Ibrar Muhammad Khan
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View article: miR-34c regulates the proliferation, apoptosis, and testosterone synthesis of bovine leydig cells by targeted ATG5 gene
miR-34c regulates the proliferation, apoptosis, and testosterone synthesis of bovine leydig cells by targeted ATG5 gene Open
The reproductive potential of bull represents a key economic trait in modern cattle husbandry. The primary determinant of bull reproductive capacity is the proper development of the testes, which is essential for the production of spermato…
View article: Effects of Varicocelectomy Surgery on Sperm Morphology and Male Fertility
Effects of Varicocelectomy Surgery on Sperm Morphology and Male Fertility Open
Background: Varicocele is associated with impaired semen parameters and reduced spermatogenesis. Microsurgical varicocelectomy has been shown to improve testicular function. This study aimed to assess its effect on sperm morphology. Method…
View article: <b>Role of Dapoxetine in Premature Ejaculation</b>
<b>Role of Dapoxetine in Premature Ejaculation</b> Open
Background: Premature ejaculation (PE) is a prevalent male sexual dysfunction that significantly impacts psychological wellbeing and relationship satisfaction. While traditionally managed with behavioral interventions, pharmacologic therap…
View article: Comparative analysis of milk production, composition, and plasma metabolomics across various dairy goat breeds in Yunnan Province, China
Comparative analysis of milk production, composition, and plasma metabolomics across various dairy goat breeds in Yunnan Province, China Open
The present study involved crossing Alpine goats with Yunshang black bucks from Yunnan Province to produce Alpine-Yunshang dual-purpose F1 (AYF1) goats. The AYF1 goats were compared with Saanen and Toggenburg goats by evaluating milk yield…
View article: Green tea polyphenol epigallocatechin-3-gallate mediates an antioxidant response via Nrf2 pathway in heat-stressed poultry: A review
Green tea polyphenol epigallocatechin-3-gallate mediates an antioxidant response via Nrf2 pathway in heat-stressed poultry: A review Open
Heat stress is a critical challenge in the poultry industry. It arises when birds are exposed to elevated ambient temperatures beyond their thermoneutral zone, often exacerbated by high humidity and inadequate ventilation. This condition d…
View article: Impact of Breed, Age and Gender on Beef Quality Traits; A Comparison from Native to Crossbred Cattle
Impact of Breed, Age and Gender on Beef Quality Traits; A Comparison from Native to Crossbred Cattle Open
View article: The microbiota: a key regulator of health, productivity, and reproductive success in mammals
The microbiota: a key regulator of health, productivity, and reproductive success in mammals Open
The microbiota, intensely intertwined with mammalian physiology, significantly impacts health, productivity, and reproductive functions. The normal microbiota interacts with the host through the following key mechanisms: acting as a protec…
View article: Effect of black soldier fly (Hermetia illucens) larvae meal and oil on the performance, biochemical profile, intestinal health and gut microbial dynamics in laying hens
Effect of black soldier fly (Hermetia illucens) larvae meal and oil on the performance, biochemical profile, intestinal health and gut microbial dynamics in laying hens Open
View article: Assessing the performance, egg quality, serum analysis, heavy metals and essential trace metals accumulation in laying hen eggs and tissues fed black soldier fly (Hermetia illucens) larvae meal
Assessing the performance, egg quality, serum analysis, heavy metals and essential trace metals accumulation in laying hen eggs and tissues fed black soldier fly (Hermetia illucens) larvae meal Open
Black soldier fly (BSF) larvae convert wastes into protein, playing a vital role in addressing the challenge of sustainable poultry production. These larvae accumulate toxic substances, posing a risk to feed and food safety. This study inv…
View article: Unraveling the ecotoxicological effects of micro and nano-plastics on aquatic organisms and human health
Unraveling the ecotoxicological effects of micro and nano-plastics on aquatic organisms and human health Open
Plastic pollution ranks among the most severe environmental disasters caused by humans, generating millions of tonnes of waste annually. The extensive and unregulated use of plastics has led to ecotoxicity and environmental imbalance. Micr…
View article: Enhancing bovine immune, antioxidant and anti-inflammatory responses with vitamins, rumen-protected amino acids, and trace minerals to prevent periparturient mastitis
Enhancing bovine immune, antioxidant and anti-inflammatory responses with vitamins, rumen-protected amino acids, and trace minerals to prevent periparturient mastitis Open
Mastitis, the inflammatory condition of mammary glands, has been closely associated with immune suppression and imbalances between antioxidants and free radicals in cattle. During the periparturient period, dairy cows experience negative e…
View article: Exploring Oncogenic Factors Influence on Multiple Myeloma Progression and Patient Survival
Exploring Oncogenic Factors Influence on Multiple Myeloma Progression and Patient Survival Open
Backgrounds Multiple myeloma (MM), one of the most prevalent hematological malignancies, is characterized by the proliferation of plasma cells within bone marrow and concurrent development of osteolytic lesions. The persi…
View article: Genetics, environmental stress, and amino acid supplementation affect lactational performance via mTOR signaling pathway in bovine mammary epithelial cells
Genetics, environmental stress, and amino acid supplementation affect lactational performance via mTOR signaling pathway in bovine mammary epithelial cells Open
Mammary glands are known for their ability to convert nutrients present in the blood into milk contents. In cows, milk synthesis and the proliferation of cow mammary epithelial cells (CMECs) are regulated by various factors, including nutr…
View article: Editorial: Genetic markers identification for animal production and disease resistance
Editorial: Genetic markers identification for animal production and disease resistance Open
EDITORIAL article Front. Genet., 12 July 2023Sec. Livestock Genomics Volume 14 - 2023 | https://doi.org/10.3389/fgene.2023.1243793
View article: TME-targeted approaches of brain metastases and its clinical therapeutic evidence
TME-targeted approaches of brain metastases and its clinical therapeutic evidence Open
The tumor microenvironment (TME), which includes both cellular and non-cellular elements, is now recognized as one of the major regulators of the development of primary tumors, the metastasis of which occurs to specific organs, and the res…
View article: Reprogramming tumor-associated macrophages as a unique approach to target tumor immunotherapy
Reprogramming tumor-associated macrophages as a unique approach to target tumor immunotherapy Open
In the last ten years, it has become increasingly clear that tumor-infiltrating myeloid cells drive not just carcinogenesis via cancer-related inflammatory processes, but also tumor development, invasion, and metastasis. Tumor-associated m…
View article: Factors affecting superovulation induction in goats (Capra hericus): An analysis of various approaches
Factors affecting superovulation induction in goats (Capra hericus): An analysis of various approaches Open
Goats are generally called a “poor man's cow” because they not only provide meat and milk but also other assistance to their owners, including skins for leather production and their waste, which can be used as compost for fertilizer. Multi…
View article: Genetic polymorphisms in immune- and inflammation-associated genes and their association with bovine mastitis resistance/susceptibility
Genetic polymorphisms in immune- and inflammation-associated genes and their association with bovine mastitis resistance/susceptibility Open
Bovine mastitis, the inflammation of the mammary gland, is a contagious disease characterized by chemical and physical changes in milk and pathological changes in udder tissues. Depressed immunity and higher expression of inflammatory cyto…
View article: Role of LGMN in tumor development and its progression and connection with the tumor microenvironment
Role of LGMN in tumor development and its progression and connection with the tumor microenvironment Open
Legumain (LGMN) has been demonstrated to be overexpressed not just in breast, prostatic, and liver tumor cells, but also in the macrophages that compose the tumor microenvironment. This supports the idea that LGMN is a pivotal protein in r…
View article: Knowledge, Attitude and Practice towards Covid-19 in Different Universities across Khyber Pakhtunkhwa, Pakistan
Knowledge, Attitude and Practice towards Covid-19 in Different Universities across Khyber Pakhtunkhwa, Pakistan Open
There have been 6,566,610 fatalities and 626,337,158 reported cases of COVID-19 worldwide. Pakistan presently has over 1,573,922 confirmed cases and 30,625 deaths. A survey-based study was performed from January to September 2022 among dif…
View article: Overview of the effect of rumen-protected limiting amino acids (methionine and lysine) and choline on the immunity, antioxidative, and inflammatory status of periparturient ruminants
Overview of the effect of rumen-protected limiting amino acids (methionine and lysine) and choline on the immunity, antioxidative, and inflammatory status of periparturient ruminants Open
Overproduction of reactive oxygen species (ROS) is a well-known phenomenon experienced by ruminants, especially during the transition from late gestation to successful lactation. This overproduction of ROS may lead to oxidative stress (OS)…
View article: Immunoinformatics design of B and T-cell epitope-based SARS-CoV-2 peptide vaccination
Immunoinformatics design of B and T-cell epitope-based SARS-CoV-2 peptide vaccination Open
SARS-COV-2 is a virulent respiratory virus, first identified in China (Wuhan) at the end of 2019. Scientists and researchers are trying to find any possible solution to this deadly viral disease. Different drug source agents have been iden…
View article: A Comprehensive Sequencing Analysis of Testis-Born miRNAs in Immature and Mature Indigenous Wandong Cattle (Bos taurus)
A Comprehensive Sequencing Analysis of Testis-Born miRNAs in Immature and Mature Indigenous Wandong Cattle (Bos taurus) Open
Micro RNAs (miRNAs) have been recognized as important regulators that are indispensable for testicular development and spermatogenesis. miRNAs are endogenous transcriptomic elements and mainly regulate the gene expression at post-transcrip…
View article: Genetic resilience in chickens against bacterial, viral and protozoal pathogens
Genetic resilience in chickens against bacterial, viral and protozoal pathogens Open
The genome contributes to the uniqueness of an individual breed, and enables distinctive characteristics to be passed from one generation to the next. The allelic heterogeneity of a certain breed results in a different response to a pathog…
View article: A genome-wide integrated analysis of lncRNA-mRNA in melanocytes from white and brown skin hair boer goats (Capra aegagrus hircus)
A genome-wide integrated analysis of lncRNA-mRNA in melanocytes from white and brown skin hair boer goats (Capra aegagrus hircus) Open
Long noncoding RNAs (lncRNAs) are involved in many biological processes and have been extensively researched. Nonetheless, literature focusing on the roles of lncRNA in melanocytes is limited. Melanocytes are located in the basal layer of …
View article: Comparison of Low Back Pain in Working and Non-Working Pregnant Females
Comparison of Low Back Pain in Working and Non-Working Pregnant Females Open
Background: Pregnancy is the period during which a fetus develops inside the uterus or womb of a female. Low back pain is common during pregnancy, and it can have serious effects on physical, mental, emotional health during daily activitie…
View article: Circular RNA Expression and Regulation Profiling in Testicular Tissues of Immature and Mature Wandong Cattle (Bos taurus)
Circular RNA Expression and Regulation Profiling in Testicular Tissues of Immature and Mature Wandong Cattle (Bos taurus) Open
Wandong cattle are an autochthonous Chinese breed used extensively for beef production. The breed tolerates extreme weather conditions and raw feed and is resistant to tick-borne diseases. However, the genetic basis of testis development a…
View article: Association of DGAT1 With Cattle, Buffalo, Goat, and Sheep Milk and Meat Production Traits
Association of DGAT1 With Cattle, Buffalo, Goat, and Sheep Milk and Meat Production Traits Open
Milk fatty acids are essential for many dairy product productions, while intramuscular fat (IMF) is associated with the quality of meat. The triacylglycerols (TAGs) are the major components of IMF and milk fat. Therefore, understanding the…
View article: Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profiles in Testes of Calves and Sexually Mature Wandong Bulls (Bos taurus)
Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profiles in Testes of Calves and Sexually Mature Wandong Bulls (Bos taurus) Open
The mRNAs and long non-coding RNAs axes are playing a vital role in the regulating of post-transcriptional gene expression. Thereby, elucidating the expression pattern of mRNAs and long non-coding RNAs underlying testis development is cruc…
View article: Impact of Cryopreservation on Spermatozoa Freeze-Thawed Traits and Relevance OMICS to Assess Sperm Cryo-Tolerance in Farm Animals
Impact of Cryopreservation on Spermatozoa Freeze-Thawed Traits and Relevance OMICS to Assess Sperm Cryo-Tolerance in Farm Animals Open
Sperm cryopreservation is a powerful tool for the livestock breeding program. Several technical attempts have been made to enhance the efficiency of spermatozoa cryopreservation in different farm animal species. However, it is well-recogni…