Akram Khan
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View article: The impact of 4% versus 3% hypopnea scoring criteria on obstructive sleep apnea diagnosis in women: a scoping review and commentary
The impact of 4% versus 3% hypopnea scoring criteria on obstructive sleep apnea diagnosis in women: a scoping review and commentary Open
Introduction Women are underdiagnosed with obstructive sleep apnea (OSA) due to differences in anatomy, clinical presentation, and sociocultural factors. The diagnostic criteria for hypopneas, a key component of the apnea–hypopnea index (A…
View article: Effectiveness of 2024–2025 COVID-19 Vaccination Against COVID-19 Hospitalization and Severe In-Hospital Outcomes — IVY Network, 26 Hospitals, September 1, 2024–April 30, 2025
Effectiveness of 2024–2025 COVID-19 Vaccination Against COVID-19 Hospitalization and Severe In-Hospital Outcomes — IVY Network, 26 Hospitals, September 1, 2024–April 30, 2025 Open
Importance As SARS-CoV-2 JN.1 lineage descendants continue to evolve, evaluating COVID-19 vaccine effectiveness (VE) against severe COVID-19 is necessary to inform vaccine composition updates. Objective To estimate effectiveness of 2024–20…
View article: Peripheral Vasopressor Use in Early Sepsis-Induced Hypotension
Peripheral Vasopressor Use in Early Sepsis-Induced Hypotension Open
Importance Evidence supporting the safety of infusing vasopressors through peripheral intravenous catheters (peripheral vasopressors) is largely derived from single-center studies, limiting generalizability. Objective To evaluate factors a…
View article: Treatment with Allogenic Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome: A Double-Blind, Placebo-controlled, Multi-Center, Phase 2b Clinical Trial (STAT)
Treatment with Allogenic Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome: A Double-Blind, Placebo-controlled, Multi-Center, Phase 2b Clinical Trial (STAT) Open
gov, ID: NCT03818854.
View article: Multimorbidity Profiles and Severe In-Hospital Outcomes in Adults with Respiratory Syncytial Virus
Multimorbidity Profiles and Severe In-Hospital Outcomes in Adults with Respiratory Syncytial Virus Open
Background Adults hospitalized with acute respiratory infections, including respiratory syncytial virus (RSV), often have multiple underlying conditions. Few data are available on the combined effect of conditions on risk of severe outcome…
View article: 1359 Utilization of Electronic Consults to Reduce Wait Times for an Academic Sleep Medicine Program and Improve Timely Diagnosis of Obstructive Sleep Apnea
1359 Utilization of Electronic Consults to Reduce Wait Times for an Academic Sleep Medicine Program and Improve Timely Diagnosis of Obstructive Sleep Apnea Open
Introduction Approximately 29.4 million adults in the United States have obstructive sleep apnea (OSA) and prevalence continues to rise. At Oregon Health & Science University (OHSU), access to sleep medicine is limited and clinic wait time…
View article: Patient- and Community-Level Characteristics Associated With Respiratory Syncytial Virus Vaccination
Patient- and Community-Level Characteristics Associated With Respiratory Syncytial Virus Vaccination Open
Importance In 2023, the first respiratory syncytial virus (RSV) vaccines were recommended for US adults 60 years or older, but few data are available about which patients were most likely to receive vaccine to inform future RSV vaccine out…
View article: FREQUENCY OF PULMONARY HYPERTENSION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE PRESENTING AT TERTIARY CARE HOSPITAL
FREQUENCY OF PULMONARY HYPERTENSION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE PRESENTING AT TERTIARY CARE HOSPITAL Open
Background: Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder frequently complicated by pulmonary hypertension (PH), a condition associated with increased morbidity and mortality. PH in COPD results from ch…
View article: Abatacept, Cenicriviroc, or Infliximab for Treatment of Adults Hospitalized With COVID-19 Pneumonia
Abatacept, Cenicriviroc, or Infliximab for Treatment of Adults Hospitalized With COVID-19 Pneumonia Open
Importance: Immune dysregulation contributes to poorer outcomes in COVID-19. Objective: To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added to standard care for COVID-19 pneumonia. Design, Setting, and…
View article: Genomic Characterization of RSV in the US by Vaccination Status
Genomic Characterization of RSV in the US by Vaccination Status Open
This study examines respiratory syncytial virus (RSV) genomic surveillance results from 2 large US networks after the introduction of RSV vaccines.
View article: Interim Estimates of 2024–2025 Seasonal Influenza Vaccine Effectiveness — Four Vaccine Effectiveness Networks, United States, October 2024–February 2025
Interim Estimates of 2024–2025 Seasonal Influenza Vaccine Effectiveness — Four Vaccine Effectiveness Networks, United States, October 2024–February 2025 Open
Annual influenza vaccination is recommended for all persons aged ≥6 months in the United States. Interim influenza vaccine effectiveness (VE) was calculated among patients with acute respiratory illness-associated outpatient visits and hos…
View article: Interim Estimates of 2024–2025 COVID-19 Vaccine Effectiveness Among Adults Aged ≥18 Years — VISION and IVY Networks, September 2024–January 2025
Interim Estimates of 2024–2025 COVID-19 Vaccine Effectiveness Among Adults Aged ≥18 Years — VISION and IVY Networks, September 2024–January 2025 Open
COVID-19 vaccination averted approximately 68,000 hospitalizations during the 2023-24 respiratory season. In June 2024, CDC and the Advisory Committee on Immunization Practices (ACIP) recommended that all persons aged ≥6 months receive a 2…
View article: Future practice plans of internal medicine fellowship graduates: a focus on pulmonary and critical care medicine
Future practice plans of internal medicine fellowship graduates: a focus on pulmonary and critical care medicine Open
PCCM fellowship graduates exhibited a preference for academic practice and a reduced likelihood of pursuing further subspecialty training. The percentage of internal medicine subspecialists practicing in underserved areas remains low.
View article: P-2069. Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccine Effectiveness Against COVID-19–associated Hospitalization Among Adults — IVY Network, 20 U.S. States
P-2069. Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccine Effectiveness Against COVID-19–associated Hospitalization Among Adults — IVY Network, 20 U.S. States Open
Background On September 12, 2023, the Advisory Committee on Immunization Practices recommended updated 2023–2024 (Monovalent XBB.1.5) COVID-19 vaccination for all persons aged ≥6 months to prevent COVID-19. Few data are available on the ef…
View article: Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia
Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia Open
Fostamatinib, a spleen tyrosine kinase inhibitor, has been reported to improve outcomes of COVID-19. To evaluate the efficacy and safety of fostamatinib in adults hospitalized with COVID-19 and hypoxemia. This multicenter, phase 3, placebo…
View article: Early Therapeutic Plasma Exchange in Pediatric Transverse Myelitis: A Case Report and Scoping Review
Early Therapeutic Plasma Exchange in Pediatric Transverse Myelitis: A Case Report and Scoping Review Open
Background/Objectives: Transverse myelitis (TM) is a rare, acute inflammatory disorder affecting the spinal cord, with severe potential consequences, particularly in pediatric patients. Therapeutic plasma exchange (TPE) has emerged as a po…
View article: Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia
Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia Open
Importance Fostamatinib, a spleen tyrosine kinase inhibitor, has been reported to improve outcomes of COVID-19. Objective To evaluate the efficacy and safety of fostamatinib in adults hospitalized with COVID-19 and hypoxemia. Design, Setti…
View article: Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis-Study of Treatment’s Echocardiographic Mechanisms (CLOVERS-STEM)
Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis-Study of Treatment’s Echocardiographic Mechanisms (CLOVERS-STEM) Open
IMPORTANCE: Receipt of fluid and vasopressors, common treatments in septic shock, may affect cardiac function. OBJECTIVES: We sought to determine whether a liberal or restrictive fluid resuscitation strategy was associated with changes in …
View article: Benefit of Early Oseltamivir Therapy for Adults Hospitalized With Influenza A: An Observational Study
Benefit of Early Oseltamivir Therapy for Adults Hospitalized With Influenza A: An Observational Study Open
Background Clinical guidelines recommend initiation of antiviral therapy as soon as possible for patients hospitalized with confirmed or suspected influenza. Methods A multicenter US observational sentinel surveillance network prospectivel…
View article: Effectiveness of Original Monovalent and Bivalent COVID‐19 Vaccines Against COVID‐19‐Associated Hospitalization and Severe In‐Hospital Outcomes Among Adults in the United States, September 2022–August 2023
Effectiveness of Original Monovalent and Bivalent COVID‐19 Vaccines Against COVID‐19‐Associated Hospitalization and Severe In‐Hospital Outcomes Among Adults in the United States, September 2022–August 2023 Open
Background Assessments of COVID‐19 vaccine effectiveness are needed to monitor the protection provided by updated vaccines against severe COVID‐19. We evaluated the effectiveness of original monovalent and bivalent (ancestral strain and Om…
View article: Optimizing Postoperative Glucose Management in CABG Patients: Exploring Early Transition to Subcutaneous Insulin
Optimizing Postoperative Glucose Management in CABG Patients: Exploring Early Transition to Subcutaneous Insulin Open
Introduction: Tight glycemic control is essential for optimal outcomes after coronary artery bypass graft (CABG) surgery, regardless of pre-operative diabetes status. The ideal timing for transitioning from intravenous (IV) to subcutaneous…
View article: Diabetes Mellitus Is Not a Risk Factor for Difficult Intubation Among Critically Ill Adults: A Secondary Analysis of Multicenter Trials
Diabetes Mellitus Is Not a Risk Factor for Difficult Intubation Among Critically Ill Adults: A Secondary Analysis of Multicenter Trials Open
OBJECTIVES: Diabetes mellitus has been associated with greater difficulty of tracheal intubation in the operating room. This relationship has not been examined for tracheal intubation of critically ill adults. We examined whether diabetes …
View article: Effectiveness of the Original Monovalent Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination Series Against Hospitalization for COVID-19–Associated Venous Thromboembolism
Effectiveness of the Original Monovalent Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination Series Against Hospitalization for COVID-19–Associated Venous Thromboembolism Open
Background Coronavirus disease 2019 (COVID-19) is a strong risk factor for venous thromboembolism (VTE). Few studies have evaluated the effectiveness of COVID-19 vaccination in preventing hospitalization for COVID-19 with VTE. Methods Adul…
View article: Association Between Neuromuscular Blocking Agents and Outcomes of Emergency Tracheal Intubation: A Secondary Analysis of Randomized Trials
Association Between Neuromuscular Blocking Agents and Outcomes of Emergency Tracheal Intubation: A Secondary Analysis of Randomized Trials Open
Among critically ill adults undergoing tracheal intubation, the incidences of successful intubation on the first attempt and severe complications were not significantly different between patients who received succinylcholine and patients w…