Mahmoud S. Tolba
YOU?
Author Swipe
View article: Synthesis of Antimicrobial Quinoline Derivatives Enabled by Synergistic Pd/Enamine Catalysis: Experimental and Computational Study
Synthesis of Antimicrobial Quinoline Derivatives Enabled by Synergistic Pd/Enamine Catalysis: Experimental and Computational Study Open
View article: Thiopental-Inspired alkylpyrimidines as dual-target antimicrobial agents: Synthesis, biological activity, and molecular docking validation
Thiopental-Inspired alkylpyrimidines as dual-target antimicrobial agents: Synthesis, biological activity, and molecular docking validation Open
Alkylpyrimidine derivatives, particularly thiopental-based analogs, have emerged as promising scaffolds for antimicrobial drug development. In this study, we designed and synthesized a series of novel thiopental-pyrimidine hybrids (3a–c, 4…
View article: Psychological antecedents of vaccine inequity: keys to improve the rates of vaccination
Psychological antecedents of vaccine inequity: keys to improve the rates of vaccination Open
View article: Multicomponent approach to the synthesis and spectral characterization of some 3,5-pyrazolididione derivatives and evaluation as anti-inflammatory agents
Multicomponent approach to the synthesis and spectral characterization of some 3,5-pyrazolididione derivatives and evaluation as anti-inflammatory agents Open
Pyrazolones are a class of heterocyclic compounds that contain a pyrazole ring fused to a ketone group. Recent scientific research has focused extensively on the potential anti-inflammatory properties of pyrazolone compounds due to their d…
View article: Green synthesis of some tetrahydroquinoline derivatives and evaluation as anticancer agents
Green synthesis of some tetrahydroquinoline derivatives and evaluation as anticancer agents Open
This study demonstrates the design and synthesis of heterocyclic compounds with diverse biological effects. Using an ionic liquid catalyst, a sonosynthetic approach for the assembly of bis-arylidene cycloalkanone derivatives (bis-chalcones…
View article: Combined experimental and TD-DFT/DMOl3 investigations, optical properties, and photoluminescence behavior of a thiazolopyrimidine derivative
Combined experimental and TD-DFT/DMOl3 investigations, optical properties, and photoluminescence behavior of a thiazolopyrimidine derivative Open
View article: Detection of Ceftriaxone antibiotic and removal via complexation with Fe (III)
Detection of Ceftriaxone antibiotic and removal via complexation with Fe (III) Open
Antibiotic pollution in the aquatic environment has emerged as one of the most serious concerns caused by the use of pharmaceuticals and personal care products (PPCPs).Antibiotic levels in wastewater from pharmaceutical factories and hospi…
View article: CCDC 2122824: Experimental Crystal Structure Determination
CCDC 2122824: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis, crystal structure, and a molecular modeling approach to identify effective antiviral hydrazide derivative against the main protease of SARS-CoV-2
Synthesis, crystal structure, and a molecular modeling approach to identify effective antiviral hydrazide derivative against the main protease of SARS-CoV-2 Open
View article: Solid-State Luminescent Materials Containing Both Indole and Pyrimidine Moieties: Design, Synthesis, and Density Functional Theory Calculations
Solid-State Luminescent Materials Containing Both Indole and Pyrimidine Moieties: Design, Synthesis, and Density Functional Theory Calculations Open
Heterocyclic compounds with effective solid-state luminescence offer a wide range of uses. It has been observed that combining pyrimidine and indole moieties in a single molecule can enhance material behavior dramatically. Here, different …
View article: Design, synthesis and antimicrobial screening of some new thienopyrimidines
Design, synthesis and antimicrobial screening of some new thienopyrimidines Open
Heterocyclic compounds play an important role in our life due to their biological importance in the struggle of microorganisms.Herein, a series of novel hybrid compounds of thienopyrimidine with triazine and pyrimidine scaffolds were synth…
View article: An overview on synthesis and reactions of coumarin based compounds
An overview on synthesis and reactions of coumarin based compounds Open
Oxygen-containing heterocycles are largely distributed in natural and synthetic compounds. Coumarins are among the most famous heterocycles which possess one oxygen atom in their rings. Coumarins are classified as multifunctional scaffold …
View article: Synthesis of new distyrylpyridine analogues bearing amide substructure as effective insecticidal agents
Synthesis of new distyrylpyridine analogues bearing amide substructure as effective insecticidal agents Open
In examining for unique insecticidal agents, two derivatives namely, 2-((3-cyano-4,6-distyrylpyridin-2-yl)thio)-N-(4-nitrophenyl)acetamide (2) and 3-amino-N-(4-nitrophenyl)-4,6-distyrylthieno[2,3-b]pyridine-2-carboxamide (3) were synthesiz…
View article: Synthesis, reactions, and applications of pyrimidine derivatives
Synthesis, reactions, and applications of pyrimidine derivatives Open
Pyrimidine compounds continue to attract great interest in the field of organic synthesis due to their various chemical and biological applications observed, especially in recent times. As a result, this review covering some periods from 1…
View article: Synthesis and spectral characterization of some new thiazolopyrimidine derivatives
Synthesis and spectral characterization of some new thiazolopyrimidine derivatives Open
Thiazolopyrimidnes are considered one of the most interesting classes in heterocyclic chemistry due to their pharmaceutical importance. Herein, we report the synthesis of some new heterocyclic compounds containing thiazolopyrimidine starti…
View article: Mechanistic Similarity of Immuno-modulatory and Anti-viral Effects of Chloroquine and Quercetin (The Naturally Occurring Flavonoid)
Mechanistic Similarity of Immuno-modulatory and Anti-viral Effects of Chloroquine and Quercetin (The Naturally Occurring Flavonoid) Open
In the Pandemic of COVID-19 infection caused by SARS-CoV-2, no longer the age and preliminary health status are barriers against this disease-associated morbidity and mortality.In COVID-19 a dysregulated immune response and an exaggerated …
View article: Synthesis and antimicrobial activity of some new thienopyrimidine derivatives
Synthesis and antimicrobial activity of some new thienopyrimidine derivatives Open
Due to the biological activities of pyrimidine and thienopyrimidine as antimicrobial agents, so in the present work, a series of new heterocyclic compounds containing thienopyrimidine moiety were synthesized such as, tetrazolo[1",5":1',6']…