Muhammad Usman Minhas
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View article: Sepsis in the ICU: are we missing the basics while chasing biomarkers?
Sepsis in the ICU: are we missing the basics while chasing biomarkers? Open
Sepsis remains one of the most challenging issues related to the intensive care unit, where the morbidity and mortality remain high, despite progress in diagnostic and treatment. Early identification, early administration of antibiotics, v…
View article: Impact of Coping Strategies on Behavioral Problems among Rescue 1122 Employees
Impact of Coping Strategies on Behavioral Problems among Rescue 1122 Employees Open
The present study aimed to examine the level of depression anxiety and stress with coping strategies among employees of Rescue1122. The sample consisted of N=450 Rescue 1122 employees (males). The participants were selected through stratif…
View article: Post-intensive care syndrome (PICS): A call for continuity beyond discharge
Post-intensive care syndrome (PICS): A call for continuity beyond discharge Open
Innovations in Intensive Care Units (ICU) have increased survival rates, but several patients experience Post-Intensive Care Syndrome (PICS), which encompasses persistent physical, cognitive, and psychological disability. The research emph…
View article: The Role of Neurotrophic Modulation in COPD and Its Influence on Airway Pathophysiology: A Systematic Review and Meta-Analysis
The Role of Neurotrophic Modulation in COPD and Its Influence on Airway Pathophysiology: A Systematic Review and Meta-Analysis Open
Background: Chronic obstructive pulmonary disease (COPD) is a chronic pulmonary disorder that is characterized by inflammation in the airways and their remodeling. Neurotrophic factors, such as nerve growth factor (NGF) and brain-derived n…
View article: Frequency and Characteristics of Hypothyroidism in Neonatal Intensive Care Unit Patients in a Tertiary Care Hospital
Frequency and Characteristics of Hypothyroidism in Neonatal Intensive Care Unit Patients in a Tertiary Care Hospital Open
Objective: To Investigate frequency, clinical and laboratory profiles of hypothyroidism in neonates admitted to the Neonatal Intensive Care Unit (NICU) in a tertiary care hospital. Methodology: This Prospective, cross-sectional study Neona…
View article: Correction: Ijaz et al. Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing. Polymers 2022, 14, 376
Correction: Ijaz et al. Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing. Polymers 2022, 14, 376 Open
In the original publication [...]
View article: Insights Into the Assessment of WHO-Recommended Practices Based on Surgical Operations in Tertiary Healthcare Settings
Insights Into the Assessment of WHO-Recommended Practices Based on Surgical Operations in Tertiary Healthcare Settings Open
View article: A Systematic Review on Insights to Community Medicine and Clinical Research: Competency Training in Medical and Dental Education
A Systematic Review on Insights to Community Medicine and Clinical Research: Competency Training in Medical and Dental Education Open
Background: Competency based training in medical and dental education has become important to train healthcare professionals to tackle clinical, cultural, and social aspects of healthcare. The innovations and developments in these training…
View article: β-Cyclodextrin-based Stimuli-Responsive Nanogels for Gymnema sylvestre: Therapeutic Potential and Safety evaluation in Diabetic conditions
β-Cyclodextrin-based Stimuli-Responsive Nanogels for Gymnema sylvestre: Therapeutic Potential and Safety evaluation in Diabetic conditions Open
Historically, herbal medicines have played a significant role in treating various illnesses. Specifically concerning diabetes, numerous plant-based remedies have been utilized to regulate blood sugar levels and improve insulin sensitivity.…
View article: Outcome and Associated Clinical Features of Neonates with Acute Kidney Injury (AKI) admitted in NICU of a Tertiary care set up: A Cross-Sectional Study
Outcome and Associated Clinical Features of Neonates with Acute Kidney Injury (AKI) admitted in NICU of a Tertiary care set up: A Cross-Sectional Study Open
Objective: To determine the clinical features, risk factors and outcome of neonates developed early AKI in neonates admitted in NICU of a tertiary care set up. Methodology: This Cross sectional study was conducted at Neonatal ICUs of Fatim…
View article: Role of Microbiology in Tackling Antimicrobial Resistance: Implications for Food Safety and Public Health
Role of Microbiology in Tackling Antimicrobial Resistance: Implications for Food Safety and Public Health Open
Antimicrobial resistance (AMR) represents a burgeoning worldwide health hazard with profound consequences for public health, food safety, and the efficacy of contemporary treatment. This review examines the significance of microbiology in …
View article: Predictive Analysis of Breast Cancer Survival Using Machine Learning, Deep Learning, and GPT-4
Predictive Analysis of Breast Cancer Survival Using Machine Learning, Deep Learning, and GPT-4 Open
View article: Enumeration of CD3ˉCD56⁺CD16⁺ and NKG2D⁺ Natural Killer Cells in Breast Cancer Patients
Enumeration of CD3ˉCD56⁺CD16⁺ and NKG2D⁺ Natural Killer Cells in Breast Cancer Patients Open
Introduction: Breast cancer is a malignant disease of breast tissue. The immune system consists of cells, molecules, and organs that play a vital role in eliminating pathogens, toxins, allergens, and tumor cells. Cytotoxic T cells (CD8+) a…
View article: Circulating Tumor Cells may be an Early Diagnostic Marker for Disease Progression in Patients with Breast Carcinoma
Circulating Tumor Cells may be an Early Diagnostic Marker for Disease Progression in Patients with Breast Carcinoma Open
Background: Cancer affects millions of people around the world. In Pakistan, breast cancer (BC) is the leading cause of death in women. Once the tumor has established itself, tumor cells shed and enter the blood circulation to metastasize …
View article: IOT IN HEALTHCARE: EXPLORING THE INTEGRATION OF INTERNET OF THINGS DEVICES IN ENHANCING PATIENT CARE. A BIBLIOMETRIC REVIEW
IOT IN HEALTHCARE: EXPLORING THE INTEGRATION OF INTERNET OF THINGS DEVICES IN ENHANCING PATIENT CARE. A BIBLIOMETRIC REVIEW Open
Background: The Internet of Things (IoT) has emerged as a transformative force in healthcare, offering significant potential to enhance patient care through connected devices. Understanding the research trends and contributions in this fie…
View article: Deferasirox nanosuspension loaded dissolving microneedles for ocular drug delivery
Deferasirox nanosuspension loaded dissolving microneedles for ocular drug delivery Open
Deferasirox (DFS) is an oral iron chelator that is employed in retinal ailments as a neuroprotectant against retinal injury and thus has utility in treating disorders such as excitoneurotoxicity and age-related macular degeneration (AMD). …
View article: pH-Sensitive Hydrogels Fabricated with Hyaluronic Acid as a Polymer for Site-Specific Delivery of Mesalamine
pH-Sensitive Hydrogels Fabricated with Hyaluronic Acid as a Polymer for Site-Specific Delivery of Mesalamine Open
Hydrogels with the main objective of releasing mesalamine (5-aminosalicylic acid) in the colon in a modified manner were formulated in the present work using a free-radical polymerization approach. Different ratios of hyaluronic acid were …
View article: Retraction Note: Understanding mechanical characteristics of pH-responsive PEG 4000-based polymeric network for colorectal carcinoma: its acute oral toxicity study
Retraction Note: Understanding mechanical characteristics of pH-responsive PEG 4000-based polymeric network for colorectal carcinoma: its acute oral toxicity study Open
View article: Author Correction: Evaluation of the anti-inflammatory, analgesic, anti-pyretic and anti-ulcerogenic potentials of synthetic indole derivatives
Author Correction: Evaluation of the anti-inflammatory, analgesic, anti-pyretic and anti-ulcerogenic potentials of synthetic indole derivatives Open
View article: A multiparametric study for size and stability of hybrid Fe <sub>2</sub> O <sub>3</sub> -NiO nanoparticles and their statistical transformation
A multiparametric study for size and stability of hybrid Fe <sub>2</sub> O <sub>3</sub> -NiO nanoparticles and their statistical transformation Open
Bimetallic mixed metal oxide hybrid nanoparticles of iron and nickel are prepared via the co-precipitation method and are characterized by various techniques. Optimization of these nanoparticles involves finding the optimal synthetic condi…
View article: Retraction Note: pH-responsive CAP-co-poly(methacrylic acid)-based hydrogel as an efficient platform for controlled gastrointestinal delivery: fabrication, characterization, in vitro and in vivo toxicity evaluation
Retraction Note: pH-responsive CAP-co-poly(methacrylic acid)-based hydrogel as an efficient platform for controlled gastrointestinal delivery: fabrication, characterization, in vitro and in vivo toxicity evaluation Open
View article: Retraction Note: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation
Retraction Note: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation Open
View article: RETRACTED: Khan et al. Poly (N-vinylcaprolactam-grafted-sodium alginate) Based Injectable pH/Thermo Responsive In Situ Forming Depot Hydrogels for Prolonged Controlled Anticancer Drug Delivery; In Vitro, In Vivo Characterization and Toxicity Evaluation. Pharmaceutics 2022, 14, 1050
RETRACTED: Khan et al. Poly (N-vinylcaprolactam-grafted-sodium alginate) Based Injectable pH/Thermo Responsive In Situ Forming Depot Hydrogels for Prolonged Controlled Anticancer Drug Delivery; In Vitro, In Vivo Characterization and Toxicity Evaluation. Pharmaceutics 2022, 14, 1050 Open
The journal retracts the article, “Poly (N-vinylcaprolactam-grafted-sodium alginate) Based Injectable pH/Thermo Responsive In Situ Forming Depot Hy-drogels for Prolonged Controlled Anticancer Drug Delivery; In Vitro, In Vivo Characterizati…
View article: Preparation, characterization, in-vitro and toxicological evaluation of carbopol based nanogels for solubility enhancement of Valsartan
Preparation, characterization, in-vitro and toxicological evaluation of carbopol based nanogels for solubility enhancement of Valsartan Open
Solubility is an essential criterion for attaining desired concentration of the drug within the systemic circulation to ensure intended pharmacological action. The main setback for the formulation development of new chemical entities and g…
View article: Deferasirox Nanosuspension Loaded Dissolving Microneedles for Intradermal Delivery
Deferasirox Nanosuspension Loaded Dissolving Microneedles for Intradermal Delivery Open
Microneedles are minimally invasive systems that can deliver drugs intradermally without pain and bleeding and can advantageously replace the hypodermal needles and oral routes of delivery. Deferasirox (DFS) is an iron chelator employed in…
View article: Carbopol Based Hydrogels for ITOPRIDE Hydrochloride Delivery; Synthesis, Characterization and Comparative Assessment with Various Monomers
Carbopol Based Hydrogels for ITOPRIDE Hydrochloride Delivery; Synthesis, Characterization and Comparative Assessment with Various Monomers Open
The objective of the current study was to synthesize and characterize carbopol containing hydrogels with different monomers such as methacrylic acid (MAA), 2-acrylamido-2-methylpropane sulfonic acid (AMPS) and itaconic acid (ITA). Free rad…
View article: Preparation, In Vitro Characterization, and Cytotoxicity Evaluation of Polymeric pH-Responsive Hydrogels for Controlled Drug Release
Preparation, In Vitro Characterization, and Cytotoxicity Evaluation of Polymeric pH-Responsive Hydrogels for Controlled Drug Release Open
The aim of the current investigation was based on the development of pH-responsive hydrogels of chondroitin sulfate, carbopol, and polyvinyl alcohol polymerized with acrylic acid in the presence of ammonium persulfate and ethylene glycol d…
View article: Fabrication, characterization and toxicological evaluation of polyethylene glycol/sodium polystyrene sulfonate hydrogels for controlled delivery of Acetaminophen
Fabrication, characterization and toxicological evaluation of polyethylene glycol/sodium polystyrene sulfonate hydrogels for controlled delivery of Acetaminophen Open
Acetaminophen is a white crystalline odorless drug. It decreases the formation of prostaglandins by inhibiting the cyclooxygenase enzyme (COX-3), thus, used in the relieving of pain and fever. The recommended dose of acetaminophen is very …
View article: RETRACTED: Poly (N-vinylcaprolactam-grafted-sodium alginate) Based Injectable pH/Thermo Responsive In Situ Forming Depot Hydrogels for Prolonged Controlled Anticancer Drug Delivery; In Vitro, In Vivo Characterization and Toxicity Evaluation
RETRACTED: Poly (N-vinylcaprolactam-grafted-sodium alginate) Based Injectable pH/Thermo Responsive In Situ Forming Depot Hydrogels for Prolonged Controlled Anticancer Drug Delivery; In Vitro, In Vivo Characterization and Toxicity Evaluation Open
This study was aimed to develop novel in situ forming gels based on N-vinylcaprolactam, sodium alginate, and N,N-methylenebisacrylamide. The in situ Poly (NVRCL-g-NaAlg) gels were developed using the cold and free radical polymerization me…
View article: Development of mucus-penetrating iodine loaded self-emulsifying system for local vaginal delivery
Development of mucus-penetrating iodine loaded self-emulsifying system for local vaginal delivery Open
The major goal of this project was to formulate iodine-based self nano-emulsifying drug delivery system to provide improve antimicrobial activity and enhanced mucosal residence time via mucus penetration. Iodine SNEDDS (Self nano-emulsifyi…