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View article: Immunological phenotype in asthma and its impact on long-term renal outcomes
Immunological phenotype in asthma and its impact on long-term renal outcomes Open
Asthma is associated with both airway and systemic inflammation as well as non-respiratory adverse outcomes. However, data regarding its impact on long-term renal outcomes is lacking. We classified all asthma patients who were followed at …
View article: Exploring health literacy, perceived needs, information preferences and acceptability of smartphone-based messaging interventions among individuals with obstructive sleep apnoea in Hong Kong: a mixed-method approach
Exploring health literacy, perceived needs, information preferences and acceptability of smartphone-based messaging interventions among individuals with obstructive sleep apnoea in Hong Kong: a mixed-method approach Open
This study highlights low OSA-related health literacy and a strong demand for authoritative health information. Most found that the messaging intervention was feasible and useful in improving health-related habits and OSA management. The s…
View article: Assessment of cough in asthma patients attending clinic using the cough questionnaire for asthma (CQA)
Assessment of cough in asthma patients attending clinic using the cough questionnaire for asthma (CQA) Open
CQA6 is a reliable and valid tool for assessing cough severity and its impact in asthma patients. It will help in the evaluation of cough as an important contributory symptom for asthma management.
View article: Clinical outcomes after implementation of a lung nodule surveillance programme in Hong Kong
Clinical outcomes after implementation of a lung nodule surveillance programme in Hong Kong Open
The implementation of a lung nodule surveillance programme resulted in the detection of early-stage lung cancer in more than half of diagnosed cases, with the potential to improve patient survival.
View article: Medical Comorbidities as the Independent Risk Factors of Severe Adenovirus Respiratory Tract Infection in Adults
Medical Comorbidities as the Independent Risk Factors of Severe Adenovirus Respiratory Tract Infection in Adults Open
Adenovirus is an important respiratory virus that causes severe diseases in immunocompromised patients. Data on its impact in immunocompetent patients are relatively limited. We conducted a territory-wide retrospective study on adult patie…
View article: Correlation of FE<sub>NO</sub> With Spirometric Measurements and Blood Eosinophil Level in Patients With Severe Asthma
Correlation of FE<sub>NO</sub> With Spirometric Measurements and Blood Eosinophil Level in Patients With Severe Asthma Open
Background Fractional exhaled nitric oxide (FE NO ) serves as a marker of eosinophil‐mediated airway inflammation and has been used in asthma diagnosis, phenotyping, and guidance regarding selection and adjustment of asthma therapy. Studie…
View article: In‐Hospital Mortality and Severe Respiratory and Renal Outcomes—A Territory‐Wide Comparison Between RSV and Influenza
In‐Hospital Mortality and Severe Respiratory and Renal Outcomes—A Territory‐Wide Comparison Between RSV and Influenza Open
Introduction Respiratory syncytial virus (RSV) and influenza virus are important respiratory viruses. Although RSV vaccines have been developed and recommended for patients aged ≥ 60, there is limited data on the clinical impact among the …
View article: Association of Self-Reported Sleep Metrics With Imaging Markers of Small Vessel Disease and Cognition in Patients With TIA or Mild Stroke
Association of Self-Reported Sleep Metrics With Imaging Markers of Small Vessel Disease and Cognition in Patients With TIA or Mild Stroke Open
Disturbed sleep, including longer in-bed time and longer sleep duration, was cross-sectionally associated with greater SVD burden and worse cognitive performance in patients with TIA/mild stroke. Future longitudinal studies are warranted t…
View article: Pneumococcal Vaccine Uptake in Adults Before and After Hospitalization for Pneumococcal Infections in Hong Kong, 2015 to 2024
Pneumococcal Vaccine Uptake in Adults Before and After Hospitalization for Pneumococcal Infections in Hong Kong, 2015 to 2024 Open
Background/Objectives: Vaccination is a key preventive measure against pneumococcal disease, but uptake rates remain low in high-risk populations. Limited information exists on pneumococcal vaccine uptake in individuals with a history of p…
View article: Dose of Inhaled Corticosteroid in Chronic Obstructive Pulmonary Disease and Risks of Osteoporosis or Fracture—A Systematic Review and Meta‐Analysis
Dose of Inhaled Corticosteroid in Chronic Obstructive Pulmonary Disease and Risks of Osteoporosis or Fracture—A Systematic Review and Meta‐Analysis Open
Background Inhaled corticosteroid (ICS) is a major pharmacotherapy for chronic obstructive pulmonary disease (COPD), which is associated with various adverse effects. Controversies exist in whether ICS use in COPD is associated with osteop…
View article: Changes in the incidence, viral coinfection pattern and outcomes of pneumococcal hospitalizations during and after the COVID-19 pandemic
Changes in the incidence, viral coinfection pattern and outcomes of pneumococcal hospitalizations during and after the COVID-19 pandemic Open
Background The incidence of pneumococcal pneumonia in the context of the Coronavirus Disease 2019 (COVID-19) pandemic, along with the real-world data on the ratio of non-invasive to invasive pneumococcal pneumonia, is an area that has not …
View article: Implication of Admission Eosinophil Count and Prognosis of Coronavirus Disease 2019 (COVID‐19) in Elderly Patients With COPD: A Territory‐Wide Cohort Study
Implication of Admission Eosinophil Count and Prognosis of Coronavirus Disease 2019 (COVID‐19) in Elderly Patients With COPD: A Territory‐Wide Cohort Study Open
Objectives This study aims to investigate the association between elderly patients with COPD with different blood eosinophil on admission and those without COPD and the prognosis of COVID‐19. Method A territory‐wide retrospective study was…
View article: Impact of Hyponatraemia at Clinical Stable-State on Survival in Patients with Chronic Obstructive Pulmonary Disease
Impact of Hyponatraemia at Clinical Stable-State on Survival in Patients with Chronic Obstructive Pulmonary Disease Open
Stable-state hyponatraemia was associated with increased mortality and probably AECOPD frequency among patients with COPD.
View article: Health Communication and Adherence to Noninvasive Ventilation in Chronic Hypercapnic Respiratory Failure
Health Communication and Adherence to Noninvasive Ventilation in Chronic Hypercapnic Respiratory Failure Open
Importance Domiciliary noninvasive ventilation (NIV) is a standard treatment for improving health outcomes among patients with chronic hypercapnic respiratory failure (CHRF). However, poor adherence substantially limits its therapeutic eff…
View article: Changes in the incidence, clinical features and outcomes of tuberculosis during COVID-19 pandemic
Changes in the incidence, clinical features and outcomes of tuberculosis during COVID-19 pandemic Open
The epidemiology and outcomes of TB were changed during COVID-19 period. Mortality was higher during COVID-19 period and with co-infection by influenza and COVID-19.
View article: Baseline neutrophil-to-lymphocyte ratio as a predictor of response to hospitalized bronchiectasis exacerbation risks
Baseline neutrophil-to-lymphocyte ratio as a predictor of response to hospitalized bronchiectasis exacerbation risks Open
Blood NLR may serve as a marker to predict the need for hospitalization due to bronchiectasis exacerbation.
View article: Protective Effects from Prior Pneumococcal Vaccination in Patients with Chronic Airway Diseases during Hospitalization for Influenza—A Territory-Wide Study
Protective Effects from Prior Pneumococcal Vaccination in Patients with Chronic Airway Diseases during Hospitalization for Influenza—A Territory-Wide Study Open
Influenza is an important respiratory viral pathogen in adults, with secondary bacterial pneumonia being a common complication. While pneumococcal vaccines can prevent pneumococcal pneumonia and invasive pneumococcal disease, whether they …
View article: Systemic immune-inflammation index in predicting hospitalized bronchiectasis exacerbation risks and disease severity
Systemic immune-inflammation index in predicting hospitalized bronchiectasis exacerbation risks and disease severity Open
SII could serve as biomarker to predict the risks of hospitalized exacerbation in bronchiectasis patients, as well as correlating with the disease severity.
View article: Increased exacerbations of bronchiectasis following recovery from mild <scp>COVID</scp>‐19 in patients with non‐cystic fibrosis bronchiectasis
Increased exacerbations of bronchiectasis following recovery from mild <span>COVID</span>‐19 in patients with non‐cystic fibrosis bronchiectasis Open
Background and Objective Respiratory viral infection is a common trigger of bronchiectasis exacerbation. Knowledge of the intermediate to long‐term effect of COVID‐19 on bronchiectasis is poor. Methods A retrospective cohort study of patie…
View article: Real-World Effectiveness Study of Nirmatrelvir-Ritonavir or Molnupiravir in Hospitalized Unvaccinated Patients with Chronic Respiratory Diseases and Moderate COVID-19 at Presentation
Real-World Effectiveness Study of Nirmatrelvir-Ritonavir or Molnupiravir in Hospitalized Unvaccinated Patients with Chronic Respiratory Diseases and Moderate COVID-19 at Presentation Open
NMV-r was more effective than MOL among unvaccinated adults with chronic respiratory diseases who were hospitalized for moderate COVID-19 without hypoxaemia on admission.
View article: Strategies to Assess the Effect of Continuous Positive Airway Pressure on Long-Term Clinically Important Outcomes among Patients with Symptomatic Obstructive Sleep Apnea: An Official American Thoracic Society Workshop Report
Strategies to Assess the Effect of Continuous Positive Airway Pressure on Long-Term Clinically Important Outcomes among Patients with Symptomatic Obstructive Sleep Apnea: An Official American Thoracic Society Workshop Report Open
Continuous positive airway pressure (CPAP) is the first-line treatment for obstructive sleep apnea (OSA). Although CPAP improves symptoms (e.g., daytime sleepiness), there is a lack of high-quality evidence that CPAP prevents many long-ter…
View article: The burden of systemic corticosteroid use in asthma management in Asia
The burden of systemic corticosteroid use in asthma management in Asia Open
For most patients, asthma can be effectively managed using inhaled medications. However, patients who have severe and/or uncontrolled asthma, or who experience exacerbations, may require systemic corticosteroids (SCSs) to maintain asthma c…
View article: Prediction model on disease recurrence for low risk resected stage I lung adenocarcinoma
Prediction model on disease recurrence for low risk resected stage I lung adenocarcinoma Open
Background and Objective Although stage I non‐small cell lung carcinoma (NSCLC) typically carries a good prognosis following complete resection, early disease recurrence can occur. An accurate survival prediction model would help refine a …
View article: Blood eosinophil percentage as a predictor of response to inhaled corticosteroid in bronchiectasis
Blood eosinophil percentage as a predictor of response to inhaled corticosteroid in bronchiectasis Open
Introduction The role of inhaled corticosteroid (ICS) among patients with bronchiectasis remains controversial. There is limited evidence of using baseline eosinophil count (absolute and percentage) as a marker to predict the role of ICS a…
View article: A Multi-Center Study of the Prevalence and Characteristics of Eosinophilic Phenotype and High IgE Levels Among Chinese Patients with Severe Asthma [Corrigendum]
A Multi-Center Study of the Prevalence and Characteristics of Eosinophilic Phenotype and High IgE Levels Among Chinese Patients with Severe Asthma [Corrigendum] Open
[This corrects the article DOI: 10.2147/JAA.S391970.].
View article: Real-World Study on Effectiveness of Molnupiravir and Nirmatrelvir–Ritonavir in Unvaccinated Patients with Chronic Respiratory Diseases with Confirmed SARS-CoV-2 Infection Managed in Out-Patient Setting
Real-World Study on Effectiveness of Molnupiravir and Nirmatrelvir–Ritonavir in Unvaccinated Patients with Chronic Respiratory Diseases with Confirmed SARS-CoV-2 Infection Managed in Out-Patient Setting Open
While molnupiravir (MOV) and nirmatrelvir–ritonavir (NMV-r) were developed for treatment of mild to moderate COVID-19 infection, there has been a lack of data on the efficacy among unvaccinated adult patients with chronic respiratory disea…
View article: Worsening of asthma control after recovery from mild to moderate COVID-19 in patients from Hong Kong
Worsening of asthma control after recovery from mild to moderate COVID-19 in patients from Hong Kong Open
Background While there are postulations that asthma is potentially associated with severe coronavirus disease 2019 (COVID-19), there has been conflicting results from studies on the impact mild-to-moderate COVID-19 on asthma control after …