Syed Nisar Hussain Shah
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View article: <b>COMPARATIVE STUDY OF HI-TECH AND SUPREME AQUA FEEDS ON THE GROWTH, HEMATOLOGY, AND SERUM BIOCHEMISTRY OF GIFT TILAPIA IN CAGE CULTURE</b>
<b>COMPARATIVE STUDY OF HI-TECH AND SUPREME AQUA FEEDS ON THE GROWTH, HEMATOLOGY, AND SERUM BIOCHEMISTRY OF GIFT TILAPIA IN CAGE CULTURE</b> Open
This study evaluated the growth performance, hematology, and serum biochemistry of Genetically Improved Farmed Tilapia (GIFT, Oreochromis niloticus) reared in cage culture using two commercial feeds, Hi-Tech (pelleted) and Supreme Aqua (gr…
View article: A STUDY TO PREDICT PATHOGENIC VARIANTS OF METTL5 GENE CAUSING INTELLECTUAL DISABILITY USING IN-SILICO ANALYSIS
A STUDY TO PREDICT PATHOGENIC VARIANTS OF METTL5 GENE CAUSING INTELLECTUAL DISABILITY USING IN-SILICO ANALYSIS Open
The METTL5 gene encodes a methyltransferase enzyme crucial for the modification of ribosomal RNA (rRNA), a process essential for the proper functioning of ribosomes. Mutations in this gene have been associated with neurodevelopmental disor…
View article: A Correlational Study Between Emotional Intelligence and Self-Esteem Among University Students in Quetta
A Correlational Study Between Emotional Intelligence and Self-Esteem Among University Students in Quetta Open
Background: In daily life, emotional intelligence, or EI, is crucial. Humans must engage in a variety of social activities and interact with others on a regular basis since they are social creatures. To communicate effectively and construc…
View article: Mid-term functional and structural analysis arthroscopic single-row repair in full thickness rotator cuff tear
Mid-term functional and structural analysis arthroscopic single-row repair in full thickness rotator cuff tear Open
Background: Purpose is to analyses functional scores and structural integration of cuff in Full thickness cuff tear patients treated with single row Arthroscopic rotator cuff repair (SR-ARCR) making it cost effective surgery in developing …
View article: Evaluation and Characterization of Wool of the Rakshani Sheep Breed
Evaluation and Characterization of Wool of the Rakshani Sheep Breed Open
This study aimed to evaluate and characterized wool quality traits of Rakshani Sheep Breed, focusing on the effect of different factors such as gender, age, and geographic area. A total of 190 sheep were randomly selected for wool sample c…
View article: Development and Validation of HPLC Method for Simultaneous Estimation of Ondansetron Dihydrochloride, Famotidine, and Drotaverine Hydrochloride in Rabbit Plasma
Development and Validation of HPLC Method for Simultaneous Estimation of Ondansetron Dihydrochloride, Famotidine, and Drotaverine Hydrochloride in Rabbit Plasma Open
Several methods have been reported for the individual determination of Ondansetron (OND), Famotidine (FAM), and Drotaverine (DRO); however, they are not suitable for simultaneously estimating these drugs. Hence, a simple and accurate high-…
View article: Assessment and evaluation of melatonin loaded PLGA injectable nanosuspension for the treatment of subarachnoid hemorrhage: Preclinical study
Assessment and evaluation of melatonin loaded PLGA injectable nanosuspension for the treatment of subarachnoid hemorrhage: Preclinical study Open
Oxidative stress has connection in the development of acute brain injury after SAH, according to a large body of research. Strong antioxidant melatonin is non-toxic and readily crosses the blood-brain barrier when converted to nanoparticle…
View article: Robust Radio Frequency Fingerprinting With Signal Denoising and Stacked Multivariate Ensemble Learning for Secure Wireless Communications
Robust Radio Frequency Fingerprinting With Signal Denoising and Stacked Multivariate Ensemble Learning for Secure Wireless Communications Open
Radio Frequency Fingerprinting (RFF) has gained significant attention in wireless communication and security research due to its potential for device authentication and intrusion detection. While deep learning-based approaches have shown p…
View article: Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation on gene expression and DNA methylation
Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation on gene expression and DNA methylation Open
Structural variants (SVs) drive gene expression in the human brain and are causative of many neurological conditions. However, most existing genetic studies have been based on short-read sequencing methods, which capture fewer than half of…
View article: MANAGEMENT OF MILD-CHRONIC PSORIASIS WITH THE DEVELOPED CURCUMIN WHEAT OIL-BASED NANOEMULGEL – A CASE STUDY
MANAGEMENT OF MILD-CHRONIC PSORIASIS WITH THE DEVELOPED CURCUMIN WHEAT OIL-BASED NANOEMULGEL – A CASE STUDY Open
Background: Curcumin and wheat oil are used to reduce psoriasis symptoms by inhibiting inflammation. Objectives: The Case-1 study involved a 41-year-old male who had been grappling with severe psoriatic lesions for several years, while Cas…
View article: SPE-UHPLC-ESI-MS/MS Analysis of Cocaine and Its Metabolites in Conventional and Alternative Biological Specimens: Application to Real Samples
SPE-UHPLC-ESI-MS/MS Analysis of Cocaine and Its Metabolites in Conventional and Alternative Biological Specimens: Application to Real Samples Open
An increase in cocaine abuse has been observed globally since the past decade. Cocaine is among the commonly abused stimulants used for recreational purposes. In this study, the SPE-UHPLC-MS/MS method was developed and validated to be appl…
View article: ProtPipe: A Multifunctional Data Analysis Pipeline for Proteomics and Peptidomics
ProtPipe: A Multifunctional Data Analysis Pipeline for Proteomics and Peptidomics Open
Mass spectrometry (MS) is a technique widely employed for the identification and characterization of proteins, personalized medicine, systems biology and biomedical applications. By combining MS with different proteomics approaches such as…
View article: Antidepressant and Pharmacokinetic Evaluation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) of Escitalopram
Antidepressant and Pharmacokinetic Evaluation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) of Escitalopram Open
Escitalopram (ETP) has poor oral bioavailability due to its low water solubility, hence the goal of this work was to design and optimize a self-nano-emulsifying drug delivery system (SNEDDS). Using the results of the investigations on solu…
View article: Porous and highly responsive polymeric fabricated nanometrices for solubility enhancement of acyclovir; characterization and toxicological evaluation
Porous and highly responsive polymeric fabricated nanometrices for solubility enhancement of acyclovir; characterization and toxicological evaluation Open
Solubility is one of the major factors which affects several therapeutic mioeties in terms of their therapeutic efficacy. In the current study, we presented a porous and amorphous nanometrices system for the enhancement of the solubility o…
View article: Spilanthes acmella Extract-Based Natural Oils Loaded Emulgel for Anti-Microbial Action against Dermatitis
Spilanthes acmella Extract-Based Natural Oils Loaded Emulgel for Anti-Microbial Action against Dermatitis Open
Background: Dermatitis is skin disorder that is complicated by recurrent infections of skin by bacteria, viruses, and fungi. Spilanthol is an active constituent of Spilanthes acmella, which possess strong anti-bacterial properties. The pur…
View article: Experimental and in silico evaluation of Carthamus tinctorius L. oil emulgel: a promising treatment for bacterial skin infections
Experimental and in silico evaluation of Carthamus tinctorius L. oil emulgel: a promising treatment for bacterial skin infections Open
Purpose The current study aimed to develop a topical herbal emulgel containing Carthamus tinctorius L. (CT) oil extract, which has been scientifically proven for its antibacterial and antioxidant activities for the ailment of bacterial ski…
View article: Amidated Pluronic Decorated Muco-Penetrating Self-Nano Emulsifying Drug Delivery System (SNEDDS) for Improved Anti-Salmonella typhi Potential
Amidated Pluronic Decorated Muco-Penetrating Self-Nano Emulsifying Drug Delivery System (SNEDDS) for Improved Anti-Salmonella typhi Potential Open
The enteric system residing notorious Salmonella typhimurium (S. typhi) is an intracellular, food-borne, and zoonotic pathogen causing typhoid fever. Typhoid fever is one of the leading causes of mortality and morbidity in developing and u…
View article: Efficacy Of Using Cationorm and Systane Eye Drops on Post-Lasik Dry Eye
Efficacy Of Using Cationorm and Systane Eye Drops on Post-Lasik Dry Eye Open
LASIK is famous procedure for correcting refractive errors. The post-LASIK dry eye is very common. Systane and cationorm eye drops are good for post-LASIK dry eye. Objectives: To evaluate and compare the efficacy of Cationorm and Systane e…
View article: Formulation and evaluation of niosomes-based chlorpheniramine gel for the treatment of mild to moderate skin allergy
Formulation and evaluation of niosomes-based chlorpheniramine gel for the treatment of mild to moderate skin allergy Open
Purpose of present study was to develop eight formulations of chlorpheniramine (CPM) niosomes according to 23 factorial design, characterise on the basis of various evaluation tests, i.e. in vitro drug release, SEM, FTIR, TGA and release k…
View article: Mild – Moderate Acne TreatmentMild – Moderate Acne Treatment and Skin Allergic Reaction Treatment Using Aloevera Emulgel - A Case Study
Mild – Moderate Acne TreatmentMild – Moderate Acne Treatment and Skin Allergic Reaction Treatment Using Aloevera Emulgel - A Case Study Open
Purpose: We are presenting a case 1 of 35 year’s old female suffered with mild-moderate acne for more than a year and the case 2 study was on a 14 year’s old male suffered with some skin allergy on his arms, in order to see the effects of …
View article: Synthesis and in vitro characterization of chlorpheneramine-laden liposomes for topical applications.
Synthesis and in vitro characterization of chlorpheneramine-laden liposomes for topical applications. Open
This study was aimed at synthesizing liposomes for the topical delivery of chlorpheneramine maleate using three-level factorial design. Each experiment consisted of a varying proportion of cholesterol, lecithin and a permeation enhancer mi…
View article: Characterization of major chromatin assembly proteins in tetrahymena thermophile using proeomic and molecular evolutionary analyses
Characterization of major chromatin assembly proteins in tetrahymena thermophile using proeomic and molecular evolutionary analyses Open
Histones H3/H4 are deposited onto DNA in a replication-dependent or independent fashion by the CAF1 and HIRA protein complexes. Despite the identification of these protein complexes, mechanistic details remain unclear. Recently, we showed …
View article: Development and Validation of HPLC Method for Diphenhydramine Hydrochloride
Development and Validation of HPLC Method for Diphenhydramine Hydrochloride Open
Aim: The aim of present method development for Diphenhydramine HCl performed on HPLC is to obtain specific, more accurate and precise results as compare to spectrophotometric method.
Methods: HPLC analysis was performed according to USP m…
View article: Formulation and optimization of dimenhydrinate emulgels for topical delivery using response surface methodology.
Formulation and optimization of dimenhydrinate emulgels for topical delivery using response surface methodology. Open
Development of dimenhydrinate (DMN) emulgel formulation has been described in this work with enhanced permeation for transdermal delivery of DMN for effective management of motion sickness. Various DMN emulgel formulations were prepared us…
View article: DAPT decreases the permeability of the BBB by reducing the ubiquitination and degradation of occludin during permanent brain ischemia
DAPT decreases the permeability of the BBB by reducing the ubiquitination and degradation of occludin during permanent brain ischemia Open
Background Tight junction protein degradation is a principal characteristic of the blood‐brain barrier (BBB) damage that occurs during brain ischemia.The aim of this study is to investigate the mechanisms of occludin degradation that under…