Tengku Sifzizul Tengku Muhammad
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The Interplay of Inflammation and Gut-Microbiota Dysbiosis in Alzheimer’s Disease: Mechanisms and Therapeutic Potential Open
Alzheimer’s disease (AD) represents a major global health challenge, characterised by progressive neurodegeneration that leads to cognitive decline. Inflammation is a key factor in the pathogenesis of AD, affecting both neuroinflammation a…
Aaptamine attenuates the action of statin on PCSK9 and LDLR expression as well as LDL-C uptake in human liver cells Open
Atherosclerosis is characterized by the buildup of lipid deposits and plaque formation resulting from consistently elevated levels of LDL-cholesterol (LDL-C) in the blood. This study investigates the effects of aaptamine on the regulation …
Cytotoxic effect and apoptotic induction of tricyclohexyltin p-methoxycinnamate on HT-29 colorectal cancer cells: Implications for anticancer therapeutics Open
Colorectal cancer’s escalating prevalence in Malaysia prompts the exploration of innovative anticancer agents; amidst this backdrop, tricyclohexyltin p-methoxycinnamate emerges as a synthesized organotin complex with unique bioactive prope…
Aaptamine Counteracts Statin-Induced PCSK9 Elevation to Improve LDL Receptor Expression and Cholesterol Uptake Open
Atherosclerosis arises from lipid accumulation and plaque formation, primarily driven by elevated levels of LDL-cholesterol (LDL-C). PCSK9 plays a critical role by degrading LDL receptors (LDL-R), which are responsible for the clearance of…
Advancing Research on Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors: A Scientometric Analysis Open
Atherosclerosis is characterised by the accumulation of fatty deposits and plaque as a result of a continuously high level of low-density lipoprotein cholesterol (LDL-C) in the blood. The primary objective of this research is to assess the…
View article: Melaleuca cajuputi: Metabolites profiling and its potential against biofouling
Melaleuca cajuputi: Metabolites profiling and its potential against biofouling Open
Antifouling paint was introduced and utilized as a control to prevent the problem of biofouling. The Methanolic Crude Extract (MCE) and the Essential Oil (EO) were extracted from Melaleuca cajuputi. Gas Chromatography-Mass Spectrometry (GC…
View article: Effect of <i>Gracilaria changii</i> extract and its fraction in reverse cholesterol transport by targeting <i>SR-BI</i> gene
Effect of <i>Gracilaria changii</i> extract and its fraction in reverse cholesterol transport by targeting <i>SR-BI</i> gene Open
This present study aimed to investigate the effects of Gracilaria changii (Red seaweed) extract and its fraction on scavenger receptor class B type I (SR-BI) gene expressions. In vitro studies of the activity of G. changii extract and its …
The Interpretasi Keterampilan Proses Sains pada Mata Kuliah Praktikum Mekatronika 2 Open
This research was conducted to determine the level of Science Process Skills (SPS) of D4 Electrical Industrial Engineering students at Universitas Negeri Padang who programmed the mechatronics 2 laboratory course in the July-December 2023 …
Comprehensive Review on Mechanistic Insights, Optimal Dosages, and Safety Prospective of Natural Products in Anticancer Therapeutics Open
Cancer remains a formidable global health challenge, necessitating sustained research efforts to develop innovative and efficacious therapeutic modalities. The exploration of alternative cancer therapies has gained prominence, given the ad…
Cytotoxicity assays for cancer drug screening: methodological insights and considerations for reliable assessment in drug discovery Open
The importance of cytotoxicity assays in in vitro drug discovery investigations has led to their rising profile. Drugs and other substances can disrupt cell membranes, limit protein synthesis, and bind irreversibly to receptors, all of whi…
Selected Coastal Plants as Potential Treatment for Pneumonia Disease: Determination of Their Phytochemicals and Antibacterial Activity Against some Pneumonia Bacteria Open
Pneumonia is a respiratory infection caused by microorganisms including bacteria. Current treatment with antibiotics leads to bacterial resistance. An alternative treatment involves utilizing coastal plants. In this study, five parts of el…
Combined Multivariate Statistical Techniques and Water Quality Index (WQI) to Evaluate Spatial Variation in Water Quality Open
In present study, Water Quality Index (WQI) has been assessed of the Rawal Lake which is a major source of drinking water for people in the Federal Capital, Islamabad, and its adjacent city Rawalpindi in Pakistan. For this, the principal c…
Antibacterial activity of hexane and methanol fractions of some selected plants against Klebsiella pneumoniae Open
Besides adenovirus, pneumonia can also be caused by bacteria. One of the most common bacteria causing the pneumonia is Klebsiella pneumonia e. Currently, treatment by antibiotics has been widely used. Nevertheless, the increasing failure o…
Transcriptomic analysis reveals the differential genes associated with skin growth and pigmentation between Red Melon and Red Cover Discus Open
This is the first report to describe the differential growth of cutaneous pigments and the molecular processes involved in two red discus ( Symphysodon spp.), Red Melon and Red Cover, with different tones of red pigmentation develop from j…
Cutaneous transcriptomic profiling and candidate pigment genes in the wild discus (<i>Symphysodon</i> spp.) Open
Discus (Symphysodon spp.) is a popular freshwater ornamental fish with high market value due to its extraordinary skin pigmentation. The molecular mechanisms that govern skin colouration have yet to be identified. Six skin samples from wil…
View article: Effect of Linoleic Acid on Cholesterol Levels in a High-Fat Diet-Induced Hypercholesterolemia Rat Model
Effect of Linoleic Acid on Cholesterol Levels in a High-Fat Diet-Induced Hypercholesterolemia Rat Model Open
Cardiovascular disease is the leading cause of morbidity and mortality worldwide, accounting for almost one-third of all deaths. The risk factors for developing this disease include high levels of serum total cholesterol (TC), triglyceride…
View article: Xestospongia muta Fraction-7 and Linoleic Acid: Effects on SR-BI Gene Expression and HDL Cholesterol Uptake
Xestospongia muta Fraction-7 and Linoleic Acid: Effects on SR-BI Gene Expression and HDL Cholesterol Uptake Open
Xestospongia muta is a marine sponge belonging to the family Petrosiidae. It is an important source of biologically active marine natural products, with different kinds of essential fatty acids. Scavenger receptor class B type I (SR-BI) is…
Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection Open
Analysis of cancer biomarkers has enormous promise for advancing our molecular understanding of illness and facilitating more precise and timely diagnosis and follow-up care. MicroRNA, exosomes, ctDNA, CTCs, and proteins are only some of t…
View article: Carbon Stock Estimation of Selected Subtropical Broad-Leaved Evergreen Scrub Forest
Carbon Stock Estimation of Selected Subtropical Broad-Leaved Evergreen Scrub Forest Open
This research estimates the carbon stock of the subtropical broad-leaved evergreen scrub forest of Lehtrar, a revenue estate of Kotli Sattian, Rawalpindi, Punjab, Pakistan. A total of six nested co-centric plots of 17.84 m2 each were laid …
Formulation and Characterization of SNEDDS of Pandanus tectorius Fruit Extract and in vitro Antioxidant Activity Open
Excess reactive oxygen species can cause oxidative stress and lead to the progression of cardiovascular diseases. Pandanus tectorius fruit (PTF) is a promising source of herbal medicine with antioxidant activity. However, the oral administ…
Acanthaster planci Inhibits PCSK9 Gene Expression via Peroxisome Proliferator Response Element (PPRE) and Activation of MEK and PKC Signaling Pathways in Human Liver Cells Open
A constantly elevated level of low-density lipoprotein cholesterol (LDL-C) is mainly associated with the development of atherosclerosis. The use of statins as a treatment for reducing plasma LDL-C levels has led, in some cases, to adverse …
CCDC 2061050: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2061049: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
Characterization and cytotoxicity of low-molecular-weight chitosan and chito-oligosaccharides derived from tilapia fish scales Open
The present study evaluated the physicochemical characterization and cytotoxicity activity of chitosan and chito-oligosaccharides (COSs). The extraction of chitosan and COSs was executed by chemical hydrolysis. The physicochemical characte…
Acanthaster planci Inhibits PCSK9 and Lowers Cholesterol Levels in Rats Open
Atherosclerosis is the main cause of cardiovascular diseases which in turn, lead to the highest number of mortalities globally. This pathophysiological condition is developed due to a constant elevated level of plasma cholesterols. Statin …
Acaudina molpadioides mediates lipid uptake by suppressing PCSK9 transcription and increasing LDL receptor in human liver cells Open
Acaudina molpadioides has been long used as traditional medicinal resources and reported to demonstrate various important bioactivities such as anticoagulation, antithrombosis, anti-hyperglycemia and anticancer. However, its lipid lowering…
Natural Compound 3β,7β,25-trihydroxycucurbita-5,23(E)-dien-19-al from Momordica charantia Acts as PPARγ Ligand Open
Momordica charantia is a popular vegetable associated with effective complementary and alternative diabetes management in some parts of the world. However, the molecular mechanism is less commonly investigated. In this study, we investigat…
Induction of Apoptosis by Acanthaster planci sp., and Diadema setosum sp., Fractions in Human Cervical Cancer Cell Line, HeLa Open
The potent bioactive compounds might be responsible for inducing apoptosis in cancer cells and, thus, the potential to be a successful candidate for exploring upcoming chemotherapeutic drugs.
Xylocarpus Moluccensis Induces Cytotoxicity in Human Hepatocellular Carcinoma HepG2 Cell Line via Activation of the Extrinsic Pathway Open
Thus, the present study suggests the remarkable potential of active metabolites in the extract of Xylocarpus moluccensis as a future therapeutic agent for the treatment of cancer..