Explanipedia

Targeting hyperlipidemia: A polarity-driven ternary extraction of Apium graveolens bioactives—A coupled in-vivo, in-vitro and in-silico investigation Open

Nargis Sultana Chowdhury, Tasnuva Sharmin Zaman, Rifah Noor Chowdhury, Md. Abdur Rahman, Md Shafiul Alam , et al. · 2025

Introduction: An important factor in the onset and progression of atherosclerosis and coronary heart disease (CHD) is hyperlipidemia. Though numerous medication classes are available to regulate our body's fat content, the current fascinat…

Network Pharmacology, Molecular Docking and Experimental Validation on Potential Application of Diabetic Wound Healing of Cinnamomum zeylanicum Through Matrix Metalloproteinases-8 And 9 (MMP-8 And MMP-9) Open

Sharmin Akter, Shihab Ahmad, Mohiuddin Ahmed Bhuiyan, Irin Dewan, Rumman Reza , et al. · 2025

Cinnamomum zeylanicum exhibits promising potential in diabetic wound healing by modulating MMP-8 and MMP-9 activities, enhancing antioxidant defenses, and improving glucose regulation. These findings support its therapeutic applicat…

Improved Biopharmaceutical Performance of Coenzyme Q10 Through Solid Lipid Nanoparticles for Enhanced Brain Delivery Open

Shimul Halder, Faria Nasrin, Manik Chandra Shill, Madhabi Lata Shuma, Md Zakir Sultan , et al. · 2025

Coenzyme Q10 (CoQ) is a powerful antioxidant with neuroprotective characteristics; nevertheless, its clinical use is constrained by inadequate solubility, diminished bioavailability, and limited blood–brain barrier (BBB) penetration. Solid…

Brucella infection in a dairy herd of Chattogram, Bangladesh Open

Farhan Hasib, Md. Ariful Islam, Chandan Nath, Md Selim Reza, Md. Masuduzzaman , et al. · 2025

Objective: This study aimed to confirm probable causes of abortion with subsequent characterization of Brucella isolates from a dairy herd in the Chattogram district of Bangladesh. Materials and Methods: This study was conducted on a dairy…

Comprehensive Analysis of Groundwater Quality and Contamination in Primary Educational Institutions in the Coastal Region of Bangladesh: Health Risks to School-Going Children Open

Md. Shiblur Rahaman, Jannatul Mawya Liza, Md Rayhanul Islam Rayhan, Abu Sufian Shohag, Md Selim Reza , et al. · 2025

Heavy metals in commonly consumed rice grains in Bangladesh and associated probabilistic human health risks Open

Shamaila Islam, Md. Ahedul Akbor, Farah Noshin Chowdhury, Mehedi Hasan, Aynun Nahar , et al. · 2024

Mapping of in Vivo Therapeutic Association of Potential Hypolipidemic Activity of Apium Graveolens with its Hepatoprotective and Anti-Diabetic Properties by in Vivo and In-Silico Approach Using a Ternary Extraction Solvent Open

Nargis Chowdhury, Tasnuva Sharmin Zaman, Rifah Noor Chowdhury, Md. Abdur Rahman, Md Shafiul Alam , et al. · 2024

Isolation of Terpenoids and Derivatives From a Bangladeshi Mangrove Plant, <i>Rhizophora mucronata</i> Lam., and Its Bioactivity Evaluation: In Vitro and In Silico Study Open

P. Das, Sania Ashrafi, Juhaer Anjum, Md. Emdad Hossain, Md Selim Reza , et al. · 2024

Rhizophora mucronata Lam., a plant with a rich history of traditional use in various cultures, was subjected to chemical investigation, resulting in the isolation of five terpenoids and derivatives. The structures of these compounds, namel…

Mapping of in Vivo Therapeutic Association of Potential Anti-Hyperlipidemic Activity of Gynura Procumbens with its Diabetes Amelioration and Hepatoprotective Activity with In-Silico Approach Open

Md. Rafat Tahsin, Nasiba Binte Bahar, Maniza Muni, Fahima Aktar, Ishrat Jahan , et al. · 2024

Exploring the Abundance of Hydrophilic Analgesic and Anti-Inflammatory Compounds in Crocus Sativus Through Polarity-Directed Quaternary Solvent Extraction: Integrating In-Silico and In-Vivo Analysis Open

Md Shafiul Alam, Najibah Nasrin, Nargis Chowdhury, Romana Akter, Md. Abdur Rahman , et al. · 2024

A Preliminary Investigation of the Abundance of Hydrophobic Hepato-Protective Compounds in Piper Cubeba Adopting a Polarity-Directed Quaternary Form of Extraction Solvent Based Approach: A Combined In-Silico and In-Vivo Assessment Open

Md. Rafat Tahsin, Romana Akter, Tasniv Ahsan Arnob, Md. Abdur Rahman, Jannatun Noor Oishy , et al. · 2024

Metformin Hydrochloride Loaded Mucoadhesive Microspheres and Nanoparticles for Anti-Hyperglycemic and Anticancer Effects Using Factorial Experimental Design Open

Amina Alam Kotha, Shihab Ahmad, Irin Dewan, Mohiuddin Ahmed Bhuiyan, Fahad Imtiaz Rahman , et al. · 2023

This study suggests that the proposed metformin HCl formulation can dramatically reduce hyperglycemic conditions and may also have anticancer potential.

Pharmacophore mapping approach to find anti-cancer phytochemicals with metformin-like activities against transforming growth factor (TGF)-beta receptor I kinase: An in silico study Open

Rumman Reza, Niaz Morshed, Md. Nazmus Samdani, Md Selim Reza · 2023

The most frequently prescribed first-line treatment for type II diabetes mellitus is metformin. Recent reports asserted that this diabetes medication can also shield users from cancer. Metformin induces cell cycle arrest in cancer cells. H…

An in vivo and in silico evaluation of the hepatoprotective potential of Gynura procumbens: A promising agent for combating hepatotoxicity Open

Tanzia Islam Tithi, Md. Rafat Tahsin, Juhaer Anjum, Tasnuva Sharmin Zaman, Fahima Aktar , et al. · 2023

Introduction The liver, the most important metabolic organ of the body, performs a wide variety of vital functions. Hepatic cell injury occurs by the activation of reactive oxygen species (ROS) that are generated by carbon tetrachloride (C…

Physicochemical and Pharmacokinetic Studies of Metformin for Development of Controlled Release Matrix Tablet: Formulation Optimization Using in silico Tools Open

Rumman Reza, Niaz Morshed, Md. Nazmus Samdani, Amina Alam Kotha, Fahad Imtiaz Rahman , et al. · 2023

Metformin, taken by nearly 120 million people across the world as a treatment for type 2 diabetes, has a relatively short plasma half-life and low absolute bioavailability. In this study, physicochemical and pharmacokinetics properties of …

NIR-light-triggered delivery of doxorubicin-loaded PLGA nanoparticles for synergistic cancer therapy on DMBA/TPA induced tumor-bearing mice Open

Tunazzina Zaman Khan, Shekh Md Newaj, Ashikur Rahman, Rahnuma Tabassum, Khandaker Nujhat Tasnim , et al. · 2023

In this study, we developed NIR-light responsive poly(lactic- co -glycolic acid) (PLGA) nanoparticles (NPs) by incorporating the ICG dye for the local delivery of small-molecule drugs and therapeutics.

Disease-specific recommendation for rehabilitation: perspective from neurodegenerative diseases Open

Ikramul Hasan, Md Selim Reza, Syed Shabbir Haider, M. Emdadul Haque, Talha Bin Emran · 2023

Dear Editor, Rehabilitation is defined by the WHO as 'a set of interventions designed to optimize functioning and reduce disability in individuals with health conditions in interaction with their environment'1,2. The health conditions caus…

Low-cost approach plan and development of GSM-based smart home automation system Open

Md Selim Reza · 2022

Modern residential and office spaces provide important elements like home security systems. Homes are protected by this structure from harmful gases, fire, and gatecrashers. It ought to be sensible, trustworthy, and practical an implementa…

Nanotechnology in COVID-19 Diagnosis and Treatment: A Bibliometric Analysis Open

Ripa Kundu, Faria Nasrin, Tushar Saha, Md Selim Reza · 2022

There is an utmost urgency of having new and advanced diagnostics as well as therapeutic alternatives along with the conventional methods to treat coronavirus disease 2019 (COVID-19). For this purpose, different strategies must be explored…

A Study on the Prescription Trend of Proton Pump Inhibitors in Major Divisions of Bangladesh Open

Md Mamunur Rashid, Jesmin Sultana, Afsana Jahan, Mohammad Saifuddin, Md Selim Reza · 2022

The objective of this study is to investigate the prescription pattern of proton pump inhibitors (PPIs) in association with patients’ age, gender and type of hospital visited (government or private), location of the hospital and doctors’ s…

Factors Affecting the Prescription Pattern of Generic Cardiovascular Medicines: A Cross-Sectional Study in Dhaka City Open

Jesmin Sultana, Afsana Jahan, Mohammad Saifuddin, Md Selim Reza · 2022

A growing trend of cardiovascular disease is a threat to national health. The objectives of the research are to analyze the association between prescribed generics with doctors’ gender, academic degrees, location of practice and categories…

A comprehensive analysis of selected medicines collected from private drug outlets of Dhaka city, Bangladesh in a simple random survey Open

Mohammad Sofiqur Rahman, Naoko Yoshida, Hirohito Tsuboi, James Regun Karmoker, Nadia Kabir , et al. · 2022

Comprehensive data are needed to prevent substandard and falsified (SF) medicines as they pose a major risk to human health. To assess the quality of selected medicines, samples were collected from random private drug outlets of Dhaka Nort…

CCDC 2070085: Experimental Crystal Structure Determination Open