Muhammad Shahzeb Khan
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View article: Global Trends and Forecast of Cardiovascular Diseases, Cancer, and Shared Risk Factors: Insights From the GBD 2021
Global Trends and Forecast of Cardiovascular Diseases, Cancer, and Shared Risk Factors: Insights From the GBD 2021 Open
Background Cardiovascular disease (CVD) and cancer share multiple risk factors and are the leading causes of morbidity and death worldwide. This study aims to examine historical and projected trends of the combined CVD–cancer global estima…
View article: Population‐Based Study on the Coexistence of Metabolic Dysfunction‐Associated Steatotic Liver Disease and Chronic Kidney Disease
Population‐Based Study on the Coexistence of Metabolic Dysfunction‐Associated Steatotic Liver Disease and Chronic Kidney Disease Open
Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) and chronic kidney disease (CKD) are important cardiovascular risk factors. However, the prognostic impact of coexisting MASLD and CKD remains understudied. Method…
View article: Trends and disparities in mortality due to hypertensive disease and coexisting obesity in the USA: 1999–2023
Trends and disparities in mortality due to hypertensive disease and coexisting obesity in the USA: 1999–2023 Open
Background Hypertensive disease and obesity frequently coexist and synergistically increase the risk of cardiovascular morbidity and mortality in the USA. Despite this intersection, national trends and disparities in mortality attributable…
View article: Exploring Critical Efficiency Factors in Public Procurement of Goods Type: An Input for Designing an Efficient Decision Support System
Exploring Critical Efficiency Factors in Public Procurement of Goods Type: An Input for Designing an Efficient Decision Support System Open
The public finance management and public procurement, work in close integration to achieve the policy goals & strategic development objectives. It is estimated that the size of public procurement is more than 13 trillion US dollars per yea…
View article: iCARDIO Alliance Global Implementation Guidelines on Heart Failure 2025
iCARDIO Alliance Global Implementation Guidelines on Heart Failure 2025 Open
Inconsistencies in healthcare access, varying infrastructure, resource constraints and diverse local practices as well as practical and political issues restrict the global applicability of currently available guidelines. There is a need f…
View article: Outdoor RGB and Point Cloud Depth Dataset for Palm Oil Fresh Fruit Bunch Ripeness Classification and Localization
Outdoor RGB and Point Cloud Depth Dataset for Palm Oil Fresh Fruit Bunch Ripeness Classification and Localization Open
View article: Cardiac wasting in patients with advanced cancer: state of the art review
Cardiac wasting in patients with advanced cancer: state of the art review Open
Cardiac wasting, a complex and understudied phenomenon, is observed in up to 40% of patients with advanced cancer, contributing to 20-30% of mortality within this cohort. This condition represents a significant determinant of impaired qual…
View article: Intravenous Ferric Carboxymaltose in Heart Failure With Iron Deficiency
Intravenous Ferric Carboxymaltose in Heart Failure With Iron Deficiency Open
Importance Uncertainty remains about the efficacy of intravenous iron in patients with heart failure and iron deficiency. Objective To assess the efficacy and safety of ferric carboxymaltose in patients with heart failure and iron deficien…
View article: Procedural Complications and Inpatient Outcomes of Leadless Pacemaker Implantations in Rural Versus Urban Hospitals in the United States
Procedural Complications and Inpatient Outcomes of Leadless Pacemaker Implantations in Rural Versus Urban Hospitals in the United States Open
Background Disparities in invasive cardiovascular care and outcomes in rural and urban hospitals across the United States have been reported. However, studies investigating disparities regarding leadless pacemaker outcomes and complication…
View article: Cerebral Blood Flow in Orthostatic Intolerance
Cerebral Blood Flow in Orthostatic Intolerance Open
Cerebral blood flow (CBF) is vital for delivering oxygen and nutrients to the brain. Many forms of orthostatic intolerance (OI) involve impaired regulation of CBF in the upright posture, which results in disabling symptoms that decrease qu…
View article: Efficacy of GLP-1 Receptor Agonists in Patients With Heart Failure and Mildly Reduced or Preserved Ejection Fraction: A Systematic Review and Meta-Analysis
Efficacy of GLP-1 Receptor Agonists in Patients With Heart Failure and Mildly Reduced or Preserved Ejection Fraction: A Systematic Review and Meta-Analysis Open
GLP-1RAs reduce worsening HF events and the composite of CV death or worsening HF in HFpEF, particularly in patients with obesity or diabetes. These findings support their role as a promising therapy requiring further HFpEF-focused trials.
View article: Diuretic Potentiation Strategies in Acute Heart Failure
Diuretic Potentiation Strategies in Acute Heart Failure Open
View article: Aldosterone and Potassium in Heart Failure: Overcoming This Major Impediment in Clinical Practice
Aldosterone and Potassium in Heart Failure: Overcoming This Major Impediment in Clinical Practice Open
Aldosterone is a key regulator of fluid and electrolyte balance in the body. It is often dysregulated in heart failure (HF) and is a key driver of cardiac remodelling and worse clinical outcomes. Potassium regulation is essential for norma…
View article: Trends and disparities in cardiovascular disease–related mortality among adults with myeloproliferative neoplasms in USA
Trends and disparities in cardiovascular disease–related mortality among adults with myeloproliferative neoplasms in USA Open
Aims We aimed to perform a retrospective cohort study using the Centers for Disease Control and Prevention’s (CDC’s) Wide-Ranging Online Data for Epidemiologic Research (WONDER) database to analyse the trends in cardiovascular disease (CVD…
View article: Incidence of atrial fibrillation in patients with an insertable cardiac monitor and symptomatic heart failure
Incidence of atrial fibrillation in patients with an insertable cardiac monitor and symptomatic heart failure Open
Aims We aim to evaluate the incidence of atrial fibrillation (AF) in a large real‐world cohort of patients implanted with an insertable cardiac monitor (ICM) who had a clinical history of symptomatic heart failure (HF) with reduced or pres…
View article: Sodium-Glucose Cotransporter 2 Inhibitor Use and Outcomes in Transthyretin Amyloid Cardiomyopathy
Sodium-Glucose Cotransporter 2 Inhibitor Use and Outcomes in Transthyretin Amyloid Cardiomyopathy Open
View article: Personalized Intervention Strategy Based on a Risk Score Generated From Subcutaneous Insertable Cardiac Monitor: Results From Phase 1 of ALLEVIATE‐HF
Personalized Intervention Strategy Based on a Risk Score Generated From Subcutaneous Insertable Cardiac Monitor: Results From Phase 1 of ALLEVIATE‐HF Open
Background Diagnostic variables from insertable cardiac monitors may be useful in identifying patients at increased risk of heart failure (HF) events. High‐risk alerts must be coupled with interventions to improve outcomes. We aim to asses…
View article: Hospitalization of Symptomatic Patients With Heart Failure and Moderate to Severe Functional Mitral Regurgitation Treated With MitraClip
Hospitalization of Symptomatic Patients With Heart Failure and Moderate to Severe Functional Mitral Regurgitation Treated With MitraClip Open
These results indicate that a broader application of M-TEER in addition to optimal guideline-directed medical therapy should be considered among patients with symptomatic HF and moderate to severe FMR, particularly in those with a history …
View article: Trajectory of C-Reactive Protein and Incident Heart Failure in Black Adults: The Jackson Heart Study
Trajectory of C-Reactive Protein and Incident Heart Failure in Black Adults: The Jackson Heart Study Open
BACKGROUND: Increased hsCRP (high-sensitivity C-reactive protein), a marker of inflammation, is associated with incident cardiovascular events. We aim to determine whether the baseline or trajectory of hsCRP levels over time predicts incid…
View article: From Hospital to Home
From Hospital to Home Open
Heart failure (HF) is a leading cause of hospitalization in older adults. Patients are at high risk of readmission and death following hospitalization for HF. There is no standard approach of health care delivery during the hospital-to-hom…
View article: Interleukin-6 and Cardiovascular Events in Healthy Adults
Interleukin-6 and Cardiovascular Events in Healthy Adults Open
View article: Chitosan-Based Adsorbents and Catalysts for Removal of Toxic Pollutants from Water and Wastewater
Chitosan-Based Adsorbents and Catalysts for Removal of Toxic Pollutants from Water and Wastewater Open
View article: The effect of SGLT2 inhibitors on health status in patients with heart failure: a systematic review and meta-analysis
The effect of SGLT2 inhibitors on health status in patients with heart failure: a systematic review and meta-analysis Open
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been shown to improve health status in patients with heart failure (HF). We aim to evaluate the effect of SGLT2i on health status [by Kansas City Cardiomyopathy Questionnaire (KCCQ)] …
View article: Vericiguat and Cardiovascular Outcomes in Heart Failure by Baseline Diabetes Status
Vericiguat and Cardiovascular Outcomes in Heart Failure by Baseline Diabetes Status Open
View article: Percutaneous repair of moderate‐to‐severe or severe functional mitral regurgitation in patients with symptomatic heart failure: Baseline characteristics of patients in the <scp>RESHAPE‐HF2</scp> trial and comparison to <scp>COAPT</scp> and <scp>MITRA‐FR</scp> trials
Percutaneous repair of moderate‐to‐severe or severe functional mitral regurgitation in patients with symptomatic heart failure: Baseline characteristics of patients in the <span>RESHAPE‐HF2</span> trial and comparison to <span>COAPT</span> and <span>MITRA‐FR</span> trials Open
Aim The RESHAPE‐HF2 trial is designed to assess the efficacy and safety of the MitraClip device system for the treatment of clinically important functional mitral regurgitation (FMR) in patients with heart failure (HF). This report describ…
View article: Effect of SGLT2 inhibitors on heart failure outcomes and cardiovascular death across the cardiometabolic disease spectrum: a systematic review and meta-analysis
Effect of SGLT2 inhibitors on heart failure outcomes and cardiovascular death across the cardiometabolic disease spectrum: a systematic review and meta-analysis Open
None.
View article: Empagliflozin in the treatment of heart failure
Empagliflozin in the treatment of heart failure Open
Heart failure (HF) affects more than 60 million individuals globally. Empagliflozin is currently approved for type 2 diabetes and chronic HF. Clinical trials have demonstrated that empagliflozin reduces the composite end point of hospitali…
View article: Eligibility and Projected Benefits of Rapid Initiation of Quadruple Therapy for Newly Diagnosed Heart Failure
Eligibility and Projected Benefits of Rapid Initiation of Quadruple Therapy for Newly Diagnosed Heart Failure Open
In this nationwide U.S. cohort of patients hospitalized for newly diagnosed HFrEF, >4 of 5 patients were projected as eligible for quadruple therapy at discharge; yet, <1 in 6 were prescribed it. If clinical trial benefits can be fully rea…
View article: Closing the Last Mile Gap in Access to Multimodality Imaging in Rural Settings: Design of the Imaging Core of the Risk Underlying Rural Areas Longitudinal Study
Closing the Last Mile Gap in Access to Multimodality Imaging in Rural Settings: Design of the Imaging Core of the Risk Underlying Rural Areas Longitudinal Study Open
Achieving optimal cardiovascular health in rural populations can be challenging for several reasons including decreased access to care with limited availability of imaging modalities, specialist physicians, and other important health care …
View article: Disparities in heart failure between White, Black, and Hispanic young adults: insights from the National Health and Nutrition Examination Survey
Disparities in heart failure between White, Black, and Hispanic young adults: insights from the National Health and Nutrition Examination Survey Open
Background: The prevalence of heart failure (HF) is increasing among young adults in the United States with pervasive racial and ethnic differences in this population. Objective: To evaluate contemporary associations between race and ethni…