Mu‐Hong Chen
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View article: Role of the retinoid X receptor–peroxisome proliferator-activated receptor-γ axis in adolescent attention-deficit hyperactivity disorder
Role of the retinoid X receptor–peroxisome proliferator-activated receptor-γ axis in adolescent attention-deficit hyperactivity disorder Open
Background Studies have reported the retinoid X receptor (RXR)–peroxisome proliferator-activated receptor-γ (PPAR-γ) axis, a heterodimeric nuclear receptor complex regulating synaptic plasticity and neuroinflammation, in neurodevelopment, …
View article: Catatonia and elevated mortality: A population‐wide cohort study with healthy, sibling, and schizophrenia spectrum controls
Catatonia and elevated mortality: A population‐wide cohort study with healthy, sibling, and schizophrenia spectrum controls Open
Aim To determine whether catatonia is associated with increased long‐term all‐cause and cause‐specific mortality. Methods Using Taiwan's National Health Insurance Database (2000–2022), we assembled a population‐based cohort of all adults (…
View article: Risk of Stroke in Patients With Schizophrenia, Bipolar Disorder, and Major Depressive Disorder: A Cohort Study of 183,504 Subjects
Risk of Stroke in Patients With Schizophrenia, Bipolar Disorder, and Major Depressive Disorder: A Cohort Study of 183,504 Subjects Open
Background Major psychiatric disorder, including schizophrenia, bipolar disorder, and major depressive disorder, has been individually associated with increased risk of stroke. However, few studies have directly compared the stroke risk ac…
View article: Drug-centered or drug-assisted? Epistemic perspectives and methodological tensions in psychedelic psychotherapy
Drug-centered or drug-assisted? Epistemic perspectives and methodological tensions in psychedelic psychotherapy Open
This paper distinguishes the drug-centered view of psychedelics (DCP) and the drug-assisted view of psychedelics (DAP). While these approaches differ conceptually, both rely on the methodology of evidence-based medicine, using randomized c…
View article: Anterior cingulate cortex–related functional dysconnectivity in adolescents with major depressive disorder with and without severe loneliness
Anterior cingulate cortex–related functional dysconnectivity in adolescents with major depressive disorder with and without severe loneliness Open
Aberrant FCs between the left dACC and left PCC as well as the left ventroanterior ACC were specific to loneliness among adolescents with MDD, with functional dysconnectivity between the left dACC and right precuneus being common to depres…
View article: Predicting 5-Year Survival and Mortality in Dementia Patients: A Data-Driven Approach Using XGBoost for Enhanced Care and Resource Allocation
Predicting 5-Year Survival and Mortality in Dementia Patients: A Data-Driven Approach Using XGBoost for Enhanced Care and Resource Allocation Open
Objective This study develops an eXtreme Gradient Boosting (XGBoost) regression model to identify key predictors of mortality and 5-year survival in dementia patients, highlighting the role of comorbidities. The findings highlight key risk…
View article: Illicit substance exposure in pregnancy and infant mortality risk: a nationwide Taiwan study
Illicit substance exposure in pregnancy and infant mortality risk: a nationwide Taiwan study Open
Background To investigate the association between prenatal illicit substance exposure and infant mortality, addressing the unclear links between specific and multiple substances and increased mortality. Methods This 16-year retrospective c…
View article: Bidirectional association between bullous pemphigoid and Parkinson’s disease: A nationwide population-based study
Bidirectional association between bullous pemphigoid and Parkinson’s disease: A nationwide population-based study Open
Background: Bullous pemphigoid (BP) has long been associated with Parkinson’s disease (PD). However, most of the existing evidence has been obtained from cross-sectional or case–control studies. Objectives: In this study, we aimed to inves…
View article: All‐Cause Mortality and Suicide Mortality in Patients With Tic Disorder: An Entire Population Longitudinal Study in Taiwan
All‐Cause Mortality and Suicide Mortality in Patients With Tic Disorder: An Entire Population Longitudinal Study in Taiwan Open
Background Few studies investigate cause‐specific mortality in individuals with tic disorders. We aimed to examine all‐cause, natural‐cause, and unnatural‐cause mortality in individuals with tic disorders. Methods Using the nationwide data…
View article: Gene clusters linked to insulin resistance identified in a genome-wide study of the Taiwan Biobank population
Gene clusters linked to insulin resistance identified in a genome-wide study of the Taiwan Biobank population Open
This pioneering genome-wide association study examined surrogate markers for insulin resistance (IR) in 147,880 Taiwanese individuals using data from the Taiwan Biobank. The study focused on two IR surrogate markers: the triglyceride to hi…
View article: Distinct effects of psychiatric disorder diagnoses and severe emotional dysregulation on matrix metalloproteinase-9, proinflammatory cytokines, and inhibitory control function in adolescents with attention-deficit hyperactivity disorder or first-episode major affective disorders
Distinct effects of psychiatric disorder diagnoses and severe emotional dysregulation on matrix metalloproteinase-9, proinflammatory cytokines, and inhibitory control function in adolescents with attention-deficit hyperactivity disorder or first-episode major affective disorders Open
Background Severe emotional dysregulation (SED) may represent an endophenotype of attention-deficit hyperactivity disorder (ADHD) and major affective disorders. However, the specific effects of SED and related psychiatric disorders, includ…
View article: Triple-network model–based graph theory analysis of the effectiveness of low-dose ketamine in patients with treatment-resistant depression: two resting-state functional MRI clinical trials
Triple-network model–based graph theory analysis of the effectiveness of low-dose ketamine in patients with treatment-resistant depression: two resting-state functional MRI clinical trials Open
Background Evidence suggests the crucial role of dysfunctional default mode (DMN), salience and frontoparietal (FPN) networks, collectively termed the triple network model, in the pathophysiology of treatment-resistant depression (TRD). Ai…
View article: Social and obstetric risk factors of antenatal depression: A cross-sectional study in China
Social and obstetric risk factors of antenatal depression: A cross-sectional study in China Open
BACKGROUND Antenatal depression is a disabling mental disorder among pregnant women and may cause adverse outcomes for both the mother and the offspring. Early identification and intervention of antenatal depression can help to prevent adv…
View article: ASSOCIATION OF NEUROFILAMENT LIGHT CHAIN WITH THE ANTIDEPRESSANT EFFECTS OF LOW-DOSE KETAMINE INFUSION AMONG PATIENTS WITH TREATMENT-RESISTANT DEPRESSION
ASSOCIATION OF NEUROFILAMENT LIGHT CHAIN WITH THE ANTIDEPRESSANT EFFECTS OF LOW-DOSE KETAMINE INFUSION AMONG PATIENTS WITH TREATMENT-RESISTANT DEPRESSION Open
Background The role of neurofilament light chain (NFL) in treatment-resistant depression (TRD) is unclear. Whether baseline NFL concentrations are associated with the antidepressant effects of low- dose ketamine infusion has not been deter…
View article: ROLE OF KLOTHO ON ANTIDEPRESSANT AND ANTISUICIDAL EFFECTS OF LOW-DOSE KETAMINE INFUSION AMONG PATIENTS WITH TREATMENT-RESISTANT DEPRESSION AND SUICIDAL IDEATION
ROLE OF KLOTHO ON ANTIDEPRESSANT AND ANTISUICIDAL EFFECTS OF LOW-DOSE KETAMINE INFUSION AMONG PATIENTS WITH TREATMENT-RESISTANT DEPRESSION AND SUICIDAL IDEATION Open
Objective Previous studies have found an association between klotho, an anti-aging hormone, and major depressive disorder. However, whether low-dose ketamine infusion alters klotho levels among patients with treatment-resistant depression …
View article: RISK OF DEMENTIA IN CANCER SURVIVORS: A NATIONWIDE COHORT STUDY
RISK OF DEMENTIA IN CANCER SURVIVORS: A NATIONWIDE COHORT STUDY Open
Background Several observational studies have identified a positive association between cancer survivors and subsequent dementia whereas others have negative or no association. Aims & Objectives This study aimed to determine the associatio…
View article: MODULATION OF THE ANTIDEPRESSANT RESPONSE OF KETAMINE BY AN IMMUNOSUPPRESSANT RAPAMYCIN: A PROSPECTIVE RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED STUDY IN THE PATIENTS WITH REFRACTORY DEPRESSION
MODULATION OF THE ANTIDEPRESSANT RESPONSE OF KETAMINE BY AN IMMUNOSUPPRESSANT RAPAMYCIN: A PROSPECTIVE RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED STUDY IN THE PATIENTS WITH REFRACTORY DEPRESSION Open
Background Our ketamine studies on the refractory depression (TRD) in the past 10 years have observed a short effect of a single dose of ketamine infusion lasting less than14 days. The antidepressant effect of ketamine was believed to acti…
View article: Panic disorder and suicide
Panic disorder and suicide Open
Background Panic disorder (PD) may increase the likelihood of suicidal ideation and behaviors because of psychiatric comorbidities such as major depressive disorder (MDD). However, research has yet to demonstrate a direct relationship betw…
View article: Increased risk of suicide among patients with social anxiety disorder
Increased risk of suicide among patients with social anxiety disorder Open
Aims Increasing evidence has established a strong association between social anxiety disorder and suicidal behaviours, including suicidal ideation and suicide attempts. However, the association between social anxiety disorder and suicide m…
View article: Associations between subjective sleep quality and inflammatory markers in patients with treatment-resistant depression
Associations between subjective sleep quality and inflammatory markers in patients with treatment-resistant depression Open
Background Sleep disturbances are prevalent in major depressive disorder (MDD). Emerging evidence suggests a bidirectional relationship between inflammation and sleep disturbances, but the role of peripheral inflammatory markers in subject…
View article: Mined Block Withholding and Imposed Fork by Using Mining Pool Alliance Strategic—A Case Study in Bitcoin System
Mined Block Withholding and Imposed Fork by Using Mining Pool Alliance Strategic—A Case Study in Bitcoin System Open
In the proof-of-work (PoW) blockchain consensus mechanism, miners perform numerous hash calculations to obtain a value below the difficulty threshold to generate a new block and obtain rewards. As the difficulty of mining increases, pools …
View article: Risk of subsequent Parkinson's disease among patients with bipolar disorder or major depression: A nationwide longitudinal study in Taiwan
Risk of subsequent Parkinson's disease among patients with bipolar disorder or major depression: A nationwide longitudinal study in Taiwan Open
Aim Bipolar disorder (BD) and major depression have been associated with an increased risk of developing Parkinson's disease (PD); however, few studies have directly compared the risk of PD development between patients with BD and major de…
View article: Thalamocortical Dysconnectivity in Treatment‐Resistant Depression
Thalamocortical Dysconnectivity in Treatment‐Resistant Depression Open
Thalamocortical connectivity is associated with cognitive and affective processing. The role of thalamocortical connectivity in the pathomechanism of treatment‐resistant depression (TRD) remains unclear. This study included 48 patients wit…
View article: Distinct Effects of Major Affective Disorder Diagnoses and Suicidal Symptom Severity on Inhibitory Control Function and Proinflammatory Cytokines: Single-Site Analysis of 800 Adolescents and Adults
Distinct Effects of Major Affective Disorder Diagnoses and Suicidal Symptom Severity on Inhibitory Control Function and Proinflammatory Cytokines: Single-Site Analysis of 800 Adolescents and Adults Open
Background Inhibitory control function and proinflammatory cytokines play a role in the pathomechanisms underlying major affective disorders and suicidal behavior. However, the distinct or interactive effects of major affective disorders a…
View article: The association between diverse psychological protocols and the efficacy of psilocybin-assisted therapy for clinical depressive symptoms: a Bayesian meta-analysis
The association between diverse psychological protocols and the efficacy of psilocybin-assisted therapy for clinical depressive symptoms: a Bayesian meta-analysis Open
Objective Psilocybin-assisted therapy has shown promising efficacy on clinical depressive symptoms. However, diverse psychological support or psychotherapy was performed with psilocybin treatment. This study aimed to explore the associatio…