Mridu Gulati
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View article: Profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in systemic sclerosis-associated interstitial lung disease
Profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in systemic sclerosis-associated interstitial lung disease Open
Interstitial lung disease (ILD) is present in over 60% of patients with systemic sclerosis (SSc) and is the leading cause of SSc-related deaths. Profibrotic monocyte-derived alveolar macrophages (MoAM) play a causal role in the pathogenesi…
View article: Hypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis
Hypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis Open
Background Home mold exposure is a commonly overlooked cause of hypersensitivity pneumonitis. This is in part due to the limited literature supporting the association as well as the lack of exposure characterization available in reported c…
View article: Predictors of Long-Term Survival in Patients with Idiopathic Pulmonary Fibrosis: Data from the IPF-PRO Registry
Predictors of Long-Term Survival in Patients with Idiopathic Pulmonary Fibrosis: Data from the IPF-PRO Registry Open
View article: Changes in Lung Function and Mortality Risk in Patients With Idiopathic Pulmonary Fibrosis
Changes in Lung Function and Mortality Risk in Patients With Idiopathic Pulmonary Fibrosis Open
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View article: Development and evaluation of a questionnaire to capture environmental and occupational inhalational exposures in adults with fibrotic interstitial lung disease
Development and evaluation of a questionnaire to capture environmental and occupational inhalational exposures in adults with fibrotic interstitial lung disease Open
View article: Plasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts
Plasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts Open
Introduction The pathogenesis of sarcoidosis involves tissue remodelling mediated by the accumulation of abnormal extracellular matrix, which is partly the result of an imbalance in collagen synthesis, cross-linking and degradation. During…
View article: Circulating Mitochondrial DNA Is Associated With High Levels of Fatigue in Two Independent Sarcoidosis Cohorts
Circulating Mitochondrial DNA Is Associated With High Levels of Fatigue in Two Independent Sarcoidosis Cohorts Open
View article: Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome
Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome Open
Approximately 50% of patients who recover from the acute SARS‐CoV‐2 experience Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. The pathophysiological hallmark of PASC is characterized by impaired system oxygen extraction (EO 2…
View article: Autoimmune comorbidities associated with sarcoidosis: a case-control study in the All of Us research program
Autoimmune comorbidities associated with sarcoidosis: a case-control study in the All of Us research program Open
Objective The degree to which sarcoidosis patients are affected by autoimmune diseases is poorly understood. Prior studies of autoimmune co-morbidities in sarcoidosis have focused on populations outside the USA or have been impeded by smal…
View article: Rationale and design of the SARCoidosis Outcomes in all respiratory Viral Infectious Diseases (SARCOVID) Study
Rationale and design of the SARCoidosis Outcomes in all respiratory Viral Infectious Diseases (SARCOVID) Study Open
Introduction Respiratory infections are ubiquitous. The COVID-19 pandemic has refocused our attention on how morbid and potentially fatal they can be, and how host factors have an impact on the clinical course and outcomes. Due to a range …
View article: Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis
Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis Open
View article: Cough-Specific Quality of Life Predicts Disease Progression Among Patients With Interstitial Lung Disease
Cough-Specific Quality of Life Predicts Disease Progression Among Patients With Interstitial Lung Disease Open
View article: Correction to: Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort
Correction to: Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort Open
View article: Disparities in Lung Transplant among Patients with Idiopathic Pulmonary Fibrosis: An Analysis of the IPF-PRO Registry
Disparities in Lung Transplant among Patients with Idiopathic Pulmonary Fibrosis: An Analysis of the IPF-PRO Registry Open
Rationale: Lung transplant offers the potential to extend life for patients with idiopathic pulmonary fibrosis (IPF); yet, this therapeutic modality is only available to a small proportion of patients. Objectives: To identify…
View article: Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort
Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort Open
View article: Associations between resources and practices of ILD centers and outcomes in patients with idiopathic pulmonary fibrosis: data from the IPF-PRO Registry
Associations between resources and practices of ILD centers and outcomes in patients with idiopathic pulmonary fibrosis: data from the IPF-PRO Registry Open
View article: Occupational and Environmental Exposures in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (Grads)Study
Occupational and Environmental Exposures in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (Grads)Study Open
View article: Table of Contents
Table of Contents Open
View article: UNEXPLAINED DYSPNEA IN A PATIENT WITH A HISTORY OF COVID-19
UNEXPLAINED DYSPNEA IN A PATIENT WITH A HISTORY OF COVID-19 Open
View article: Hospitalizations in patients with idiopathic pulmonary fibrosis
Hospitalizations in patients with idiopathic pulmonary fibrosis Open
View article: Persistent Exertional Intolerance After COVID-19
Persistent Exertional Intolerance After COVID-19 Open
View article: Treatment of sarcoidosis with cutaneous involvement with tofacitinib
Treatment of sarcoidosis with cutaneous involvement with tofacitinib Open
Sarcoidosis is an idiopathic inflammatory disorder that is commonly treated with glucocorticoids and there are no approved steroid-sparing medications. There is emerging evidence that Janus kinase (JAK) inhibitors, which inhibit JAK-depend…
View article: Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis
Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis Open
Background Sarcoidosis is a multisystem granulomatous disease of unknown origin with a variable and often unpredictable course and pattern of organ involvement. In this study we sought to identify specific bronchoalveolar lavage (BAL) cell…
View article: Biophysical and Biochemical Contributions to Leukocyte Phenotypes in Scleroderma Associated Interstitial Lung Disease
Biophysical and Biochemical Contributions to Leukocyte Phenotypes in Scleroderma Associated Interstitial Lung Disease Open
View article: IL-15 Is Independent of Pulmonary Sarcoid Granuloma Formation In Vivo
IL-15 Is Independent of Pulmonary Sarcoid Granuloma Formation In Vivo Open
View article: Regulation of Immune Cell Matrix Metalloproteinase Production by the Sarcoidosis Lung Matrisome
Regulation of Immune Cell Matrix Metalloproteinase Production by the Sarcoidosis Lung Matrisome Open
View article: Non-steroidal treatment of cardiac sarcoidosis: A systematic review
Non-steroidal treatment of cardiac sarcoidosis: A systematic review Open
View article: Elevated IL-15 concentrations in the sarcoidosis lung are independent of granuloma burden and disease phenotypes
Elevated IL-15 concentrations in the sarcoidosis lung are independent of granuloma burden and disease phenotypes Open
Sarcoidosis is a systemic granulomatous disease predominantly affecting the lungs. The mechanisms promoting disease pathogenesis and progression are unknown, although interleukin-15 (IL-15) has been associated with the immune-mediated infl…
View article: COVID‐19 as an occupational disease
COVID‐19 as an occupational disease Open
The impact of coronavirus disease 2019 (COVID‐19) caused by the severe acute respiratory syndrome coronavirus 2 permeates all aspects of society worldwide. Initial medical reports and media coverage have increased awareness of the risk imp…
View article: Macrophage-derived netrin-1 drives adrenergic nerve–associated lung fibrosis
Macrophage-derived netrin-1 drives adrenergic nerve–associated lung fibrosis Open
Fibrosis is a macrophage-driven process of uncontrolled extracellular matrix accumulation. Neuronal guidance proteins such as netrin-1 promote inflammatory scarring. We found that macrophage-derived netrin-1 stimulates fibrosis through its…