Moyra E. Mortby
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View article: Humor styles and subjective wellbeing in older adults: Identifying mediators and associated implications for healthy aging
Humor styles and subjective wellbeing in older adults: Identifying mediators and associated implications for healthy aging Open
View article: Adapting epidemiological research through unexpected environmental events: COVID-19 and bushfires impacts on the administration of the PATH cohort study
Adapting epidemiological research through unexpected environmental events: COVID-19 and bushfires impacts on the administration of the PATH cohort study Open
View article: Apathy is distinct from depression or fatigue and is associated with poor physical health in an older community cohort
Apathy is distinct from depression or fatigue and is associated with poor physical health in an older community cohort Open
Apathy is more common than depression or fatigue in dementia-free older adults. It does not typically co-occur with these symptoms, but is accompanied by poorer physical health, including multimorbidity and metabolic dysregulation. Apathy …
View article: Mapping of validated apathy scales onto the apathy diagnostic criteria for neurocognitive disorders
Mapping of validated apathy scales onto the apathy diagnostic criteria for neurocognitive disorders Open
More NPI-C apathy than AES items mapped strongly and uniquely onto the DCA-NCD and its dimensions. The NPI-C apathy may better capture the DCA-NCD and its dimensions compared with the AES.
View article: Apathy, dementia risk and mortality: long-term associations in a population-based prospective cohort of older adults
Apathy, dementia risk and mortality: long-term associations in a population-based prospective cohort of older adults Open
Background Understanding whether apathy in older adults is related to incident dementia and mortality could help identify at-risk individuals, and inform public health efforts. This study aimed to investigate associations between apathy an…
View article: Updates and future perspectives on neuropsychiatric symptoms in Alzheimer's disease
Updates and future perspectives on neuropsychiatric symptoms in Alzheimer's disease Open
Neuropsychiatric symptoms (NPS) are common throughout the Alzheimer's disease (AD) continuum and profoundly affect patients, caregivers, and health‐care systems. This review synthesizes key research presented in the 2022 and 2023 Alzheimer…
View article: Maintaining level of modifiable dementia risk scores is associated with better cognitive outcomes than increasing risk scores: A population-based prospective cohort study
Maintaining level of modifiable dementia risk scores is associated with better cognitive outcomes than increasing risk scores: A population-based prospective cohort study Open
View article: Apathy and fatigue, but not depression, associated with inflammatory biomarkers in older adults
Apathy and fatigue, but not depression, associated with inflammatory biomarkers in older adults Open
Background Apathy (loss of motivation or goal‐directed behaviour) and depression each confer risk for dementia, cardiovascular disease and mortality in older adults. Mechanisms for this are not yet understood, and may involve systemic infl…
View article: Functional impairment in a dementia‐free sample associated with a higher risk of Mild Behavioral Impairment
Functional impairment in a dementia‐free sample associated with a higher risk of Mild Behavioral Impairment Open
Background Mild Behavioral Impairment (MBI) and functional ability are two non‐cognitive markers of dementia. To date, little is known about the impact of functional ability on the clinical manifestation of MBI. Using data from the Austral…
View article: Linking cognitive and behavioral reserve: Evidence from the CAN‐PROTECT study
Linking cognitive and behavioral reserve: Evidence from the CAN‐PROTECT study Open
INTRODUCTION Changes to the brain due to Alzheimer's disease and other age‐related neuropathologies may present with cognitive and behavioral symptoms, even during preclinical and prodromal stages. While cognitive reserve is known to mitig…
View article: No Association Found: Adverse Childhood Experiences and Cognitive Impairment in Older Australian Adults
No Association Found: Adverse Childhood Experiences and Cognitive Impairment in Older Australian Adults Open
OBJECTIVE: This study aimed to investigate the relationship between childhood adversity and cognitive impairment in older adults. METHODS: We analysed data from 1568 participants aged 72–79 (M = 75.1, SD = 1.5, % male = 52.6%) from Wave 4 …
View article: Associations between fruit and vegetable intakes and incident depression in middle-aged and older adults from 10 diverse international longitudinal cohorts
Associations between fruit and vegetable intakes and incident depression in middle-aged and older adults from 10 diverse international longitudinal cohorts Open
View article: Risk factors and cognitive correlates of white matter hyperintensities in ethnically diverse populations without dementia: The COSMIC consortium
Risk factors and cognitive correlates of white matter hyperintensities in ethnically diverse populations without dementia: The COSMIC consortium Open
INTRODUCTION White matter hyperintensities (WMHs) are an important imaging marker for cerebral small vessel diseases, but their risk factors and cognitive associations have not been well documented in populations of different ethnicities a…
View article: Estimating Gender Differences in the Association between Cognitive Resilience and Mild Cognitive Impairment Incidence
Estimating Gender Differences in the Association between Cognitive Resilience and Mild Cognitive Impairment Incidence Open
Introduction: Recent evidence suggests that the influence of verbal intelligence and education on the onset of subjective cognitive decline may be modulated by gender, where education contributes less to cognitive resilience …
View article: Sex‐specific neuropsychiatric burden distinguished by APOE4 status and cortical thickness
Sex‐specific neuropsychiatric burden distinguished by APOE4 status and cortical thickness Open
Background The APOE ε4 (APOE4) allele is a genetic risk factor for Alzheimer’s disease (AD). Prior work by our group found a significant association between the APOE4 allele and presence of psychosis as well as overall increased neuropsych…
View article: Apathy, depression and risk of incident dementia in community‐dwelling older adults
Apathy, depression and risk of incident dementia in community‐dwelling older adults Open
Background Apathy, which may be a risk or prognostic factor for incident dementia in older adults, has been little investigated in cognitively normal populations and has largely lacked consideration of comorbid depression. Understanding th…
View article: Mapping of validated apathy scales onto the apathy diagnostic criteria for neurocognitive disorders
Mapping of validated apathy scales onto the apathy diagnostic criteria for neurocognitive disorders Open
Background Diagnostic criteria for apathy ( DCA ) in neurocognitive disorders were developed in 2021. As next steps, we assessed whether commonly‐used validated apathy scales map onto the DCA and identified which scales map best. Method Us…
View article: Risk of Mild Behavioral Impairment: the role of gender and APOE allele carrier status
Risk of Mild Behavioral Impairment: the role of gender and APOE allele carrier status Open
Background Gender differences in dementia and dementia‐related neuropsychiatric symptoms are well described. Similarly, the Apolipoprotein E (APOE) ε4 allele is a well‐known predictor of Alzheimer’s disease. However, their impact on the cl…
View article: The effect of baseline and longitudinal cognitive reserve on memory ageing in middle and older age adults over a 12‐year period
The effect of baseline and longitudinal cognitive reserve on memory ageing in middle and older age adults over a 12‐year period Open
Background ‘Cognitive reserve’ (CR) refers to a model of active protection against cognitive decline conferred by the adaptability of one’s cognitive processes. Research on life‐course accumulation of reserve and impact of factors like gen…
View article: Apathy as a determinant of health behaviors in older adults: Implications for dementia risk reduction
Apathy as a determinant of health behaviors in older adults: Implications for dementia risk reduction Open
INTRODUCTION Long‐term improvements in physical inactivity and other behavioral risk factors are integral to dementia risk reduction; however, sustained behavior change is challenging. Apathy, depression, and fatigue may impact engagement …
View article: Risk factors and cognitive correlates of white matter hyperintensities in ethnically diverse populations without dementia: the COSMIC consortium
Risk factors and cognitive correlates of white matter hyperintensities in ethnically diverse populations without dementia: the COSMIC consortium Open
INTRODUCTION White matter hyperintensities (WMH) are an important imaging marker for cerebral small vessel diseases, but their risk factors and cognitive associations have not been well-documented in populations of different ethnicities an…
View article: The link between apathy and depressive symptoms and healthy lifestyles in older community‐dwelling adults
The link between apathy and depressive symptoms and healthy lifestyles in older community‐dwelling adults Open
Background Apathy (loss of motivation or goal‐directed behaviour) and depression each confer risk for dementia, cardiovascular disease and mortality in older adults. The mechanisms by which these neuropsychiatric symptoms are linked with h…
View article: Parental history of dementia and the risk of dementia: A cross‐sectional analysis of a global collaborative study
Parental history of dementia and the risk of dementia: A cross‐sectional analysis of a global collaborative study Open
Background Parental history of dementia appears to increase the risk of dementia, but there have been inconsistent results. We aimed to investigate whether the association between parental history of dementia and the risk of dementia are d…
View article: Distinguishing apathy from depression: A review differentiating the behavioral, neuroanatomic, and treatment‐related aspects of apathy from depression in neurocognitive disorders
Distinguishing apathy from depression: A review differentiating the behavioral, neuroanatomic, and treatment‐related aspects of apathy from depression in neurocognitive disorders Open
Objectives This narrative review describes the clinical features of apathy and depression in individuals with neurocognitive disorders (NCDs), with the goal of differentiating the two syndromes on the basis of clinical presentation, diagno…
View article: The impact of mild cognitive impairment on decision-making under explicit risk conditions: Evidence from the Personality and Total Health (PATH) Through Life longitudinal study
The impact of mild cognitive impairment on decision-making under explicit risk conditions: Evidence from the Personality and Total Health (PATH) Through Life longitudinal study Open
Objective: Previous research has indicated that cognition and executive function are associated with decision-making, however the impact of mild cognitive impairment (MCI) on decision-making under explicit risk conditions is unclear. This …
View article: Psychosis as a Treatment Target in Dementia: A Roadmap for Designing Interventions
Psychosis as a Treatment Target in Dementia: A Roadmap for Designing Interventions Open
Psychotic phenomena are among the most severe and disruptive symptoms of dementias and appear in 30% to 50% of patients. They are associated with a worse evolution and great suffering to patients and caregivers. Their current treatments ob…
View article: Mixed Evidence of an Association between Self-Rated Hearing Difficulties and Falls: Prospective Analysis of Two Longitudinal Studies
Mixed Evidence of an Association between Self-Rated Hearing Difficulties and Falls: Prospective Analysis of Two Longitudinal Studies Open
Introduction: This study aimed to assess the extent to which a single item of self-reported hearing difficulties is associated with future risk of falling among community-dwelling older adults. Methods: We used data from two Australian pop…
View article: Sex differences in neuropsychiatric symptoms in Alzheimer’s disease dementia: a meta-analysis
Sex differences in neuropsychiatric symptoms in Alzheimer’s disease dementia: a meta-analysis Open
View article: Who displays dementia-related stigma and what does the general public know about dementia? Findings from a nationally representative survey
Who displays dementia-related stigma and what does the general public know about dementia? Findings from a nationally representative survey Open
This study identifies a need for improved public education about dementia. A structured approach to the development of strategies that is specifically tailored to different age, gender and cultural groups may provide a beneficial approach …
View article: Residential aged care staff perceptions and responses towards neuropsychiatric symptoms: a mixed methods analysis of electronic healthcare records
Residential aged care staff perceptions and responses towards neuropsychiatric symptoms: a mixed methods analysis of electronic healthcare records Open
Supplemental data for this article is available online at https://doi.org/10.1080/13607863.2022.2032597 .