Munishwar Nath Gupta
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View article: The cellular economy while crafting regulatory processes relies on protein intrinsic disorder: how and why precision comes at a cost in protein structure
The cellular economy while crafting regulatory processes relies on protein intrinsic disorder: how and why precision comes at a cost in protein structure Open
Regulatory proteins, including those involved in signal transduction, invariably have intrinsic disorder. Enzymes, on the other hand, rely on unique structures for their pre-formed active sites to carry out catalysis. Disorder-promoting am…
View article: Predicting Under Five Mortality in Bihar Through Machine Learning and SDG Metrics
Predicting Under Five Mortality in Bihar Through Machine Learning and SDG Metrics Open
Child mortality is a vital indicator of a nation’s health and development, closely aligned with the Sustainable Development Goals (SDGs). This study investigates the determinants of under-five mortality in Bihar, India, utilizing data from…
View article: Sustainable dressings for wound healing
Sustainable dressings for wound healing Open
The field of chronic wound care has been rapidly evolving. With a market size for care of chronic wounds in billions of USD, this is not an insignificant area to encourage more sustainable practices and processes. The sourcing of starting …
View article: Enhancing Productivity of Chickpea Through Cluster Front Line Demonstration in Jaipur District of Rajasthan
Enhancing Productivity of Chickpea Through Cluster Front Line Demonstration in Jaipur District of Rajasthan Open
Background: Chickpea is the premier pulse crop widely grown and consumed in India. Chickpea is an important pulse crop during winter season in Rajasthan. It also plays an important role in sustainable agriculture by improving the soil heal…
View article: Decoding the Promiscuous Activity of Bile Salt Hydrolase
Decoding the Promiscuous Activity of Bile Salt Hydrolase Open
The recently identified bile salt hydrolase (BSH) from gastrointestinal bacteria catalyzes the formation of bacterial bile acid amidates (BBAAs), significantly impacting host metabolism. While this activity was characterized as promiscuous…
View article: Decoding the Promiscuous Activity of Bile Salt Hydrolase
Decoding the Promiscuous Activity of Bile Salt Hydrolase Open
The recently identified bile salt hydrolase (BSH) from gastrointestinal bacteria catalyzes the formation of bacterial bile acid amidates (BBAAs), significantly impacting host metabolism. While this activity was characterized as promiscuous…
View article: Protein structure–function continuum model: Emerging nexuses between specificity, evolution, and structure
Protein structure–function continuum model: Emerging nexuses between specificity, evolution, and structure Open
The rationale for replacing the old binary of structure–function with the trinity of structure, disorder, and function has gained considerable ground in recent years. A continuum model based on the expanded form of the existing paradigm ca…
View article: Biological Importance of Arginine: Roles in Structure, Disorder, and Functionality of Peptides and Proteins
Biological Importance of Arginine: Roles in Structure, Disorder, and Functionality of Peptides and Proteins Open
Arginine shows Jekyll and Hyde behavior in several respects. It participates in protein folding via ionic and H-bonds and cation-pi interactions; the charge and hydrophobicity of its side chain makes it a disorder-promoting amino acid. Its…
View article: Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins
Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins Open
Transitions between the unfolded and native states of the ordered globular proteins are accompanied by the accumulation of several intermediates, such as pre-molten globules, wet molten globules, and dry molten globules. Structurally equiv…
View article: Pre-Molten, Wet, and Dry Molten Globules <i>En Route</i> to the Functional State of Proteins
Pre-Molten, Wet, and Dry Molten Globules <i>En Route</i> to the Functional State of Proteins Open
Transition between the unfolded and native states of the ordered globular proteins is accompanied by accumulation of several intermediates, such as pre-molten globule, wet molten globule, and dry molten globule. Structurally equivalent con…
View article: White & grey biotechnologies for shaping a sustainable future
White & grey biotechnologies for shaping a sustainable future Open
The developments in enzymology and biocatalytic processes designed as per the rules of green chemistry and green engineering are the keys to the concepts of biorefinery and bioeconomy which in turn enable sustainable development.
View article: Nickel Ferrite Nanoparticles as an Adsorbent for Immobilized Metal Affinity Chromatography of Proteins
Nickel Ferrite Nanoparticles as an Adsorbent for Immobilized Metal Affinity Chromatography of Proteins Open
A simple method of preparing amorphous nickel ferrite nanoparticles of about 5 nm diameter is described. These particles were characterized by dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FT-IR), transmission el…
View article: Intrinsic disorder in proteins: Relevance to protein assemblies, drug design and host-pathogen interactions
Intrinsic disorder in proteins: Relevance to protein assemblies, drug design and host-pathogen interactions Open
Intrinsic disorder in proteins resulting in considerable variation in structure can lead to multiple functions including multi-specificity and diverse pathologies. Protein interfaces can involve disordered regions that assemble through a c…
View article: Solid state fluorescence of proteins in high throughput mode and its applications
Solid state fluorescence of proteins in high throughput mode and its applications Open
Direct comparison between fluorescence spectra of a sample in solution and solid state form is valuable to monitor the changes in protein structure when it is “dried” or immobilized on a solid surface (for biocatalysis or sensor applicatio…
View article: Rear Mirror View of some Biological Tools and Processes
Rear Mirror View of some Biological Tools and Processes Open
It is indeed remarkable how many developments in biological sciences have their origin in earlier ideas which were nearly forgotten and were buried. This review illustrates this with a few examples. Free solution capillary electrophoresis …
View article: Secondary structure content (%) as determined by K2D2 software from the Far-UV CD spectra as given in Figure 6A.
Secondary structure content (%) as determined by K2D2 software from the Far-UV CD spectra as given in Figure 6A. Open
Secondary structure content (%) as determined by K2D2 software from the Far-UV CD spectra as given in Figure 6A.