Motohiro Esaki
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View article: Efficacy and recovery of remimazolam versus midazolam in sedated upper gastrointestinal endoscopy: a multicenter randomized controlled trial in Japan (RECOVER Study)
Efficacy and recovery of remimazolam versus midazolam in sedated upper gastrointestinal endoscopy: a multicenter randomized controlled trial in Japan (RECOVER Study) Open
Objectives Sedation is increasingly essential for gastrointestinal endoscopy. Remimazolam, an ultra-short-acting benzodiazepine, has a shorter pharmacokinetic half-life than midazolam. The aim of this study was to determine whether remimaz…
View article: Comparison of In‐Hospital and At‐Home Administration of Bowel Preparation Agents Before Outpatient Colonoscopy in Elderly Patients
Comparison of In‐Hospital and At‐Home Administration of Bowel Preparation Agents Before Outpatient Colonoscopy in Elderly Patients Open
Background Most patients take bowel preparation agents at home before undergoing outpatient colonoscopy. However, some elderly patients undergo bowel preparation at the hospital. This study compared the outcomes of in‐hospital (Group A) ve…
View article: Induction Efficacy and Safety of Upadacitinib for Active Crohn's Disease in Japanese Patients: A Multicenter Retrospective Study
Induction Efficacy and Safety of Upadacitinib for Active Crohn's Disease in Japanese Patients: A Multicenter Retrospective Study Open
Background While Western real‐world studies have demonstrated the therapeutic effect of upadacitinib in Crohn's disease (CD), data on Asian populations are scarce, and no real‐world data from Japan have been reported. Therefore, this study…
View article: Chronic Enteropathy Associated with SLCO2A1 Gene
Chronic Enteropathy Associated with SLCO2A1 Gene Open
Background: Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare hereditary disorder characterized by multiple small intestinal ulcers, chronic anemia, and hypoproteinemia. Initially reported by Okabe et al. [J Jpn Soc Gastroe…
View article: Guidelines for endoscopic diagnosis and treatment of inflammatory bowel diseases
Guidelines for endoscopic diagnosis and treatment of inflammatory bowel diseases Open
In recent years, we have seen a considerable increase in the number of patients with inflammatory bowel diseases of unknown etiology, including both Crohn's disease and ulcerative colitis. Inflammatory bowel diseases can cause intestinal l…
View article: Serum Periostin is Able to Stratify Type 2-Dominant Ulcerative Colitis
Serum Periostin is Able to Stratify Type 2-Dominant Ulcerative Colitis Open
Background Ulcerative colitis (UC) is a heterogeneous disease composed of different endotypes. It is important to develop useful biomarkers for endotyping UC; however, available biomarkers are insufficient. We have already established that…
View article: Remimazolam: Promising sedative for upper gastrointestinal endoscopy
Remimazolam: Promising sedative for upper gastrointestinal endoscopy Open
View article: Involvement of Mediterranean fever gene mutations in colchicine-responsive enterocolitis: a retrospective cohort study
Involvement of Mediterranean fever gene mutations in colchicine-responsive enterocolitis: a retrospective cohort study Open
View article: Differences in regions of interest to identify deeply invasive colorectal cancers: Computer-aided diagnosis vs expert endoscopists
Differences in regions of interest to identify deeply invasive colorectal cancers: Computer-aided diagnosis vs expert endoscopists Open
Background and study aims Diagnostic performance of a computer-aided diagnosis (CAD) system for deep submucosally invasive (T1b) colorectal cancer was excellent, but the “regions of interest” (ROI) within images are not obvious. Class acti…
View article: Combined eosinophilic gastroenteritis and ulcerative colitis successfully treated by vedolizumab: a case report
Combined eosinophilic gastroenteritis and ulcerative colitis successfully treated by vedolizumab: a case report Open
A 47-year-old man with over 10 years’ duration of ulcerative colitis treated by 5-aminosalicylic acid and intermittent topical steroids complained of acute epigastric pain. Esophagogastroduodenoscopy revealed diffuse mucosal edema with pat…
View article: Clinicopathological features and prognosis of primary small bowel adenocarcinoma: a large multicenter analysis of the JSCCR database in Japan
Clinicopathological features and prognosis of primary small bowel adenocarcinoma: a large multicenter analysis of the JSCCR database in Japan Open
Background The clinicopathological features and prognosis of primary small bowel adenocarcinoma (PSBA), excluding duodenal cancer, remain undetermined due to its rarity in Japan. Methods We analyzed 354 patients with 358 PSBAs, between Jan…
View article: Outcomes of Metastatic and Unresectable Small Bowel Adenocarcinoma in Japan According to the Treatment Strategy: A Nationwide Observational Study
Outcomes of Metastatic and Unresectable Small Bowel Adenocarcinoma in Japan According to the Treatment Strategy: A Nationwide Observational Study Open
PURPOSE Limited information is available regarding the characteristics and outcomes of stage IV small bowel adenocarcinoma (SBA) in Japan. This study examined the clinical and pathological characteristics and outcomes according to the trea…
View article: Involvement of Mediterranean Fever Gene Mutations in Colchicine-Responsive Enterocolitis: A Retrospective Cohort Study
Involvement of Mediterranean Fever Gene Mutations in Colchicine-Responsive Enterocolitis: A Retrospective Cohort Study Open
View article: Positioning of Endoscopy for the Management of Crohn's Disease
Positioning of Endoscopy for the Management of Crohn's Disease Open
View article: Gut-spine axis: a possible correlation between gut microbiota and spinal degenerative diseases
Gut-spine axis: a possible correlation between gut microbiota and spinal degenerative diseases Open
As society ages, the number of patients with spinal degenerative diseases (SDD) is increasing, posing a major socioeconomic problem for patients and their families. SDD refers to a generic term for degenerative diseases of spinal structure…
View article: Fecal calprotectin measurement to detect recurrence of solitary juvenile polyps: A case report
Fecal calprotectin measurement to detect recurrence of solitary juvenile polyps: A case report Open
Rationale: Juvenile polyps (JPs) are the most common polyp type and can be observed in 1% of all preschoolers. The peak incidence is observed at ages 3 to 5 years, constituting 90% of all polyps in children. Elevated levels of fecal calpro…
View article: Polybacterial Iliopsoas Muscle Abscess as an Indication for Early Diagnosis of Crohn\'s Disease
Polybacterial Iliopsoas Muscle Abscess as an Indication for Early Diagnosis of Crohn\'s Disease Open
BACKGROUND Crohn disease (CD) is a chronic, relapsing inflammatory bowel disease characterized by penetrations or fistulae in the gastrointestinal tract and abscesses in the surrounding tissues. Diagnosis of CD is difficult with an iliopso…
View article: Multicenter prospective registration study of efficacy and safety of capsule endoscopy in Crohn’s disease in Japan (SPREAD-J study)
Multicenter prospective registration study of efficacy and safety of capsule endoscopy in Crohn’s disease in Japan (SPREAD-J study) Open
Background Evidence of small-bowel capsule endoscopy (SBCE) for evaluating lesions in Crohn’s disease (CD) is lacking. We aimed to clarify the effectiveness and safety of SBCE in a large sample of patients with CD. Methods This multicenter…
View article: HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis
HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis Open
View article: Effectiveness of endoscopic resection for colorectal neoplasms in ulcerative colitis: a multicenter registration study
Effectiveness of endoscopic resection for colorectal neoplasms in ulcerative colitis: a multicenter registration study Open
View article: Clinical Guidelines for Diagnosis and Management of Juvenile Polyposis Syndrome in Children and Adults-Secondary Publication
Clinical Guidelines for Diagnosis and Management of Juvenile Polyposis Syndrome in Children and Adults-Secondary Publication Open
Juvenile polyposis syndrome (JPS) is a rare disease characterized by multiple hamartomatous polyps within the gastrointestinal tract. SMAD4 or BMPR1A is known as a causative gene of JPS. Approximately 75% of newly diagnosed cases have an a…
View article: Impact of an artificial intelligence‐aided endoscopic diagnosis system on improving endoscopy quality for trainees in colonoscopy: Prospective, randomized, multicenter study
Impact of an artificial intelligence‐aided endoscopic diagnosis system on improving endoscopy quality for trainees in colonoscopy: Prospective, randomized, multicenter study Open
Objective This study was performed to evaluate whether the use of CAD EYE (Fujifilm, Tokyo, Japan) for colonoscopy improves colonoscopy quality in gastroenterology trainees. Methods The patients in this multicenter randomized controlled tr…
View article: A new endoscopic scoring system corresponding to histological healing using linked color imaging in ulcerative colitis: the SOUL study
A new endoscopic scoring system corresponding to histological healing using linked color imaging in ulcerative colitis: the SOUL study Open
Background and study aims An important therapeutic aim in ulcerative colitis (UC) is endoscopic remission. Although an endoscopic score with white light imaging (WLI) is mainly used to evaluate endoscopic findings, the usefulness of linked…
View article: Treatment escalation and de-escalation decisions in Crohn’s disease: Delphi consensus recommendations from Japan, 2021
Treatment escalation and de-escalation decisions in Crohn’s disease: Delphi consensus recommendations from Japan, 2021 Open
Background We aimed to develop criteria for treatment intensification in patients with (1) luminal Crohn’s disease (CD), (2) CD with perianal disease and/or fistula, (3) CD with small bowel stenosis, (4) in the postoperative setting, and (…
View article: P868 Clinical features of chronic enteropathy associated with SLCO2A1 gene
P868 Clinical features of chronic enteropathy associated with SLCO2A1 gene Open
Background Chronic enteropathy associated with the SLCO2A1 gene (CEAS) is a hereditary disease caused by mutations of the SLCO2A1 gene which encodes a prostaglandin transporter. This disease is rare and intractable characterized by persist…
View article: P308 A new endoscopic scoring system corresponding to histological healing using linked color imaging in ulcerative colitis: SOUL study
P308 A new endoscopic scoring system corresponding to histological healing using linked color imaging in ulcerative colitis: SOUL study Open
Background An important therapeutic aim in ulcerative colitis (UC) is endoscopic remission. Although an endoscopic score with white light imaging (WLI) is mainly used to evaluate endoscopic findings, recently, the usefulness of linked colo…
View article: Usefulness of Biomarkers in the Management of Ulcerative Colitis
Usefulness of Biomarkers in the Management of Ulcerative Colitis Open
潰瘍性大腸炎診療において，腸管炎症評価のゴールドスタンダードは内視鏡検査であるが，頻回の検査は困難であることから，その代替となる簡便で非侵襲的なバイオマーカーの重要性が高まっている．活動性モニタリングを目的としたものには，便中マーカーとして便中カルプロテクチン，免疫学的便潜血検査，血液マーカーとして従来のCRPや赤沈に加え，ロイシンリッチα2グリコプロテイン，尿中マーカーとして尿中プロスタグランジンE主要代謝産物などの有用性が報告されており，実臨床でも利用可能となっている．…
View article: Final Analysis of COVID-19 Patients With Inflammatory Bowel Disease in Japan (J-COSMOS): A Multicenter Registry Cohort Study
Final Analysis of COVID-19 Patients With Inflammatory Bowel Disease in Japan (J-COSMOS): A Multicenter Registry Cohort Study Open
The impact of COVID-19 on IBD disease activity and factors associated with COVID-19 severity were consistent with findings of previous reports. No deaths in Japanese patients with IBD were observed.
View article: Clinical Impact of Endoscopic Evaluation of the Small Bowel in Crohn’s Disease
Clinical Impact of Endoscopic Evaluation of the Small Bowel in Crohn’s Disease Open
Background: The STRIDE-II position statement has established endoscopic healing as the long-term target of treatment for inflammatory bowel disease, and ileocolonoscopy is considered the gold standard for assessment of endoscopic healing. …
View article: Usefulness of discharge standards in outpatients undergoing sedative endoscopy: a propensity score-matched study of the modified post-anesthetic discharge scoring system and the modified Aldrete score
Usefulness of discharge standards in outpatients undergoing sedative endoscopy: a propensity score-matched study of the modified post-anesthetic discharge scoring system and the modified Aldrete score Open