Saima Hilal
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View article: Comparison of the additive value of blood-based and retinal biomarkers to clinical features in predicting cognitive decline
Comparison of the additive value of blood-based and retinal biomarkers to clinical features in predicting cognitive decline Open
A multimodal model comprising blood, retinal and clinical variables may represent an accessible, non-invasive tool for predicting cognitive decline.
View article: Multi-population genome-wide association study identifies multiple novel loci associated with asymptomatic intracranial large artery stenosis
Multi-population genome-wide association study identifies multiple novel loci associated with asymptomatic intracranial large artery stenosis Open
Introduction: Intracranial large artery stenosis (ILAS) is one of the most common causes of stroke worldwide and is associated with the risk for future vascular events. Asymptomatic ILAS is a frequent finding on neuroimaging and shares man…
View article: Signature White Matter Hyperintensity Locations Associated With Vascular Risk Factors Derived From 15 653 Individuals
Signature White Matter Hyperintensity Locations Associated With Vascular Risk Factors Derived From 15 653 Individuals Open
BACKGROUND: White matter hyperintensities (WMHs) of presumed vascular origin are common in the elderly and are associated with vascular risk factors. There is evidence that vascular risk factors, in particular hypertension, are associated …
View article: Healthy lifestyle mitigates the adverse association of particulate matter with cognitive function: a 10-year longitudinal analysis of older adults in China
Healthy lifestyle mitigates the adverse association of particulate matter with cognitive function: a 10-year longitudinal analysis of older adults in China Open
Background Both air pollution and lifestyle are associated with cognitive function, with air pollution showing detrimental associations and healthy lifestyles showing beneficial ones. The extent to which a favorable lifestyle can mitigate …
View article: Facilitators and barriers for use of digital technology in chronic disease management
Facilitators and barriers for use of digital technology in chronic disease management Open
Despite increased screening efforts and accessibility of healthcare services, the prevalence of chronic disease is on the rise in Singapore. Digital technology has become a valuable tool to aid management of chronic diseases. However, its …
View article: Synergistic effect between cortical cerebral microinfarcts and brain atrophy on cognitive decline
Synergistic effect between cortical cerebral microinfarcts and brain atrophy on cognitive decline Open
Cortical cerebral microinfarcts are associated with brain atrophy in cross-sectional studies, with further investigation using longitudinal datasets being warranted. Moreover, little is known about their combined impact on cognition. This …
View article: An Analysis of Financial Performance: A Case Study of Village Cooperatives in Ciamis Regency
An Analysis of Financial Performance: A Case Study of Village Cooperatives in Ciamis Regency Open
Financial performance is an important indicator of the health and sustainability of an organization, including village cooperatives. By analyzing financial performance through key ratios such as liquidity, solvency, and profitability, coop…
View article: Rate of brain aging associates with future executive function in Asian children and older adults
Rate of brain aging associates with future executive function in Asian children and older adults Open
Brain age has emerged as a powerful tool to understand neuroanatomical aging and its link to health outcomes like cognition. However, there remains a lack of studies investigating the rate of brain aging and its relationship to cognition. …
View article: Multi-population Genome-Wide Association Study Identifies Multiple Novel Loci associated with Asymptomatic Intracranial Large Artery Stenosis
Multi-population Genome-Wide Association Study Identifies Multiple Novel Loci associated with Asymptomatic Intracranial Large Artery Stenosis Open
Background Intracranial large artery stenosis (ILAS) is one of the most common causes of stroke worldwide and is associated with the risk for future vascular events. Asymptomatic ILAS is a frequent finding on neuroimaging and shares many r…
View article: Multi-cohort, multi-sequence harmonisation for cerebrovascular brain age
Multi-cohort, multi-sequence harmonisation for cerebrovascular brain age Open
Introduction Higher brain-predicted age gaps (BAG), based on anatomical brain scans, have been associated with cognitive decline among elderly participants. Adding a cerebrovascular component, in the form of arterial spin labelling (ASL) p…
View article: <scp>WMH</scp> ‐ <scp>DualTasker</scp> : A Weakly Supervised Deep Learning Model for Automated White Matter Hyperintensities Segmentation and Visual Rating Prediction
<span>WMH</span> ‐ <span>DualTasker</span> : A Weakly Supervised Deep Learning Model for Automated White Matter Hyperintensities Segmentation and Visual Rating Prediction Open
White matter hyperintensities (WMH) are neuroimaging markers linked to an elevated risk of cognitive decline. WMH severity is typically assessed via visual rating scales and through volumetric segmentation. While visual rating scales are c…
View article: Left Atrial Myocardial Mechanics: Association With Cognitive Dysfunction, Cerebrovascular Disease, and Circulating Biomarkers
Left Atrial Myocardial Mechanics: Association With Cognitive Dysfunction, Cerebrovascular Disease, and Circulating Biomarkers Open
Background The relationship of left atrial ( LA ) strain with cognition in the absence of atrial fibrillation is poorly understood. We investigated the association of LA strain with cognitive impairment and its pathogenetic subtype (vascul…
View article: A deep‐learning retinal aging biomarker for cognitive decline and incident dementia
A deep‐learning retinal aging biomarker for cognitive decline and incident dementia Open
INTRODUCTION The utility of retinal photography‐derived aging biomarkers for predicting cognitive decline remains under‐explored. METHODS A memory‐clinic cohort in Singapore was followed‐up for 5 years. RetiPhenoAge, a retinal aging biomar…
View article: Prediction of Cognitive Impairment Using a Deep Learning Autoencoder Algorithm from a Singapore Study
Prediction of Cognitive Impairment Using a Deep Learning Autoencoder Algorithm from a Singapore Study Open
Dementia is a decline in cognitive function, typically diagnosed when the acquired impairment becomes severe enough to impact social or occupational functioning. Between no cognitive impairment (NCI) and dementia, there are many intermedia…
View article: Rate of brain aging associates with future executive function in Asian children and older adults
Rate of brain aging associates with future executive function in Asian children and older adults Open
Brain age has emerged as a powerful tool to understand neuroanatomical aging and its link to health outcomes like cognition. However, there remains a lack of studies investigating the rate of brain aging and its relationship to cognition. …
View article: Plasma proteomics for cognitive decline and dementia—A Southeast Asian cohort study
Plasma proteomics for cognitive decline and dementia—A Southeast Asian cohort study Open
INTRODUCTION The prognostic utility of plasma proteomics for cognitive decline and dementia in a Southeast Asian population characterized by high cerebrovascular disease (CeVD) burden is underexplored. METHODS We examined this in a Singapo…
View article: Cross‐Sectional Association Between Left Ventricular Geometric Patterns, Cortical Cerebral Microinfarcts, and Cognition
Cross‐Sectional Association Between Left Ventricular Geometric Patterns, Cortical Cerebral Microinfarcts, and Cognition Open
Background Left ventricular (LV) geometric patterns are associated with cognitive impairment and cerebral small vessel disease. As a novel magnetic resonance imaging marker of cerebral small vessel disease and a risk factor for cognitive d…
View article: Clinical utility of plasma p‐tau217 in identifying abnormal brain amyloid burden in an Asian cohort with high prevalence of concomitant cerebrovascular disease
Clinical utility of plasma p‐tau217 in identifying abnormal brain amyloid burden in an Asian cohort with high prevalence of concomitant cerebrovascular disease Open
INTRODUCTION Using an Asian cohort with high prevalence of concomitant cerebrovascular disease (CeVD), we evaluated the performance of a plasma immunoassay for tau phosphorylated at threonine 217 (p‐tau217) in detecting amyloid beta positi…
View article: Association of arterial structure and function with incident cardiovascular diseases and cognitive decline
Association of arterial structure and function with incident cardiovascular diseases and cognitive decline Open
Introduction We examined the associations of carotid intima‐media thickness (CIMT), arterial stiffness index (ASI), and pulse pressure (PP) with cerebrovascular disease, cognitive function and decline, and incident cardiovascular diseases …
View article: U-shaped association of resting heart rate with cognitive decline
U-shaped association of resting heart rate with cognitive decline Open
Reports of associations between bradycardia and elevated resting heart rate with cognitive decline are inconsistent, and the underlying mechanisms unclear. Resting heart rate was recorded in a prospective cohort of memory clinic subjects, …
View article: Utilizing deep learning to predict Alzheimer's disease and mild cognitive impairment with optical coherence tomography
Utilizing deep learning to predict Alzheimer's disease and mild cognitive impairment with optical coherence tomography Open
INTRODUCTION Diagnostic performance of optical coherence tomography (OCT) to detect Alzheimer's disease (AD) and mild cognitive impairment (MCI) remains limited. We aimed to develop a deep‐learning algorithm using OCT to detect AD and MCI.…
View article: Multi-cohort, multi-sequence harmonisation for cerebrovascular brain age
Multi-cohort, multi-sequence harmonisation for cerebrovascular brain age Open
Higher brain-predicted age gaps (BAG), based on anatomical brain scans, have been associated with cognitive decline amongst elderly participants. Adding a cerebrovascular component, in the form of arterial spin labelling (ASL) perfusion MR…