Samuel R. Moxon
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View article: Electro‐Actuation of a Smart Hydrogel Compatible With <scp>3D</scp> Printing
Electro‐Actuation of a Smart Hydrogel Compatible With <span>3D</span> Printing Open
Hydrogels that can change shape on the application of an electric field are receiving increasing attention due to their potential to fulfill a range of functions in biomedicine, including the controlled release of therapeutic agents or the…
View article: Structuring of gellan hydrogel enables the production of inherently antifibrotic, lubricating eye drops
Structuring of gellan hydrogel enables the production of inherently antifibrotic, lubricating eye drops Open
Gellan is an anionic polysaccharide that forms optically clear hydrogels, making it suitable for use in ocular applications. Previous research has demonstrated that gellan fluid gels, when used alongside standard treatments (antibiotics an…
View article: Suspension bioprinted whole intervertebral disc analogues enable regional stiffness- and hypoxia-regulated matrix secretion by primary human nucleus pulposus and annulus fibrosus cells
Suspension bioprinted whole intervertebral disc analogues enable regional stiffness- and hypoxia-regulated matrix secretion by primary human nucleus pulposus and annulus fibrosus cells Open
Intervertebral disc (IVD) degeneration is a leading cause of back pain, and while studies have revealed the roles resident nucleus pulposus (NP) and annulus fibrosus (AF) cells play in degeneration, tissue-engineered IVD models are needed …
View article: Suspension Bioprinted Whole Intervertebral Disc Analogues Enable Regional Stiffness- and Hypoxia-Regulated Matrix Secretion by Primary Human Nucleus Pulposus and Annulus Fibrosus Cells
Suspension Bioprinted Whole Intervertebral Disc Analogues Enable Regional Stiffness- and Hypoxia-Regulated Matrix Secretion by Primary Human Nucleus Pulposus and Annulus Fibrosus Cells Open
View article: 3D bioprinting of an intervertebral disc tissue analogue with a highly aligned annulus fibrosus via suspended layer additive manufacture
3D bioprinting of an intervertebral disc tissue analogue with a highly aligned annulus fibrosus via suspended layer additive manufacture Open
Intervertebral disc (IVD) function is achieved through integration of its two component regions: the nucleus pulposus (NP) and the annulus fibrosus (AF). The NP is soft (0.3–5 kPa), gelatinous and populated by spherical NP cells in a polys…
View article: Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition
Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition Open
Alzheimer’s disease (AD) is characterised by the aggregation and deposition of amyloid-β (Aβ) peptides in the human brain. In age-related late-onset AD, deficient degradation and clearance, rather than enhanced production, of Aβ contribute…
View article: Agarose Fluid Gels Formed by Shear Processing During Gelation for Suspended 3D Bioprinting
Agarose Fluid Gels Formed by Shear Processing During Gelation for Suspended 3D Bioprinting Open
The use of granular matrices to support parts during the bioprinting process was first reported by Bhattacharjee et al. in 2015, and since then, several approaches have been developed for the preparation and use of supporting gel beds in 3…
View article: Regulation of Mesenchymal Stem Cell Morphology Using Hydrogel Substrates with Tunable Topography and Photoswitchable Stiffness
Regulation of Mesenchymal Stem Cell Morphology Using Hydrogel Substrates with Tunable Topography and Photoswitchable Stiffness Open
Cell function can be directly influenced by the mechanical and structural properties of the extracellular environment. In particular, cell morphology and phenotype can be regulated via the modulation of both the stiffness and surface topog…
View article: Impact of type-1 collagen hydrogel density on integrin-linked morphogenic response of SH-SY5Y neuronal cells
Impact of type-1 collagen hydrogel density on integrin-linked morphogenic response of SH-SY5Y neuronal cells Open
Cellular metabolism and behaviour is closely linked to cytoskeletal tension and scaffold mechanics.
View article: Emulating Human Tissues and Organs: A Bioprinting Perspective Toward Personalized Medicine
Emulating Human Tissues and Organs: A Bioprinting Perspective Toward Personalized Medicine Open
The lack of in vitro tissue and organ models capable of mimicking human physiology severely hinders the development and clinical translation of therapies and drugs with higher in vivo efficacy. Bioprinting allow us to fill this gap and gen…
View article: A Preliminary Evaluation of the Pro-Chondrogenic Potential of 3D-Bioprinted Poly(ester Urea) Scaffolds
A Preliminary Evaluation of the Pro-Chondrogenic Potential of 3D-Bioprinted Poly(ester Urea) Scaffolds Open
Degeneration of articular cartilage (AC) is a common healthcare issue that can result in significantly impaired function and mobility for affected patients. The avascular nature of the tissue strongly burdens its regenerative capacity cont…
View article: Investigating potential wound healing properties of polysaccharides extracted from Grewia mollis Juss. and Hoheria populnea A. Cunn. (Malvaceae)
Investigating potential wound healing properties of polysaccharides extracted from Grewia mollis Juss. and Hoheria populnea A. Cunn. (Malvaceae) Open
View article: Blended alginate/collagen hydrogels promote neurogenesis and neuronal maturation
Blended alginate/collagen hydrogels promote neurogenesis and neuronal maturation Open
View article: Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective
Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective Open
View article: Suspended Manufacture of Biological Structures
Suspended Manufacture of Biological Structures Open
A method for the production of complex cell-laden structures is reported, which allows high-levels of spatial control over mechanical and chemical properties. The potential of this method for producing complicated tissues is demonstrated b…
View article: Development of biopolymer hydrogels as complex tissue engineering scaffolds
Development of biopolymer hydrogels as complex tissue engineering scaffolds Open
As global life expectancy increases, so does the demand for new technologies to address healthcare issues associated with disease and degradation of biological tissues and organs. Implantation is still a heavily relied upon method but pati…
View article: Controlling the rheology of gellan gum hydrogels in cell culture conditions
Controlling the rheology of gellan gum hydrogels in cell culture conditions Open
View article: Healthcare Applications of Okra Biopolymer
Healthcare Applications of Okra Biopolymer Open