Muhammad Imran Malik
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View article: iBitter-Stack: A multi-representation ensemble learning model for accurate bitter peptide identification
iBitter-Stack: A multi-representation ensemble learning model for accurate bitter peptide identification Open
View article: Evaluation of GPT-4 Accuracy in the Interpretation of Medical Imaging: Potential Benefits, Limitations, and the Future
Evaluation of GPT-4 Accuracy in the Interpretation of Medical Imaging: Potential Benefits, Limitations, and the Future Open
View article: iBitter-Stack: A Multi-Representation Ensemble Learning Model for Accurate Bitter Peptide Identification
iBitter-Stack: A Multi-Representation Ensemble Learning Model for Accurate Bitter Peptide Identification Open
The identification of bitter peptides is crucial in various domains, including food science, drug discovery, and biochemical research. These peptides not only contribute to the undesirable taste of hydrolyzed proteins but also play key rol…
View article: THE FRAGMENTATION OF GLOBAL TRADE: FROM PROTECTIONISM TO GATED GLOBALIZATION
THE FRAGMENTATION OF GLOBAL TRADE: FROM PROTECTIONISM TO GATED GLOBALIZATION Open
The fragmentation of global trade, evolving from traditional protectionism to the modern paradigm of gated globalization, reflects a strategic shift by nations toward prioritizing sovereignty and security over multilateral cooperation. Thi…
View article: Assessing the Impact of Trump's 'America First' Policy on EU-US Trade Relations (2017-2021): A Realist and Liberal Analysis
Assessing the Impact of Trump's 'America First' Policy on EU-US Trade Relations (2017-2021): A Realist and Liberal Analysis Open
This study examines the economic and geopolitical consequences of President Donald Trump’s “America First” policy on EU-US trade relations between 2017 and 2021. Through a realist theoretical lens, the paper analyzes three key case studies…
View article: CHANGING GLOBAL AND REGIONAL ORDER: IMPLICATIONS FOR PAKISTAN
CHANGING GLOBAL AND REGIONAL ORDER: IMPLICATIONS FOR PAKISTAN Open
The notion that unipolarity does not define the existing world order is a misconception. The United States sits comfortably above all others in every power metric. However, China’s meteoric ascent, expanding outreach, and increasing assert…
View article: Diverse clinical manifestations and management strategies in autoimmune polyglandular syndrome: a review of cases
Diverse clinical manifestations and management strategies in autoimmune polyglandular syndrome: a review of cases Open
Autoimmune polyglandular syndrome (APS) is a rare autoimmune disease that affects multiple endocrine glands. It can lead to various clinical manifestations. The primary objective of this review was to provide a comprehensive analysis of th…
View article: SHARED GENETIC FACTORS IN HELICOBACTER PYLORI-INDUCED GASTRITIS AND GASTRIC CANCER: A NETWORK-DRIVEN ANALYSIS OF GENE EXPRESSION DATA
SHARED GENETIC FACTORS IN HELICOBACTER PYLORI-INDUCED GASTRITIS AND GASTRIC CANCER: A NETWORK-DRIVEN ANALYSIS OF GENE EXPRESSION DATA Open
Two of the most common medical conditions in the world, gastritis and stomach cancer, are caused by the Helicobacter pylori (H. pylori). Gastric cancer and H. pylori-induced gastritis has both been the subject of molecular research, but th…
View article: Unraveling the Hidden Diversity of Gut Microbiota: A Genome Sequencing and Comparative Genome Analysis of Novel Bacterial Strains in Human Stool
Unraveling the Hidden Diversity of Gut Microbiota: A Genome Sequencing and Comparative Genome Analysis of Novel Bacterial Strains in Human Stool Open
E. coli strains have been isolated and identified in Pakistan, but detailed genomic data specific to these strains is still lacking. This gap in knowledge prevents a full understanding of E. coli’s genomics in the region. Research indicate…
View article: The Impact of Artificial Intelligence on Strategic Decision-Making in Corporations
The Impact of Artificial Intelligence on Strategic Decision-Making in Corporations Open
The data-driven insights, predictive analytics, and automation capabilities of Artificial intelligence (AI) have made it a transformative factor in corporate strategic decision-making. This research examines how AI affects strategic decisi…
View article: Splenectomy for Beta Thalassemia Major Among Transfusion Dependent Patients, its Effectiveness and Complications
Splenectomy for Beta Thalassemia Major Among Transfusion Dependent Patients, its Effectiveness and Complications Open
Objectives: To evaluate the effectiveness and complications of splenectomy among thalassemia major patients who need repeated blood transfusion. Study design: retrospective descriptive Place and duration of study: Conducted at paediatric a…
View article: Ibitter-Stack: A Multi-Representation Ensemble Learning Model for Accurate Bitter Peptide Identification
Ibitter-Stack: A Multi-Representation Ensemble Learning Model for Accurate Bitter Peptide Identification Open
View article: Efficacy and safety of esophageal stenting for esophageal perforation: a systematic review and meta-analysis
Efficacy and safety of esophageal stenting for esophageal perforation: a systematic review and meta-analysis Open
Esophageal stenting is considered an efficient and well-tolerated method for managing esophageal perforation.
View article: Block Induced Signature Generative Adversarial Network (BISGAN): Signature Spoofing Using GANs and Their Evaluation
Block Induced Signature Generative Adversarial Network (BISGAN): Signature Spoofing Using GANs and Their Evaluation Open
Deep learning is actively being used in biometrics to develop efficient identification and verification systems. Handwritten signatures are a common subset of biometric data for authentication purposes. Generative adversarial networks (GAN…
View article: Segmentation of Overlapping Pixels in Multi-spectral Document Images by Statistical Techniques
Segmentation of Overlapping Pixels in Multi-spectral Document Images by Statistical Techniques Open
The examination of hyperspectral data has become a powerful tool in the field of document image processing, offering unprecedented levels of information and insights across various applications. Traditionally, tasks like document forgery d…
View article: Histopathological features of idiopathic portal hypertension: A systematic review and meta-analysis
Histopathological features of idiopathic portal hypertension: A systematic review and meta-analysis Open
Background Portal hypertension (PH) is a clinically significant entity that could present with life-threatening gastrointestinal bleeding. Cirrhosis is the most common cause of PH, with well-documented histopathology and etiology. However,…
View article: Efficacy and safety of terlipressin and albumin vs. noradrenaline and albumin in adult patients with hepatorenal syndrome: A systematic review and meta-analysis
Efficacy and safety of terlipressin and albumin vs. noradrenaline and albumin in adult patients with hepatorenal syndrome: A systematic review and meta-analysis Open
Noradrenaline is a safe alternative medical therapy for HRS.
View article: Effects of curcumin in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis
Effects of curcumin in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis Open
Background: Curcumin is an anti-inflammatory that is proposed to have a positive impact on patients with non-alcoholic fatty liver disease (NAFLD). We aim to assess the effects of curcumin in patients with NAFLD. Methods: Clinical trials f…
View article: Endmember Analysis of Overlapping Handwritten Text in Hyperspectral Document Images
Endmember Analysis of Overlapping Handwritten Text in Hyperspectral Document Images Open
Hyperspectral Imaging (HSI) uses large portions of the electromagnetic spectrum to obtain information from images that would be very difficult to get otherwise. An important task in forensic analysis of documents is to extract signatures f…
View article: CMMRD-Associated Brain Tumors: A Molecular Analysis from a Tertiary Care Center in a Lower Middle-Income Country
CMMRD-Associated Brain Tumors: A Molecular Analysis from a Tertiary Care Center in a Lower Middle-Income Country Open
View article: Vision-Based 3-D Localization of UAV Using Deep Image Matching
Vision-Based 3-D Localization of UAV Using Deep Image Matching Open
Unmanned aerial vehicles (UAVs) have revolutionized various industries by providing efficient and automated flight capabilities. However, reliance on GPS and traditional navigation systems poses challenges in scenarios where signal interfe…
View article: Intracranial Spread of Infections Among the Patients of Chronic Suppurative Otitis Media
Intracranial Spread of Infections Among the Patients of Chronic Suppurative Otitis Media Open
Objective: To determine the frequency of intracranial spread of infections among the patients of chronic suppurative otitis media presenting at a tertiary care hospital in Karachi.Study Design: Cross-Sectional Study.Place and Duration of S…
View article: Analysis of Hyperspectral Data to Develop an Approach for Document Images
Analysis of Hyperspectral Data to Develop an Approach for Document Images Open
Hyperspectral data analysis is being utilized as an effective and compelling tool for image processing, providing unprecedented levels of information and insights for various applications. In this manuscript, we have compiled and presented…
View article: Fecal Microbiota Transplantation in Human Immunodeficiency Virus-Infected Patient Population: A Systematic Review and Meta-Analysis
Fecal Microbiota Transplantation in Human Immunodeficiency Virus-Infected Patient Population: A Systematic Review and Meta-Analysis Open
Current evidence demonstrated that FMT is safe and effective in HIV patients suffering from alterations in gut microbiota. We recommend further multi-centric clinical studies to address the optimal transplant amount and source for FMT. To …
View article: Comparison of Repetitive Modified Epley’s manoeuvre in single sitting vs. thrice daily In Refractory Benign Paroxysmal Positional Vertigo.
Comparison of Repetitive Modified Epley’s manoeuvre in single sitting vs. thrice daily In Refractory Benign Paroxysmal Positional Vertigo. Open
Introduction: Benign paroxysmal positional vertigo (BPPV) was recognized by Robert Barany in 1921. It is the commonest cause of peripheral vertigo presenting to vertigo clinics. Among several treatment modalities, Epley manoeuvre carries a…
View article: Efficacy of endoscopic trans-papillary gallbladder stenting and drainage in acute calculous cholecystitis in high-risk patients: a systematic review and meta-analysis
Efficacy of endoscopic trans-papillary gallbladder stenting and drainage in acute calculous cholecystitis in high-risk patients: a systematic review and meta-analysis Open
Background and aims: Acute calculous cholecystitis (ACC) represents about one-third of all surgical emergencies. The gold standard management of ACC is laparoscopic cholecystectomy. Although cholecystectomy is a safe procedure, it may be d…
View article: Exploring the mono-/bistability range of positively autoregulated signaling systems in the presence of competing transcription factor binding sites
Exploring the mono-/bistability range of positively autoregulated signaling systems in the presence of competing transcription factor binding sites Open
Binding of transcription factor (TF) proteins to regulatory DNA sites is key to accurate control of gene expression in response to environmental stimuli. Theoretical modeling of transcription regulation is often focused on a limited set of…
View article: Colibactin possessing E. coli isolates in association with colorectal cancer and their genetic diversity among Pakistani population
Colibactin possessing E. coli isolates in association with colorectal cancer and their genetic diversity among Pakistani population Open
Colorectal cancer (CRC) is the third most prevalent cause of tumorigenesis and several pathogenic bacteria have been correlated with aggressive cases of cancer i.e., genotoxin (colibactin) producing Escherichia coli ( E . coli) . This stud…
View article: ADH-PPI: An attention-based deep hybrid model for protein-protein interaction prediction
ADH-PPI: An attention-based deep hybrid model for protein-protein interaction prediction Open
View article: Circ-LocNet: A Computational Framework for Circular RNA Sub-Cellular Localization Prediction
Circ-LocNet: A Computational Framework for Circular RNA Sub-Cellular Localization Prediction Open
Circular ribonucleic acids (circRNAs) are novel non-coding RNAs that emanate from alternative splicing of precursor mRNA in reversed order across exons. Despite the abundant presence of circRNAs in human genes and their involvement in dive…