Mozhdeh Sojoodi
YOU?
Author Swipe
View article: Precision-cut liver slices as an ex vivo model to evaluate antifibrotic therapies for liver fibrosis and cirrhosis
Precision-cut liver slices as an ex vivo model to evaluate antifibrotic therapies for liver fibrosis and cirrhosis Open
Background: Considering the lack of successful treatment options and poor prognosis for cirrhosis and cirrhosis-induced HCC, new platforms to investigate antifibrotic therapies are urgently needed. Precision-cut liver slice (PCLS) is a pow…
View article: Editorial: Prebiotics in the management of obesity and associated metabolic disorders
Editorial: Prebiotics in the management of obesity and associated metabolic disorders Open
Citation: Khosravi S, Tabatabaei-Malazy O, Emamgholipour S, Sojoodi M and Shabani P (2024) Editorial: Prebiotics in the management of obesity and associated metabolic disorders. Front. Endocrinol. 15:1432530. doi: 10.3389/fendo.2024.1432530
View article: Increased susceptibility to ischemia causes exacerbated response to microinjuries in the cirrhotic liver
Increased susceptibility to ischemia causes exacerbated response to microinjuries in the cirrhotic liver Open
Fractional laser ablation is a technique developed in dermatology to induce remodeling of skin scars by creating a dense pattern of microinjuries. Despite remarkable clinical results, this technique has yet to be tested for scars in other …
View article: Precision-Cut Liver Slices as an<i>ex vivo</i>model to evaluate antifibrotic therapies for liver fibrosis and cirrhosis
Precision-Cut Liver Slices as an<i>ex vivo</i>model to evaluate antifibrotic therapies for liver fibrosis and cirrhosis Open
Background Precision-Cut Liver Slices (PCLS) are an ex vivo culture model developed to study hepatic drug metabolism. One of the main benefits of this model is that it retains the structure and cellular composition of the native liver. PCL…
View article: Tailored Chemical Reactivity Probes for Systemic Imaging of Aldehydes in Fibroproliferative Diseases
Tailored Chemical Reactivity Probes for Systemic Imaging of Aldehydes in Fibroproliferative Diseases Open
During fibroproliferation, protein-associated extracellular aldehydes are formed by the oxidation of lysine residues on extracellular matrix proteins to form the aldehyde allysine. Here we report three Mn(II)-based, small-molecule magnetic…
View article: Increased susceptibility to ischemia causes exacerbated response to microinjuries in the cirrhotic liver
Increased susceptibility to ischemia causes exacerbated response to microinjuries in the cirrhotic liver Open
Background Fractional laser ablation is a technique developed in dermatology to induce remodeling of skin scars by creating a dense pattern of microinjuries. Despite remarkable clinical results, this technique has yet to be tested for scar…
View article: Molecular magnetic resonance imaging of liver inflammation using an oxidatively activated probe
Molecular magnetic resonance imaging of liver inflammation using an oxidatively activated probe Open
Non-invasive tests to diagnose and measure liver inflammation are underdeveloped. Inflammatory cells such as neutrophils release reactive oxygen species which creates an inflammatory liver microenvironment that can drive chemical oxidation…
View article: Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via <i>T</i> <sub>1</sub> -weighted MRI
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via <i>T</i> <sub>1</sub> -weighted MRI Open
SNIO–CBP, a single-nanometer iron oxide (SNIO) nanoparticle functionalized with a type I collagen-binding peptide (CBP), was developed as a T 1 -weighted MRI contrast agent with only endogenous elements for fast and noninvasive detection o…
View article: Tailored chemical reactivity probes for systemic imaging of aldehydes in fibroproliferative diseases
Tailored chemical reactivity probes for systemic imaging of aldehydes in fibroproliferative diseases Open
During fibroproliferation, protein-associated extracellular aldehydes are formed by the oxidation of lysine residues on extracellular matrix proteins to form the aldehyde allysine. Here we report three Mn(II)-based, small molecule magnetic…
View article: Data from Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI
Data from Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI Open
Purpose:To evaluate the prognostic value of posttreatment fibrosis in human PDAC patients, and to compare a type I collagen targeted MRI probe, CM-101, to the standard contrast agent, Gd-DOTA, for their abilities to identify FOLFIRINOX-ind…
View article: Figure from Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI
Figure from Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI Open
Supplementary figures
View article: Supplementary Legends, Table from Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI
Supplementary Legends, Table from Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI Open
Supplementary Legends, Table
View article: Data from Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI
Data from Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI Open
Purpose:To evaluate the prognostic value of posttreatment fibrosis in human PDAC patients, and to compare a type I collagen targeted MRI probe, CM-101, to the standard contrast agent, Gd-DOTA, for their abilities to identify FOLFIRINOX-ind…
View article: Supplementary Legends, Table from Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI
Supplementary Legends, Table from Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI Open
Supplementary Legends, Table
View article: Figure from Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI
Figure from Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI Open
Supplementary figures
View article: A Rationally Designed Complex Replenishes the Transferrin Iron Pool Directly and with High Specificity
A Rationally Designed Complex Replenishes the Transferrin Iron Pool Directly and with High Specificity Open
Many forms of anemia are caused or complicated by pathologic restriction of iron (Fe). Chronic inflammation and certain genetic mutations decrease the activity of ferroportin, the only Fe-exporter protein, so that endogenously recycled or …
View article: Molecular MRI quantification of extracellular aldehyde pairs for early detection of liver fibrogenesis and response to treatment
Molecular MRI quantification of extracellular aldehyde pairs for early detection of liver fibrogenesis and response to treatment Open
Liver fibrosis plays a critical role in the evolution of most chronic liver diseases and is characterized by a buildup of extracellular matrix, which can progress to cirrhosis, hepatocellular carcinoma, liver failure, or death. Now, there …
View article: Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury
Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury Open
Altered host-microbe interactions and increased intestinal permeability have been implicated in disease pathogenesis. However, the mechanisms by which intestinal microbes affect epithelial barrier integrity remain unclear. Here, we investi…
View article: Dual Hydrazine-Equipped Turn-On Manganese-Based Probes for Magnetic Resonance Imaging of Liver Fibrogenesis
Dual Hydrazine-Equipped Turn-On Manganese-Based Probes for Magnetic Resonance Imaging of Liver Fibrogenesis Open
Liver fibrogenesis is accompanied by upregulation of lysyl oxidase enzymes, which catalyze oxidation of lysine ε-amino groups on the extracellular matrix proteins to form the aldehyde containing amino acid allysine (LysAld). Here, we descr…
View article: Hepatocellular carcinoma chemoprevention by targeting the angiotensin-converting enzyme and EGFR transactivation
Hepatocellular carcinoma chemoprevention by targeting the angiotensin-converting enzyme and EGFR transactivation Open
Hepatocellular carcinoma (HCC) is a leading cause of death among cirrhotic patients, for which chemopreventive strategies are lacking. Recently, we developed a simple human cell-based system modeling a clinical prognostic liver signature (…
View article: Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury
Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury Open
Altered host-microbe interactions and increased intestinal permeability have been implicated in the pathogenesis of a range of diseases. However, the mechanisms by which gut microbes affect epithelial barrier integrity remain unclear. Few …