Muhammad Suleman
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Exploring the hub gene CERS6 as a therapeutic target in type 1 diabetes through a bioinformatics and network analyst approach Open
Insulin-producing β-cells are destroyed in type 1 diabetes mellitus (T1DM), a chronic autoimmune disease that results in complete insulin insufficiency and metabolic dysfunction. According to a survival study that used p values, some hub g…
An Econometric Analysis of Income, Education and Residential Status on Family Education Expenditures Open
This study assesses family spending on higher education in Pakistan. It researches the components and variables completing the families spending on schooling utilizing information from PSLM data 2018-19. The results derived from estimation…
Radiation shielding properties of selenium-based lead borate PbO-SeO2-B2O3 glass for X-ray and gamma radiation Open
The radiation shielding properties of selenium-based lead borate glass systems xSeO2 + (25-x) B2O3 + 75PbO (x = 0, 0.2, 0.4, 0.6) were investigated using the MCNPx simulation and the Phy-x/PSD program in the energy range of 0.015–15 MeV. T…
The homoplasmic MT-TK m.8357T > C mtDNA variant as a cause of multiorgan mitochondrial disease Open
The diagnosis of disorders associated with mitochondrial DNA (mtDNA) variants presents substantial complexity due to their genetic and clinical heterogeneity, which is largely influenced by mtDNA heteroplasmy. However, the level of heterop…
View article: Integrated systems biology and structural approaches to discover novel biomarkers and small molecule inhibitors using the gene expression data from drug-resistant breast cancer cell lines
Integrated systems biology and structural approaches to discover novel biomarkers and small molecule inhibitors using the gene expression data from drug-resistant breast cancer cell lines Open
Breast cancer, the leading cause of cancer-related deaths in women, is driven by multidrug resistance, highlighting the urgent need for novel therapeutic targets. Consequently, we employed network-based gene expression profiling to analyse…
View article: Trained Immunity and Its Potential Implications in the Etiopathogenesis of Hidradenitis Suppurativa: A New Paradigm in Chronic Inflammation?
Trained Immunity and Its Potential Implications in the Etiopathogenesis of Hidradenitis Suppurativa: A New Paradigm in Chronic Inflammation? Open
Hidradenitis suppurativa (HS) is a chronic auto‐inflammatory skin disorder characterised by recurrent, painful nodules, abscesses and tunnels, often leading to tissue destruction with a significant impairment in quality of life. Despite ad…
View article: Repurposing Nirmatrelvir for Hepatocellular Carcinoma: Network Pharmacology and Molecular Dynamics Simulations Identify HDAC3 as a Key Molecular Target
Repurposing Nirmatrelvir for Hepatocellular Carcinoma: Network Pharmacology and Molecular Dynamics Simulations Identify HDAC3 as a Key Molecular Target Open
Background: Hepatocellular carcinoma (HCC) is one of the most common and fatal malignancies worldwide, characterized by remarkable molecular heterogeneity and poor clinical outcomes. Despite advancements in diagnosis and treatment, the pro…
View article: Phytocompounds in Precision Dermatology: COX-2 Inhibitors as a Therapeutic Target in Atopic-Prone Skin
Phytocompounds in Precision Dermatology: COX-2 Inhibitors as a Therapeutic Target in Atopic-Prone Skin Open
Atopic dermatitis (AD) is a chronic, multifactorial inflammatory skin disease characterized by persistent pruritus, immune system dysregulation, and an increased expression of cyclooxygenase-2 (COX-2), an enzyme that plays a central role i…
View article: Genomic profiling in hidradenitis suppurativa: InterOmics pipeline for DNA-RNA sequencing highlights HLA variants, keratin-associated mutations and extracellular matrix alterations as contributing factors to HS pathogenesis
Genomic profiling in hidradenitis suppurativa: InterOmics pipeline for DNA-RNA sequencing highlights HLA variants, keratin-associated mutations and extracellular matrix alterations as contributing factors to HS pathogenesis Open
Hidradenitis suppurativa (HS) is a chronic autoinflammatory skin disorder with a complex genetic and molecular basis. To advance its characterization, we applied InterOmics, a novel bioinformatics pipeline integrating whole exome sequencin…
View article: Molecular Screening and Free Energy Calculations‐Based Exploration of Medicinal Phytocompounds Chemical Space to Abrogate G9R‐E4R Complex from Monkeypox: A Current Global Health Threat
Molecular Screening and Free Energy Calculations‐Based Exploration of Medicinal Phytocompounds Chemical Space to Abrogate G9R‐E4R Complex from Monkeypox: A Current Global Health Threat Open
The current monkeypox virus outbreak is probably linked with the novel substitutions in the G9R protein of the replication complex. The G9R‐E4R interface act as a potential druggable site for the inhibition of monkeypox replication. Theref…
View article: Large bore ultrasound guided vascular access: Single tertiary center experience.
Large bore ultrasound guided vascular access: Single tertiary center experience. Open
Objective: To share our ultrasound guided experience and demonstrate the need for implementation of ultrasound guided access in interventional cardiology and structural heart disease training programs in Pakistan. Design: Non-randomized, C…
View article: Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1α Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study
Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1α Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study Open
Background: Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1). For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional coactivator p…
Phase-field-informed machine learning on creep behavior of Ni-based single-crystal superalloys Open
Creep strain characterizes the degree of creep damage and the creep life of superalloys. The creep process is accompanied by element redistribution and microstructure evolution; understanding the multi-characteristic relationships of creep…
Antimicrobial Peptides Designed in silico: Safeguarding Against Botrytis cinerea and Food spoilage Open
Botrytis cinerea, a fungal pathogen known for causing grey mold diseases in post-harvest plant products, presents a serious global concern due to its impact on food safety and economic stability. To address this challenge, various studies …
View article: Stabilization of expansive soil using different combinations of glass powder and rice husk ash
Stabilization of expansive soil using different combinations of glass powder and rice husk ash Open
The global issue of expansive soil is the root cause of significant harm to structures designed for civil engineering. The difficulty with expansive soils is that they expand when water is absorbed and contract when it evaporates because o…
DETERMINATION OF RADIONUCLIDES IN SOME SELECTED DUMPSITES WITHIN KANO METROPOLIS, KANO STATE NIGERIA Open
This research investigated the emission of radiation from refuse dumpsites in some selected areas in Kano metropolis. The readings were taken using Geiger Muller tube detector at gonad level (about 1 meter above the ground level) and at an…
Impact of Meteorological Conditions on the Photocatalytic Efficiency and Stability of Titanium Dioxide-Based Paint Open
Photocatalytic paints have proven to be a promising solution for combating air pollution in urban environments by breaking down harmful pollutants into harmless by-products. These paints interact with meteorological parameters when exposed…
Editorial: Experimental and computational methods in the development of diagnostics and therapeutics for colon cancer Open
Cancer continues to be one of the major causes of illness and death worldwide. It is growing an alarming rate, and affects every geographic region of the world. Therefore, the goal is to investigate novel biomarkers both experimentally and…
Experimental and Numerical Dynamic Analysis of a Water Conservation Nozzle for Sustainable Water Management in Pakistan Open
The water crisis is a global issue, and the situation in Pakistan is no different. With rapid population growth, improper resource management and climate change effects, Pakistan is approaching a state of water scarcity. Tap water is a maj…
Inappropriate antibiotic use in upper respiratory tract infections: prevalence and predictors from an outpatient cohort Open
Objectives Upper respiratory tract infections (URTIs) are among the most common reasons for outpatient visits, yet the majority are viral in origin and do not require antibiotics. Inappropriate antibiotic consumption contributes to antimic…
View article: Guillain-Barré Syndrome as Initial Presentation of Systemic Lupus Erythematosus: A Rare Diagnostic Challenge
Guillain-Barré Syndrome as Initial Presentation of Systemic Lupus Erythematosus: A Rare Diagnostic Challenge Open
Background: Guillain-Barré Syndrome (GBS) is a rare but serious autoimmune disorder that typically follows an infection and presents with ascending weakness and areflexia. Systemic Lupus Erythematosus (SLE), a multisystem autoimmune diseas…
View article: Evaluating the impact of Renewable and Non-Renewable Resources on CO2 Emissions and Sustainability
Evaluating the impact of Renewable and Non-Renewable Resources on CO2 Emissions and Sustainability Open
This study analyzes Pakistan’s energy system, distinguishing between renewable and non-renewable energy sources. We examine energy production decisions as Pakistan’s energy sector faces significant challenges including environmental concer…
Metabolomics Biomarkers in Prediction of Sudden Infant Death Syndrome: The Role of Short Chain Fatty Acids Open
Sudden Infant Death Syndrome (SIDS) presents a significant challenge, necessitating ongoing research and preventive measures. The intricate landscape of lipid metabolism plays a crucial role in SIDS, with disruptions in key lipid component…
Natural Compounds Targeting Thymic Stromal Lymphopoietin (TSLP): A Promising Therapeutic Strategy for Atopic Dermatitis Open
Atopic dermatitis (AD) is a chronic inflammatory skin disease with rising prevalence, marked by eczematous lesions, itching, and a weakened skin barrier often tied to filaggrin gene mutations. This breakdown allows allergen and microbe ent…