Mrityunjoy Mondal
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View article: Interaction with AK2A links AIFM1 to cellular energy metabolism
Interaction with AK2A links AIFM1 to cellular energy metabolism Open
Apoptosis-inducing factor 1 (AIFM1) is a flavoprotein essential for mitochondrial function and biogenesis. Its interaction with MIA40/CHCHD4, the central component of the mitochondrial disulfide relay, accounts for some, but not all, aspec…
View article: Actin-nucleation promoting factor N-WASP influences alpha-synuclein condensates and pathology
Actin-nucleation promoting factor N-WASP influences alpha-synuclein condensates and pathology Open
View article: Olanzapine, Risperidone and Clozapine prescribing is associated with increased risk for Alzheimer’s Disease reflecting antipsychotic-specific effects on microglial phagocytosis
Olanzapine, Risperidone and Clozapine prescribing is associated with increased risk for Alzheimer’s Disease reflecting antipsychotic-specific effects on microglial phagocytosis Open
Epidemiological data provides evidence for a positive correlation between schizophrenia diagnosis and an increased risk to develop dementia. Whether and how use of antipsychotic medication may contribute to this association is however unkn…
View article: Diagnosis and Therapeutic Management of Canine Pyoderma in and around Kolkata, West Bengal, India
Diagnosis and Therapeutic Management of Canine Pyoderma in and around Kolkata, West Bengal, India Open
Canine pyoderma is one of the most common causes of dermatitis with worldwide occurrence in small animal practice. The condition is diagnosed on the basis of clinical manifestations, isolation and identification of causative organisms by b…
View article: Epidemiological Studies of Canine dermatoses in and around Kolkata,West Bengal, India
Epidemiological Studies of Canine dermatoses in and around Kolkata,West Bengal, India Open
A study was undertaken to determine the prevalence of different dermatological conditions in dogs during the period from May 2018 to April 2019. Out of total 19,668 dogs, presented in the Belgachia Veterinary Clinics, 1420 (7.22%) dogs wer…
View article: Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses
Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses Open
Background A rare coding variant, P522R , in the phospholipase C gamma 2 ( PLCG2) gene has been identified as protective against late-onset Alzheimer’s disease (AD), but the mechanism is unknown. PLCG2 is exclusively expressed in microglia…
View article: Heterozygous expression of the Alzheimer’s disease protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.
Heterozygous expression of the Alzheimer’s disease protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses. Open
BACKGROUND: A rare coding variant, P522R, in the phosphoplipase C gamme 2 (PLCG2) gene has been identified as protective against late onset Alzheimer’s disease (AD), but the mechanism is unknown. PLCG2 is exclusively expressed in microglia…
View article: Heterozygous expression of the Alzheimer’s disease protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.
Heterozygous expression of the Alzheimer’s disease protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses. Open
Background: A rare coding variant, P522R, in the phosphoplipase C gamme 2 (PLCG2) gene has been identified as protective against late onset Alzheimer’s disease (AD), but the mechanism of protection is unknown. PLCG2 is exclusively expresse…
View article: RNA-Seq is not required to determine stable reference genes for qPCR normalization
RNA-Seq is not required to determine stable reference genes for qPCR normalization Open
Assessment of differential gene expression by qPCR is heavily influenced by the choice of reference genes. Although numerous statistical approaches have been proposed to determine the best reference genes, they can give rise to conflicting…
View article: Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau
Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau Open
View article: RNA-Seq is not required to determine stable reference genes for qPCR normalization
RNA-Seq is not required to determine stable reference genes for qPCR normalization Open
Assessment of differential gene expression by qPCR is heavily influenced by the choice of reference genes. Although numerous statistical approaches have been proposed to determine the best reference genes, they can give rise to conflicting…
View article: Nutrient signaling pathways regulate amyloid clearance and synaptic loss in Alzheimer’s disease
Nutrient signaling pathways regulate amyloid clearance and synaptic loss in Alzheimer’s disease Open
Summary Extra-cellular accumulation of Amyloid-β (Aβ) plaques is causatively associated with Alzheimer’s disease (AD). However, mechanisms that mediate the pre-pathological state of amyloid plaque formation remain elusive. Here, using pair…
View article: Glycosaminoglycans have variable effects on α-synuclein aggregation and differentially affect the activities of the resulting amyloid fibrils
Glycosaminoglycans have variable effects on α-synuclein aggregation and differentially affect the activities of the resulting amyloid fibrils Open
Parkinson's disease is mainly a sporadic disorder in which both environmental and cellular factors play a major role in the initiation of this disease. Glycosaminoglycans (GAG) are integral components of the extracellular matrix and are kn…