Muhammad Aqib Shabbir
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View article: Molecular insights in potentiation of antibiotic activity by apple cider vinegar in diabetic wound pathogens
Molecular insights in potentiation of antibiotic activity by apple cider vinegar in diabetic wound pathogens Open
Background The prevalence of antibiotic resistance has become a critical global health concern. In particular, resistant strains of S taphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) against commonly prescribed antibiotics for var…
View article: Correction to “Synthesis of Iron Oxide Nanoparticles from <i>Madhuca indica</i> Plant Extract and Assessment of Their Cytotoxic, Antioxidant, Anti-Inflammatory, and Anti-Diabetic Properties via Different Nanoinformatics Approaches”
Correction to “Synthesis of Iron Oxide Nanoparticles from <i>Madhuca indica</i> Plant Extract and Assessment of Their Cytotoxic, Antioxidant, Anti-Inflammatory, and Anti-Diabetic Properties via Different Nanoinformatics Approaches” Open
[This corrects the article DOI: 10.1021/acsomega.3c02744.].
View article: Immunoinformatics-driven design of a multi-epitope vaccine against nipah virus: A promising approach for global health protection
Immunoinformatics-driven design of a multi-epitope vaccine against nipah virus: A promising approach for global health protection Open
This study focuses on developing a multi-epitope vaccine against the highly pathogenic Nipah virus using immunoinformatics. It aims to design a vaccine targeting the viral nucleoprotein to elicit robust immune responses. The approach integ…
View article: AI-driven in silico discovery, design, and evaluation of novel antiviral candidates targeting Marburg virus nucleoprotein for advanced therapeutic development
AI-driven in silico discovery, design, and evaluation of novel antiviral candidates targeting Marburg virus nucleoprotein for advanced therapeutic development Open
View article: Genomic profiling of pediococcus acidilactici BCB1H and identification of its key features for Biotechnological innovation, food technology and medicine
Genomic profiling of pediococcus acidilactici BCB1H and identification of its key features for Biotechnological innovation, food technology and medicine Open
View article: Unveiling the whole genomic features and potential probiotic characteristics of novel Lactiplantibacillus plantarum HMX2
Unveiling the whole genomic features and potential probiotic characteristics of novel Lactiplantibacillus plantarum HMX2 Open
This study investigates the genomic features and probiotic potential of Lactiplantibacillus plantarum HMX2, isolated from Chinese Sauerkraut, using whole-genome sequencing (WGS) and bioinformatics for the first time. This study also aims t…
View article: CRISPR-Cas9 guided RNA-based model for the silencing of spinal bulbarmuscular atrophy: A functional genetic disorder
CRISPR-Cas9 guided RNA-based model for the silencing of spinal bulbarmuscular atrophy: A functional genetic disorder Open
This study explores a novel therapeutic approach for spinal bulbar muscular atrophy (SBMA), a neurodegenerative disorder caused by a mutation in the Androgen Receptor (AR) gene. The aim is to investigate the potential of CRISPR-Cas9 techno…
View article: Mix-match synthesis of nanosynbiotics from probiotics and prebiotics to counter gut dysbiosis via AI integrated formulation profiling
Mix-match synthesis of nanosynbiotics from probiotics and prebiotics to counter gut dysbiosis via AI integrated formulation profiling Open
Antibiotics, improper food, and stress have created a dysbiotic state in the gut and almost 81% of the world's population has been affected due to the pandemic of COVID-19 and the prevalence of dengue virus in the past few years. The main …
View article: Revolutionizing the probiotic functionality, biochemical activity, antibiotic resistance and specialty genes of <i>Pediococcus acidilactici</i> BCB1H via <i>in-vitro</i> and <i>in-silico</i> approaches
Revolutionizing the probiotic functionality, biochemical activity, antibiotic resistance and specialty genes of <i>Pediococcus acidilactici</i> BCB1H via <i>in-vitro</i> and <i>in-silico</i> approaches Open
This study presents a comprehensive genomic exploration, biochemical characterization, and the identification of antibiotic resistance and specialty genes of Pediococcus acidilactici BCB1H strain. The functional characterization, genetic m…
View article: Designing a Multiepitope Vaccine against the Foodborne Pathogenic Bacteria Listeria monocytogenes Using Subtractive Immunoinformatics Approaches
Designing a Multiepitope Vaccine against the Foodborne Pathogenic Bacteria Listeria monocytogenes Using Subtractive Immunoinformatics Approaches Open
Background: Listeria monocytogenes, a Gram-positive bacterium, is a prominent foodborne pathogen that causes listeriosis and poses substantial health hazards worldwide. The continuing risk of listeriosis outbreaks underlies the importance …
View article: Whole Genome Analysis of Tibetan Kefir-Derived Lactiplantibacillus Plantarum 12-3 Elucidates Its Genomic Architecture, Antimicrobial and Drug Resistance, Potential Probiotic Functionality and Safety
Whole Genome Analysis of Tibetan Kefir-Derived Lactiplantibacillus Plantarum 12-3 Elucidates Its Genomic Architecture, Antimicrobial and Drug Resistance, Potential Probiotic Functionality and Safety Open
Background: Lactiplantibacillus plantarum 12-3 holds great promise as a probiotic bacterial strain, yet its full potential remains untapped. This study aimed to better understand this potential therapeutic strain by exploring its genomic l…
View article: Assessment of the whole genome sequencing of <i>Lactiplantibacillus plantarum</i> 13-3 for elucidation of novel bacteriocin producing gene cluster and confirmation of its potential probiotic functionality and safety applications
Assessment of the whole genome sequencing of <i>Lactiplantibacillus plantarum</i> 13-3 for elucidation of novel bacteriocin producing gene cluster and confirmation of its potential probiotic functionality and safety applications Open
Lactiplantibacillus plantarum is a probiotic starter culture that improves the flavor and nutritional content of fermented foods. It also shows potential in enhancing mucosal and systemic immunity, which contributes to overall health. We a…
View article: Revolutionizing the virulent protein Internalin a in <i>Listeria monocytogenes</i> and designing multi epitope-based vaccine via immunoinformatic approaches
Revolutionizing the virulent protein Internalin a in <i>Listeria monocytogenes</i> and designing multi epitope-based vaccine via immunoinformatic approaches Open
This study addresses the crucial protein Internalin A in the development of a possible vaccination against Listeria monocytogenes. A meticulous in silico strategy was used which included physiochemical analysis, epitope prediction, and mol…
View article: Integrated track of nano-informatics coupling with the enrichment concept in developing a novel nanoparticle targeting ERK protein in <i>Naegleria fowleri</i>
Integrated track of nano-informatics coupling with the enrichment concept in developing a novel nanoparticle targeting ERK protein in <i>Naegleria fowleri</i> Open
Naegleria fowleri is a free-living amoeba that causes primary amoebic meningoencephalitis. Despite combination drug therapies, N. fowleri is not sensitive to current drug therapies, contributing to the pathogen’s mortality rate of 98%. To …
View article: Juicy Gems of Nutrition: Exploring the Nutrient Profile and Antioxidant Activity of Rosaceae Fruits
Juicy Gems of Nutrition: Exploring the Nutrient Profile and Antioxidant Activity of Rosaceae Fruits Open
Fruit consumption provides valuable phenolic antioxidants and nutrients that are essential to subsidize consumers' health. The functional food value of many fruits belonging to the Rosaceae family is considerably high which is derived from…
View article: COMPARATIVE EVALUATION OF PROTEIN AND LIGAND-BASED DOCKING PROTOCOLS THROUGH PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 2 COMPLEX
COMPARATIVE EVALUATION OF PROTEIN AND LIGAND-BASED DOCKING PROTOCOLS THROUGH PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 2 COMPLEX Open
A molecular docking study is used to investigate the interactions between the two molecules. These interactions may be covalent, hydrogen, or Van der Waals forces. Various web-based and stand-alone tools have been discovered for molecular …
View article: Assessing the probiotic potential, antioxidant, and antibacterial activities of oat and soy milk fermented with Lactiplantibacillus plantarum strains isolated from Tibetan Kefir
Assessing the probiotic potential, antioxidant, and antibacterial activities of oat and soy milk fermented with Lactiplantibacillus plantarum strains isolated from Tibetan Kefir Open
Sufficient intake of probiotics has been shown to help in the digestion, protect the body against pathogenic microorganisms and boost the immune system. Recently, due to high prevalence of milk allergies and lactose intolerance in populati…
View article: Synthesis of Iron Oxide Nanoparticles from <i>Madhuca indica</i> Plant Extract and Assessment of Their Cytotoxic, Antioxidant, Anti-Inflammatory, and Anti-Diabetic Properties via Different Nanoinformatics Approaches
Synthesis of Iron Oxide Nanoparticles from <i>Madhuca indica</i> Plant Extract and Assessment of Their Cytotoxic, Antioxidant, Anti-Inflammatory, and Anti-Diabetic Properties via Different Nanoinformatics Approaches Open
Recently, nanobiotechnology has attracted a lot of attention, as it is a rapidly emerging field that is still growing and developing efficient and advanced therapeutic protocols under the umbrella of nanomedicine. It can revolutionize solu…
View article: In silico explorations of bacterial mercuric reductase as an ecofriendly bioremediator for noxious mercuric intoxications
In silico explorations of bacterial mercuric reductase as an ecofriendly bioremediator for noxious mercuric intoxications Open
Mercury is a major pollutant in the environment due to its high concentration in the soil. In this study, a mercuric reductase was extracted from Pseudomonas aeruginosa. The sequence of the enzyme was retrieved from the literature and stru…
View article: CRISPR-Cas9 guided rna based model for the treatment of Amyotrophic Lateral Sclerosis: A progressive neurodegenerative disorder
CRISPR-Cas9 guided rna based model for the treatment of Amyotrophic Lateral Sclerosis: A progressive neurodegenerative disorder Open
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that leads to the degeneration of motor neurons and the weakening of muscles. Despite extensive research efforts, there is currently no cure for ALS and existi…
View article: Comparative genomics of food-derived probiotic Lactiplantibacillus plantarum K25 reveals its hidden potential, compactness, and efficiency
Comparative genomics of food-derived probiotic Lactiplantibacillus plantarum K25 reveals its hidden potential, compactness, and efficiency Open
This study aimed to investigate the intricate genetic makeup of the Lactiplantibacillus plantarum K25 strain by conducting a comprehensive analysis of comparative genomics. The results of our study demonstrate that the genome exhibits a hi…
View article: Molecular docking and density functional theory (DFT) studies on the conversion of linoleic acid into fatty acid metabolites by <i>Lactiplantibacillus plantarum</i> 12-3
Molecular docking and density functional theory (DFT) studies on the conversion of linoleic acid into fatty acid metabolites by <i>Lactiplantibacillus plantarum</i> 12-3 Open
The aim of this study was to evaluate the competency of Lactiplantibacillus plantarum 12-3 isolated from Tibetan kefir grains that how it converts linoleic acid (LA) into fatty acid metabolites and what are the main reactions involved in i…
View article: Integrated genome based evaluation of safety and probiotic characteristics of Lactiplantibacillus plantarum YW11 isolated from Tibetan kefir
Integrated genome based evaluation of safety and probiotic characteristics of Lactiplantibacillus plantarum YW11 isolated from Tibetan kefir Open
The comparative genomic analysis of Lactiplantibacillus plantarum YW11 ( L. plantarum YW11) isolated from Tibetan kefir involves comparison of the complete genome sequences of the isolated strain with other closely related L. plantarum str…
View article: Artificial Intelligence Assisted Pharmacophore Design for Philadelphia Chromosome-Positive Leukemia with Gamma-Tocotrienol: A Toxicity Comparison Approach with Asciminib
Artificial Intelligence Assisted Pharmacophore Design for Philadelphia Chromosome-Positive Leukemia with Gamma-Tocotrienol: A Toxicity Comparison Approach with Asciminib Open
BCR-ABL1 is a fusion protein as a result of a unique chromosomal translocation (producing the so-called Philadelphia chromosome) that serves as a clinical biomarker primarily for chronic myeloid leukemia (CML); the Philadelphia chromosome …
View article: CRISPR-Cas9 Guided RNA Based Model for the Silencing of Spinal Bulbar Muscular Atrophy: A Functional Genetic Disorder
CRISPR-Cas9 Guided RNA Based Model for the Silencing of Spinal Bulbar Muscular Atrophy: A Functional Genetic Disorder Open
Spinal bulbar muscular atrophy (SBMA) is a neurodegenerative genetic disorder, which results because of a mutation in the start codon of the Androgen Receptor (AR) gene. The mutant Androgen Receptor gene features the polyglutamine expansio…
View article: In Silico Investigation of a Chimeric IL24-LK6 Fusion Protein as a Potent Candidate Against Breast Cancer
In Silico Investigation of a Chimeric IL24-LK6 Fusion Protein as a Potent Candidate Against Breast Cancer Open
Targeted delivery of therapeutic anticancer chimeric molecules enhances the efficacy of drug by improving cellular uptake and circulation time. Engineering the molecules to facilitate the specific interaction between chimeric protein and i…
View article: Chain-Engineering-Based De Novo Drug Design against MPXVgp169 Virulent Protein of Monkeypox Virus: A Molecular Modification Approach
Chain-Engineering-Based De Novo Drug Design against MPXVgp169 Virulent Protein of Monkeypox Virus: A Molecular Modification Approach Open
The unexpected appearance of the monkeypox virus and the extensive geographic dispersal of cases have prompted researchers to concentrate on potential therapeutic approaches. In addition to its vaccine build techniques, there should be som…
View article: Dissemination of Water-Mediated Infections due to Torrential Rainfalls Leading to Havoc Floods: A Dreadful Curve for Pakistan
Dissemination of Water-Mediated Infections due to Torrential Rainfalls Leading to Havoc Floods: A Dreadful Curve for Pakistan Open
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View article: Designing of Thiazolidinones for COVID‐19 and its Allied Diseases: An <i>In silico</i> Evaluation
Designing of Thiazolidinones for COVID‐19 and its Allied Diseases: An <i>In silico</i> Evaluation Open
In silico studies in terms of density functional theory (DFT), molecular docking, and ADMET (absorption, distribution, metabolism, excretion and toxicity) were performed for 55 thiazolidinones compounds derived from different amines and al…
View article: Pharmacophore based drug designing of COL7A1; The causative gene of Dystrophic Epidermolysis Bullosa
Pharmacophore based drug designing of COL7A1; The causative gene of Dystrophic Epidermolysis Bullosa Open
Epidermolysis Bullosa is a rare genetic disorder that causes skin fragility, trauma induced dissociations of the skin, and painful wound growth. More than 20 types of genes are involved in causing EB as it is a polygenic disease and each g…