Manoj Jain
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View article: Advancing Bloom’s Cognitive Levels through Socratic Dialogue: A DPO-Based Multi-Agent AI Framework for K-12 Learners
Advancing Bloom’s Cognitive Levels through Socratic Dialogue: A DPO-Based Multi-Agent AI Framework for K-12 Learners Open
The widespread adoption of Generative AI technologies in K-12 education is accompanied by tremendous opportunities for reform as well as significant challenges, including the tendency of students to look for quick answers with less intelle…
View article: CONVENTIONAL ESR V/S AUTOMATED TEST 1(ALIFAX) ESR: A COMPARATIVE STUDY AT TERTIARY CARE CENTER
CONVENTIONAL ESR V/S AUTOMATED TEST 1(ALIFAX) ESR: A COMPARATIVE STUDY AT TERTIARY CARE CENTER Open
Objective: The erythrocyte sedimentation rate (ESR) is a key test for detecting inflammation, typically measured using the manual Westergren method. Implementing automated systems like Test 1 (ALIFAX) offers advantages like quicker results…
View article: A Comprehensive Look at Focal Segmental Glomerulosclerosis Recurrence in Adult Transplant Patients: Findings from a Single Institution with Review of Literature
A Comprehensive Look at Focal Segmental Glomerulosclerosis Recurrence in Adult Transplant Patients: Findings from a Single Institution with Review of Literature Open
Background: Focal segmental glomerulosclerosis (FSGS) is a kidney disease with diverse causes, classified as primary, genetic, or secondary. There is a high recurrence rate of FSGS posttransplant and is associated with a significant risk o…
View article: Long-Term Outcomes of Anticomplement Factor H Antibody Positive Versus Negative Atypical Hemolytic Uremic Syndrome
Long-Term Outcomes of Anticomplement Factor H Antibody Positive Versus Negative Atypical Hemolytic Uremic Syndrome Open
Background Atypical hemolytic uremic syndrome (aHUS) is a severe thrombotic microangiopathy predominantly affecting the kidneys, often associated with complement dysregulation. This study is aimed to analyze the clinical characteristics, t…
View article: Clinical, Biochemical, and Histological Manifestations and Long-Term Outcomes of Renal Sarcoidosis - A Single Center Study
Clinical, Biochemical, and Histological Manifestations and Long-Term Outcomes of Renal Sarcoidosis - A Single Center Study Open
Background Renal involvement in sarcoidosis is rare. We evaluated the pattern of renal involvement in sarcoidosis, its clinical course, renal histology, and response to treatment. Materials and Methods We retrospectively analyzed the data …
View article: WCN24-999 IMPACT OF HLA DONOR SPECIFIC ANTIBODY VERSUS HLA NONDONOR SPECIFIC ANTIBODIES BY SINGLE ANTIGEN BEAD METHOD IN PREDICTING OUTCOMES OF LIVING DONOR RENAL ALLOGRAFT RECIPIENTS
WCN24-999 IMPACT OF HLA DONOR SPECIFIC ANTIBODY VERSUS HLA NONDONOR SPECIFIC ANTIBODIES BY SINGLE ANTIGEN BEAD METHOD IN PREDICTING OUTCOMES OF LIVING DONOR RENAL ALLOGRAFT RECIPIENTS Open
Human leukocyte antigen (HLA) donor-specific antibodies (DSA) play a crucial role in the risk assessment of antibodymediated rejection and graft survival in kidney transplantation. However, the significance of HLA non-donor specific antibo…
View article: A rare case of isoniazid mono-resistant tuberculosis presenting as cardiac tamponade along with an anterior mediastinal mass in a 15-year-old immunocompetent patient
A rare case of isoniazid mono-resistant tuberculosis presenting as cardiac tamponade along with an anterior mediastinal mass in a 15-year-old immunocompetent patient Open
A 15-year-old boy presented with a sudden onset of breathlessness for 7 days, gradual loss of weight of 17.6 lbs over the last month and progressive hoarseness of voice for 7 months. The contrast-enhanced computed tomography (CECT) scan re…
View article: Assessment of Oral Health Status and Treatment Needs of School Teachers in Indore City, Madhya Pradesh, India: A Cross-Sectional Study
Assessment of Oral Health Status and Treatment Needs of School Teachers in Indore City, Madhya Pradesh, India: A Cross-Sectional Study Open
High proportion of dental caries and periodontal disease was seen which could be related to their oral health care-seeking behavior and the impairment related to age changes.
View article: #3404 UTILITY OF RENAL BIOPSY IN THE ETIOLOGY, MANAGEMENT AND OUTCOME OF POSTPARTUM ACUTE KIDNEY INJURY
#3404 UTILITY OF RENAL BIOPSY IN THE ETIOLOGY, MANAGEMENT AND OUTCOME OF POSTPARTUM ACUTE KIDNEY INJURY Open
Background and Aims Acute kidney injury (AKI) is a serious complication during pregnancy and postpartum period resulting in significant maternal morbidity, mortality and fetal loss. Pregnancy related acute kidney injury is still more preva…
View article: #5035 CRESCENTIC GLOMERULONEPHRITIS IN A PAEDIATRIC POPULATION: A SINGLE-CENTRE EXPERIENCE FROM SOUTH ASIA
#5035 CRESCENTIC GLOMERULONEPHRITIS IN A PAEDIATRIC POPULATION: A SINGLE-CENTRE EXPERIENCE FROM SOUTH ASIA Open
Background and Aims Crescentic glomerulonephritis (CrGN) is defined clinically by Rapidly progressive renal failure due to crescent formation in ≥ 50% of glomeruli. Most of these patients have a relatively poor prognosis. Therefore, early …
View article: Spectrum of Renal Histopathologic Lesions in Patients with Nonlupus Rheumatologic Diseases
Spectrum of Renal Histopathologic Lesions in Patients with Nonlupus Rheumatologic Diseases Open
Background: Nonlupus rheumatic diseases regularly involve solid organs, including the kidney. Renal lesions can be either a manifestation of the same systemic disease, a side effect of drug therapy, or an unrelated renal disease. Our aim w…
View article: Non-Diabetic Kidney Disease in Type 2 Diabetes Mellitus: A Changing Spectrum with Therapeutic Ascendancy
Non-Diabetic Kidney Disease in Type 2 Diabetes Mellitus: A Changing Spectrum with Therapeutic Ascendancy Open
Background and objectives: Owing to changing epidemiology and therapeutic practices, a change in the spectrum of renal involvement in Type-2 diabetes mellitus (T2DM) has also been noted. The treatment of non-diabetic kidney disease (NDKD) …
View article: Isolated Cardiac Paraganglioma Encasing Right Coronary Artery With Evidence of Succinyl Dehydrogenase Gene Mutation: Successful Management Using Multimodality Imaging
Isolated Cardiac Paraganglioma Encasing Right Coronary Artery With Evidence of Succinyl Dehydrogenase Gene Mutation: Successful Management Using Multimodality Imaging Open
This report involves a young woman with isolated cardiac paraganglioma that was diagnosed using 68 Gallium-labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-NaI3-octreotide positron emission tomographic scintigraphy. For…
View article: Clinicopathologic manifestations of immunoglobulin a nephropathy in a northern Indian cohort: A mute assassin with delayed diagnosis
Clinicopathologic manifestations of immunoglobulin a nephropathy in a northern Indian cohort: A mute assassin with delayed diagnosis Open
IgAN patients with late presentation and advanced disease became less amenable to immunomodulation in our cohort. The implementation of point-of-care screening strategies, early diagnosis, and retarding disease progression should be priori…
View article: Pediatric glomerular diseases in North India–Epidemiology and clinicopathologic correlation
Pediatric glomerular diseases in North India–Epidemiology and clinicopathologic correlation Open
MCD and lupus nephritis are the most common pediatric primary and secondary histopathologic diagnoses, respectively. The adolescent-onset glomerular diseases have a higher frequency of IgAN, membranous nephropathy, and DPGN. PIGN is still …
View article: Feto-maternal and renal outcomes of nephrotic syndrome in pregnancy.
Feto-maternal and renal outcomes of nephrotic syndrome in pregnancy. Open
Proteinuria can range from subnephrotic to nephrotic amounts during pregnancy, though nephrotic syndrome (NS) is rare (0.012%-0.025%). Without a renal biopsy, this distinction may be difficult at times. The objective of our study was asses…
View article: Management of tibial condyle fractures with different treatment modalities and assessment with modified Rasmussen score
Management of tibial condyle fractures with different treatment modalities and assessment with modified Rasmussen score Open
Background: Fractures of the tibial plateau involve the articular surface of the proximal tibia. The principles and techniques of treating tibial plateau fractures have evolved dramatically over the past 50 years. Tibial plateau fractures …
View article: Two decades outcomes of posttransplant immunoglobulin a nephropathy in live donor renal transplantation
Two decades outcomes of posttransplant immunoglobulin a nephropathy in live donor renal transplantation Open
Posttransplant IgAN is associated with poor long-term graft outcomes in live donor renal transplants. Proteinuria and MEST scoring were not predictive of graft failure in living donor posttransplant IgAN.
View article: Clinico-histological features of thrombotic microangiopathy in renal biopsies: a retrospective study
Clinico-histological features of thrombotic microangiopathy in renal biopsies: a retrospective study Open
Most postpartum TMA and aHUS had systemic features of TMA while malignant hypertension and lupus nephritis showed 'isolated renal TMA'. This emphasizes the importance of careful evaluation of renal biopsies even in the absence of systemic …
View article: Assessment of Inflammatory Markers IL- 6 and TNF- Alpha in Newly Diagnosed Type II Diabetics without Hypertension in Comparison with Non-Diabetic Normotensive Subjects
Assessment of Inflammatory Markers IL- 6 and TNF- Alpha in Newly Diagnosed Type II Diabetics without Hypertension in Comparison with Non-Diabetic Normotensive Subjects Open
Background: The present study was conducted to assess inflammatory markers IL- 6 and TNF- alpha in newly diagnosed type II diabetics without hypertension. Subjects and Methods: 68 types of II diabetes mellitus patients and equal numbers of…
View article: Clinicopathological characteristics and predictors of poor outcome in anti-glomerular basement membrane disease – a fifteen year single center experience
Clinicopathological characteristics and predictors of poor outcome in anti-glomerular basement membrane disease – a fifteen year single center experience Open
Anti-GBM is a rare disease with poor prognosis and varied presentations. Patients with pulmonary-renal syndrome showed severe disease whereas double positive had more of chronic changes. The predictors of poor prognosis include advanced ag…
View article: Systematic reporting of computed tomography enterography/enteroclysis as an aid to reduce diagnostic dilemma when differentiating between intestinal tuberculosis and Crohn's disease: A prospective study at a tertiary care hospital
Systematic reporting of computed tomography enterography/enteroclysis as an aid to reduce diagnostic dilemma when differentiating between intestinal tuberculosis and Crohn's disease: A prospective study at a tertiary care hospital Open
Background and Aim Crohn's disease (CD) and intestinal tuberculosis (ITB) have similar symptomatology and overlapping features on imaging, endoscopy, and histopathology. It is important to differentiate ITB from CD to initiate correct medi…
View article: Rare case of focal mass like perirenal extramedullary haematopoiesis in a renal transplant recipient
Rare case of focal mass like perirenal extramedullary haematopoiesis in a renal transplant recipient Open
Extramedullary haematopoiesis (EMH) is a physiological process of formation of blood cells outside the bone marrow in response to insufficient production or excessive destruction of blood cells. Most common sites of EMH are liver, spleen, …
View article: Clinical profile and outcomes of De novo posttransplant thrombotic microangiopathy
Clinical profile and outcomes of De novo posttransplant thrombotic microangiopathy Open
Thrombotic microangiopathy (TMA) after kidney transplant is rather uncommon but an important reversible cause of graft loss. This retrospective study of biopsy-proven posttransplant TMA was done to identify the important etiological factor…
View article: COMPARATIVE EVALUATION OF PRE-OPERATIVE SUBMUCOSAL DEXAMETHASONE INJECTION IN MANDIBULAR 3RD MOLAR SURGERIES WITH THAT OF THE CONTROL GROUP
COMPARATIVE EVALUATION OF PRE-OPERATIVE SUBMUCOSAL DEXAMETHASONE INJECTION IN MANDIBULAR 3RD MOLAR SURGERIES WITH THAT OF THE CONTROL GROUP Open
Background: Surgical removal of third molar is most common surgical procedures carried out in oral and maxillofacial surgery and is quite stressful for many patients. Surgical removal of third molar results in an intense inflammatory respo…
View article: A prospective study of association of cancer stem cell marker aldehyde dehydrogenase 1 with clinicopathological profile in lung carcinoma patients
A prospective study of association of cancer stem cell marker aldehyde dehydrogenase 1 with clinicopathological profile in lung carcinoma patients Open
Strong ALDH1 expression correlates with higher stage of lung carcinoma making it a prognostic marker needing in-depth study.
View article: Role of blood oxygen level-dependent MRI in differentiation of acute renal allograft dysfunction
Role of blood oxygen level-dependent MRI in differentiation of acute renal allograft dysfunction Open
Early graft dysfunction after renal transplantation manifests as acute rejection (AR) or acute tubular necrosis (ATN). Blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging is a noninvasive method of assessing tissue oxygenat…
View article: Metastatic primary seminal vesicle adenocarcinoma: management of a rare tumour with multiagent chemotherapy and hormonal therapy
Metastatic primary seminal vesicle adenocarcinoma: management of a rare tumour with multiagent chemotherapy and hormonal therapy Open
Primary seminal vesicle adenocarcinoma is one of the rarest genitourinary cancers. The pathogenesis is unknown and clinical manifestations are protean. There is no defined treatment for this disease and various combinations of surgery, che…
View article: Neuropathy in cases of Hypothyroidism as Confirmed by Motor Nerve Conduction Studies: A Prospective Study in a Tertiary Care Hospital
Neuropathy in cases of Hypothyroidism as Confirmed by Motor Nerve Conduction Studies: A Prospective Study in a Tertiary Care Hospital Open
Background: Thyroid hormone play important role in development of Central Nervous System and in myelination of neurons. Patients of hypothyroidism may suffer from peripheral nervous dysfunction. Aim of our study is to find out the neuropat…