Muhammed Murtaza
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View article: Fragment end motif analysis to distinguish pathogens from contaminants in enriched plasma microbial DNA
Fragment end motif analysis to distinguish pathogens from contaminants in enriched plasma microbial DNA Open
Introduction Despite its promise, accuracy of microbial cell-free DNA (mDNA) in plasma as a diagnostic tool is hindered by its low abundance and process contaminants. We have previously shown that combining size selection with single-stran…
View article: Detection of PIK3CA Mutations in Anal Dysplasia
Detection of PIK3CA Mutations in Anal Dysplasia Open
PIK3CA mutations can be detected in anal tissue samples across the spectrum of carcinogenesis with increasing incidence with higher grade of disease. Our results warrant further evaluation of PIK3CA mutations as a biomarker for identifying…
View article: Spatial Politics and the Construction of Home in As Long as the Lemon Trees Grow
Spatial Politics and the Construction of Home in As Long as the Lemon Trees Grow Open
In the time of conflicts the place we call home, as in where we live, becomes so much more than just that. It is the site of trauma, resilience and hope. The novel As Long As the Lemon Trees Grow by Zoulfa Katouh (2022) is a story of a gir…
View article: Accuracy of Day 1 Procalcitonin and C-Reactive Protein Levels for Predicting Mortality in Burn Patients
Accuracy of Day 1 Procalcitonin and C-Reactive Protein Levels for Predicting Mortality in Burn Patients Open
Objective: Although serum procalcitonin (PCT) and C-reactive protein (CRP) are currently used to predict infection, sepsis, and death in intensive care units, their application in burn mortality has received little attention. Thus, it is e…
View article: Autopsy as a Teaching Methodology In Forensic Medicine: Students’ Perspective
Autopsy as a Teaching Methodology In Forensic Medicine: Students’ Perspective Open
Autopsy as a teaching tool has been historically accepted as a valued method for medical students but its usage has been reduced due to newer technologies being available. Objective: To assess the students opinions’ on autopsy as a learnin…
View article: Efficient nonviral integration of large transgenes into human T cells using Cas9-CLIPT
Efficient nonviral integration of large transgenes into human T cells using Cas9-CLIPT Open
View article: S-block elements: pharmacological properties and potential medical applications of alkali and alkaline earth metals
S-block elements: pharmacological properties and potential medical applications of alkali and alkaline earth metals Open
Background The periodic table contains the s-block elements in groups 1 and 2. In the periodic table, they reside in the first two columns. S-block consists of 14 elements that include hydrogen (H), lithium (Li), helium (He), sodium (Na), …
View article: Multianalyte blood-based risk stratification of incidental pancreas lesions
Multianalyte blood-based risk stratification of incidental pancreas lesions Open
Purpose Incidental detection of pancreas lesions (IPLs) is common and creates an opportunity to intercept pancreatic ductal adenocarcinoma (PDAC). However, identifying patients at risk for progression who can benefit from surgical resectio…
View article: Influence of transformational leadership on innovative work behavior and task performance of individuals: The mediating role of knowledge sharing
Influence of transformational leadership on innovative work behavior and task performance of individuals: The mediating role of knowledge sharing Open
This research tries to investigate the dynamic link between higher education institution (HEIs) transformational leaders (TFL) and follower's outcome innovative work behavior (IWB) and Task Performance) through Knowledge sharing (KNS) in P…
View article: Colon Cancer Survival Among South Asian Americans: A Cross-Sectional Analysis of a National Dataset
Colon Cancer Survival Among South Asian Americans: A Cross-Sectional Analysis of a National Dataset Open
View article: Performance analysis of self compacting concrete by incorporating fly ash, coal gangue powder, cement kiln dust and recycled concrete powder by absolute volume method
Performance analysis of self compacting concrete by incorporating fly ash, coal gangue powder, cement kiln dust and recycled concrete powder by absolute volume method Open
To achieve environmental sustainability and improve material characteristics, this study examines the performance of self-compacting concrete (SCC) that incorporates different industrial by-products, including fly ash (FA), coal gangue pow…
View article: COMPARATIVE STUDY OF BIOCHEMICAL AND ANTIOXIDATIVE STATUS IN PROSTATE CANCER PATIENTS RECEIVING DIFFERENT THERAPIES
COMPARATIVE STUDY OF BIOCHEMICAL AND ANTIOXIDATIVE STATUS IN PROSTATE CANCER PATIENTS RECEIVING DIFFERENT THERAPIES Open
Introduction: The management of prostate cancer involves a spectrum of treatment modalities, ranging from surgery and radiation therapy to hormonal manipulation and chemotherapy. Objectives: The basic aim of the study is to find the compar…
View article: Association of Neighborhood Disadvantage with Short- and Long-Term Outcomes After Pancreatectomy for Pancreatic Ductal Adenocarcinoma
Association of Neighborhood Disadvantage with Short- and Long-Term Outcomes After Pancreatectomy for Pancreatic Ductal Adenocarcinoma Open
View article: Characterization of copy number alterations in Pakistani patients with colorectal cancer
Characterization of copy number alterations in Pakistani patients with colorectal cancer Open
Purpose Incidence and mortality rates of colorectal cancer (CRC) in South Asia are expected to rise by 70% between 2020 and 2040. Despite recent advances in the understanding of molecular alterations in CRC, the representation of South Asi…
View article: Ultrasensitive Circulating Tumor DNA Pilot Study Distinguishes Complete Response and Partial Response With Immunotherapy in Patients With Metastatic Renal Cell Carcinoma
Ultrasensitive Circulating Tumor DNA Pilot Study Distinguishes Complete Response and Partial Response With Immunotherapy in Patients With Metastatic Renal Cell Carcinoma Open
PURPOSE Circulating tumor DNA (ctDNA) has been validated across multiple indications in the adjuvant and surveillance settings. We evaluated whether targeted digital sequencing (TARDIS) may distinguish a partial response (PR) from a comple…
View article: Figure S2 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma
Figure S2 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma Open
Somatic copy number plots derived from exome sequencing of five primary canine pulmonary adenocarcinomas (cPAC) and matched constitutional DNA. Tumor copy number states determined by tCoNutT analysis of tumors and matched constitutional DN…
View article: Figure S6 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma
Figure S6 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma Open
HER2 cellular location and function in primary canine lung cancer. (A) Canine papillary adenocarcinoma with intense, complete, circumferential membrane (white arrow) and lateral cytoplasmic membrane (black arrow) anti-HER2 antibody positiv…
View article: Figure S8 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma
Figure S8 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma Open
Canine primary lung cancer cell line sensitivity to erlotinib. Five canine cell lines (three HER2WT and two HER2V659E) and one human cell line BT474 (HER2amp) were treated with 10 erlotinib doses ranging from 5x10-8 to 50 μM for 72 hours …
View article: Figure S7 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma
Figure S7 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma Open
Canine primary lung cancer cell line sensitivity to lapatinib. Four canine cell lines (three HER2WT and one HER2V659E) were treated with 14 lapatinib doses ranging from 100 μM to 5.5x10-2 nM for 72 hours with CellTiterGlo viability endpoi…
View article: Figure S3 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma
Figure S3 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma Open
Somatic mutation signatures identified by exome sequencing in primary canine lung cancers. (A) The distribution of somatic single nucleotide mutation types in their trinucleotide context from tumor/normal exome sequencing of five cPAC case…
View article: Tables S1 to S13 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma
Tables S1 to S13 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma Open
Supplementary Table 1. Informatic tools utilized in primary canine lung cancer analysis Supplementary Table 2. Extended clinical and multiplatform annotation of primary canine lung cancer cases. Supplementary Table 3 : Sequencing metrics f…
View article: Supplementary Legend from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma
Supplementary Legend from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma Open
Supplementary Legend
View article: Figure S1 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma
Figure S1 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma Open
Extended clinical annotation of primary canine lung cancer patients. Cohort distribution of: (A) Affected breeds, (B) Age at diagnosis, (C) Primary tumor location distribution, (D) Sex, (E) Adenocarcinoma subtype, and (F) Treatment. Yr=yea…
View article: Figure S9 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma
Figure S9 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma Open
Canine primary lung cancer cell line sensitivity to trastuzumab. Five canine cell lines (three HER2WT and two HER2V659E) and one human cell line BT474 (HER2amp) were treated with 10 trastuzumab doses ranging from 1x10-6 μg/ml to 1000 μg/…
View article: Figure S5 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma
Figure S5 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma Open
HER2 expression in primary canine lung cancer based on quantitative real-time PCR analyses. Box plots are shown for HER2 2^(-Î"Î"Ct) expression fold-change relative to the housekeeping gene HPRT (x-axis) in 49 tumors and 14 matched normal …
View article: Figure S2 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma
Figure S2 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma Open
Somatic copy number plots derived from exome sequencing of five primary canine pulmonary adenocarcinomas (cPAC) and matched constitutional DNA. Tumor copy number states determined by tCoNutT analysis of tumors and matched constitutional DN…
View article: Data from Harmonizing Cell-Free DNA Collection and Processing Practices through Evidence-Based Guidance
Data from Harmonizing Cell-Free DNA Collection and Processing Practices through Evidence-Based Guidance Open
Circulating cell-free DNA (cfDNA) is rapidly transitioning from discovery research to an important tool in clinical decision making. However, the lack of harmonization of preanalytic practices across institutions may compromise the reprodu…
View article: Figure S4 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma
Figure S4 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma Open
Comparison of HER2 mutant allele fractions measured using droplet digital PCR and targeted sequencing in tumor tissue. HER2V659E was evaluated by ddPCR in tumor DNA samples in which these mutations were also detected using amplicon sequenc…
View article: Figure S9 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma
Figure S9 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma Open
Canine primary lung cancer cell line sensitivity to trastuzumab. Five canine cell lines (three HER2WT and two HER2V659E) and one human cell line BT474 (HER2amp) were treated with 10 trastuzumab doses ranging from 1x10-6 μg/ml to 1000 μg/…
View article: Figure S8 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma
Figure S8 from Identification of Recurrent Activating <i>HER2</i> Mutations in Primary Canine Pulmonary Adenocarcinoma Open
Canine primary lung cancer cell line sensitivity to erlotinib. Five canine cell lines (three HER2WT and two HER2V659E) and one human cell line BT474 (HER2amp) were treated with 10 erlotinib doses ranging from 5x10-8 to 50 μM for 72 hours …