Yu‐Mu Chen
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Author Swipe
View article: The importance of high total body water/fat free mass ratio and serial changes in body composition for predicting hospital mortality in patients with severe pneumonia: a prospective cohort study
The importance of high total body water/fat free mass ratio and serial changes in body composition for predicting hospital mortality in patients with severe pneumonia: a prospective cohort study Open
View article: Risk factors for prolonged mechanical ventilation in critically ill patients with influenza-related acute respiratory distress syndrome
Risk factors for prolonged mechanical ventilation in critically ill patients with influenza-related acute respiratory distress syndrome Open
BackgroundPatients with influenza-related acute respiratory distress syndrome (ARDS) are critically ill and require mechanical ventilation (MV) support. Prolonged mechanical ventilation (PMV) is often seen in these cases and the optimal ma…
View article: Survival outcomes of east Asian patients with advanced non‐small cell lung cancer treated with first‐line <scp>EGFR</scp> tyrosine kinase inhibitors: A network meta‐analysis of real‐world evidence
Survival outcomes of east Asian patients with advanced non‐small cell lung cancer treated with first‐line <span>EGFR</span> tyrosine kinase inhibitors: A network meta‐analysis of real‐world evidence Open
Background The comparative efficacies of different generation tyrosine kinase inhibitors (TKIs) in epidermal growth factor receptor ( EGFR )‐mutated advanced non‐small cell lung cancer (NSCLC) remain largely unknown. Moreover, whether one …
View article: E-cadherin expression in the tumor microenvironment of advanced epidermal growth factor receptor-mutant lung adenocarcinoma and the association with prognosis
E-cadherin expression in the tumor microenvironment of advanced epidermal growth factor receptor-mutant lung adenocarcinoma and the association with prognosis Open
Background The expression of programmed death-ligand 1 (PD-L1), tumor-infiltrating lymphocytes (TILs), E-cadherin, and vimentin in lung cancer tumor microenvironment is known to impact patient survival or response to therapy. The expressio…
View article: Association of Hypernatremia with Immune Profiles and Clinical Outcomes in Adult Intensive Care Unit Patients with Sepsis
Association of Hypernatremia with Immune Profiles and Clinical Outcomes in Adult Intensive Care Unit Patients with Sepsis Open
Both hypernatremia and an abnormal immune response may increase hospital mortality in patients with sepsis. This study examined the association of hypernatremia with abnormal immune response and mortality in 520 adult patients with sepsis …
View article: Association of baseline parameters with year 0 and year 1 acute exacerbations in male patients with chronic obstructive pulmonary disease
Association of baseline parameters with year 0 and year 1 acute exacerbations in male patients with chronic obstructive pulmonary disease Open
Objectives Acute exacerbations (AEs) of chronic obstructive pulmonary disease (COPD) can affect health status, hospitalization and readmission rates, and disease progression. This study aimed to identify independent markers associated with…
View article: Body Mass Index, Weight Loss, and Mortality Risk in Advanced-Stage Non-Small Cell Lung Cancer Patients: A Focus on EGFR Mutation
Body Mass Index, Weight Loss, and Mortality Risk in Advanced-Stage Non-Small Cell Lung Cancer Patients: A Focus on EGFR Mutation Open
Body mass index (BMI) influences the prognosis of patients with non-small cell lung cancer (NSCLC), including both early-stage and late-stage NSCLC patients that are undergoing chemotherapies. However, earlier research on the relationship …
View article: Comparison of prone positioning and extracorporeal membrane oxygenation in acute respiratory distress syndrome: A multicenter cohort study and propensity-matched analysis
Comparison of prone positioning and extracorporeal membrane oxygenation in acute respiratory distress syndrome: A multicenter cohort study and propensity-matched analysis Open
While the patients receiving prone positioning had better outcome, the causality between prone positioning and the prognosis is unknown. However, the current data suggested that patients with influenza-related ARDS may receive prone positi…
View article: Disrupted Expression of Circadian Clock Genes in Patients with Bronchial Asthma [Corrigendum]
Disrupted Expression of Circadian Clock Genes in Patients with Bronchial Asthma [Corrigendum] Open
[This corrects the article DOI: 10.2147/JAA.S302508.].
View article: Renal Replacement Therapy in Patients with Influenza Pneumonia Related Acute Respiratory Distress Syndrome
Renal Replacement Therapy in Patients with Influenza Pneumonia Related Acute Respiratory Distress Syndrome Open
Acute kidney injury (AKI) requiring renal replacement therapy (RRT) increases the mortality of acute respiratory distress syndrome (ARDS) patients. The aim of this study was to investigate the outcomes and predictors of RRT in patients wit…
View article: Disrupted Expression of Circadian Clock Genes in Patients with Bronchial Asthma
Disrupted Expression of Circadian Clock Genes in Patients with Bronchial Asthma Open
Our results showed altered expression of circadian clock genes in patients with bronchial asthma and down-regulated PER3 in patients with nocturnal symptoms. Altered expression of circadian clock genes was also observed in asthmatic…
View article: Benefits of Multiple-Intervention Pulmonary Rehabilitation to Older Adults with High-Risk Multimorbidity after Coronary Artery Bypass Grafting
Benefits of Multiple-Intervention Pulmonary Rehabilitation to Older Adults with High-Risk Multimorbidity after Coronary Artery Bypass Grafting Open
Objective: Multimorbidity in elderly patients increases complications and retards the recovery of pulmonary function after coronary artery bypass grafting (CABG) surgery. We aimed to evaluate the impact of multiple-intervention pulmonary r…
View article: Effect of do-not-resuscitate orders on patients with sepsis in the medical intensive care unit: a retrospective, observational and propensity score-matched study in a tertiary referral hospital in Taiwan
Effect of do-not-resuscitate orders on patients with sepsis in the medical intensive care unit: a retrospective, observational and propensity score-matched study in a tertiary referral hospital in Taiwan Open
Objective The aim of this study was to determine whether do-not-resuscitate (DNR) orders affect outcomes in patients with sepsis admitted to intensive care unit (ICU). Design This is a retrospective observational study. Participants We enr…
View article: Gas Exchange of prone positioning in influenza pneumonia-related acute respiratory distress syndrome: A multicenter retrospective cohort study in Taiwan
Gas Exchange of prone positioning in influenza pneumonia-related acute respiratory distress syndrome: A multicenter retrospective cohort study in Taiwan Open
Background: Prone positioning has demonstrated decreased mortality in severe acute respiratory distress syndrome (ARDS) patients. The aim of this study was to investigate the effect of prone positioning in patients with influenza pneumonia…
View article: GENOTYPIC CHARACTERISTICS OF CARBAPENEM‐RESISTANT <i>ENTEROBACTERIACEAE</i> IN PATIENTS WITH SEPSIS
GENOTYPIC CHARACTERISTICS OF CARBAPENEM‐RESISTANT <i>ENTEROBACTERIACEAE</i> IN PATIENTS WITH SEPSIS Open
Background and Aims: To determine whether ICU patients with sepsis due to pneumonia or non-pneumonia were associated with different characteristics and outcomes.Methods: This study evaluated adult medical ICU patients (18 y/o) with sepsis …
View article: Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning
Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning Open
Background Patients with influenza complicated with pneumonia are at high risk of rapid progression to acute respiratory distress syndrome (ARDS). Prone positioning with longer duration and lung-protective strategies might reduce the morta…
View article: Effectiveness of a perioperative pulmonary rehabilitation program following coronary artery bypass graft surgery in patients with and without COPD
Effectiveness of a perioperative pulmonary rehabilitation program following coronary artery bypass graft surgery in patients with and without COPD Open
PRP significantly improved respiratory muscle strength and lung function in patients with and without COPD who underwent CABG surgery. However, PRP is more effective in improving PEF and FEF25-75 in COPD patients.
View article: Ventilator Dependence Risk Score for the Prediction of Prolonged Mechanical Ventilation in Patients Who Survive Sepsis/Septic Shock with Respiratory Failure
Ventilator Dependence Risk Score for the Prediction of Prolonged Mechanical Ventilation in Patients Who Survive Sepsis/Septic Shock with Respiratory Failure Open
View article: Association of day 4 cumulative fluid balance with mortality in critically ill patients with influenza: A multicenter retrospective cohort study in Taiwan
Association of day 4 cumulative fluid balance with mortality in critically ill patients with influenza: A multicenter retrospective cohort study in Taiwan Open
Fluid balance is a fundamental management of patients with sepsis, and this study aimed to investigate the impact of cumulative fluid balance on critically ill patients with influenza admitted to an intensive care unit (ICU).This multicent…
View article: The impact of de novo liver metastasis on clinical outcome in patients with advanced non-small-cell lung cancer
The impact of de novo liver metastasis on clinical outcome in patients with advanced non-small-cell lung cancer Open
Liver metastasis has been found to affect outcome in prostate cancer and colorectal cancer, but its role in lung cancer is unclear. The current study aimed to evaluate the impact of de novo liver metastasis (DLM) on stage IV non-small cell…
View article: Circulating microparticles are prognostic biomarkers in advanced non-small cell lung cancer patients
Circulating microparticles are prognostic biomarkers in advanced non-small cell lung cancer patients Open
We investigated whether circulating microparticles (MPs) could serve as prognostic biomarkers in non-small cell lung cancer (NSCLC) patients. We enrolled 25 control subjects and 136 NSCLC patients categorized into disease-progression (DP, …
View article: Increased S100A15 expression and decreased DNA methylation of its gene promoter are involved in high metastasis potential and poor outcome of lung adenocarcinoma
Increased S100A15 expression and decreased DNA methylation of its gene promoter are involved in high metastasis potential and poor outcome of lung adenocarcinoma Open
Increased S100A15 expression and decreased DNA methylation of its gene promoter region were associated with high metastasis potential and poor outcome in lung adenocarcinoma, probably through triggering CTNNB1 -centered pathways.
View article: Impact of epidermal growth factor receptor gene expression level on clinical outcomes in epidermal growth factor receptor mutant lung adenocarcinoma patients taking first-line epidermal growth factor receptor–tyrosine kinase inhibitors
Impact of epidermal growth factor receptor gene expression level on clinical outcomes in epidermal growth factor receptor mutant lung adenocarcinoma patients taking first-line epidermal growth factor receptor–tyrosine kinase inhibitors Open
Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are first-choice treatments for advanced non-small-cell lung cancer patients harboring EGFR mutations. Although EGFR mutations are strongly predictive of patients’ o…
View article: Inhaled corticosteroids have a protective effect against lung cancer in female patients with chronic obstructive pulmonary disease: a nationwide population-based cohort study
Inhaled corticosteroids have a protective effect against lung cancer in female patients with chronic obstructive pulmonary disease: a nationwide population-based cohort study Open
Whether the use of inhaled corticosteroids (ICS) protects patients with chronic obstructive pulmonary disease (COPD) from lung cancer remains undetermined. In this retrospective nationwide population-based cohort study, we extracted data o…
View article: PUB001 Advanced NSCLC Patients at the Extremes of Age in the Era of EGFR-TKIs
PUB001 Advanced NSCLC Patients at the Extremes of Age in the Era of EGFR-TKIs Open
View article: A Survival Scoring System for Non-Small Cell Lung Cancer Patients with De Novo Bone Metastases
A Survival Scoring System for Non-Small Cell Lung Cancer Patients with De Novo Bone Metastases Open
In the pre-tyrosine kinase inhibitors (TKIs) era, non-small cell lung cancer (NSCLC) patients with de novo bone metastases had a worse prognosis than those without. However, whether epidermal growth factor receptor (EGFR)-TKIs affect the o…
View article: Impact of clinical parameters and systemic inflammatory status on epidermal growth factor receptor-mutant non-small cell lung cancer patients readministration with epidermal growth factor receptor tyrosine kinase inhibitors
Impact of clinical parameters and systemic inflammatory status on epidermal growth factor receptor-mutant non-small cell lung cancer patients readministration with epidermal growth factor receptor tyrosine kinase inhibitors Open
View article: Inhaled corticosteroids can reduce osteoporosis in female patients with COPD
Inhaled corticosteroids can reduce osteoporosis in female patients with COPD Open
Female patients with COPD using ICS have a dose-response protective effect for osteoporosis.
View article: Risk factors of multidrug-resistant Acinetobacter baumannii recurrence after successful eradication in ventilated patients
Risk factors of multidrug-resistant Acinetobacter baumannii recurrence after successful eradication in ventilated patients Open
View article: Antacid Use and De Novo Brain Metastases in Patients with Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer Who Were Treated Using First-Line First-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
Antacid Use and De Novo Brain Metastases in Patients with Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer Who Were Treated Using First-Line First-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Open
Antacid use reduced OS among patients with EGFR-mutant NSCLC who were treated using first-line first-generation EGFR-TKIs, and especially among patients with de novo brain metastases.