Mohammad Athar
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View article: Inhibition of BRD4 prevents peribronchial fibrosis in mice with cutaneous lewisite exposure
Inhibition of BRD4 prevents peribronchial fibrosis in mice with cutaneous lewisite exposure Open
Introduction Arsenicals like lewisite are highly toxic vesicant chemical warfare agents that cause severe skin damage and systemic inflammation. Exposure activates cytokine release, leading to pulmonary injury, including edema, hemorrhage,…
View article: Sustained delivery of 4-phenylbutyric acid via chitosan nanoparticles in foam for decontamination and treatment of lewisite-mediated skin injury
Sustained delivery of 4-phenylbutyric acid via chitosan nanoparticles in foam for decontamination and treatment of lewisite-mediated skin injury Open
Lewisite, a chemical warfare agent, induces severe skin injury by oxidative stress and endoplasmic reticulum (ER) dysfunction, necessitating innovative antidote strategies. This study developed chitosan nanoparticle-loaded foam formulation…
View article: High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals
High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals Open
Warfare arsenicals are potent blistering agents and cause severe inflammation following their skin exposure. Data from our group (unpublished) show that these chemicals act by activating bromodomain-4 and RIPK signaling. To develop a dual …
View article: Topical Foam for Simultaneous Treatment and Decontamination of Chemical Warfare Agents on Dermal Exposure
Topical Foam for Simultaneous Treatment and Decontamination of Chemical Warfare Agents on Dermal Exposure Open
Being highly toxic and a quick-acting vesicant, even small amounts of lewisite if not decontaminated immediately are rapidly absorbed into systemic circulation via skin exposure, leading to acute poisoning and death. The skin is the first …
View article: Patient-Derived Three-Dimensional Lung Tumor Models to Evaluate Response to Immunotherapy
Patient-Derived Three-Dimensional Lung Tumor Models to Evaluate Response to Immunotherapy Open
Novel preclinical models that better mimic the in vivo tumor microenvironment are needed for advanced understanding of tumor biology and resistance/response to therapy. Herein, we report development of a novel ex vivo patient-derived three…
View article: Grape constituents for protection against photodamage to skin
Grape constituents for protection against photodamage to skin Open
Cutaneous overexposure to ultraviolet radiation has a variety of deleterious effects. The extent to which dietary factors are effective at moderating UV damage is a significant issue. Grapes contain phytochemicals that protect against exce…
View article: A multiomic study of retinal tissues in mice with direct ocular exposure to vesicants
A multiomic study of retinal tissues in mice with direct ocular exposure to vesicants Open
This study employed a multiomic approach to investigate retinal tissue damage following direct ocular exposure (DOE) to vesicants (VSs)-namely, nitrogen mustard (NM) and lewisite (Lew). We explored both the acute and chronic stages of reti…
View article: Celecoxib as Heterotopic Ossification Prophylaxis in Total Ankle Arthroplasty: A Retrospective Cohort Study
Celecoxib as Heterotopic Ossification Prophylaxis in Total Ankle Arthroplasty: A Retrospective Cohort Study Open
Background: This study aimed to determine whether prophylactic celecoxib reduces the prevalence of radiographic heterotopic ossification (HO) following total ankle arthroplasty (TAA). Secondary aims included evaluating its effect on the se…
View article: Common molecular profile of multiple structurally distinct warfare arsenicals in causing cutaneous chemical vesicant injury
Common molecular profile of multiple structurally distinct warfare arsenicals in causing cutaneous chemical vesicant injury Open
Skin exposure to arsenicals such as lewisite and phenylarsine oxide leads to severe cutaneous damage. Here, we characterized the molecular pathogenesis of skin injury caused by additionally structurally distinct warfare arsenicals includin…
View article: Celecoxib Decreases Risk of Developing Heterotopic Ossification after Total Ankle Arthroplasty
Celecoxib Decreases Risk of Developing Heterotopic Ossification after Total Ankle Arthroplasty Open
Submission Type: Ankle Arthritis Research Type: Level 3 - Retrospective cohort study, Case-control study, Meta-analysis of Level 3 studies Introduction/Purpose: Total ankle arthroplasty (TAA) is an effective procedure for end-stage ankle a…
View article: CD2 expressing innate lymphoid and T cells are critical effectors of immunopathogenesis in hidradenitis suppurativa
CD2 expressing innate lymphoid and T cells are critical effectors of immunopathogenesis in hidradenitis suppurativa Open
Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disease with a poorly understood immunopathogenesis. Here, we report that HS lesional skin is characterized by the expansion of innate lymphocytes and T cells expre…
View article: Bromodomain inhibitor treatment leads to overexpression of multiple kinases in cancer cells
Bromodomain inhibitor treatment leads to overexpression of multiple kinases in cancer cells Open
The bromodomain and extraterminal (BET) family of proteins show altered expression across various cancers. The members of the bromodomain (BRD) family contain epigenetic reader domains that bind to acetylated lysine residues in both histon…
View article: Reply to Nebo et al.: Pathogenesis of advanced hidradenitis suppurativa: Are there differences based on anatomical location, gender, and race?
Reply to Nebo et al.: Pathogenesis of advanced hidradenitis suppurativa: Are there differences based on anatomical location, gender, and race? Open
The origin of the German cockroach, Blattella germanica, is enigmatic, in part because it is ubiquitous worldwide in human-built structures but absent from any natural habitats. The first historical records of this species are from ca. 250…
View article: Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma
Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma Open
Small extracellular vesicles (sEVs) are known to orchestrate cell-cell communication, but the role of sEV signaling via mitochondria in perpetuating asthmatic airway inflammation is unknown. Myeloid-derived regulatory cells (MDRCs) are kno…
View article: Epigenetic switch reshapes epithelial progenitor cell signatures and drives inflammatory pathogenesis in hidradenitis suppurativa
Epigenetic switch reshapes epithelial progenitor cell signatures and drives inflammatory pathogenesis in hidradenitis suppurativa Open
Hidradenitis suppurativa (HS) is a complex inflammatory skin disease with undefined mechanistic underpinnings. Here, we investigated HS epithelial cells and demonstrated that HS basal progenitors modulate their lineage restriction and give…
View article: NK and NKT cells in the pathogenesis of Hidradenitis suppurativa: Novel therapeutic strategy through targeting of CD2
NK and NKT cells in the pathogenesis of Hidradenitis suppurativa: Novel therapeutic strategy through targeting of CD2 Open
Hidradenitis suppurativa (HS) is a chronic debilitating inflammatory skin disease with poorly understood pathogenesis. Single-cell RNAseq analysis of HS lesional and healthy individual skins revealed that NKT and NK cell populations were g…
View article: Integrative systems biology framework discovers common gene regulatory signatures in multiple mechanistically distinct inflammatory skin diseases
Integrative systems biology framework discovers common gene regulatory signatures in multiple mechanistically distinct inflammatory skin diseases Open
Aim More than 20% of the population across the world is affected by non-communicable inflammatory skin diseases including psoriasis, atopic dermatitis, hidradenitis suppurativa, rosacea, etc. Many of these chronic diseases are painful and …
View article: Altered sphingolipid pathway in SARS-CoV-2 infected human lung tissue
Altered sphingolipid pathway in SARS-CoV-2 infected human lung tissue Open
Introduction The SARS-CoV-2 mediated COVID-19 pandemic has impacted millions worldwide. Hyper-inflammatory processes, including cytokine storm, contribute to long-standing tissue injury and damage in COVID-19. The metabolism of sphingolipi…
View article: Genetic variability for early seed vigor traits for enhanced performance under sub-optimum temperatures in sweet corn (Zea mays Convar. saccharata L.)
Genetic variability for early seed vigor traits for enhanced performance under sub-optimum temperatures in sweet corn (Zea mays Convar. saccharata L.) Open
High germination and seed vigor under sub-optimum temperature is desirable for successful stand establishment in Sweet Corn. Aninvestigation was undertaken to assess the performance of shrunken2 based Sweet Corn hybrids; CMVL Sweet Corn-1 …