Ala‐Eddin Al Moustafa
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View article: Crosstalk Between the Oncoproteins of High‐Risk Human Papillomaviruses Types 16 and 18 in Colorectal Cancer Cell Models
Crosstalk Between the Oncoproteins of High‐Risk Human Papillomaviruses Types 16 and 18 in Colorectal Cancer Cell Models Open
Background Colorectal cancer (CRC) represents a major fraction of the total cancer burden worldwide. It has been recently identified that various high‐risk Human Papillomaviruses (HPVs) are present in human CRCs, where they play a critical…
View article: Neratinib and metformin: A novel therapeutic approach against HER2-Positive Breast Cancer
Neratinib and metformin: A novel therapeutic approach against HER2-Positive Breast Cancer Open
These findings suggest that neratinib and metformin combination can present a promising strategy for targeting multiple pathways in HER2-positive BC.
View article: Pancreatic ductal adenocarcinoma: the latest on diagnosis, molecular profiling, and systemic treatments
Pancreatic ductal adenocarcinoma: the latest on diagnosis, molecular profiling, and systemic treatments Open
Pancreatic ductal adenocarcinoma (PDAC) is currently the fourth leading cause of death in the United States and is expected to be ranked second in the next 10 years due to poor prognosis and a rising incidence. Distant metastatic PDAC is a…
View article: Oncoproteins E6/E7 of the Human Papillomavirus Types 16 & 18 Cooperate in Modulating Oncogenes and Tumor Suppressor Proteins in Colorectal Cancer
Oncoproteins E6/E7 of the Human Papillomavirus Types 16 & 18 Cooperate in Modulating Oncogenes and Tumor Suppressor Proteins in Colorectal Cancer Open
Background This study presents a novel analysis of the oncogenes and tumor suppressor proteins directly modulated by E6/E7 of high-risk HPV types 16 and 18, in two mutational cell models of colorectal cancer (CRC).Methods Two distinct muta…
View article: Elaeagnus Angustifolia Plant Extract inhibits Epithelial- mesenchymal Transition in Human Colorectal Cancer via β-catenin/JNK signaling Pathways
Elaeagnus Angustifolia Plant Extract inhibits Epithelial- mesenchymal Transition in Human Colorectal Cancer via β-catenin/JNK signaling Pathways Open
Elaeagnus angustifolia (EA) is a traditional plant that has been used as an alternative medicine for centuries. EA roles as anti-cancer has been investigated against different types of cancer, however, its effect against human cancer has n…
View article: Metformin and HER2-positive breast cancer: Mechanisms and therapeutic implications
Metformin and HER2-positive breast cancer: Mechanisms and therapeutic implications Open
Due to the strong association between diabetes and cancer incidents, several anti-diabetic drugs, including metformin, have been examined for their anticancer activity. Metformin is a biguanide antihyperglycemic agent used as a first-line …
View article: Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor
Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor Open
Introduction Immune checkpoint blockade (ICB)-based therapy is revolutionizing cancer treatment by fostering successful immune surveillance and effector cell responses against various types of cancers. However, patients with HER2+ cancers …
View article: Developmental Toxicity of Surface-Modified Gold Nanorods in the Zebrafish Model
Developmental Toxicity of Surface-Modified Gold Nanorods in the Zebrafish Model Open
our results revealed that AuNR treatment at the EC50 induces apoptosis significantly through the P53, BAX/BCL-2, and CASPASE pathways as a suggested mechanism of action and toxicity modality.
View article: Haematococcus pluvialis Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells
Haematococcus pluvialis Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells Open
Breast cancer (BC) is the most common malignant cancer in females worldwide. Drug resistance, toxicity, and the failure of current therapies to completely cure BC has challenged conventional medicine. Consequently, complementary alternativ…
View article: Antibacterial and Antibiofilm Activity of Mercaptophenol Functionalized-Gold Nanorods Against a Clinical Isolate of Methicillin-Resistant Staphylococcus aureus
Antibacterial and Antibiofilm Activity of Mercaptophenol Functionalized-Gold Nanorods Against a Clinical Isolate of Methicillin-Resistant Staphylococcus aureus Open
Gold nanorods (AuNRs) were synthesized by the seed-mediated wet chemical method using a binary surfactant system. AuNRs were stabilized with polyethylene glycol, then functionalized with 4-mercaptophenol (4-MPH) ligand by surface ligand ex…
View article: Elaeagnus angustifolia Plant Extract Induces Apoptosis via P53 and Signal Transducer and Activator of Transcription 3 Signaling Pathways in Triple-Negative Breast Cancer Cells
Elaeagnus angustifolia Plant Extract Induces Apoptosis via P53 and Signal Transducer and Activator of Transcription 3 Signaling Pathways in Triple-Negative Breast Cancer Cells Open
Elaeagnus angustifolia ( EA ) is used as an alternative medicine in the Middle East to manage numerous human diseases. We recently reported that EA flower extract inhibits cell proliferation and invasion of human oral and HER2-positive bre…
View article: Incidence of HPVs, EBV, and MMTV-Like Virus in Breast Cancer in Qatar
Incidence of HPVs, EBV, and MMTV-Like Virus in Breast Cancer in Qatar Open
Introduction: Human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and mouse mammary tumor virus-like virus (MMTV-like virus) can be present and contribute to breast cancer development and progression. However, the role of these oncovi…
View article: Antibacterial and Antibiofilm Activity of Mercaptophenol Functionalized-Gold Nanorods Against a Clinical Isolate of Methicillin-Resistant Staphylococcus Aureus
Antibacterial and Antibiofilm Activity of Mercaptophenol Functionalized-Gold Nanorods Against a Clinical Isolate of Methicillin-Resistant Staphylococcus Aureus Open
Gold nanorods (AuNRs) were synthesized and surface functionalized with 4-mercaptophenol (4-MPH) ligand. The surface-functionalized AuNRs, 4-MPH-AuNRs, were characterized by UV-Vis spectroscopy, dynamic light scattering (DLS), transmission …
View article: DNA Damage/Repair Management in Cancers
DNA Damage/Repair Management in Cancers Open
DNA damage is well recognized as a critical factor in cancer development and progression.DNA lesions create an abnormal nucleotide or nucleotide fragment, causing a break in one or both chains of the DNA strand.When DNA damage occurs, the …
View article: The Combination of Dasatinib and PD L1 inhibitor prevents the progression of epithelial mesenchymal transition and dramatically blocks cell invasion of HER2 positive breast cancer cells
The Combination of Dasatinib and PD L1 inhibitor prevents the progression of epithelial mesenchymal transition and dramatically blocks cell invasion of HER2 positive breast cancer cells Open
Introduction: Both Dasatinib (DA), a tyrosine kinase inhibitor that is used for targeted cancer therapy, and programmed death-ligand 1 (PD-1/PD-L1) inhibitor that is an immune checkpoint therapy, play a vital role in the management of seve…
View article: Oncoproteins of High-Risk HPV and EBV Cooperate to Enhance Cell Motility and Invasion of Human Breast Cancer Cells via Erk1/Erk2 and β-Catenin Signaling Pathways
Oncoproteins of High-Risk HPV and EBV Cooperate to Enhance Cell Motility and Invasion of Human Breast Cancer Cells via Erk1/Erk2 and β-Catenin Signaling Pathways Open
Breast cancer is a leading cause of death in women around the world. Most breast cancer-related deaths are a result of complications from the metastatic spread. Several recent studies reported that high-risk human papillomaviruses (HPVs) a…
View article: Gelatin-methacryloyl hydrogel based <i>in vitro</i> blood–brain barrier model for studying breast cancer-associated brain metastasis
Gelatin-methacryloyl hydrogel based <i>in vitro</i> blood–brain barrier model for studying breast cancer-associated brain metastasis Open
Breast cancer is one of the leading causes of brain metastasis. Metastasis to the brain occurs if cancer cells manage to traverse the 'blood-brain barrier' (BBB), which is a barrier with a very tight junction (TJ) of endothelial cells betw…
View article: Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways
Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways Open
HER2-positive breast cancer is one of its most challenging subtypes, forming around 15-25% of the total cases. It is characterized by aggressive behavior and treatment resistance. On the other hand, poly (amidoamine) (PAMAM) dendrimers are…
View article: Breast Cancer During Pregnancy: A Marked Propensity to Triple-Negative Phenotype
Breast Cancer During Pregnancy: A Marked Propensity to Triple-Negative Phenotype Open
Breast and cervical cancers comprise 50% of all cancers during pregnancy. In particular, gestational breast cancer is considered one of the most aggressive types of cancers, which is a rare but fatal disease. However, the incidence of this…
View article: Dasatinib and PD-L1 inhibitors provoke toxicity and inhibit angiogenesis in the embryo
Dasatinib and PD-L1 inhibitors provoke toxicity and inhibit angiogenesis in the embryo Open
Dasatinib is a targeted cancer therapy, while programmed death ligand 1 (PD-L1) inhibitors are a form of immune checkpoint therapy used to treat various types of cancers. Several studies showed the potential efficacy of these drugs in the …
View article: A comprehensive review on the antiviral activities of chalcones
A comprehensive review on the antiviral activities of chalcones Open
Some viral outbreaks have plagued the world since antiquity, including the most recent COVID-19 pandemic. The continuous spread and emergence of new viral diseases have urged the discovery of novel treatment options that can overcome the l…
View article: PAMAM Dendrimers as anti-HER2 Positive Breast Cancer Treatment
PAMAM Dendrimers as anti-HER2 Positive Breast Cancer Treatment Open
Background: Poly (amidoamine) dendrimers (PAMAMs) are widely used in drug delivery systems and gene transfection as drug carriers. They also exert several biological effects like modulating gene expression, particularly EGFR (ErbB1) signal…
View article: Design, Synthesis and Biological Evaluation of Novel Chalcone Analogs as Potential Therapeutic Agents for Castration-Resistant Prostate Cancer
Design, Synthesis and Biological Evaluation of Novel Chalcone Analogs as Potential Therapeutic Agents for Castration-Resistant Prostate Cancer Open
Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormonal targeted therapy, the majority of patients ultimatel…
View article: The co-presence of high-risk human papillomaviruses and Epstein-Barr virus is linked with tumor grade and stage in Qatari women with breast cancer
The co-presence of high-risk human papillomaviruses and Epstein-Barr virus is linked with tumor grade and stage in Qatari women with breast cancer Open
High-risk human papillomaviruses (HPV) can be present and cooperate with Epstein-Barr virus (EBV) to promote the onset and/or progression of various cancers including cervical, breast, head and neck as well as colorectal. In this investiga…