Cristiano Soares de Moura
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View article: Persistence, switching, and healthcare use after initiating calcitonin gene-related peptide inhibitors: a real-world assessment
Persistence, switching, and healthcare use after initiating calcitonin gene-related peptide inhibitors: a real-world assessment Open
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Drug Discontinuation and Persistent Symptoms Among Initiators of Bio-Originator and Biosimilar anti–Tumor Necrosis Factor Drugs in Inflammatory Bowel Disease: Real-World Contemporary Data From the CAnadian Network for Advanced Interdisciplinary Methods/CIRC Registry Open
About 80% of individuals initiating infliximab or adalimumab for IBD were still on these drugs at 12 months. Benefits (including less corticosteroid use, abdominal pain, bowel urgency, and improved QoL) were seen in individuals initiating …
View article: Persistence, Switching, and Healthcare Use after Initiating Calcitonin Gene-Related Peptide Inhibitors: A Real-world Assessment
Persistence, Switching, and Healthcare Use after Initiating Calcitonin Gene-Related Peptide Inhibitors: A Real-world Assessment Open
Background: Migraine is a prevalent and disabling condition affecting one billion people worldwide. Calcitonin gene-related peptide (CGRP) inhibitors have transformed migraine management. We describe real-world trends in CGRP inhibitor tre…
View article: Choosing Wisely: Effectiveness and Safety of Antibiotic Prophylaxis in Close Contacts of Invasive Group A Streptococci Infection
Choosing Wisely: Effectiveness and Safety of Antibiotic Prophylaxis in Close Contacts of Invasive Group A Streptococci Infection Open
Antibiotic prophylaxis is often recommended for close contacts of index cases of invasive Streptococcus pyogenes infections. Using MarketScan data (2010–2019), we found no difference in infection rates between those who received and those …
View article: Disease Remission and Sustained Remission After Etanercept Biosimilar or Originator Initiation in Rheumatoid Arthritis: An Interim Real-World Analysis
Disease Remission and Sustained Remission After Etanercept Biosimilar or Originator Initiation in Rheumatoid Arthritis: An Interim Real-World Analysis Open
Background: We compared time to first remission and prevalence of sustained remission in participants with rheumatoid arthritis (RA) initiating etanercept biosimilar (ETA-B) or originator (ETA-O). Methods: We studied etanercept-naive parti…
Administrative data ICD-10 diagnostic codes identifies most lab-confirmed SARS-CoV-2 admissions but misses many discharged from the Emergency Department Open
We estimated the operating characteristics of ICD-10 code U07.1, introduced by the World Health Organization in 2020, to identify lab-confirmed SARS-CoV-2. CCEDRRN is a national research registry of adults (March 2020–August 2021) with sus…
Validity of hospital diagnostic codes to identify SARS-CoV-2 infections in reference to polymerase chain reaction results: a descriptive study Open
The sensitivity, specificity, PPV and NPV of code U07.1 were high. This supports using code U07.1 to identify SARS-CoV-2 infection in hospitalization data.
View article: Importance of accounting for timing of time‐varying exposures in association studies: Hydrochlorothiazide and non‐melanoma skin cancer
Importance of accounting for timing of time‐varying exposures in association studies: Hydrochlorothiazide and non‐melanoma skin cancer Open
Purpose Hydrochlorothiazide (HCTZ), a widely prescribed antihypertensive drug with photosensitising properties, has been linked with non‐melanoma skin cancer (NMSC) risk. However, previous analyses did not fully explore if and how the impa…
Sex Differences in the Effectiveness of Angiotensin‐Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers, and Sacubitril–Valsartan for the Treatment of Heart Failure Open
Background PARAGON‐HF (Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction) suggested a potential benefit of sacubitril–valsartan in women with preserve…
View article: The Canadian Mother-Child Cohort Active Surveillance Initiative (CAMCCO): Comparisons between Quebec, Manitoba, Saskatchewan, and Alberta
The Canadian Mother-Child Cohort Active Surveillance Initiative (CAMCCO): Comparisons between Quebec, Manitoba, Saskatchewan, and Alberta Open
Background Given that pregnant women taking medications are excluded from clinical trials, real-world evidence is essential. We aimed to build a Canadian Mother-Child Cohort Active Surveillance Initiative (CAMCCO) and compare frequency of …
Medication use by the ?quilombola? population: a survey in Southwestern Bahia, Brazil Open
OBJECTIVE To characterize the medication use by the quilombola population. METHODS A population-based cross-sectional study was conducted with 797 adult quilombola in Vitória da Conquista, BA, Northeastern Brazil, in 2011. Analysis of vari…
P247 Comparison of discontinuation/switching between infliximab biosimilar and originator among Inflammatory Bowel Disease patients: a real-world analysis of two Canadian cohorts Open
Background Biosimilar infliximab (INF-B) has been approved in Canada for Inflammatory Bowel Disease (IBD) for over five years, but real-world descriptions of therapy persistence (discontinuation/switching) comparing INF-B to bio-originator…
Predictors of long-term use of prescription opioids in the community-dwelling population of adults without a cancer diagnosis: a retrospective cohort study Open
This study identified factors associated with long-term prescription opioid use. Limiting the initial supply to no more than 7 days and limiting doses to 90 MME/day or less are actions that could be undertaken at the point of care.
Is there an agreement between self-reported medical diagnosis in the CARTaGENE cohort and the Québec administrative health databases? Open
BackgroundPopulation health studies often use existing databases that are not necessarily constituted for research purposes. The question arises as to whether different data sources such as in administrative health data (AHD) and self-repo…
Sex Differences in Cardiovascular Effectiveness of Newer Glucose‐Lowering Drugs Added to Metformin in Type 2 Diabetes Mellitus Open
Background Randomized controlled trials showed that newer glucose‐lowering agents are cardioprotective, but most participants were men. It is unknown whether benefits are similar in women. Methods and Results Among adults with type 2 diabe…
Direct-Acting Antivirals for Hepatitis C: Predictors of Early Discontinuation in the Real World Open
This study was funded by the Canadian Institutes of Health Research. Klein has received grants for investigator-initiated trials from ViiV Healthcare, Janssen, Gilead, and Merck, as well as consulting fees from ViiV Healthcare, Merck, and …
Identifying Rheumatoid Arthritis Cases within the Quebec Health Administrative Database Open
Objective. Our objective was to calculate rheumatoid arthritis (RA) point prevalence estimates in the CARTaGENE cohort, as well as to estimate the sensitivity and specificity of our ascertainment approach, using physician billing data. We …
Associations between low- and high-dose oral fluconazole and pregnancy outcomes: 3 nested case–control studies Open
Any maternal exposure to fluconazole during pregnancy may increase risk of spontaneous abortion and doses higher than 150 mg during the first trimester may increase risk of cardiac septal closure anomalies.
View article: Restrictive measure for the commercialization of antimicrobials in Brazil: results achieved
Restrictive measure for the commercialization of antimicrobials in Brazil: results achieved Open
OBJECTIVE: To assess whether the incidence of hospital infection by a resistant microorganism decreased after the implementation of the restrictive measure of the National Health Surveillance Agency for the commercialization of antimicrobi…