Mridula Pachen
YOU?
Author Swipe
View article: Cardiac Sympathetic Nerve Activity Is Not Elevated in Ovine Hypertensive HFpEF
Cardiac Sympathetic Nerve Activity Is Not Elevated in Ovine Hypertensive HFpEF Open
BACKGROUND: The sympathetic nervous system is a crucial mediator of cardiovascular variables during exercise. However, its role in heart failure with preserved ejection fraction (HFpEF), where exercise intolerance is a cardinal feature, is…
View article: Reverse remodelling of the mitochondria and cytoskeleton after respiratory heart rate variability pacing of the failing sheep heart
Reverse remodelling of the mitochondria and cytoskeleton after respiratory heart rate variability pacing of the failing sheep heart Open
We have previously demonstrated that pacing the failing sheep heart with respiratory heart rate variability (RespHRV), a natural variability in the heart rate that is linked to respiration on a breath-by-breath basis, improves cardiac outp…
View article: Characterization of a novel ovine model of hypertensive heart failure with preserved ejection fraction
Characterization of a novel ovine model of hypertensive heart failure with preserved ejection fraction Open
We show that older, female sheep with chronic 2-kidney, 1-clip hypertension have similar cardiac and noncardiac exercise hemodynamic abnormalities as patients with HFpEF. This clinically relevant, translatable, and novel large animal model…
View article: Sympathetic transduction of cardiac sympathetic nerve activity in healthy, conscious sheep
Sympathetic transduction of cardiac sympathetic nerve activity in healthy, conscious sheep Open
Sympathetic transduction is the study of how impulses of sympathetic nerve activity (SNA) affect end‐organ function. Recently, the transduction of resting bursts of muscle SNA (MSNA) has been investigated and shown to have a role in the ma…
View article: Reverse re-modelling chronic heart failure by reinstating heart rate variability
Reverse re-modelling chronic heart failure by reinstating heart rate variability Open
Heart rate variability (HRV) is a crucial indicator of cardiovascular health. Low HRV is correlated with disease severity and mortality in heart failure. Heart rate increases and decreases with each breath in normal physiology termed respi…
View article: Regulation of Coronary Blood Flow by the Carotid Body Chemoreceptors in Ovine Heart Failure
Regulation of Coronary Blood Flow by the Carotid Body Chemoreceptors in Ovine Heart Failure Open
Carotid bodies (CBs) are peripheral chemoreceptors, which are primary sensors of systemic hypoxia and their activation produces respiratory, autonomic, and cardiovascular adjustments critical for body homeostasis. We have previously shown …
View article: Impaired Baroreflex Function in an Ovine Model of Chronic Heart Failure Induced by Multiple Coronary Microembolizations
Impaired Baroreflex Function in an Ovine Model of Chronic Heart Failure Induced by Multiple Coronary Microembolizations Open
Testing new therapies in heart failure (HF) requires a chronic stable model of HF in large animals. Microembolization of the coronary arteries has been used to model HF previously; however, neural control has not been previously explored i…