Ming Gao
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View article: A Phase I, open-label study of CTD402, a universal CD7-targeting CAR T-cell therapy, in patients with relapsed/refractory severe aplastic anemia
A Phase I, open-label study of CTD402, a universal CD7-targeting CAR T-cell therapy, in patients with relapsed/refractory severe aplastic anemia Open
Background and Significance Severe Aplastic Anemia (SAA) is a bone marrow failure disorder mediated by abnormally activated T-lymphocytes that lead to hematopoietic stem cell destruction. The standard of care for patients ineligible for or…
View article: Preliminary evaluation of KYNA ameliorates neuronal pyroptosis induced by HIV-1 gp120
Preliminary evaluation of KYNA ameliorates neuronal pyroptosis induced by HIV-1 gp120 Open
Backgrounds: HIV-associated neurocognitive disorders (HAND) are the common complications in the central nervous system (CNS), mainly causing HIV dementia and leading to serious social economic load. HIV-1 gp120, the envelope protein of HIV…
View article: Cold atmospheric plasma treatment induces oxidative stress and alters microbial community profile in the leaves of sweet basil ( <i>Ocimum basilicum</i> var. Kiera) plant
Cold atmospheric plasma treatment induces oxidative stress and alters microbial community profile in the leaves of sweet basil ( <i>Ocimum basilicum</i> var. Kiera) plant Open
The oxidative species generated by cold atmospheric plasma (CAP) treatment can impact the plant stress response system. We hypothesized that this response is not limited to the site of CAP application and it is transmitted through the plan…
View article: A novel early onset spinocerebellar ataxia 13 BAC mouse model with cerebellar atrophy, tremor, and ataxic gait
A novel early onset spinocerebellar ataxia 13 BAC mouse model with cerebellar atrophy, tremor, and ataxic gait Open
Spinocerebellar ataxia 13 (SCA13) is an autosomal dominant neurological disorder caused by mutations in KCNC3. Our previous studies revealed that KCNC3 (Potassium Voltage-Gated Channel Subfamily C Member 3) mutation R423H results in an ear…
View article: Innovative food supply chain through spatial computing technologies: A review
Innovative food supply chain through spatial computing technologies: A review Open
The global food supply chain faces significant challenges related to inefficiencies, quality variability, and traceability issues, all of which contribute to food waste and consumer distrust. Spatial computing (SC) technologies, including …
View article: A Novel Early Onset Spinocerebellar Ataxia 13 BAC Mouse Model with Cerebellar Hypoplasia, Tremor, and Ataxic Gait
A Novel Early Onset Spinocerebellar Ataxia 13 BAC Mouse Model with Cerebellar Hypoplasia, Tremor, and Ataxic Gait Open
Spinocerebellar ataxia 13 (SCA13) is an autosomal dominant neurological disorder caused by mutations in KCNC3 . Our previous studies revealed that KCNC3 mutation R423H results in an early-onset form of SCA13. Previous biological models of …
View article: Impact of Maternal Overnutrition in Central Nervous System Circuits that Regulate Feeding
Impact of Maternal Overnutrition in Central Nervous System Circuits that Regulate Feeding Open
View article: Endogenous Amyloid-formed Ca2+-permeable Channels in Aged 3xTg AD Mice
Endogenous Amyloid-formed Ca2+-permeable Channels in Aged 3xTg AD Mice Open
Alzheimer’s disease (AD), the leading cause of dementia, is characterized by the accumulation of beta-amyloid peptides (Aβ). However, whether Aβ itself is a key toxic agent in AD pathogenesis and the precise mechanism of Aβ-elicited neurot…
View article: 1D and 3D co-simulation and self-adaptive position control of electrostatic levitation in China’s Space Station
1D and 3D co-simulation and self-adaptive position control of electrostatic levitation in China’s Space Station Open
The greatest challenge of electrostatic levitation for containerless material processing is the stable control of charged material during heating. Recently, high-precision self-adaptive control of electrostatic levitation has been achieved…
View article: Endothelial Dysfunction and Platelet Hyperactivation in Diabetic Complications Induced by Glycemic Variability
Endothelial Dysfunction and Platelet Hyperactivation in Diabetic Complications Induced by Glycemic Variability Open
The development and progression of the complications of chronic diabetes mellitus are attributed not only to increased blood glucose levels but also to glycemic variability. Therefore, a deeper understanding of the role of glycemic variabi…
View article: Adenosine-A2A Receptor Signaling Plays a Crucial Role in Sudden Unexpected Death in Epilepsy
Adenosine-A2A Receptor Signaling Plays a Crucial Role in Sudden Unexpected Death in Epilepsy Open
Adenosinergic activities are suggested to participate in SUDEP pathophysiology; this study aimed to evaluate the adenosine hypothesis of SUDEP and specifically the role of adenosine A 2A receptor (A 2A R) in the development of a SUDEP mous…
View article: Levo-tetrahydropalmatine inhibits α4β2 nicotinic receptor response to nicotine in cultured SH-EP1 cells
Levo-tetrahydropalmatine inhibits α4β2 nicotinic receptor response to nicotine in cultured SH-EP1 cells Open
View article: Cannabinoid CB2 receptors are expressed in glutamate neurons in the red nucleus and functionally modulate motor behavior in mice
Cannabinoid CB2 receptors are expressed in glutamate neurons in the red nucleus and functionally modulate motor behavior in mice Open
View article: Plasma Neurofilament Light Combined with Risk Genes for the Diagnosis of Alzheimer?s Disease
Plasma Neurofilament Light Combined with Risk Genes for the Diagnosis of Alzheimer?s Disease Open
To explore the association of plasma neurofilament light and other potential biomarkers with the neurodegeneration in Alzheimer’s disease is the objective. Alzheimer’s disease is a progressive neurodegenerative disease. The levels of amylo…
View article: Optical Imaging of Electrical and Mechanical Couplings between Cells
Optical Imaging of Electrical and Mechanical Couplings between Cells Open
Intercellular communication plays a pivotal role in multicellular organisms. Studying the electrical and mechanical coupling among multiple cells has been a difficult task due to the lack of suitable techniques. In this study, we developed…
View article: Presentation_1_Molecular Characterization, Expression Pattern and Function Analysis of Glycine-Rich Protein Genes Under Stresses in Chinese Cabbage (Brassica rapa L. ssp. pekinensis).pdf
Presentation_1_Molecular Characterization, Expression Pattern and Function Analysis of Glycine-Rich Protein Genes Under Stresses in Chinese Cabbage (Brassica rapa L. ssp. pekinensis).pdf Open
Plant Glycine-rich proteins (GRP), a superfamily with a glycine-rich domain, play an important role in various stresses such as high or low temperature stress and drought stress. GRP genes have been studied in many plants, but seldom in Ch…
View article: Molecular Characterization, Expression Pattern and Function Analysis of Glycine-Rich Protein Genes Under Stresses in Chinese Cabbage (Brassica rapa L. ssp. pekinensis)
Molecular Characterization, Expression Pattern and Function Analysis of Glycine-Rich Protein Genes Under Stresses in Chinese Cabbage (Brassica rapa L. ssp. pekinensis) Open
Plant Glycine-rich proteins (GRP), a superfamily with a glycine-rich domain, play an important role in various stresses such as high or low temperature stress and drought stress. GRP genes have been studied in many plants, but seldo…
View article: Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling
Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling Open
View article: Disruption of NMDAR Function Prevents Normal Experience-Dependent Homeostatic Synaptic Plasticity in Mouse Primary Visual Cortex
Disruption of NMDAR Function Prevents Normal Experience-Dependent Homeostatic Synaptic Plasticity in Mouse Primary Visual Cortex Open
Homeostatic regulation of synaptic strength allows for maintenance of neural activity within a dynamic range for proper circuit function. There are largely two distinct modes of synaptic plasticity that allow for homeostatic adaptation of …
View article: Cocaine potently blocks neuronal α3β4 nicotinic acetylcholine receptors in SH-SY5Y cells
Cocaine potently blocks neuronal α3β4 nicotinic acetylcholine receptors in SH-SY5Y cells Open
View article: Mechanisms of cannabinoid CB2 receptor-mediated reduction of dopamine neuronal excitability in mouse ventral tegmental area
Mechanisms of cannabinoid CB2 receptor-mediated reduction of dopamine neuronal excitability in mouse ventral tegmental area Open
View article: Cocaine Directly Inhibits α6-Containing Nicotinic Acetylcholine Receptors in Human SH-EP1 Cells and Mouse VTA DA Neurons
Cocaine Directly Inhibits α6-Containing Nicotinic Acetylcholine Receptors in Human SH-EP1 Cells and Mouse VTA DA Neurons Open
Alpha6-containing nicotinic acetylcholine receptors are primarily found in neurons of the midbrain dopaminergic (DA) system, suggesting these receptors are potentially involved in drug reward and dependence. Here, we report a novel effect …
View article: Alpha6-containing nicotinic acetylcholine receptor is a highly sensitive target of alcohol
Alpha6-containing nicotinic acetylcholine receptor is a highly sensitive target of alcohol Open
View article: Mechanisms of Cannabinoid CB2 Receptor-Mediated Reduction of Dopamine Neuronal Excitability in Mouse Ventral Tegmental Area
Mechanisms of Cannabinoid CB2 Receptor-Mediated Reduction of Dopamine Neuronal Excitability in Mouse Ventral Tegmental Area Open
View article: Heterogeneity of cannabinoid ligand-induced modulations in intracellular Ca2+ signals of mouse pancreatic acinar cells in vitro
Heterogeneity of cannabinoid ligand-induced modulations in intracellular Ca2+ signals of mouse pancreatic acinar cells in vitro Open
View article: Pharmacological and functional comparisons of α6/α3β2β3-nAChRs and α4β2-nAChRs heterologously expressed in the human epithelial SH-EP1 cell line
Pharmacological and functional comparisons of α6/α3β2β3-nAChRs and α4β2-nAChRs heterologously expressed in the human epithelial SH-EP1 cell line Open
View article: Cocaine-induced locomotor sensitization associates with slow oscillatory firing of neurons in the ventral tegmental area
Cocaine-induced locomotor sensitization associates with slow oscillatory firing of neurons in the ventral tegmental area Open
The initiation of psychostimulant sensitization depends on the mesocorticolimbic dopamine (DA) system. Although many cellular adaptations has been reported to be associated with this addictive behavior, the overall influence of these adapt…
View article: Alcohol is a Positive Allosteric Modulator on Alpha6-Containing Nicotinic Acetylcholine Receptors
Alcohol is a Positive Allosteric Modulator on Alpha6-Containing Nicotinic Acetylcholine Receptors Open
View article: Hippocampal synaptic and neural network deficits in young mice carrying the human<i><scp>APOE</scp>4</i>gene
Hippocampal synaptic and neural network deficits in young mice carrying the human<i><span>APOE</span>4</i>gene Open
Summary Introduction Apolipoprotein E4 ( APOE 4 ) is a major genetic risk factor for late‐onset sporadic Alzheimer disease. Emerging evidence demonstrates a hippocampus‐associated learning and memory deficit in aged APOE 4 human carriers a…