenge result in children with egg allergies: A multicenter questionnaire survey in Japan Open
About half of the children after negative OFC had an egg aversion, and it was associated with older age during negative OFC. Careful follow-up and guidance with consideration of less aversive cooking methods are important in older age grou…
View article: Low‐dose oral cow's milk challenge outcome for patients on complete avoidance: A multicenter study in Japan
Low‐dose oral cow's milk challenge outcome for patients on complete avoidance: A multicenter study in Japan Open
Background Few studies have reported significant risk factors for allergic symptoms during low‐dose (1–3 mL) cow's milk (CM) oral food challenges (OFCs). We investigated patients from multiple centers in Japan to identify high‐risk, low‐do…
View article: Genome-wide association study of common side effects following COVID-19 booster vaccination in a cohort of corporate employees in Japan
Genome-wide association study of common side effects following COVID-19 booster vaccination in a cohort of corporate employees in Japan Open
Individual differences have been observed in side effects after vaccination for COVID-19, and host genetic factors have been suggested as a contributing factor. Here, we conducted a genome-wide association study (GWAS) involving 2,554 Japa…
View article: Cutting edge of oral immunotherapy (OIT): Differences between Japan and overseas
Cutting edge of oral immunotherapy (OIT): Differences between Japan and overseas Open
View article: WAO - ARIA consensus on chronic cough: Executive summary
WAO - ARIA consensus on chronic cough: Executive summary Open
View article: Three-year prognoses after low-dose oral food challenge for cow's milk
Three-year prognoses after low-dose oral food challenge for cow's milk Open
Failure in LD-OFC is associated with persistent CMA, whereas successful LD-OFC outcomes are associated with a favorable prognosis thereafter, irrespective of a history of anaphylaxis.
View article: Peach component-specific IgE measurement helps to differentiate between local and systemic reactions in peach-allergic Japanese patients
Peach component-specific IgE measurement helps to differentiate between local and systemic reactions in peach-allergic Japanese patients Open
Sensitization to Pru p 1 was associated with LRs, while sensitization to Pru p 7 was associated with SRs; approximately one-third of patients in the SR group tested negative for the titer of peach crude sIgE ab, many of whom tested positiv…
View article: 10 practical priorities to prevent and manage serious allergic reactions: GA<sup>2</sup>LEN ANACare and EFA Anaphylaxis Manifesto
10 practical priorities to prevent and manage serious allergic reactions: GA<sup>2</sup>LEN ANACare and EFA Anaphylaxis Manifesto Open
This Anaphylaxis Manifesto calls on communities to prioritise 10 practical actions to improve the lives of people at risk of serious allergic reactions. The Global Allergy and Asthma European Network and the European Federation of Allergy …
View article: Evaluating clinical importance of sensitization to Ara h 6 quantitively in Japanese children
Evaluating clinical importance of sensitization to Ara h 6 quantitively in Japanese children Open
View article: GA<sup>2</sup>LEN ANACARE consensus statement: Potential of omalizumab in food allergy management
GA<sup>2</sup>LEN ANACARE consensus statement: Potential of omalizumab in food allergy management Open
Immunoglobulin E (IgE)‐mediated food allergies are the most common type of food allergy, often causing rapid symptoms after exposure to allergens posing a serious health risk and a high impact on patient's and caregiver's quality of life. …
View article: EAACI guidelines on the management of IgE‐mediated food allergy
EAACI guidelines on the management of IgE‐mediated food allergy Open
This European Academy of Allergy and Clinical Immunology (EAACI) guideline provides recommendations for the management of IgE‐mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluat…
View article: Aktualisiertes Klassifikationssystem für systemische allergische Reaktionen: Gemeinsame Stellungnahme des World Allergy Organization Anaphylaxis Committee und des Allergen Immunotherapy Committee
Aktualisiertes Klassifikationssystem für systemische allergische Reaktionen: Gemeinsame Stellungnahme des World Allergy Organization Anaphylaxis Committee und des Allergen Immunotherapy Committee Open
Es gibt keinen Konsens über die Beschreibung und Schweregradeinteilung allergischer Nebenwirkungen bei Immuntherapien, obwohl zumindest hinsichtlich der Verwendung der Klassifikationssysteme der World Allergy Organisation (WAO) zur Beschre…
View article: Low‐dose oral food challenges
Low‐dose oral food challenges Open
Background Infants aged <1 year with confirmed food allergies generally need to avoid causative foods completely for a certain period. Low‐dose oral food challenges (LD‐OFCs) may be an effective strategy for safely introducing small amount…
View article: Time to ACT-UP: Update on precautionary allergen labelling (PAL)
Time to ACT-UP: Update on precautionary allergen labelling (PAL) Open
At a time when CCFL is considering the results of the FAO/WHO Expert Consultation 2020-2023, we summarise the prospects to develop an effective and homogeneous legislation at a global level, and the areas of uncertainty that might hinder i…
View article: World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guideline update – XI – Milk supplement/replacement formulas for infants and toddlers with CMA – Systematic review
World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guideline update – XI – Milk supplement/replacement formulas for infants and toddlers with CMA – Systematic review Open
View article: Current perspective on allergen immunotherapy for food allergies
Current perspective on allergen immunotherapy for food allergies Open
Food allergies are an increasing global problem and societal issue. In addition to the potential for severe allergic reactions from accidental ingestion, food allergies impose a significant burden on the quality of life, nutrition, cost of…
View article: In vitro cross-reactivity between hen's egg and quail's egg in children with hen's egg allergy
In vitro cross-reactivity between hen's egg and quail's egg in children with hen's egg allergy Open
View article: Allergic and hypersensitivity condition in the International Patients’ Summary (IPS) standard: The need of updates through the International Classification of Diseases (ICD)-11
Allergic and hypersensitivity condition in the International Patients’ Summary (IPS) standard: The need of updates through the International Classification of Diseases (ICD)-11 Open
View article: Prevalence of food allergy increased 1.7 times in the past 10 years among Japanese patients below 6 years of age
Prevalence of food allergy increased 1.7 times in the past 10 years among Japanese patients below 6 years of age Open
Background While food allergy (FA) has been increasingly recognized as a growing public health burden worldwide, epidemiological studies on FA in Japan are limited. Methods This was a noninterventional, observational study using the admini…
View article: Chapter 3 Epidemiology and risk factors for pediatric asthma and those managements
Chapter 3 Epidemiology and risk factors for pediatric asthma and those managements Open
「小児気管支喘息・治療ガイドライン(JPGL)2023」の第3章 疫学,発症の危険因子と一次,二次予防では,章立ての再編に伴い2点の大きな変更があった.1点目はJPGL2020までは異なる章で記載されていた小児喘息の疫学および発症の危険因子と予防の内容を一つの章にまとめて記載した点,2点目は急性増悪の危険因子を別章(第6章)での記載とした点である.その他では,「厚生労働省,小児アレルギー学会が実施している疫学調査」のデータを最新版に変更した点,近年の複数の国内大規模調査の結…
View article: Fenugreek allergy caused by cross-reactivity with peanut: An in vitro analysis
Fenugreek allergy caused by cross-reactivity with peanut: An in vitro analysis Open
View article: Efficacy and safety of dupilumab with concomitant topical corticosteroids in Japanese pediatric patients with moderate-to-severe atopic dermatitis: A randomized, double-blind, placebo-controlled phase 3 study
Efficacy and safety of dupilumab with concomitant topical corticosteroids in Japanese pediatric patients with moderate-to-severe atopic dermatitis: A randomized, double-blind, placebo-controlled phase 3 study Open
Dupilumab showed consistent efficacy and was well tolerated in Japanese patients aged ≥6 months to <18 years with moderate-to-severe atopic dermatitis previously insufficiently controlled with existing therapies.